Details of the Target

General Information of Target

Target ID LDTP13365
Target Name Plexin-A1 (PLXNA1)
Gene Name PLXNA1
Gene ID 5361
Synonyms
NOV; PLXN1; Plexin-A1; Semaphorin receptor NOV
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDGGAERDRGPARRAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRES
GADSDGQPGPGEADHCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEME
FQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDLEKRASSSASEAFATS
NILRLLEQGRLLSVPRAPSLLALTPSLPGLPASHRGTSLGDPRNSSPRLNPLSSASASPP
LPPPLPAVCFSSAPLLDLPAGYELGSSAFEPYSWLERKVGSASSCKKANT
Target Bioclass
Other
Family
Plexin family
Subcellular location
Cell membrane
Function
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Uniprot ID
Q9UIW2
Ensemble ID
ENST00000393409.3
HGNC ID
HGNC:9099

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K868(1.37); K1084(2.49)  LDD3494  [1]
DBIA
 Probe Info  		C104(0.89); C95(0.89)  LDD0078  [2]
N1
 Probe Info  		H153(0.00); H154(0.00)  LDD0245  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C104(1.34); C95(1.34)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C104(1.59); C95(1.59)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C104(0.75); C95(0.75)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C104(0.81); C95(0.81)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C104(0.94); C95(0.94)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C104(0.98); C95(0.98)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C104(0.92); C95(0.92)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C104(0.82); C95(0.82)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C104(0.87); C95(0.87)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C104(0.92); C95(0.92)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C104(0.71); C95(0.71)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C104(0.71); C95(0.71)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C104(1.42); C95(1.42)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C104(0.94); C95(0.94)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C104(0.77); C95(0.77)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C104(0.80); C95(0.80)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C104(1.03); C95(1.03)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C104(1.24); C95(1.24)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C104(1.43); C95(1.43)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C104(1.65); C95(1.65)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C104(1.26); C95(1.26)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C104(1.11); C95(1.11)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C104(1.21); C95(1.21)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C104(1.63); C95(1.63)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C104(1.15); C95(1.15)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C104(1.16); C95(1.16)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C104(1.20); C95(1.20)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C104(1.13); C95(1.13)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C104(1.23); C95(1.23)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C104(1.19); C95(1.19)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C104(1.45); C95(1.45)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C104(1.26); C95(1.26)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C104(1.18); C95(1.18)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C104(1.01); C95(1.01)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C104(1.07); C95(1.07)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C104(1.03); C95(1.03)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C104(0.96); C95(0.96)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C104(1.14); C95(1.14)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C104(1.14); C95(1.14)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C104(1.04); C95(1.04)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C104(1.05); C95(1.05)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C104(1.10); C95(1.10)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C104(1.07); C95(1.07)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C104(1.29); C95(1.29)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C104(1.43); C95(1.43)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C104(1.17); C95(1.17)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C104(1.06); C95(1.06)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C104(0.94); C95(0.94)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C104(0.98); C95(0.98)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C104(1.19); C95(1.19)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C104(1.20); C95(1.20)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C104(1.07); C95(1.07)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C104(1.19); C95(1.19)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C104(1.62); C95(1.62)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C104(1.17); C95(1.17)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C104(1.15); C95(1.15)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C104(1.23); C95(1.23)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C104(1.04); C95(1.04)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C104(1.45); C95(1.45)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C104(1.78); C95(1.78)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C104(1.36); C95(1.36)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C104(1.20); C95(1.20)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C104(1.06); C95(1.06)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C104(1.11); C95(1.11)  LDD2161  [2]
 LDCM0276  AC17 PaTu 8988t C104(1.40); C95(1.40)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C104(1.67); C95(1.67)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C104(1.45); C95(1.45)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C104(1.33); C95(1.33)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C104(1.47); C95(1.47)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C104(1.66); C95(1.66)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C104(1.57); C95(1.57)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C104(1.96); C95(1.96)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C104(1.16); C95(1.16)  LDD1163  [2]
 LDCM0285  AC25 HEK-293T C104(0.68); C95(0.68)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C104(0.73); C95(0.73)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C104(0.74); C95(0.74)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C104(0.99); C95(0.99)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C104(0.76); C95(0.76)  LDD0887  [2]
 LDCM0290  AC3 PaTu 8988t C104(1.30); C95(1.30)  LDD1169  [2]
 LDCM0291  AC30 HEK-293T C104(0.85); C95(0.85)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C104(0.78); C95(0.78)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C104(0.77); C95(0.77)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C104(0.82); C95(0.82)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C104(1.12); C95(1.12)  LDD0893  [2]
