Details of the Target

General Information of Target

Target ID LDTP12940
Target Name LIM and cysteine-rich domains protein 1 (LMCD1)
Gene Name LMCD1
Gene ID 29995
Synonyms
LIM and cysteine-rich domains protein 1; Dyxin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVAHPTATATTTPTATVTATVVMTTATMDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRC
DNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDE
FPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLK
LLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIA
DDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLD
LSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGP
EKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLR
LPDSNIDYPMATGDGAKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLGHSPAVGSI
TETLVQGDKTEYLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETADSYGPTTTLN
QEQNAGPMASLPLAGIIGGAVALVFLFLVLGAICWYVHQAGELLTRERAYNRGSRKKDDY
MESGTKKDNSILEIRGPGLQMLPINPYRAKEEYVVHTIFPSNGSSLCKATHTIGYGTTRG
YRDGGIPDIDYSYT
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Uniprot ID
Q9NZU5
Ensemble ID
ENST00000157600.8
HGNC ID
HGNC:6633

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.K139R .
HCC15 SNV: p.D284Y .
HCT116 SNV: p.R298C .
HT3 SNV: p.D291N .
Ishikawa (Heraklio) 02 ER SNV: p.G352C .
JURKAT Deletion: p.L161PfsTer19 .
TYKNU SNV: p.R305L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y258(9.75)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C58(2.01)  LDD0169  [3]
DBIA
 Probe Info  		C335(0.91); C338(0.91); C356(0.89); C359(0.89)  LDD0078  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C58(2.01)  LDD0169  [3]
 LDCM0215  AC10 HEK-293T C335(1.18); C338(1.18)  LDD0813  [4]
 LDCM0216  AC100 PaTu 8988t C296(0.96); C335(1.08); C338(1.08)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C296(1.33); C335(1.63); C338(1.63)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C296(0.51); C335(1.15); C338(1.15)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C296(0.94); C335(1.35); C338(1.35)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C296(0.94); C335(1.47); C338(1.47)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C296(1.06); C335(1.20); C338(1.20)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C296(0.90); C335(1.15); C338(1.15)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C296(1.34); C335(1.49); C338(1.49)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C296(1.03); C335(0.94); C338(0.94)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C296(0.76); C335(1.10); C338(1.10)  LDD1104  [4]
 LDCM0226  AC11 HEK-293T C335(1.17); C338(1.17)  LDD0824  [4]
 LDCM0227  AC110 PaTu 8988t C296(0.71); C335(1.25); C338(1.25)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C296(1.06); C335(1.48); C338(1.48)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C296(1.13); C335(1.13); C338(1.13)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C296(1.47); C335(0.58); C338(0.58)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C296(0.93); C335(0.89); C338(0.89)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C296(1.36); C335(0.53); C338(0.53)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C296(1.39); C335(0.70); C338(0.70)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C296(1.51); C335(0.50); C338(0.50)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C296(0.69); C335(0.61); C338(0.61)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C296(1.14); C335(0.76); C338(0.76)  LDD1115  [4]
 LDCM0237  AC12 HEK-293T C335(1.17); C338(1.17)  LDD0835  [4]
 LDCM0238  AC120 PaTu 8988t C296(0.94); C335(0.70); C338(0.70)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C296(1.18); C335(0.70); C338(0.70)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C296(1.01); C335(0.56); C338(0.56)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C296(1.07); C335(0.76); C338(0.76)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C296(1.09); C335(1.00); C338(1.00)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C296(0.72); C335(0.53); C338(0.53)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C296(0.94); C335(0.51); C338(0.51)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C296(0.87); C335(0.87); C338(0.87)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C296(0.77); C335(0.90); C338(0.90)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C296(0.75); C335(1.07); C338(1.07)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C296(1.16); C335(0.92); C338(0.92)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C296(0.94); C335(0.89); C338(0.89)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C296(1.06); C335(1.02); C338(1.02)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C296(0.90); C335(1.31); C338(1.31)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C296(0.91); C335(0.82); C338(0.82)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C296(0.66); C335(0.89); C338(0.89)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C296(0.92); C335(0.86); C338(0.86)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C296(0.67); C335(1.12); C338(1.12)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C296(0.75); C335(0.91); C338(0.91)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C296(1.10); C335(0.93); C338(0.93)  LDD1137  [4]
 LDCM0259  AC14 HEK-293T C335(1.13); C338(1.13)  LDD0857  [4]
 LDCM0260  AC140 PaTu 8988t C296(1.01); C335(0.89); C338(0.89)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C296(1.15); C335(0.95); C338(0.95)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C296(0.85); C335(1.05); C338(1.05)  LDD1141  [4]
 LDCM0263  AC143 PaTu 8988t C335(1.37); C338(1.37)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C335(0.97); C338(0.97)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C335(1.05); C338(1.05)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C335(1.03); C338(1.03)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C335(1.29); C338(1.29)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C335(1.12); C338(1.12)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C335(1.20); C338(1.20)  LDD1148  [4]
 LDCM0270  AC15 HEK-293T C335(1.26); C338(1.26)  LDD0868  [4]
