Details of the Target

General Information of Target

Target ID LDTP13120
Target Name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)
Gene Name GNG12
Gene ID 55970
Synonyms
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPERGGVGTGADVPQSWPSCLCHGLIS
FLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLR
TRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLK
RPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQ
QLALHFLGGSMNSMAGGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTALQP
FLSEALVSQVGACYQFNVVLPSGTQSAYFLDLTTGRGRVGHGVPDGIPDVVVEMAEADLR
ALLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLRALK
Target Bioclass
Other
Family
G protein gamma family
Subcellular location
Cell membrane
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot ID
Q9UBI6
Ensemble ID
ENST00000370982.4
HGNC ID
HGNC:19663

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.48  LDD0402  [1]
AZ-9
 Probe Info  		E45(0.90); E28(1.07)  LDD2208  [2]
OPA-S-S-alkyne
 Probe Info  		K34(2.84)  LDD3494  [3]
DBIA
 Probe Info  		C43(1.32)  LDD3311  [4]
BTD
 Probe Info  		C43(1.11)  LDD2092  [5]
IPM
 Probe Info  		C43(4.46)  LDD1701  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
ATP probe
 Probe Info  		K64(0.00); K66(0.00)  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NHS
 Probe Info  		K64(0.00); K4(0.00)  LDD0010  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C43(0.55)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C43(0.64)  LDD2112  [5]
 LDCM0214  AC1 PaTu 8988t C43(0.43)  LDD1093  [14]
 LDCM0215  AC10 PaTu 8988t C43(0.22)  LDD1094  [14]
 LDCM0226  AC11 PaTu 8988t C43(0.46)  LDD1105  [14]
 LDCM0237  AC12 PaTu 8988t C43(0.61)  LDD1116  [14]
 LDCM0246  AC128 PaTu 8988t C43(0.88)  LDD1125  [14]
 LDCM0247  AC129 PaTu 8988t C43(0.80)  LDD1126  [14]
 LDCM0249  AC130 PaTu 8988t C43(0.89)  LDD1128  [14]
 LDCM0250  AC131 PaTu 8988t C43(0.82)  LDD1129  [14]
 LDCM0251  AC132 PaTu 8988t C43(0.81)  LDD1130  [14]
 LDCM0252  AC133 PaTu 8988t C43(0.34)  LDD1131  [14]
 LDCM0253  AC134 PaTu 8988t C43(0.63)  LDD1132  [14]
 LDCM0254  AC135 PaTu 8988t C43(0.25)  LDD1133  [14]
 LDCM0255  AC136 PaTu 8988t C43(0.66)  LDD1134  [14]
 LDCM0256  AC137 PaTu 8988t C43(0.36)  LDD1135  [14]
 LDCM0257  AC138 PaTu 8988t C43(0.75)  LDD1136  [14]
 LDCM0258  AC139 PaTu 8988t C43(0.87)  LDD1137  [14]
 LDCM0259  AC14 PaTu 8988t C43(0.52)  LDD1138  [14]
 LDCM0260  AC140 PaTu 8988t C43(0.78)  LDD1139  [14]
 LDCM0261  AC141 PaTu 8988t C43(0.88)  LDD1140  [14]
 LDCM0262  AC142 PaTu 8988t C43(0.86)  LDD1141  [14]
 LDCM0263  AC143 PaTu 8988t C43(0.64)  LDD1142  [14]
 LDCM0264  AC144 PaTu 8988t C43(0.74)  LDD1143  [14]
 LDCM0265  AC145 PaTu 8988t C43(0.61)  LDD1144  [14]
 LDCM0266  AC146 PaTu 8988t C43(0.70)  LDD1145  [14]
 LDCM0267  AC147 PaTu 8988t C43(0.81)  LDD1146  [14]
 LDCM0268  AC148 PaTu 8988t C43(0.39)  LDD1147  [14]
 LDCM0269  AC149 PaTu 8988t C43(0.59)  LDD1148  [14]
 LDCM0270  AC15 PaTu 8988t C43(0.28)  LDD1149  [14]