 LDCM0296  AC35 PaTu 8988t C104(1.00); C95(1.00)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C104(1.28); C95(1.28)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C104(1.14); C95(1.14)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C104(1.46); C95(1.46)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C104(1.34); C95(1.34)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C104(1.12); C95(1.12)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C104(1.50); C95(1.50)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C104(1.48); C95(1.48)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C104(1.35); C95(1.35)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C104(1.31); C95(1.31)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C104(1.70); C95(1.70)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C104(1.42); C95(1.42)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C104(1.04); C95(1.04)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C104(1.09); C95(1.09)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C104(1.31); C95(1.31)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C104(1.21); C95(1.21)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C104(1.42); C95(1.42)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C104(1.23); C95(1.23)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C104(1.15); C95(1.15)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C104(1.21); C95(1.21)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C104(1.35); C95(1.35)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C104(1.56); C95(1.56)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C104(1.10); C95(1.10)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C104(1.14); C95(1.14)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C1744(0.97); C1525(0.93); C816(1.17)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C1744(1.05); C1525(1.10)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C1744(1.00); C1525(1.15); C1013(0.94); C286(1.03)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C104(1.21); C95(1.21)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C1744(1.07); C1525(1.19); C1013(0.92)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C1744(1.03); C1525(1.07); C302(0.74)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C1744(1.04); C1525(1.11); C1507(0.89); C944(1.08)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C1744(1.11); C1525(1.01); C816(0.96)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C1744(1.10); C1525(0.97); C1013(0.87); C944(1.18)  LDD1567  [6]
 LDCM0332  AC68 PaTu 8988t C104(1.09); C95(1.09)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C104(1.08); C95(1.08)  LDD1212  [2]
 LDCM0334  AC7 HEK-293T C104(1.37); C95(1.37)  LDD0932  [2]
 LDCM0335  AC70 PaTu 8988t C104(1.17); C95(1.17)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C104(1.09); C95(1.09)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C104(0.96); C95(0.96)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C104(1.26); C95(1.26)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C104(1.02); C95(1.02)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C104(1.09); C95(1.09)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C104(1.21); C95(1.21)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C104(1.22); C95(1.22)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C104(1.25); C95(1.25)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C104(1.17); C95(1.17)  LDD1223  [2]
 LDCM0345  AC8 HEK-293T C104(0.79); C95(0.79)  LDD0943  [2]
 LDCM0346  AC80 PaTu 8988t C104(1.25); C95(1.25)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C104(1.14); C95(1.14)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C104(1.31); C95(1.31)  LDD1227  [2]
 LDCM0365  AC98 HCT 116 C104(0.68); C95(0.68)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C104(0.67); C95(0.67)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C104(1.18); C95(1.18)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C104(1.27); C95(1.27)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C104(1.44); C95(1.44)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C104(0.89); C95(0.89)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C1744(1.26); C1525(0.98); C816(1.02); C104(0.98)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C1744(1.80); C1525(1.02); C1507(0.36); C944(1.05)  LDD1572  [6]
 LDCM0369  CL100 PaTu 8988t C104(1.21); C95(1.21)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C104(1.34); C95(1.34)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C104(1.21); C95(1.21)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C104(0.88); C95(0.88)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C104(1.06); C95(1.06)  LDD0971  [2]
 LDCM0374  CL105 PaTu 8988t C104(2.30); C95(2.30)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C104(1.81); C95(1.81)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C104(1.65); C95(1.65)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C104(2.06); C95(2.06)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C104(1.79); C95(1.79)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C1744(1.24); C1525(1.02); C816(1.10)  LDD1583  [6]
 LDCM0380  CL110 PaTu 8988t C104(2.37); C95(2.37)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C104(2.13); C95(2.13)  LDD1260  [2]
 LDCM0382  CL112 HEK-293T C104(0.79); C95(0.79)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C104(0.79); C95(0.79)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C104(0.74); C95(0.74)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C104(0.72); C95(0.72)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C104(0.74); C95(0.74)  LDD0984  [2]
 LDCM0387  CL117 PaTu 8988t C104(1.59); C95(1.59)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C104(1.60); C95(1.60)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C104(1.33); C95(1.33)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C1744(1.16); C1525(1.06); C1013(0.85); C944(1.11)  LDD1594  [6]
 LDCM0391  CL120 PaTu 8988t C104(1.35); C95(1.35)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C104(1.59); C95(1.59)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C104(1.55); C95(1.55)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C104(2.05); C95(2.05)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C104(1.62); C95(1.62)  LDD1274  [2]
 LDCM0396  CL125 HEK-293T C1744(1.06); C1525(0.92); C816(1.00); C104(0.97)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C1744(1.07); C1525(0.94); C1013(1.15); C816(1.13)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C1744(1.12); C1525(0.99)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C1744(1.00); C1525(0.99); C302(0.97); C1013(0.88)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C1744(1.03); C1525(1.06); C816(0.96); C104(1.02)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C1744(0.98); C1525(1.10); C1013(1.47); C816(1.00)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C1744(1.36); C1525(1.03)  LDD1606  [6]
 LDCM0403  CL16 PaTu 8988t C104(1.37); C95(1.37)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C104(1.14); C95(1.14)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C104(1.28); C95(1.28)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C104(1.02); C95(1.02)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C1744(0.95); C1525(0.92); C1013(1.34); C816(1.02)  LDD1611  [6]