 LDCM0271  AC150 PaTu 8988t C335(1.03); C338(1.03)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C335(1.33); C338(1.33)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C335(1.32); C338(1.32)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C335(1.34); C338(1.34)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C335(1.09); C338(1.09)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C335(1.01); C338(1.01)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C335(1.21); C338(1.21)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C335(0.89); C338(0.89)  LDD2169  [4]
 LDCM0276  AC17 PaTu 8988t C356(1.20); C359(1.20); C335(1.32); C338(1.32)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C356(1.32); C359(1.32); C335(1.39); C338(1.39)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C356(1.02); C359(1.02); C335(1.13); C338(1.13)  LDD1157  [4]
 LDCM0279  AC2 HEK-293T C278(1.23); C31(0.86)  LDD1518  [6]
 LDCM0280  AC20 PaTu 8988t C356(1.30); C359(1.30); C335(1.48); C338(1.48)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C356(1.15); C359(1.15); C335(1.54); C338(1.54)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C356(1.40); C359(1.40); C335(1.49); C338(1.49)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C356(1.61); C359(1.61); C335(1.41); C338(1.41)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C356(1.34); C359(1.34); C335(1.49); C338(1.49)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C356(1.12); C359(1.12); C335(1.09); C338(1.09)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C356(0.95); C359(0.95); C335(1.02); C338(1.02)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C356(1.16); C359(1.16); C335(1.03); C338(1.03)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C356(1.15); C359(1.15); C335(1.09); C338(1.09)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C356(1.07); C359(1.07); C335(1.64); C338(1.64)  LDD1168  [4]
 LDCM0290  AC3 HEK-293T C58(1.17); C31(0.84)  LDD1529  [6]
 LDCM0291  AC30 PaTu 8988t C356(1.17); C359(1.17); C335(1.32); C338(1.32)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C356(0.81); C359(0.81); C335(1.45); C338(1.45)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C356(1.01); C359(1.01); C335(1.21); C338(1.21)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C356(1.08); C359(1.08); C335(1.76); C338(1.76)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C356(1.49); C359(1.49); C335(1.50); C338(1.50)  LDD1174  [4]
 LDCM0296  AC35 HEK-293T C335(1.01); C338(1.01)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C335(0.85); C338(0.85)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C335(0.84); C338(0.84)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C335(1.07); C338(1.07)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C335(1.10); C338(1.10)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C278(0.94); C58(0.92)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C335(0.99); C338(0.99)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C335(1.15); C338(1.15)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C335(1.08); C338(1.08)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C335(1.13); C338(1.13)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C335(1.13); C338(1.13)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C335(1.00); C338(1.00)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C335(1.28); C338(1.28)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C335(1.10); C338(1.10)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C335(1.23); C338(1.23)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C335(1.07); C338(1.07)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C58(0.95); C356(0.95)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C335(1.10); C338(1.10)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C335(1.25); C338(1.25)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C335(1.32); C338(1.32)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C335(1.31); C338(1.31)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C335(1.23); C338(1.23)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C335(1.42); C338(1.42)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C335(1.25); C338(1.25)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C335(0.96)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C335(0.90)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C335(0.94)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C335(0.93); C338(0.93)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C335(1.02)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C335(0.95)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C335(1.00)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C335(0.91)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C335(1.03)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C335(0.99)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C335(0.91)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C335(0.86)  LDD0929  [4]
 LDCM0332  AC68 PaTu 8988t C356(0.92); C359(0.92); C335(1.25); C338(1.25)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C356(1.12); C359(1.12); C335(1.06); C338(1.06)  LDD1212  [4]
 LDCM0334  AC7 HEK-293T C335(0.97); C338(0.97)  LDD0932  [4]
 LDCM0335  AC70 PaTu 8988t C356(1.09); C359(1.09); C335(1.18); C338(1.18)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C356(1.04); C359(1.04); C335(1.02); C338(1.02)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C356(0.96); C359(0.96); C335(1.03); C338(1.03)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C356(0.99); C359(0.99); C335(0.97); C338(0.97)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C356(1.08); C359(1.08); C335(1.03); C338(1.03)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C356(1.06); C359(1.06); C335(1.10); C338(1.10)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C356(1.04); C359(1.04); C335(1.20); C338(1.20)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C356(0.97); C359(0.97); C335(0.97); C338(0.97)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C356(1.15); C359(1.15); C335(0.97); C338(0.97)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C356(1.17); C359(1.17); C335(0.92); C338(0.92)  LDD1223  [4]