 LDCM0271  AC150 PaTu 8988t C43(0.85)  LDD1150  [14]
 LDCM0272  AC151 PaTu 8988t C43(0.71)  LDD1151  [14]
 LDCM0273  AC152 PaTu 8988t C43(0.70)  LDD1152  [14]
 LDCM0274  AC153 PaTu 8988t C43(0.73)  LDD1153  [14]
 LDCM0621  AC154 PaTu 8988t C43(0.76)  LDD2166  [14]
 LDCM0622  AC155 PaTu 8988t C43(0.66)  LDD2167  [14]
 LDCM0623  AC156 PaTu 8988t C43(0.69)  LDD2168  [14]
 LDCM0624  AC157 PaTu 8988t C43(1.07)  LDD2169  [14]
 LDCM0276  AC17 PaTu 8988t C43(0.98)  LDD1155  [14]
 LDCM0277  AC18 PaTu 8988t C43(0.81)  LDD1156  [14]
 LDCM0278  AC19 PaTu 8988t C43(1.00)  LDD1157  [14]
 LDCM0279  AC2 PaTu 8988t C43(0.73)  LDD1158  [14]
 LDCM0280  AC20 PaTu 8988t C43(0.88)  LDD1159  [14]
 LDCM0281  AC21 PaTu 8988t C43(0.79)  LDD1160  [14]
 LDCM0282  AC22 PaTu 8988t C43(0.59)  LDD1161  [14]
 LDCM0283  AC23 PaTu 8988t C43(0.80)  LDD1162  [14]
 LDCM0284  AC24 PaTu 8988t C43(0.86)  LDD1163  [14]
 LDCM0285  AC25 HEK-293T C43(0.97)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C43(1.01)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C43(1.10)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C43(1.04)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C43(1.00)  LDD1528  [15]
 LDCM0290  AC3 PaTu 8988t C43(0.70)  LDD1169  [14]
 LDCM0291  AC30 HEK-293T C43(0.97)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C43(0.91)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C43(1.19)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C43(0.92)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C43(1.04)  LDD1534  [15]
 LDCM0296  AC35 PaTu 8988t C43(0.94)  LDD1175  [14]
 LDCM0297  AC36 PaTu 8988t C43(0.89)  LDD1176  [14]
 LDCM0298  AC37 PaTu 8988t C43(0.81)  LDD1177  [14]
 LDCM0299  AC38 PaTu 8988t C43(0.65)  LDD1178  [14]
 LDCM0300  AC39 PaTu 8988t C43(0.81)  LDD1179  [14]
 LDCM0301  AC4 PaTu 8988t C43(0.93)  LDD1180  [14]
 LDCM0302  AC40 PaTu 8988t C43(0.57)  LDD1181  [14]
 LDCM0303  AC41 PaTu 8988t C43(0.75)  LDD1182  [14]
 LDCM0304  AC42 PaTu 8988t C43(0.80)  LDD1183  [14]
 LDCM0305  AC43 PaTu 8988t C43(0.81)  LDD1184  [14]
 LDCM0306  AC44 PaTu 8988t C43(0.28)  LDD1185  [14]
 LDCM0307  AC45 PaTu 8988t C43(0.59)  LDD1186  [14]
 LDCM0308  AC46 PaTu 8988t C43(0.86)  LDD1187  [14]
 LDCM0309  AC47 PaTu 8988t C43(0.67)  LDD1188  [14]
 LDCM0310  AC48 PaTu 8988t C43(0.45)  LDD1189  [14]
 LDCM0311  AC49 PaTu 8988t C43(0.58)  LDD1190  [14]
 LDCM0312  AC5 PaTu 8988t C43(0.50)  LDD1191  [14]
 LDCM0313  AC50 PaTu 8988t C43(0.60)  LDD1192  [14]
 LDCM0314  AC51 PaTu 8988t C43(0.84)  LDD1193  [14]
 LDCM0315  AC52 PaTu 8988t C43(0.54)  LDD1194  [14]
 LDCM0316  AC53 PaTu 8988t C43(0.43)  LDD1195  [14]
 LDCM0317  AC54 PaTu 8988t C43(0.29)  LDD1196  [14]
 LDCM0318  AC55 PaTu 8988t C43(0.60)  LDD1197  [14]
 LDCM0319  AC56 PaTu 8988t C43(0.41)  LDD1198  [14]
 LDCM0320  AC57 HEK-293T C43(0.96)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C43(1.01)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C43(1.09)  LDD1561  [15]
 LDCM0323  AC6 PaTu 8988t C43(0.75)  LDD1202  [14]
