Details of the Target

General Information of Target

Target ID LDTP12532
Target Name Ribonuclease 3 (DROSHA)
Gene Name DROSHA
Gene ID 29102
Synonyms
RN3; RNASE3L; RNASEN; Ribonuclease 3; EC 3.1.26.3; Protein Drosha; Ribonuclease III; RNase III; p241
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEFWLCFNCCIAEQPQPKRRRRIDRSMIGEPTNFVHTAHVGSGDLFSGMNSVSSIQNQM
QSKGGYGGGMPANVQMQLVDTKAG
Target Bioclass
Enzyme
Family
Ribonuclease III family
Subcellular location
Nucleus
Function
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
Uniprot ID
Q9NRR4
Ensemble ID
ENST00000344624.8
HGNC ID
HGNC:17904

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R1213C .
CMK SNV: p.P616S .
DOTC24510 SNV: p.P156S .
DU145 SNV: p.A506S .
HCT15 SNV: p.A1013E; p.P1279T .
LS180 SNV: p.R1066H .
MEWO SNV: p.P580S .
MFE319 SNV: p.A780V .
MINO SNV: p.E727K .
MOLT4 SNV: p.R544H .
NCIH1703 SNV: p.C641S .
NCIH1944 SNV: p.H859N .
NCIH358 SNV: p.R219I .
OE33 SNV: p.R967W .
REH SNV: p.R544H .
RKO Deletion: p.L612Ter
SNV: p.A327T		 DBIA    Probe Info 
TE1 SNV: p.R1122Q DBIA    Probe Info 
THP1 SNV: p.T743A .
WM2664 Insertion: p.Y172LfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K931(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C1244(51.67)  LDD0209  [2]
IPM
 Probe Info  		C1268(2.42)  LDD1701  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		12.20  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C675(1.78); C676(1.78)  LDD0812  [9]
 LDCM0215  AC10 HCT 116 C675(0.83); C676(0.83)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C675(0.58); C676(0.58); C920(1.01)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C675(0.60); C676(0.60); C920(1.10)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C675(0.57); C676(0.57); C920(0.73)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C675(0.48); C676(0.48); C920(1.00)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C675(0.54); C676(0.54); C920(0.73)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C675(0.48); C676(0.48); C920(0.86)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C675(0.55); C676(0.55); C920(0.83)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C675(0.36); C676(0.96); C920(0.86)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C675(0.83); C676(2.32); C920(1.26)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C675(0.71); C676(2.84); C920(0.88)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C675(0.71); C676(0.71)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C675(0.80); C676(2.13); C920(0.68)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C675(0.72); C676(2.27); C920(0.88)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C675(0.47); C676(2.21); C920(0.73)  LDD0546  [9]
 LDCM0237  AC12 HCT 116 C675(0.76); C676(0.76)  LDD0554  [9]
 LDCM0246  AC128 HCT 116 C920(1.11)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C920(1.09)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C920(1.42)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C920(1.02)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C920(1.36)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C920(1.65)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C920(1.38)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C920(1.55)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C920(1.19)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C920(1.01)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C920(1.53)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C920(1.23)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C675(0.88); C676(0.88)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C920(1.99)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C920(1.20)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C920(1.56)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C675(0.91); C676(0.91)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C675(0.73); C676(0.73)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C675(0.75); C676(0.75)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C675(0.85); C676(0.85)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C675(0.73); C676(0.73)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C675(0.54); C676(0.54)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C675(0.71); C676(0.71)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C675(0.70); C676(0.70)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C675(0.85); C676(0.85)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C675(0.87); C676(0.87)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C675(0.63); C676(0.63)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C675(0.49); C676(0.49)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C675(0.69); C676(0.69)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C675(0.71); C676(0.71)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C675(0.90); C676(0.90)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C675(0.74); C676(0.74)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C675(0.77); C676(0.77)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C675(0.69); C676(0.69)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C675(0.70); C676(0.70)  LDD0595  [9]
 LDCM0279  AC2 HEK-293T C675(1.02); C676(1.02)  LDD0877  [9]
 LDCM0280  AC20 HCT 116 C675(0.83); C676(0.83)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C675(0.72); C676(0.72)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C675(0.69); C676(0.69)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C675(0.64); C676(0.64)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C675(0.76); C676(0.76)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C675(0.85); C676(0.85)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C675(0.93); C676(0.93)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C675(0.94); C676(0.94)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C675(0.86); C676(0.86)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C675(0.88); C676(0.88)  LDD0606  [9]
 LDCM0290  AC3 HEK-293T C675(0.89); C676(0.89)  LDD0888  [9]
 LDCM0291  AC30 HCT 116 C675(0.88); C676(0.88)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C675(0.97); C676(0.97)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C675(0.87); C676(0.87)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C675(0.85); C676(0.85)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C675(0.87); C676(0.87)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C920(0.73); C675(1.35); C676(1.35)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C920(0.95); C675(1.02); C676(1.02)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C675(1.18); C676(1.18); C920(1.22)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C675(1.03); C676(1.03); C920(1.10)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C920(0.94); C675(1.13); C676(1.13)  LDD0617  [9]
 LDCM0301  AC4 HEK-293T C675(1.23); C676(1.23)  LDD0899  [9]
 LDCM0302  AC40 HCT 116 C920(1.04); C675(1.37); C676(1.37)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C920(1.05); C675(1.16); C676(1.16)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C675(0.98); C676(0.98); C920(1.28)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C675(0.92); C676(0.92); C920(1.23)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C920(1.25); C675(1.39); C676(1.39)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C920(1.07); C675(1.22); C676(1.22)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C675(0.96); C676(0.96); C920(1.13)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C675(1.00); C676(1.00); C920(1.14)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C675(1.43); C676(1.43); C920(1.76)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C675(0.64); C676(0.64); C920(0.98)  LDD0628  [9]
 LDCM0312  AC5 HEK-293T C675(1.50); C676(1.50)  LDD0910  [9]