 LDCM0345  AC8 HEK-293T C335(1.02); C338(1.02)  LDD0943  [4]
 LDCM0346  AC80 PaTu 8988t C356(1.12); C359(1.12); C335(1.32); C338(1.32)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C356(1.14); C359(1.14); C335(0.97); C338(0.97)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C356(1.19); C359(1.19); C335(1.11); C338(1.11)  LDD1227  [4]
 LDCM0349  AC83 HEK-293T C338(0.90)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C338(1.60)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C338(1.13)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C338(1.22)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C338(0.92)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C338(1.15)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C338(1.50)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C338(1.30)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C338(1.26)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C338(0.96)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C338(0.85)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C338(1.29)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C338(1.96)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C338(1.14)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C338(1.56)  LDD0962  [4]
 LDCM0365  AC98 PaTu 8988t C296(0.69); C335(1.15); C338(1.15)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C296(0.88); C335(1.07); C338(1.07)  LDD1245  [4]
 LDCM0248  AKOS034007472 HEK-293T C335(1.05); C338(1.05)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C335(1.12); C338(1.12)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C335(1.27); C338(1.27)  LDD0873  [4]
 LDCM0020  ARS-1620 HCC44 C335(0.91); C338(0.91); C356(0.89); C359(0.89)  LDD0078  [4]
 LDCM0367  CL1 PaTu 8988t C296(0.81); C335(1.08); C338(1.08)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C296(0.78); C335(1.29); C338(1.15)  LDD1247  [4]
 LDCM0369  CL100 HEK-293T C278(0.72); C31(0.91)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C335(0.91); C338(0.91)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C335(1.19); C338(1.19)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C335(1.03); C338(1.03)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C335(0.79); C338(0.79)  LDD0971  [4]
 LDCM0374  CL105 PaTu 8988t C356(1.04); C359(1.04); C335(1.06); C338(1.06)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C356(1.04); C359(1.04); C335(1.27); C338(1.27)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C356(1.00); C359(1.00); C335(1.18); C338(1.18)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C356(1.10); C359(1.10); C335(1.45); C338(1.45)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C356(1.15); C359(1.15); C335(1.51); C338(1.51)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C296(0.95); C335(1.07); C338(1.02)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C356(1.20); C359(1.20); C335(1.40); C338(1.40)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C356(1.43); C359(1.43); C335(1.53); C338(1.53)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C356(0.97); C359(0.97); C335(1.50); C338(1.50)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C356(1.01); C359(1.01); C335(1.06); C338(1.06)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C356(0.97); C359(0.97); C335(0.85); C338(0.85)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C356(0.99); C359(0.99); C335(1.23); C338(1.23)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C356(0.89); C359(0.89); C335(1.24); C338(1.24)  LDD1265  [4]
 LDCM0387  CL117 HEK-293T C335(1.17); C338(1.17)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C335(0.88); C338(0.88)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C335(0.99); C338(0.99)  LDD0987  [4]
 LDCM0390  CL12 PaTu 8988t C296(0.76); C335(1.09); C338(1.05)  LDD1269  [4]
 LDCM0391  CL120 HEK-293T C335(0.96); C338(0.96)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C335(0.95); C338(0.95)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C335(1.08); C338(1.08)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C335(0.99); C338(0.99)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C335(1.12); C338(1.12)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C335(0.85)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C335(0.99)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C335(0.73)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C335(0.72)  LDD0997  [4]
 LDCM0400  CL13 PaTu 8988t C296(0.53); C335(1.33); C338(1.24)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C296(0.57); C335(1.54); C338(1.26)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C296(0.90); C335(1.10); C338(1.07)  LDD1281  [4]
 LDCM0403  CL16 PaTu 8988t C296(0.86); C335(0.77); C338(0.94)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C296(0.59); C335(0.65); C338(0.83)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C296(1.01); C335(0.86); C338(1.04)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C296(0.81); C335(0.68); C338(0.87)  LDD1285  [4]
 LDCM0407  CL2 PaTu 8988t C296(0.75); C335(1.17); C338(1.20)  LDD1286  [4]
 LDCM0408  CL20 PaTu 8988t C296(0.69); C335(0.70); C338(0.87)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C296(0.81); C335(0.72); C338(0.89)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C296(0.93); C335(0.90); C338(1.23)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C296(0.63); C335(0.98); C338(1.11)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C296(0.97); C335(0.76); C338(0.99)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C296(0.61); C335(0.73); C338(0.91)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C296(0.80); C335(0.73); C338(1.08)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C296(1.20); C335(0.81); C338(1.17)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C296(0.58); C335(0.78); C338(1.00)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C296(0.68); C335(0.74); C338(0.90)  LDD1296  [4]
 LDCM0418  CL3 PaTu 8988t C296(0.59); C335(1.14); C338(1.08)  LDD1297  [4]
