Details of the Target

General Information of Target

Target ID LDTP12730
Target Name Zinc finger protein 446 (ZNF446)
Gene Name ZNF446
Gene ID 55663
Synonyms
ZKSCAN20; Zinc finger protein 446; Zinc finger protein with KRAB and SCAN domains 20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPATLLRAVARSHHILSKAHQCRRIGHLMLKPLKEFENTTCSTLTIRQSLDLFLPDKTAS
GLNKSQILEMNQKKSDTSMLSPLNAARCQDEKAHLPTMKSFGTHRRVTHKPNLLGSKWFI
KILKRHFSSVSTETFVPKQDFPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATAD
EYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVK
DKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAIL
EKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALR
HRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHL
NEKRALRLEWMIVILITIEVMFELGRVFF
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9NWS9
Ensemble ID
ENST00000594369.6
HGNC ID
HGNC:21036

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.S405T .
HCC15 SNV: p.S236F .
HCT15 SNV: p.G150C .
HSC3 SNV: p.W85Ter .
HT3 SNV: p.S137N .
MFE280 SNV: p.W343C DBIA    Probe Info 
MOLT4 SNV: p.Q56K; p.A59E .
SW403 SNV: p.C397F DBIA    Probe Info 
YSCCC SNV: p.P392L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C33(1.47)  LDD0531  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C33(1.47)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C33(1.00); C334(1.31)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C334(1.29); C337(0.89)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C334(1.07); C337(0.90)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C334(1.30); C337(0.80)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C334(1.28); C337(0.85)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C334(1.25); C337(0.89)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C334(1.08); C337(1.04)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C334(0.87); C337(1.20)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C334(1.05); C337(0.77)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C334(0.94); C337(1.09)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C334(1.08); C337(0.93)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C33(1.28); C334(1.20)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C334(1.50); C337(0.65)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C334(1.34); C337(0.72)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C334(1.66); C337(0.79)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C33(0.89); C337(1.37)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C33(1.02); C337(0.82)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C33(0.80); C337(0.97)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C33(1.04); C337(1.11)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C33(1.12); C337(0.79)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C33(0.95); C337(0.67)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C33(1.10); C337(0.65)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C33(1.20); C334(1.23)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C33(1.05); C337(0.81)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C33(1.08); C337(0.60)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C33(1.11); C337(0.53)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C33(1.10); C337(0.55)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C33(1.12); C337(0.87)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C33(1.25); C337(0.52)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C33(1.43); C337(0.57)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C33(1.59); C337(0.58)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C33(1.05); C337(0.97)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C33(1.18); C337(0.68)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C33(1.19); C337(0.77)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C33(1.32); C337(1.07)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C33(1.31); C337(0.84)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C33(1.21); C337(0.60)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C33(1.21); C337(0.70)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C33(1.18); C337(0.77)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C33(0.86); C337(0.71)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C33(1.19); C337(0.56)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C33(1.21); C337(0.57)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C33(1.19); C337(0.62)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C33(1.27); C334(1.35)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C33(1.22); C337(0.64)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C33(1.10); C337(0.65)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C33(1.24); C337(0.64)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C33(0.96)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C33(1.22)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C33(0.87)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C33(1.24)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C33(1.40)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C33(0.96)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C33(1.38)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C33(0.99); C334(1.75)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C33(0.77)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C33(1.18)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C33(0.91)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C33(0.62)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C33(1.03)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C33(1.04)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C33(1.57)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C33(0.75)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C33(1.02)  LDD1515  [5]
 LDCM0279  AC2 HCT 116 C33(1.35)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C33(1.12)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C262(1.26)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C33(0.93)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C164(0.92); C33(0.91)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C33(0.99)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C33(1.03)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C33(0.72)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C33(0.68)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C33(0.77)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C33(1.20)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C33(0.97)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C33(0.86)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C33(1.20)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C33(1.30)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C33(1.29)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C334(0.65); C337(0.65)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C334(0.74); C337(0.74)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C334(0.84); C337(0.84)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C334(0.67); C337(0.67)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C334(0.50); C337(0.50)  LDD0898  [1]
