Details of the Target

General Information of Target

Target ID LDTP12622
Target Name Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1)
Gene Name ACSS1
Gene ID 84532
Synonyms
ACAS2L; KIAA1846; Acetyl-coenzyme A synthetase 2-like, mitochondrial; EC 6.2.1.1; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGEPRSLLFFQKPVTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVARIFL
HKPELITKLEQEEEQWRETRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQFVHNPKLTNS
CSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVC
GKSFRDQSELKRHQKIHQNQEPVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHA
PVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHPVKPSRLNVF
CCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPI
CDLSFGEKEGLMDHWRGYKGKDLCQSSHHKCRVILGQWLGFSHDVPTMAGEEWKHGGDQS
PPRIHTPRRRGLREKACKGDKTKEAVSILKHK
Target Bioclass
Enzyme
Family
ATP-dependent AMP-binding enzyme family
Subcellular location
Mitochondrion matrix
Function
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient.
Uniprot ID
Q9NUB1
Ensemble ID
ENST00000323482.9
HGNC ID
HGNC:16091

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G98D .
DU145 SNV: p.D287V DBIA    Probe Info 
G401 SNV: p.V431G .
HCT15 SNV: p.L480R .
HT1080 Insertion: p.A70DfsTer80 .
KMCH1 SNV: p.S285G .
LNCaP clone FGC SNV: p.G98V DBIA    Probe Info 
LUDLU1 SNV: p.R144K DBIA    Probe Info 
MCC13 SNV: p.Y528H .
NCIH1155 SNV: p.L104M DBIA    Probe Info 
OVCAR5 SNV: p.P69S DBIA    Probe Info 
SHP77 SNV: p.T438S DBIA    Probe Info 
SW837 SNV: p.M182K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y87(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K622(10.00); K633(10.00)  LDD0277  [2]
IPM
 Probe Info  		C422(0.00); C151(0.00)  LDD0241  [3]
DBIA
 Probe Info  		C30(2.17); C422(2.09)  LDD3312  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C93(0.00); C151(0.00); C242(0.00); C422(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C93(0.00); C151(0.00); C242(0.00); C422(0.00)  LDD0036  [5]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C93(0.00); C151(0.00); C114(0.00); C422(0.00)  LDD0037  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
W1
 Probe Info  		N.A.  LDD0236  [3]
AOyne
 Probe Info  		14.80  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C437(0.90); C452(0.59)  LDD0812  [10]
 LDCM0215  AC10 HEK-293T C437(0.96)  LDD0813  [10]
 LDCM0216  AC100 HEK-293T C422(0.92); C437(0.90)  LDD0814  [10]
 LDCM0217  AC101 HEK-293T C422(0.90); C437(0.92)  LDD0815  [10]
 LDCM0218  AC102 HEK-293T C422(0.85); C437(0.83)  LDD0816  [10]
 LDCM0219  AC103 HEK-293T C422(0.62); C437(0.80)  LDD0817  [10]
 LDCM0220  AC104 HEK-293T C422(0.74); C437(0.92)  LDD0818  [10]
 LDCM0221  AC105 HEK-293T C422(0.81); C437(1.29)  LDD0819  [10]
 LDCM0222  AC106 HEK-293T C422(0.94); C437(1.02)  LDD0820  [10]
 LDCM0223  AC107 HEK-293T C422(0.98); C437(1.11)  LDD0821  [10]
 LDCM0224  AC108 HEK-293T C422(1.07); C437(1.04)  LDD0822  [10]
 LDCM0225  AC109 HEK-293T C422(0.90); C437(0.92)  LDD0823  [10]
 LDCM0226  AC11 HEK-293T C437(1.06)  LDD0824  [10]
 LDCM0227  AC110 HEK-293T C422(0.62); C437(0.72)  LDD0825  [10]
 LDCM0228  AC111 HEK-293T C422(0.70); C437(0.80)  LDD0826  [10]
 LDCM0229  AC112 HEK-293T C422(0.66); C437(0.67)  LDD0827  [10]
 LDCM0230  AC113 HEK-293T C422(0.82); C437(0.85)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C422(0.82); C437(0.84)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C422(0.88); C437(0.85)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C422(0.87); C437(0.87)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C422(0.85); C437(0.76)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C422(0.70); C437(0.74)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C422(0.78); C437(0.84)  LDD0834  [10]
 LDCM0237  AC12 HEK-293T C437(1.09)  LDD0835  [10]
 LDCM0238  AC120 HEK-293T C422(0.92); C437(0.87)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C422(0.75); C437(0.68)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C422(0.48); C437(0.60)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C422(0.46); C437(0.58)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C422(0.76); C437(0.75)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C422(0.53); C437(0.66)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C422(0.44); C437(0.58)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C422(0.48); C437(0.76)  LDD0843  [10]
 LDCM0246  AC128 HEK-293T C422(1.09); C437(0.95)  LDD0844  [10]
 LDCM0247  AC129 HEK-293T C422(1.10); C437(0.76)  LDD0845  [10]
 LDCM0249  AC130 HEK-293T C422(1.00); C437(1.24)  LDD0847  [10]