 LDCM0324  AC60 HEK-293T C43(1.12)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C43(1.05)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C43(1.05)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C43(1.02)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C43(1.01)  LDD1567  [15]
 LDCM0334  AC7 PaTu 8988t C43(0.98)  LDD1213  [14]
 LDCM0345  AC8 PaTu 8988t C43(0.98)  LDD1224  [14]
 LDCM0248  AKOS034007472 PaTu 8988t C43(0.19)  LDD1127  [14]
 LDCM0356  AKOS034007680 PaTu 8988t C43(0.46)  LDD1235  [14]
 LDCM0275  AKOS034007705 PaTu 8988t C43(0.44)  LDD1154  [14]
 LDCM0156  Aniline NCI-H1299 11.10  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C43(0.00); H46(0.00)  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C43(1.02)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C43(1.10)  LDD1572  [15]
 LDCM0369  CL100 PaTu 8988t C43(0.73)  LDD1248  [14]
 LDCM0370  CL101 PaTu 8988t C43(0.68)  LDD1249  [14]
 LDCM0371  CL102 PaTu 8988t C43(0.81)  LDD1250  [14]
 LDCM0372  CL103 PaTu 8988t C43(0.11)  LDD1251  [14]
 LDCM0373  CL104 PaTu 8988t C43(0.56)  LDD1252  [14]
 LDCM0374  CL105 PaTu 8988t C43(0.93)  LDD1253  [14]
 LDCM0375  CL106 PaTu 8988t C43(0.88)  LDD1254  [14]
 LDCM0376  CL107 PaTu 8988t C43(1.19)  LDD1255  [14]
 LDCM0377  CL108 PaTu 8988t C43(0.82)  LDD1256  [14]
 LDCM0378  CL109 PaTu 8988t C43(0.99)  LDD1257  [14]
 LDCM0379  CL11 HEK-293T C43(1.04)  LDD1583  [15]
 LDCM0380  CL110 PaTu 8988t C43(0.99)  LDD1259  [14]
 LDCM0381  CL111 PaTu 8988t C43(0.63)  LDD1260  [14]
 LDCM0382  CL112 HEK-293T C43(1.05)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C43(0.97)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C43(1.04)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C43(1.03)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C43(1.05)  LDD1590  [15]
 LDCM0387  CL117 PaTu 8988t C43(0.73)  LDD1266  [14]
 LDCM0388  CL118 PaTu 8988t C43(0.94)  LDD1267  [14]
 LDCM0389  CL119 PaTu 8988t C43(0.81)  LDD1268  [14]
 LDCM0390  CL12 HEK-293T C43(0.93)  LDD1594  [15]
 LDCM0391  CL120 PaTu 8988t C43(0.84)  LDD1270  [14]
 LDCM0392  CL121 PaTu 8988t C43(0.64)  LDD1271  [14]
 LDCM0393  CL122 PaTu 8988t C43(0.39)  LDD1272  [14]
 LDCM0394  CL123 PaTu 8988t C43(0.38)  LDD1273  [14]
 LDCM0395  CL124 PaTu 8988t C43(0.62)  LDD1274  [14]
 LDCM0396  CL125 HEK-293T C43(0.98)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C43(0.96)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C43(1.04)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C43(0.97)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C43(0.88)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C43(1.02)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C43(1.06)  LDD1606  [15]
 LDCM0403  CL16 PaTu 8988t C43(0.86)  LDD1282  [14]
 LDCM0404  CL17 PaTu 8988t C43(0.78)  LDD1283  [14]
 LDCM0405  CL18 PaTu 8988t C43(0.85)  LDD1284  [14]
 LDCM0406  CL19 PaTu 8988t C43(0.82)  LDD1285  [14]
 LDCM0407  CL2 HEK-293T C43(1.15)  LDD1611  [15]