 LDCM0419  CL30 PaTu 8988t C296(0.53); C335(0.73); C338(0.92)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C335(1.08); C338(1.08)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C335(1.03); C338(1.03)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C335(1.10); C338(1.10)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C335(1.38); C338(1.38)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C335(1.30); C338(1.30)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C335(0.33); C338(0.33)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C335(1.24); C338(1.24)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C335(1.11); C338(1.11)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C296(0.59); C335(1.07); C338(1.15)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C335(1.11); C338(1.11)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C335(0.95); C338(0.95)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C335(1.13); C338(1.13)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C335(1.23); C338(1.23)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C335(1.57); C338(1.57)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C335(1.24); C338(1.24)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C335(1.22); C338(1.22)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C335(0.95); C338(0.95)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C335(0.98); C338(0.98)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C335(1.13); C338(1.13)  LDD1037  [4]
 LDCM0440  CL5 PaTu 8988t C296(0.64); C335(1.08); C338(1.18)  LDD1319  [4]
 LDCM0441  CL50 HEK-293T C335(0.79); C338(0.79)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C335(1.14); C338(1.14)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C335(0.98); C338(0.98)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C335(1.40); C338(1.40)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C335(0.99); C338(0.99)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C335(0.96); C338(0.96)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C335(0.92); C338(0.92)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C335(1.18); C338(1.18)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C335(1.39); C338(1.39)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C335(1.26); C338(1.26)  LDD1048  [4]
 LDCM0451  CL6 PaTu 8988t C296(0.73); C335(1.20); C338(1.09)  LDD1330  [4]
 LDCM0452  CL60 HEK-293T C335(1.19); C338(1.19)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C278(1.36); C58(1.05); C338(1.18); C243(1.37)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C58(1.03); C31(0.98)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C278(1.48); C58(1.04)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C278(0.97); C31(1.01)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C278(0.97); C31(1.11)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C58(1.02); C31(1.49)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C278(0.95); C58(0.81)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C58(1.09); C356(0.83)  LDD1664  [6]
 LDCM0462  CL7 PaTu 8988t C296(0.66); C335(1.04); C338(1.17)  LDD1341  [4]
 LDCM0463  CL70 HEK-293T C278(1.00); C58(1.34); C31(1.69)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C278(1.15); C58(1.02); C31(2.38)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C278(0.98); C35(0.84); C58(1.01)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C278(1.11); C58(0.94); C338(0.96); C243(1.13)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C58(1.22); C31(0.93)  LDD1670  [6]
 LDCM0469  CL76 PaTu 8988t C296(0.67); C335(0.92); C338(0.92)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C296(0.72); C335(0.92); C338(0.92)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C296(0.71); C335(1.01); C338(1.01)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C296(0.98); C335(0.92); C338(0.92)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C296(0.47); C335(0.87); C338(0.92)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C296(0.59); C335(1.07); C338(1.07)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C296(0.74); C335(1.21); C338(1.21)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C296(0.65); C335(1.04); C338(1.04)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C296(0.75); C335(1.52); C338(1.52)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C296(0.80); C335(1.96); C338(1.96)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C296(1.12); C335(1.16); C338(1.16)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C296(0.61); C335(1.02); C338(1.02)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C296(0.62); C335(1.59); C338(1.59)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C296(0.73); C335(1.29); C338(1.29)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C296(0.67); C335(1.40); C338(1.40)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C296(0.73); C335(1.01); C338(0.98)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C296(0.73); C335(0.98); C338(0.98)  LDD1364  [4]
 LDCM0486  CL91 HEK-293T C58(0.84); C31(1.09)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C278(1.15); C58(0.91)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C58(1.14); C356(0.79)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C278(1.02); C58(1.44); C31(1.37)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C278(0.70); C58(1.29); C31(1.62)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C278(0.92); C35(1.04); C58(0.89)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C278(0.96); C58(1.25); C338(0.88); C243(1.02)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C58(0.99); C31(0.90)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C278(1.18); C58(1.19)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C278(0.94); C58(1.07)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C278(1.53); C58(1.33)  LDD1671  [6]
 LDCM0427  Fragment51 PaTu 8988t C335(1.29); C338(1.29)  LDD1306  [4]
 LDCM0022  KB02 HCT 116 C52(2.35); C58(2.35); C28(1.64); C31(1.64)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C52(1.07); C58(1.07); C28(1.40); C31(1.40)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C52(2.02); C58(2.02); C28(1.77); C31(1.77)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide exchange factor MSS4 (RABIF) DSS4/MSS4 family P47224
Tektin-4 (TEKT4) Tektin family Q8WW24

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402