 LDCM0250  AC131 HEK-293T C422(0.97); C437(1.19)  LDD0848  [10]
 LDCM0251  AC132 HEK-293T C422(1.15); C437(1.25)  LDD0849  [10]
 LDCM0252  AC133 HEK-293T C422(0.88); C437(0.81)  LDD0850  [10]
 LDCM0253  AC134 HEK-293T C422(0.82); C437(0.87)  LDD0851  [10]
 LDCM0254  AC135 HEK-293T C422(0.99); C437(0.82)  LDD0852  [10]
 LDCM0255  AC136 HEK-293T C422(0.87); C437(0.75)  LDD0853  [10]
 LDCM0256  AC137 HEK-293T C422(0.89); C437(0.82)  LDD0854  [10]
 LDCM0257  AC138 HEK-293T C422(0.81); C437(0.81)  LDD0855  [10]
 LDCM0258  AC139 HEK-293T C422(0.78); C437(0.71)  LDD0856  [10]
 LDCM0259  AC14 HEK-293T C437(0.87)  LDD0857  [10]
 LDCM0260  AC140 HEK-293T C422(0.99); C437(0.80)  LDD0858  [10]
 LDCM0261  AC141 HEK-293T C422(0.86); C437(0.78)  LDD0859  [10]
 LDCM0262  AC142 HEK-293T C422(0.94); C437(1.01)  LDD0860  [10]
 LDCM0263  AC143 HEK-293T C437(1.10)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C437(0.91)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C437(0.86)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C437(0.92)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C437(0.87)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C437(0.79)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C437(1.16)  LDD0867  [10]
 LDCM0270  AC15 HEK-293T C437(0.82)  LDD0868  [10]
 LDCM0271  AC150 HEK-293T C437(1.11)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C437(1.00)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C437(1.05)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C437(0.99)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C437(1.07)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C437(1.04)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C437(0.83)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C437(0.93)  LDD2165  [10]
 LDCM0276  AC17 HEK-293T C452(0.49)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C452(0.58)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C452(0.70)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C437(0.90); C452(0.92)  LDD0877  [10]
 LDCM0280  AC20 HEK-293T C452(0.60)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C452(0.67)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C452(0.46)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C452(0.39)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C452(0.86)  LDD0882  [10]
 LDCM0285  AC25 HEK-293T C437(0.99); C452(0.68)  LDD0883  [10]
 LDCM0286  AC26 HEK-293T C437(0.85); C452(0.53)  LDD0884  [10]
 LDCM0287  AC27 HEK-293T C437(0.86); C452(0.60)  LDD0885  [10]
 LDCM0288  AC28 HEK-293T C437(0.91); C452(0.49)  LDD0886  [10]
 LDCM0289  AC29 HEK-293T C437(0.93); C452(0.48)  LDD0887  [10]
 LDCM0290  AC3 HEK-293T C437(0.95); C452(1.30)  LDD0888  [10]
 LDCM0291  AC30 HEK-293T C437(0.86); C452(0.56)  LDD0889  [10]
 LDCM0292  AC31 HEK-293T C437(1.16); C452(1.72)  LDD0890  [10]
 LDCM0293  AC32 HEK-293T C437(1.09); C452(1.01)  LDD0891  [10]
 LDCM0294  AC33 HEK-293T C437(0.88); C452(0.63)  LDD0892  [10]
 LDCM0295  AC34 HEK-293T C437(1.12); C452(0.81)  LDD0893  [10]
 LDCM0296  AC35 HEK-293T C437(0.88)  LDD0894  [10]
 LDCM0297  AC36 HEK-293T C437(0.95)  LDD0895  [10]
 LDCM0298  AC37 HEK-293T C437(0.74)  LDD0896  [10]
 LDCM0299  AC38 HEK-293T C437(0.98)  LDD0897  [10]
 LDCM0300  AC39 HEK-293T C437(0.83)  LDD0898  [10]
 LDCM0301  AC4 HEK-293T C437(1.16); C452(1.22)  LDD0899  [10]
 LDCM0302  AC40 HEK-293T C437(1.02)  LDD0900  [10]
 LDCM0303  AC41 HEK-293T C437(0.94)  LDD0901  [10]
 LDCM0304  AC42 HEK-293T C437(1.07)  LDD0902  [10]
 LDCM0305  AC43 HEK-293T C437(1.16)  LDD0903  [10]
 LDCM0306  AC44 HEK-293T C437(0.90)  LDD0904  [10]
 LDCM0307  AC45 HEK-293T C437(0.91)  LDD0905  [10]
 LDCM0308  AC46 HEK-293T C437(0.96); C452(1.06)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C437(1.08); C452(0.95)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C437(1.05); C452(1.66)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C437(0.96); C452(0.58)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C437(0.91); C452(0.95)  LDD0910  [10]
 LDCM0313  AC50 HEK-293T C437(0.96); C452(0.72)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C437(0.95); C452(0.45)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C437(0.99); C452(0.58)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C437(0.99); C452(0.82)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C437(1.12); C452(0.50)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C437(0.99); C452(0.62)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C437(1.11); C452(0.91)  LDD0917  [10]
