Details of the Target

General Information of Target

Target ID LDTP13052
Target Name Intraflagellar transport protein 80 homolog (IFT80)
Gene Name IFT80
Gene ID 57560
Synonyms
KIAA1374; WDR56; Intraflagellar transport protein 80 homolog; WD repeat-containing protein 56
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLAGRPGTRSAVGELGTESSDNLDRAPLGPRESGGHHRPGSYLDMKIHLEKNLEEERQIL
LQQQKICRNRARKYFVESNRRKKAFEEKRKEQEEKEHQIREQILQQRKQKFEEVTEKFQR
AHVPLSQRRKAVSRKPVPPLEEALKQIQESNLKSEVNLPFSRRPTINWRAIDSALPSALS
KNDHKHQKQLLSKINCEKEMNENMRATLATSKNVFQLKLEETQKLLEDQHLSNLQKFCDE
VNQITNSETLSSIDSLEATEHEEIYLTLNKEHSTSIQRNTISLKPANMQSTNLSCFDEDK
LAFSKTQHINNWLTNLDASNTQNVTAFSDILSKSNVLPSWEYFNSKEQNPSPLNGTVERA
TNTANNSVPFVSSPPMFVLDKKCEKTSETSTMRTTDSTSGAFKRERPLVTESPTFKFSKS
QSTSDSLTQEVATFPDQEKYSELNQENGTTSIPTSCVPVATPLVLPSNIQSARPSAKNSI
HIKEIDAVQCSDKLDELKDGKEEEIKYFNCNKEELPLFSDSFQDAYIPHNPDSKDEKQKL
AETSSLSNVTSNYDFVGQHKKMKYNIHERNGVRFLKSILKKESKYEHGYLKALIINQSFK
FGNQKAAAIRDSIELTKEKGAEIPKTIKKLRWFDETSNIENNAENSHSLKNKTGTTQQHS
QQFHIQSGAGSNIISVSTCAVNSADTKKSREDSISENVTTLGGSGADHMPLNCFIPSGYN
FAKHAWPASKKEESKIPVHDDSKTKQGKPQRGRAKIIRKPGSAKVQSGFICTNRKGAVIQ
PQSASKVNIFTQAQGKLIIPCPPPQSTSNIRSGKNIQVSQCQPVTPENPQNIITHNSFNS
KHVLPTEHSLNQWNQESSSPLSNACSDLVTVIPSLPSYCSSECQTFAKINHSNGTQAVAR
QDATLYCTQRSPVCEESYPSVTLRTAEEESVPLWKRGPNVLHQNKRATGSTVMRRKRIAE
TKRRNILEQKRQNPGSVGQKYSEQINNFGQSVLLSSSEPKQTTRGTSYIEEVSDSTSEFL
MAENLVKASVPEDEILTVLNSKQIQKSNLPLNKTQQFNICTLSAEEQKILESLNDLSERL
HYIQESICKNPSIKNTLQIIPLLEKREDRTSSCRDKR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
Uniprot ID
Q9P2H3
Ensemble ID
ENST00000326448.12
HGNC ID
HGNC:29262