 LDCM0408  CL20 PaTu 8988t C43(0.61)  LDD1287  [14]
 LDCM0409  CL21 PaTu 8988t C43(0.50)  LDD1288  [14]
 LDCM0410  CL22 PaTu 8988t C43(0.57)  LDD1289  [14]
 LDCM0411  CL23 PaTu 8988t C43(0.55)  LDD1290  [14]
 LDCM0412  CL24 PaTu 8988t C43(0.87)  LDD1291  [14]
 LDCM0413  CL25 PaTu 8988t C43(0.64)  LDD1292  [14]
 LDCM0414  CL26 PaTu 8988t C43(0.63)  LDD1293  [14]
 LDCM0415  CL27 PaTu 8988t C43(0.71)  LDD1294  [14]
 LDCM0416  CL28 PaTu 8988t C43(0.56)  LDD1295  [14]
 LDCM0417  CL29 PaTu 8988t C43(0.67)  LDD1296  [14]
 LDCM0418  CL3 HEK-293T C43(1.11)  LDD1622  [15]
 LDCM0419  CL30 PaTu 8988t C43(0.68)  LDD1298  [14]
 LDCM0420  CL31 PaTu 8988t C43(0.94)  LDD1299  [14]
 LDCM0421  CL32 PaTu 8988t C43(0.86)  LDD1300  [14]
 LDCM0422  CL33 PaTu 8988t C43(0.75)  LDD1301  [14]
 LDCM0423  CL34 PaTu 8988t C43(0.68)  LDD1302  [14]
 LDCM0424  CL35 PaTu 8988t C43(0.72)  LDD1303  [14]
 LDCM0425  CL36 PaTu 8988t C43(0.50)  LDD1304  [14]
 LDCM0426  CL37 PaTu 8988t C43(0.62)  LDD1305  [14]
 LDCM0428  CL39 PaTu 8988t C43(0.69)  LDD1307  [14]
 LDCM0429  CL4 HEK-293T C43(0.93)  LDD1633  [15]
 LDCM0430  CL40 PaTu 8988t C43(0.81)  LDD1309  [14]
 LDCM0431  CL41 PaTu 8988t C43(0.73)  LDD1310  [14]
 LDCM0432  CL42 PaTu 8988t C43(0.58)  LDD1311  [14]
 LDCM0433  CL43 PaTu 8988t C43(0.43)  LDD1312  [14]
 LDCM0434  CL44 PaTu 8988t C43(0.56)  LDD1313  [14]
 LDCM0435  CL45 PaTu 8988t C43(0.80)  LDD1314  [14]
 LDCM0436  CL46 PaTu 8988t C43(0.73)  LDD1315  [14]
 LDCM0437  CL47 PaTu 8988t C43(0.90)  LDD1316  [14]
 LDCM0438  CL48 PaTu 8988t C43(0.82)  LDD1317  [14]
 LDCM0439  CL49 PaTu 8988t C43(0.75)  LDD1318  [14]
 LDCM0440  CL5 HEK-293T C43(1.08)  LDD1644  [15]
 LDCM0441  CL50 PaTu 8988t C43(0.80)  LDD1320  [14]
 LDCM0442  CL51 PaTu 8988t C43(0.78)  LDD1321  [14]
 LDCM0443  CL52 PaTu 8988t C43(0.80)  LDD1322  [14]
 LDCM0444  CL53 PaTu 8988t C43(0.75)  LDD1323  [14]
 LDCM0445  CL54 PaTu 8988t C43(0.75)  LDD1324  [14]
 LDCM0446  CL55 PaTu 8988t C43(0.64)  LDD1325  [14]
 LDCM0447  CL56 PaTu 8988t C43(0.79)  LDD1326  [14]
 LDCM0448  CL57 PaTu 8988t C43(0.82)  LDD1327  [14]
 LDCM0449  CL58 PaTu 8988t C43(0.74)  LDD1328  [14]
 LDCM0450  CL59 PaTu 8988t C43(0.80)  LDD1329  [14]
 LDCM0451  CL6 HEK-293T C43(0.98)  LDD1654  [15]
 LDCM0452  CL60 PaTu 8988t C43(0.86)  LDD1331  [14]
 LDCM0453  CL61 PaTu 8988t C43(0.97)  LDD1332  [14]
 LDCM0454  CL62 PaTu 8988t C43(1.03)  LDD1333  [14]
 LDCM0455  CL63 PaTu 8988t C43(1.07)  LDD1334  [14]
 LDCM0456  CL64 PaTu 8988t C43(0.93)  LDD1335  [14]
 LDCM0457  CL65 PaTu 8988t C43(0.96)  LDD1336  [14]
 LDCM0458  CL66 PaTu 8988t C43(0.80)  LDD1337  [14]
 LDCM0459  CL67 PaTu 8988t C43(0.85)  LDD1338  [14]
 LDCM0460  CL68 PaTu 8988t C43(0.57)  LDD1339  [14]
 LDCM0461  CL69 PaTu 8988t C43(0.61)  LDD1340  [14]
 LDCM0462  CL7 HEK-293T C43(1.21)  LDD1665  [15]
 LDCM0463  CL70 PaTu 8988t C43(0.62)  LDD1342  [14]
 LDCM0464  CL71 PaTu 8988t C43(1.13)  LDD1343  [14]
 LDCM0465  CL72 PaTu 8988t C43(2.03)  LDD1344  [14]
 LDCM0466  CL73 PaTu 8988t C43(0.68)  LDD1345  [14]
