Details of the Target

General Information of Target

Target ID LDTP13246
Target Name Sushi domain-containing protein 2 (SUSD2)
Gene Name SUSD2
Gene ID 56241
Synonyms
Sushi domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYM
EGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALF
RKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPL
DSSRTLPSTDSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP
LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMEETNSQDHRPPSGAQKPAPSPEPCMPNTALLIKNPLAATHE
FKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPRPTKTSFVG
SYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIA
KLLKEHQGIFTFLCEICFDSKPRIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSL
KYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMTHEDIVQES
KKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKA
RHCWTKERRVLLVMSKAKRKWVSVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHS
PEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMM
GYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKA
CPDGDKCRCAHGQEELNEWLDRREVLKQKLAKARKDMLLCPRDDDFGKYNFLLQEDGDLA
GATPEAPAAAATATTGE
Target Bioclass
Other
Subcellular location
Cell membrane
Function
May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.
Uniprot ID
Q9UGT4
Ensemble ID
ENST00000358321.4
HGNC ID
HGNC:30667

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C683(1.44); C689(1.44)  LDD0531  [1]
5E-2FA
 Probe Info  		H106(0.00); H223(0.00)  LDD2235  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C683(1.44); C689(1.44)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C683(1.96); C689(1.96)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C683(1.36); C689(1.36)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C683(1.03); C689(1.03)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C683(1.66); C689(1.66)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C683(1.92); C689(1.92)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C683(1.24); C689(1.24)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C683(1.14); C689(1.14)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C683(1.14); C689(1.14)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C683(1.74); C689(1.74)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C683(0.86); C689(0.86)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C683(0.92); C689(0.92)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C683(0.86); C689(0.86)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C683(1.05); C689(1.05)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C683(1.14); C689(1.14)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C683(1.21); C689(1.21)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C683(2.08); C689(2.08)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C683(1.19); C689(1.19)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C683(1.71); C689(1.71)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C683(1.48); C689(1.48)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C683(2.25); C689(2.25)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C683(1.18); C689(1.18)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C683(1.21); C689(1.21)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C683(1.17); C689(1.17)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C683(1.16); C689(1.16)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C683(1.16); C689(1.16)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C683(0.92); C689(0.92)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C683(1.28); C689(1.28)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C683(1.07); C689(1.07)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C683(1.29); C689(1.29)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C683(1.08); C689(1.08)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C683(1.94); C689(1.94)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C683(1.08); C689(1.08)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C683(1.15); C689(1.15)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C683(0.90); C689(0.90)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C683(1.12); C689(1.12)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C683(1.03); C689(1.03)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C683(1.08); C689(1.08)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C683(1.04); C689(1.04)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C683(0.82); C689(0.82)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C683(0.98); C689(0.98)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C683(0.91); C689(0.91)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C683(1.88); C689(1.88)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C683(1.08); C689(1.08)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C683(1.14); C689(1.14)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C683(0.97); C689(0.97)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C683(0.80); C689(0.80)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C683(0.97); C689(0.97)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C683(1.09); C689(1.09)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C683(0.91); C689(0.91)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C683(0.84); C689(0.84)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C683(0.90); C689(0.90)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C683(1.10); C689(1.10)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C683(1.19); C689(1.19)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C683(0.77); C689(0.77)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C683(1.60); C689(1.60)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C683(0.84); C689(0.84)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C683(1.28); C689(1.28)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C683(1.76); C689(1.76)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C683(1.48); C689(1.48)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C683(1.28); C689(1.28)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C683(1.01); C689(1.01)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C683(1.59); C689(1.59)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C683(1.40); C689(1.40)  LDD0662  [1]
 LDCM0248  AKOS034007472 HCT 116 C683(1.16); C689(1.16)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C683(1.45); C689(1.45)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C683(1.31); C689(1.31)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C683(1.06); C689(1.06)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C683(1.31); C689(1.31)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C683(1.25); C689(1.25)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C683(1.58); C689(1.58)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C683(2.07); C689(2.07)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C683(1.13); C689(1.13)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C683(1.51); C689(1.51)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C683(2.39); C689(2.39)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C683(1.26); C689(1.26)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C683(1.21); C689(1.21)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C683(0.82); C689(0.82)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C683(1.41); C689(1.41)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C683(1.35); C689(1.35)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C683(0.75); C689(0.75)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C683(1.55); C689(1.55)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C683