 LDCM0320  AC57 HEK-293T C422(0.96); C437(0.98)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C422(1.24); C437(1.03)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C422(0.96); C437(0.73)  LDD0920  [10]
 LDCM0323  AC6 HEK-293T C437(1.40)  LDD0921  [10]
 LDCM0324  AC60 HEK-293T C422(1.02); C437(0.83)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C422(1.16); C437(0.88)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C422(1.59); C437(0.75)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C422(1.24); C437(0.80)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C422(1.39); C437(0.83)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C422(1.21); C437(0.82)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C422(1.28); C437(0.93)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C422(1.30); C437(0.86)  LDD0929  [10]
 LDCM0332  AC68 HEK-293T C422(1.05); C452(0.54)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C422(0.89); C452(1.24)  LDD0931  [10]
 LDCM0334  AC7 HEK-293T C437(1.07)  LDD0932  [10]
 LDCM0335  AC70 HEK-293T C422(0.97); C452(0.74)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C422(1.11); C452(0.94)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C422(0.96); C452(1.01)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C422(0.94); C452(1.12)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C422(0.94); C452(1.08)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C422(0.98); C452(0.90)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C422(1.06); C452(1.10)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C422(1.10); C452(0.80)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C422(0.96); C452(0.90)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C422(1.09); C452(1.19)  LDD0942  [10]
 LDCM0345  AC8 HEK-293T C437(1.00)  LDD0943  [10]
 LDCM0346  AC80 HEK-293T C422(0.96); C452(0.81)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C422(1.03); C452(0.74)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C422(0.92); C452(0.77)  LDD0946  [10]
 LDCM0349  AC83 HEK-293T C422(1.07); C437(0.95)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C422(1.12); C437(0.93)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C422(1.22); C437(0.90)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C422(1.28); C437(0.98)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C422(1.89); C437(0.93)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C422(1.81); C437(0.87)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C422(0.98); C437(0.81)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C422(0.95); C437(0.83)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C422(0.67); C437(0.93)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C422(1.38); C437(1.02)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C422(1.01); C437(0.89)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C422(1.91); C437(0.74)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C422(0.98); C437(0.93)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C422(1.16); C437(1.19)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C422(0.52); C437(0.72)  LDD0962  [10]
 LDCM0365  AC98 HEK-293T C422(0.81); C437(0.81)  LDD0963  [10]
 LDCM0366  AC99 HEK-293T C422(0.81); C437(0.92)  LDD0964  [10]
 LDCM0248  AKOS034007472 HEK-293T C437(0.93)  LDD0846  [10]
 LDCM0356  AKOS034007680 HEK-293T C437(0.82)  LDD0954  [10]
 LDCM0275  AKOS034007705 HEK-293T C437(0.96)  LDD0873  [10]
 LDCM0367  CL1 HEK-293T C437(0.81); C452(1.13)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C437(0.48); C452(0.71)  LDD0966  [10]
 LDCM0369  CL100 HEK-293T C437(0.91); C452(0.84)  LDD0967  [10]
 LDCM0370  CL101 HEK-293T C437(1.06)  LDD0968  [10]
 LDCM0371  CL102 HEK-293T C437(0.83)  LDD0969  [10]
 LDCM0372  CL103 HEK-293T C437(0.84)  LDD0970  [10]
 LDCM0373  CL104 HEK-293T C437(0.91)  LDD0971  [10]
 LDCM0374  CL105 HEK-293T C452(0.69)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C452(0.84)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C452(0.77)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C452(0.77)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C452(0.75)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C437(0.49); C452(0.70)  LDD0977  [10]
 LDCM0380  CL110 HEK-293T C452(0.69)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C452(0.80)  LDD0979  [10]
 LDCM0382  CL112 HEK-293T C437(0.91); C452(0.57)  LDD0980  [10]
 LDCM0383  CL113 HEK-293T C437(0.98); C452(0.81)  LDD0981  [10]
 LDCM0384  CL114 HEK-293T C437(0.86); C452(0.43)  LDD0982  [10]
 LDCM0385  CL115 HEK-293T C437(0.81); C452(0.72)  LDD0983  [10]
 LDCM0386  CL116 HEK-293T C437(0.90); C452(0.40)  LDD0984  [10]