 LDCM0408  CL20 PaTu 8988t C104(0.92); C95(0.92)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C104(1.29); C95(1.29)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C104(1.25); C95(1.25)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C104(0.88); C95(0.88)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C104(1.10); C95(1.10)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C104(1.26); C95(1.26)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C104(0.98); C95(0.98)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C104(1.17); C95(1.17)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C104(1.32); C95(1.32)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C104(0.93); C95(0.93)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C1744(1.12); C1525(0.89)  LDD1622  [6]
 LDCM0419  CL30 PaTu 8988t C104(1.04); C95(1.04)  LDD1298  [2]
 LDCM0420  CL31 HEK-293T C1744(1.09); C1525(1.10); C1013(0.82); C286(1.40)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C1744(1.05); C1525(1.07); C1013(1.02)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C1744(1.94); C1525(1.14); C302(1.28)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C1744(1.21); C1525(1.12); C1507(0.30); C944(1.07)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C1744(1.08); C1525(0.91); C816(1.15)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C1744(1.14); C1525(0.95); C1013(0.65); C944(1.19)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C1744(1.04); C1525(1.03); C816(0.93); C104(0.97)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C1744(1.09); C1525(0.93)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C1744(1.11); C1525(1.00); C302(1.08); C1013(1.01)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C1744(1.01); C1525(0.97); C302(0.92); C1013(0.85)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C1744(1.28); C1525(1.03); C816(1.25)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C1744(1.06); C1525(1.10)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C1744(1.01); C1525(1.10); C1013(0.66); C286(1.32)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C1744(1.07); C1525(1.03); C1013(0.90)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C1744(1.34); C1525(1.11); C302(0.97)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C1744(1.15); C1525(1.16); C1507(0.24); C944(1.04)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C1744(1.15); C1525(0.92); C816(1.00)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C1744(1.16); C1525(0.98); C1013(0.70); C944(1.08)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C1744(1.10); C1525(0.90); C816(0.96); C104(0.93)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C1744(0.95); C1525(0.80); C816(1.05)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C1744(1.10); C1525(0.83); C1013(1.82); C816(1.02)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C1744(1.03); C1525(0.96); C302(1.04); C1013(1.07)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C1744(1.36); C1525(0.99); C816(1.07)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C1744(1.55); C1525(1.11)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C1744(1.00); C1525(1.15); C1013(0.94); C286(1.21)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C1744(1.09); C1525(0.91); C1013(1.15)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C1744(1.33); C1525(1.22); C302(0.82)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C1744(1.19); C1525(0.89); C1507(0.30); C944(1.18)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C1744(1.14); C1525(0.95); C816(1.00)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C1744(1.35); C1525(1.15)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C1744(1.15); C1525(1.02); C1013(0.87); C944(1.18)  LDD1655  [6]
 LDCM0453  CL61 HCT 116 C104(1.09); C95(1.09)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C104(0.97); C95(0.97)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C104(1.13); C95(1.13)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C104(1.37); C95(1.37)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C104(1.02); C95(1.02)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C104(1.41); C95(1.41)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C104(1.12); C95(1.12)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C104(1.48); C95(1.48)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C104(1.46); C95(1.46)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C1744(1.04); C1525(1.14); C1013(1.08); C286(1.33)  LDD1665  [6]
 LDCM0463  CL70 HCT 116 C104(0.97); C95(0.97)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C104(1.11); C95(1.11)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C104(1.20); C95(1.20)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C104(1.11); C95(1.11)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C104(1.02); C95(1.02)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C1744(1.01); C1525(0.87); C302(1.00); C1013(0.72)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C1744(1.31); C1525(1.02); C816(1.44)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C1744(1.01); C1525(1.04)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C1744(1.04); C1525(1.11); C1013(0.87); C286(1.13)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C1744(2.18); C1525(1.14); C1013(0.94)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C1744(1.03); C1525(1.03); C1013(1.11)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C1744(1.01); C1525(0.98); C302(1.12)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C1744(1.08); C1525(1.02); C1507(0.35); C944(1.12)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C1744(1.21); C1525(0.95); C816(1.11)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C1744(1.36); C1525(1.15); C1013(0.76); C944(1.07)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C1744(1.12); C1525(0.88); C816(0.88); C104(0.91)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C1744(1.01); C1525(0.88); C1013(1.95); C816(0.99)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C1744(1.15); C1525(0.95)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C1744(1.00); C1525(1.06); C302(1.00); C1013(0.78)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C1744(1.00); C1525(1.07); C816(1.00)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C1744(1.09); C1525(0.91); C302(0.74)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C1744(2.08); C1525(1.03)  LDD1688  [6]
 LDCM0486  CL91 PaTu 8988t C104(1.73); C95(1.73)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C104(1.61); C95(1.61)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C104(1.60); C95(1.60)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C104(1.88); C95(1.88)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C104(1.65); C95(1.65)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C104(1.63); C95(1.63)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C104(1.90); C95(1.90)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C104(1.73); C95(1.73)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C104(1.50); C95(1.50)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C1744(1.17); C1525(0.78)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C104(1.53); C95(1.53)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C1744(1.02); C1525(0.83); C1013(1.48); C816(1.08)  LDD1631  [6]
 LDCM0022  KB02 HCT 116 C95(4.19); C104(4.19)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C95(1.67); C104(1.67)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C95(3.11); C104(3.11)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C104(1.06); C95(1.06)  LDD2173  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402