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.H562R .
DU145 SNV: p.G112R .
HCT15 SNV: p.A621S .
KNS81FD SNV: p.L545F .
LNCaP clone FGC SNV: p.K776Q .
MELJUSO SNV: p.A317P .
PC14 SNV: p.M412T .
PC9 SNV: p.M412T .
SHP77 SNV: p.C518Y .
SNU869 SNV: p.P407S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0227  [1]
DBIA
 Probe Info  		C106(1.52)  LDD0080  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C106(1.22)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C106(1.49)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C106(1.57)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C106(1.80)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C106(1.35)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C106(1.42)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C106(1.31)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C106(1.22)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C106(1.16)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C106(1.47)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C106(1.08)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C106(1.18)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C106(1.11)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C106(1.42)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C106(1.35)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C106(1.49)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C106(1.09)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C106(1.45)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C106(0.94)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C106(1.07)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C106(1.43)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C106(1.37)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C106(1.52)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C106(1.21)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C106(0.87)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C106(1.28)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C106(1.23)  LDD0575  [2]
 LDCM0260  AC140 HCT 116 C106(1.30)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C106(1.19)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C106(0.79)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C106(2.15)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C106(2.45)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C106(1.85)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C106(2.11)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C106(2.32)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C106(3.56)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C106(2.87)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C106(1.63)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C106(1.60)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C106(2.52)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C106(2.88)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C106(2.29)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C106(1.68)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C106(1.38)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C106(1.28)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C106(0.77)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C106(0.77)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C106(0.73)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C106(0.99)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C106(0.82)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C106(0.75)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C106(0.91)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C106(1.12)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C106(0.53)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C106(0.42)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C106(0.46)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C106(0.65)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C106(0.47)  LDD0887  [2]
 LDCM0291  AC30 HEK-293T C106(0.47)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C106(0.66)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C106(0.47)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C106(0.57)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C106(0.78)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C106(0.71)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C106(0.64)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C106(0.63)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C106(0.64)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C106(0.70)  LDD0898  [2]
 LDCM0302  AC40 HEK-293T C106(0.76)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C106(0.76)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C106(0.70)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C106(1.04)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C106(0.52)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C106(0.66)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C106(0.92)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C106(0.82)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C106(0.75)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C106(1.33)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C106(1.04)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C106(0.64)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C106(0.85)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C106(1.26)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C106(1.01)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C106(1.17)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C106(1.35)  LDD0636  [2]
 LDCM0332  AC68 HEK-293T C106(1.08)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C106(1.28)  LDD0931  [2]
 LDCM0335  AC70 HEK-293T C106(0.74)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C106(1.14)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C106(1.15)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C106(0.82)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C106(0.78)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C106(0.99)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C106(1.00)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C106(0.96)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C106(0.94)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C106(0.97)  LDD0942  [2]
 LDCM0346  AC80 HEK-293T C106(0.80)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C106(1.15)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C106(0.56)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C106(0.88)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C106(0.49)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C106(0.60)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C106(0.60)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C106(0.55)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C106(0.45)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C106(0.34)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C106(0.39)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C106(0.47)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C106(0.52)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C106(0.58)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C106(0.32)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C106(0.51)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C106(0.66)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C106(0.12)  LDD0962  [2]
 LDCM0367  CL1 PaTu 8988t C106(0.86)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C106(1.59)  LDD1247  [2]
 LDCM0374  CL105 HCT 116 C106(0.68)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C106(0.66)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C106(0.63)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C106(0.78)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C106(0.78)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C106(1.03)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C106(0.68)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C106(0.79)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C106(0.42)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C106(0.57)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C106(0.25)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C106(0.46)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C106(0.51)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C106(0.81)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C106(0.73)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C106(0.63)  LDD0987  [2]
 LDCM0390  CL12 PaTu 8988t C106(1.24)  LDD1269  [2]
 LDCM0391  CL120 HEK-293T C106(0.63)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C106(0.68)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C106(0.96)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C106(1.07)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C106(1.52)  LDD0712  [2]
 LDCM0400  CL13 PaTu 8988t C106(2.36)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C106(1.91)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C106(1.17)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C106(1.12)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C106(1.13)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C106(2.04)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C106(1.53)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C106(1.42)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C106(1.89)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C106(1.97)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C106(1.84)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C106(2.05)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C106(1.37)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C106(1.13)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C106(1.96)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C106(1.64)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C106(1.69)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C106(1.95)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C106(1.09)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C106(1.72)  LDD1298  [2]
 LDCM0420  CL31 HCT 116 C106(0.88)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C106(0.71)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C106(0.76)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C106(0.97)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C106(0.96)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C106(1.00)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C106(1.06)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C106(0.86)  LDD0745  [2]
 LDCM0429  CL4 PaTu 8988t C106(1.14)  LDD1308  [2]
 LDCM0430  CL40 HCT 116 C106(0.86)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C106(0.96)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C106(1.03)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C106(0.80)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C106(0.81)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C106(0.84)  LDD0752  [2]
 LDCM0440  CL5 PaTu 8988t C106(2.04)  LDD1319  [2]
 LDCM0451  CL6 PaTu 8988t C106(1.66)  LDD1330  [2]
 LDCM0453  CL61 HCT 116 C106(1.22)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C106(1.01)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C106(1.42)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C106(1.20)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C106(1.06)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C106(0.99)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C106(1.23)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C106(1.32)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C106(1.61)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C106(1.56)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C106(1.18)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C106(1.06)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C106(1.18)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C106(1.45)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C106(1.39)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C106(0.80)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C106(0.76)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C106(0.96)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C106(0.78)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C106(1.70)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C106(0.75)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C106(1.00)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C106(1.15)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C106(0.82)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C106(0.78)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C106(0.70)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C106(0.96)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C106(0.70)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C106(0.85)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C106(0.82)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C106(1.85)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C106(0.73)  LDD0802  [2]
 LDCM0468  Fragment33 HCT 116 C106(1.30)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C106(0.85)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C106(1.52)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C106(1.07)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C106(1.96)  LDD0082  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019