 LDCM0387  CL117 HEK-293T C437(1.10)  LDD0985  [10]
 LDCM0388  CL118 HEK-293T C437(0.89)  LDD0986  [10]
 LDCM0389  CL119 HEK-293T C437(0.95)  LDD0987  [10]
 LDCM0390  CL12 HEK-293T C437(0.62); C452(1.18)  LDD0988  [10]
 LDCM0391  CL120 HEK-293T C437(0.88)  LDD0989  [10]
 LDCM0392  CL121 HEK-293T C437(0.92); C452(0.92)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C437(1.15); C452(0.82)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C437(1.19); C452(0.78)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C437(1.01); C452(0.96)  LDD0993  [10]
 LDCM0396  CL125 HEK-293T C422(1.02); C437(0.87)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C422(0.95); C437(0.99)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C422(0.92); C437(0.85)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C422(1.14); C437(0.87)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C437(0.72); C452(1.08)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C437(0.70); C452(1.08)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C437(0.65); C452(0.77)  LDD1000  [10]
 LDCM0403  CL16 HEK-293T C452(0.53)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C452(0.44)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C452(0.52)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C452(0.69)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C437(0.75); C452(0.93)  LDD1005  [10]
 LDCM0408  CL20 HEK-293T C452(0.60)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C452(0.43)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C452(0.52)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C452(0.61)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C452(0.67)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C452(0.50)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C452(0.75)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C452(0.50)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C452(0.73)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C452(0.79)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C437(0.87); C452(1.26)  LDD1016  [10]
 LDCM0419  CL30 HEK-293T C452(0.48)  LDD1017  [10]
 LDCM0420  CL31 HEK-293T C422(1.02); C437(1.10)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C422(0.97); C437(0.86)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C422(0.83); C437(1.04)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C422(0.87); C437(0.87)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C422(0.80); C437(0.86)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C422(0.80); C437(0.74)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C422(0.88); C437(0.74)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C422(0.75); C437(0.58)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C437(0.74); C452(1.12)  LDD1027  [10]
 LDCM0430  CL40 HEK-293T C422(0.89); C437(0.71)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C422(0.78); C437(0.63)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C422(0.89); C437(0.57)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C422(1.05); C437(0.58)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C422(0.85); C437(0.80)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C422(1.00); C437(0.65)  LDD1033  [10]
 LDCM0436  CL46 HEK-293T C437(1.24)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C437(1.07)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C437(1.35)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C437(1.10)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C437(0.68); C452(0.80)  LDD1038  [10]
 LDCM0441  CL50 HEK-293T C437(0.89)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C437(1.00)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C437(1.34)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C437(1.04)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C437(0.99)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C437(1.04)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C437(1.16)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C437(1.05)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C437(0.86)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C437(0.90)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C437(0.56); C452(0.82)  LDD1049  [10]
 LDCM0452  CL60 HEK-293T C437(0.85)  LDD1050  [10]