 LDCM0467  CL74 PaTu 8988t C43(0.93)  LDD1346  [14]
 LDCM0469  CL76 PaTu 8988t C43(1.04)  LDD1348  [14]
 LDCM0470  CL77 PaTu 8988t C43(0.99)  LDD1349  [14]
 LDCM0471  CL78 PaTu 8988t C43(0.75)  LDD1350  [14]
 LDCM0472  CL79 PaTu 8988t C43(1.05)  LDD1351  [14]
 LDCM0473  CL8 HEK-293T C43(1.27)  LDD1676  [15]
 LDCM0474  CL80 PaTu 8988t C43(0.96)  LDD1353  [14]
 LDCM0475  CL81 PaTu 8988t C43(0.75)  LDD1354  [14]
 LDCM0476  CL82 PaTu 8988t C43(0.85)  LDD1355  [14]
 LDCM0477  CL83 PaTu 8988t C43(0.73)  LDD1356  [14]
 LDCM0478  CL84 PaTu 8988t C43(0.86)  LDD1357  [14]
 LDCM0479  CL85 PaTu 8988t C43(0.89)  LDD1358  [14]
 LDCM0480  CL86 PaTu 8988t C43(0.87)  LDD1359  [14]
 LDCM0481  CL87 PaTu 8988t C43(0.62)  LDD1360  [14]
 LDCM0482  CL88 PaTu 8988t C43(0.69)  LDD1361  [14]
 LDCM0483  CL89 PaTu 8988t C43(0.73)  LDD1362  [14]
 LDCM0484  CL9 HEK-293T C43(1.14)  LDD1687  [15]
 LDCM0485  CL90 PaTu 8988t C43(0.91)  LDD1364  [14]
 LDCM0486  CL91 PaTu 8988t C43(0.86)  LDD1365  [14]
 LDCM0487  CL92 PaTu 8988t C43(0.82)  LDD1366  [14]
 LDCM0488  CL93 PaTu 8988t C43(0.76)  LDD1367  [14]
 LDCM0489  CL94 PaTu 8988t C43(0.52)  LDD1368  [14]
 LDCM0490  CL95 PaTu 8988t C43(0.31)  LDD1369  [14]
 LDCM0491  CL96 PaTu 8988t C43(0.55)  LDD1370  [14]
 LDCM0492  CL97 PaTu 8988t C43(0.88)  LDD1371  [14]
 LDCM0493  CL98 PaTu 8988t C43(0.54)  LDD1372  [14]
 LDCM0494  CL99 PaTu 8988t C43(0.67)  LDD1373  [14]
 LDCM0495  E2913 HEK-293T C43(1.04)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C43(2.38)  LDD1702  [5]
 LDCM0468  Fragment33 PaTu 8988t C43(0.99)  LDD1347  [14]
 LDCM0427  Fragment51 PaTu 8988t C43(0.42)  LDD1306  [14]
 LDCM0107  IAA HeLa C43(0.00); H46(0.00)  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C43(0.82)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C43(0.98)  LDD1497  [15]
 LDCM0024  KB05 G361 C43(1.32)  LDD3311  [4]
 LDCM0109  NEM HeLa C43(0.00); H46(0.00)  LDD0223  [13]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C43(1.11)  LDD2092  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C43(1.04)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C43(1.09)  LDD2098  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C43(0.50)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C43(0.47)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C43(1.06)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C43(0.52)  LDD2106  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C43(0.76)  LDD2108  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C43(0.49)  LDD2110  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C43(0.58)  LDD2114  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C43(0.19)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C43(0.84)  LDD2123  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C43(0.60)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C43(1.46)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C43(0.30)  LDD2145  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402