 LDCM0301  AC4 HCT 116 C33(1.58)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C334(0.53); C337(0.53)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C334(0.31); C337(0.31)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C334(0.33); C337(0.33)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C334(0.37); C337(0.37)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C334(0.43); C337(0.43)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C334(0.40); C337(0.40)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C33(0.87)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C33(0.82)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C33(0.85)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C33(0.80)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C33(1.59)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C33(0.78)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C33(0.79)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C33(0.84)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C33(0.91)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C33(0.75)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C33(0.83)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C33(0.88)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C334(1.06)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C334(1.01)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C334(0.96)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C33(1.30); C334(1.14)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C334(0.82)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C334(1.11)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C334(0.94)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C334(1.13)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C334(1.02)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C334(1.16)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C334(0.91)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C334(1.13)  LDD0929  [1]
 LDCM0334  AC7 HEK-293T C33(1.28); C334(1.52)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C33(1.21); C334(1.54)  LDD0943  [1]
 LDCM0349  AC83 HEK-293T C33(1.01); C337(0.77)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C33(0.81); C337(0.47)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C33(0.88); C337(0.43)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C33(0.85); C337(0.49)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C33(0.81); C337(0.61)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C33(0.76); C337(0.44)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C33(0.80); C337(0.36)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C33(0.74); C337(0.39)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C33(0.80); C337(0.44)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C33(0.85); C337(0.44)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C33(0.85); C337(0.40)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C33(0.83); C337(0.42)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C33(0.83); C337(0.41)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C33(0.81); C337(0.76)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C33(1.16); C337(0.29)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C334(1.04); C337(0.99)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C334(0.99); C337(1.17)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C33(1.57); C334(1.29)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C33(1.24); C334(1.94)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C33(1.11); C334(1.27)  LDD0873  [1]
 LDCM0632  CL-Sc Hep-G2 C9(0.93)  LDD2227  [2]
 LDCM0367  CL1 PaTu 8988t C33(0.93)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C33(1.68)  LDD1247  [1]
 LDCM0369  CL100 HCT 116 C33(1.43)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C33(1.08); C334(1.50)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C33(1.20); C334(1.39)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C33(1.31); C334(1.44)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C33(1.25); C334(1.43)  LDD0971  [1]
 LDCM0375  CL106 HEK-293T C164(0.95)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C164(0.98); C33(1.05)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C33(0.98); C262(0.84)  LDD1581  [5]
 LDCM0379  CL11 PaTu 8988t C33(1.16)  LDD1258  [1]
 LDCM0380  CL110 HEK-293T C164(0.87)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C164(1.00); C33(1.04)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C33(0.75)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C33(0.94)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C33(0.80)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C33(1.13)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C33(1.18)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C334(0.38); C337(0.38)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C334(0.53); C337(0.53)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C334(0.37); C337(0.37)  LDD0987  [1]
 LDCM0390  CL12 PaTu 8988t C33(1.15)  LDD1269  [1]
 LDCM0391  CL120 HEK-293T C334(0.36); C337(0.36)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C33(0.85)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C33(0.84)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C33(1.18)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C33(0.88)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C334(1.16)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C334(1.01)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C334(0.96)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C334(0.93)  LDD0997  [1]
 LDCM0400  CL13 PaTu 8988t C33(1.48)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C33(1.45)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C33(1.30)  LDD1281  [1]
 LDCM0403  CL16 HEK-293T C33(1.19); C334(1.08)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C33(1.24); C334(0.84)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C33(1.13); C334(1.02)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C33(1.22); C334(1.03)  LDD1004  [1]