(1.73); C689(1.73)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C683(2.01); C689(2.01)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C683(1.09); C689(1.09)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C683(1.89); C689(1.89)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C683(3.04); C689(3.04)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C683(0.98); C689(0.98)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C683(1.04); C689(1.04)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C683(0.92); C689(0.92)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C683(1.34); C689(1.34)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C683(1.05); C689(1.05)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C683(1.08); C689(1.08)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C683(2.91); C689(2.91)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C683(1.00); C689(1.00)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C683(1.17); C689(1.17)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C683(1.16); C689(1.16)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C683(1.74); C689(1.74)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C683(1.26); C689(1.26)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C683(1.43); C689(1.43)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C683(1.06); C689(1.06)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C683(0.96); C689(0.96)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C683(1.15); C689(1.15)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C683(1.35); C689(1.35)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C683(1.56); C689(1.56)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C683(1.73); C689(1.73)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C683(1.42); C689(1.42)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C683(1.31); C689(1.31)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C683(1.13); C689(1.13)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C683(1.42); C689(1.42)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C683(1.40); C689(1.40)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C683(1.37); C689(1.37)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C683(1.23); C689(1.23)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C683(1.42); C689(1.42)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C683(1.58); C689(1.58)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C683(1.31); C689(1.31)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C683(2.13); C689(2.13)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C683(1.78); C689(1.78)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C683(1.26); C689(1.26)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C683(1.35); C689(1.35)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C683(1.57); C689(1.57)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C683(1.26); C689(1.26)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C683(1.53); C689(1.53)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C683(2.71); C689(2.71)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C683(1.27); C689(1.27)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C683(0.89); C689(0.89)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C683(1.66); C689(1.66)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C683(1.11); C689(1.11)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C683(1.29); C689(1.29)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C683(1.17); C689(1.17)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C683(1.62); C689(1.62)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C683(1.14); C689(1.14)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C683(1.14); C689(1.14)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C683(0.89); C689(0.89)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C683(1.40); C689(1.40)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C683(1.68); C689(1.68)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C683(0.83); C689(0.83)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C683(1.23); C689(1.23)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C683(0.95); C689(1.08)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C683(1.24); C689(1.19)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C683(0.87); C689(0.92)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C683(1.32); C689(1.30)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C683(0.88); C689(0.94)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C683(1.01); C689(0.95)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C683(0.88); C689(0.94)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C683(0.88); C689(1.00)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C683(1.05); C689(1.08)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C683(0.94); C689(0.94)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C683(0.89); C689(0.96)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C683(1.25); C689(1.27)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C683(0.84); C689(0.99)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C683(0.88); C689(0.92)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C683(0.89); C689(0.93)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C683(0.62); C689(0.62)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C683(0.74); C689(0.74)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C683(0.56); C689(0.56)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C683(0.70); C689(0.70)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C683(0.83); C689(0.83)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C683(0.73); C689(0.73)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C683(0.68); C689(0.68)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C683(0.86); C689(0.86)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C683(0.77); C689(0.77)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C683(0.66); C689(0.66)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C683(0.56); C689(0.56)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C683(0.58); C689(0.58)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C683(0.84); C689(0.84)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C683(0.75); C689(0.75)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C683(0.74); C689(0.74)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C683(0.97); C689(0.97)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C683(1.11); C689(1.11)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C683(1.29); C689(1.29)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C683(1.68); C689(1.68)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C683(1.47); C689(1.47)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C683(1.32); C689(1.32)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C683(1.34); C689(1.34)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C683(1.50); C689(1.50)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C683(2.19); C689(2.19)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C683(1.72); C689(1.72)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C683(1.73); C689(1.73)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C683(0.99); C689(1.03)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C683(1.05); C689(1.05)  LDD0744  [1]
 LDCM0022  KB02 AU565 C725(3.64); C438(2.87)  LDD2265  [3]
 LDCM0023  KB03 AU565 C725(6.09); C438(3.40)  LDD2682  [3]
 LDCM0024  KB05 IGR37 C95(1.70)  LDD3314  [3]
 LDCM0021  THZ1 HCT 116 C683(1.06); C689(1.06)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840