 LDCM0453  CL61 HEK-293T C422(0.94); C437(1.19); C452(1.68)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C422(1.16); C437(0.99); C452(1.17)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C422(1.06); C437(1.19); C452(0.47)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C422(0.90); C437(1.23); C452(0.73)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C422(1.00); C437(0.95); C452(0.78)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C422(0.88); C437(1.04); C452(0.71)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C422(0.99); C437(0.94); C452(0.72)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C422(0.90); C437(0.85); C452(0.61)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C422(0.87); C437(0.95); C452(0.82)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C437(0.59); C452(0.67)  LDD1060  [10]
 LDCM0463  CL70 HEK-293T C422(0.87); C437(0.91); C452(0.70)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C422(0.85); C437(0.80); C452(0.59)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C422(1.07); C437(0.96); C452(1.47)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C422(0.88); C437(0.80); C452(0.66)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C422(0.79); C437(0.75); C452(0.56)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C437(1.12)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C437(1.19)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C437(1.38)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C437(1.28)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C422(0.68); C242(0.86)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C437(1.10)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C437(1.23)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C437(1.09)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C437(0.98)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C437(1.07)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C437(1.05)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C437(1.10)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C437(1.08)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C437(0.95)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C437(1.22)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C422(1.04)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C437(1.11)  LDD1083  [10]
 LDCM0486  CL91 HEK-293T C437(1.44); C452(1.00)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C437(1.10); C452(0.89)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C437(1.44); C452(1.06)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C437(1.23); C452(0.59)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C437(0.82); C452(0.44)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C437(1.01); C452(1.12)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C437(1.04); C452(1.40)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C437(1.03); C452(1.09)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C437(1.04); C452(1.84)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C422(0.89); C242(0.93)  LDD1698  [11]
 LDCM0625  F8 Ramos C422(1.06); C185(1.58)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C422(0.70); C185(0.64)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C422(0.48); C185(0.44)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C422(0.72); C185(0.64)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C422(0.67)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C422(0.88); C185(3.69)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C422(0.90); C185(0.38)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C422(1.08); C185(1.15)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C422(0.82)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C422(1.20); C185(0.93)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C422(0.95); C185(2.17)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C422(0.75); C185(1.15)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C422(1.00); C185(0.78)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C422(0.69); C185(0.71)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C422(0.75); C437(1.05); C452(0.51)  LDD1066  [10]
 LDCM0596  Fragment38 Ramos C422(0.72); C185(1.31)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C422(1.80); C185(0.86)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C422(0.91); C437(1.08)  LDD1025  [10]
 LDCM0610  Fragment52 Ramos C422(0.77)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C422(0.83); C185(2.06)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C422(0.67); C185(1.46)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C422(0.65); C185(0.88)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C242(1.11); C422(0.93)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C242(1.10); C422(1.28)  LDD1497  [11]
 LDCM0024  KB05 HMCB C30(2.17); C422(2.09)  LDD3312  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578