 LDCM0407  CL2 PaTu 8988t C33(1.18)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C33(1.20); C334(0.92)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C33(1.24); C334(0.86)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C33(1.23); C334(0.99)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C33(1.07); C334(0.91)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C33(1.06); C334(0.97)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C33(1.06); C334(0.97)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C33(1.04); C334(1.06)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C33(1.05); C334(1.04)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C33(1.06); C334(0.98)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C33(1.05); C334(0.88)  LDD1015  [1]
 LDCM0418  CL3 PaTu 8988t C33(1.23)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C33(1.17); C334(1.11)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C334(1.51)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C334(1.15)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C334(2.01)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C334(1.02)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C334(1.04)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C334(1.07)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C334(1.27)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C334(1.69)  LDD1026  [1]
 LDCM0429  CL4 PaTu 8988t C33(1.12)  LDD1308  [1]
 LDCM0430  CL40 HEK-293T C334(1.24)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C334(1.70)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C334(1.53)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C334(1.61)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C334(1.13)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C334(1.51)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C33(1.00); C337(0.79)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C33(0.88); C337(0.91)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C33(0.94); C337(0.92)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C33(0.96); C337(0.79)  LDD1037  [1]
 LDCM0440  CL5 PaTu 8988t C33(1.30)  LDD1319  [1]
 LDCM0441  CL50 HEK-293T C33(1.20); C337(0.43)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C33(1.10); C337(0.78)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C33(0.92); C337(1.25)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C33(0.94); C337(1.23)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C33(1.06); C337(0.94)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C33(0.92); C337(0.87)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C33(0.83); C337(1.07)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C33(1.06); C337(0.93)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C33(0.86); C337(0.88)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C33(0.96); C337(0.55)  LDD1048  [1]
 LDCM0451  CL6 PaTu 8988t C33(1.20)  LDD1330  [1]
 LDCM0452  CL60 HEK-293T C33(1.10); C337(0.39)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C33(0.67)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C33(0.87)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C33(1.24)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C33(1.37)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C33(0.94)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C33(1.94)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C33(1.65)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C33(0.88)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C33(0.72)  LDD0778  [1]
 LDCM0462  CL7 PaTu 8988t C33(1.34)  LDD1341  [1]
 LDCM0463  CL70 HCT 116 C33(0.73)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C33(1.36)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C33(2.85)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C33(0.94)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C33(1.03)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C33(1.03); C262(1.14)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C33(1.16)  LDD1673  [5]
 LDCM0473  CL8 PaTu 8988t C33(1.28)  LDD1352  [1]
 LDCM0474  CL80 HEK-293T C33(1.07)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C262(1.14)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C33(1.04)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C164(1.06); C33(1.02)  LDD1681  [5]
 LDCM0480  CL86 HEK-293T C164(0.95)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C164(0.92); C33(1.21)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C33(1.07); C262(1.06)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C33(1.04)  LDD1686  [5]
 LDCM0484  CL9 PaTu 8988t C33(1.20)  LDD1363  [1]
 LDCM0486  CL91 HCT 116 C33(1.14)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C33(1.14)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C33(1.27)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C33(1.41)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C33(1.38)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C33(1.31)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C33(0.96)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C33(1.52)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C33(1.28)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C164(1.01); C33(1.14)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C33(1.16)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C334(1.30)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C164(0.93)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C164(1.00)  LDD1497  [5]
 LDCM0024  KB05 OCUG-1 C164(2.64)  LDD3373  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) Krueppel C2H2-type zinc-finger protein family Q9H4T2
Zinc finger and SCAN domain-containing protein 21 (ZSCAN21) Krueppel C2H2-type zinc-finger protein family Q9Y5A6
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger and SCAN domain-containing protein 30 (ZSCAN30) Krueppel C2H2-type zinc-finger protein family Q86W11
Zinc finger and SCAN domain-containing protein 32 (ZSCAN32) Krueppel C2H2-type zinc-finger protein family Q9NX65
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 18 (ZNF18) Krueppel C2H2-type zinc-finger protein family P17022
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 397 (ZNF397) Krueppel C2H2-type zinc-finger protein family Q8NF99
Zinc finger protein 496 (ZNF496) Krueppel C2H2-type zinc-finger protein family Q96IT1
Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) Krueppel C2H2-type zinc-finger protein family Q969J2
Zinc finger protein with KRAB and SCAN domains 7 (ZKSCAN7) Krueppel C2H2-type zinc-finger protein family Q9P0L1
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Zinc finger and SCAN domain-containing protein 18 (ZSCAN18) Krueppel C2H2-type zinc-finger protein family Q8TBC5
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
Ankyrin repeat domain-containing protein 1 (ANKRD1) . Q15327
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
FERM domain-containing protein 8 (FRMD8) . Q9BZ67
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
PiggyBac transposable element-derived protein 1 (PGBD1) . Q96JS3
SCAN domain-containing protein 1 (SCAND1) . P57086
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840