 LDCM0313  AC50 HCT 116 C675(0.72); C676(0.72); C920(0.99)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C675(1.19); C676(1.19); C920(1.57)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C675(0.89); C676(0.89); C920(1.33)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C675(0.82); C676(0.82); C920(1.21)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C675(0.74); C676(0.74); C920(0.98)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C675(0.60); C676(0.60); C920(1.12)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C675(0.60); C676(0.60); C920(1.08)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C675(0.63); C676(0.63); C920(1.37)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C675(0.70); C676(0.70); C920(1.53)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C675(0.64); C676(0.64); C920(1.17)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C675(0.70); C676(0.70)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C675(0.58); C676(0.58); C920(1.54)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C675(1.13); C676(1.13); C920(2.15)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C675(0.70); C676(0.70); C920(1.61)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C675(0.76); C676(0.76); C920(1.51)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C675(0.73); C676(0.73); C920(1.44)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C675(1.01); C676(1.01); C920(1.68)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C675(1.17); C676(1.17); C920(1.60)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C675(0.55); C676(0.55); C920(1.40)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C920(0.98); C675(1.11); C676(1.11)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C920(0.85); C675(1.08); C676(1.08)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C675(0.96); C676(0.96)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C920(0.71); C675(1.03); C676(1.03)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C920(1.10); C675(1.16); C676(1.16)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C920(0.87); C675(0.99); C676(0.99)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C675(0.76); C676(0.76); C920(1.15)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C675(0.84); C676(0.84); C920(0.96)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C675(0.66); C676(0.66); C920(1.06)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C675(1.00); C676(1.00); C920(1.06)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C675(0.89); C676(0.89); C920(1.54)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C675(1.20); C676(1.20); C920(1.39)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C675(1.16); C676(1.16); C920(1.22)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C675(0.73); C676(0.73)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C920(0.82); C675(1.04); C676(1.04)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C920(1.13); C675(1.40); C676(1.40)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C675(0.81); C676(0.81); C920(0.87)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C920(0.67)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C920(0.65)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C920(0.71)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C920(1.10)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C920(0.86)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C920(0.99)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C920(1.01)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C920(0.99)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C920(0.86)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C920(0.78)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C920(0.61)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C920(0.53)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C920(1.30)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C920(0.77)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C920(0.71)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C675(0.32); C676(0.32); C920(0.70)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C675(0.58); C676(0.58); C920(1.21)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C675(0.76); C676(0.76)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C675(0.70); C676(0.70)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C675(0.63); C676(0.63)  LDD0592  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C920(0.97)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C920(1.07)  LDD0685  [9]
 LDCM0369  CL100 HEK-293T C675(0.97); C676(0.97)  LDD0967  [9]
 LDCM0370  CL101 HCT 116 C675(0.72); C676(0.72)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C675(0.75); C676(0.75)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C675(0.74); C676(0.74)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C675(0.69); C676(0.69)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C675(0.64); C676(0.64)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C675(0.61); C676(0.61)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C675(0.66); C676(0.66)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C675(0.65); C676(0.65)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C675(0.69); C676(0.69)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C920(0.99)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C675(0.65); C676(0.65)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C675(0.65); C676(0.65)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C675(0.93); C676(0.93)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C675(0.87); C676(0.87)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C675(0.82); C676(0.82)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C675(0.98); C676(0.98)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C675(0.84); C676(0.84)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C920(0.88); C675(0.88); C676(0.88)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C920(0.93); C675(0.98); C676(0.98)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C920(0.90); C675(0.98); C676(0.98)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C920(1.17)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C675(0.95); C676(0.95); C920(1.17)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C920(0.94); C675(1.13); C676(1.13)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C675(0.91); C676(0.91); C920(1.23)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C675(0.83); C676(0.83); C920(1.02)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C675(0.81); C676(0.81); C920(1.00)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C675(0.72); C676(0.72); C920(1.46)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C675(0.82); C676(0.82); C920(1.28)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C675(0.77); C676(0.77); C920(1.31)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C675(0.66); C676(0.66); C920(1.52)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C920(0.99)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C920(1.17)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C920(1.00)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C920(0.88)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C920(0.99)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C920(0.87)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C920(0.94)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C920(1.34)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C920(0.89)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C920(1.09)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C920(1.35)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C920(1.14)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C920(1.31)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C920(0.97)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C920(0.85)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C920(1.09)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C920(1.17)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C920(1.05)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C920(1.03)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C920(0.86)  LDD0736  [9]
 LDCM0420  CL31 HEK-293T C675(1.51); C676(1.51)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C675(1.39); C676(1.39)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C675(1.24); C676(1.24)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C675(1.00); C676(1.00)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C675(1.22); C676(1.22)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C675(0.85); C676(0.85)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C675(1.03); C676(1.03)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C675(1.02); C676(1.02)  LDD1026  [9]
 LDCM0429  CL4 HCT 116 C920(1.15)  LDD0746  [9]
 LDCM0430  CL40 HEK-293T C675(1.17); C676(1.17)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C675(1.14); C676(1.14)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C675(0.99); C676(0.99)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C675(0.88); C676(0.88)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C675(1.14); C676(1.14)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C675(0.89); C676(0.89)  LDD1033  [9]
 LDCM0436  CL46 HCT 116 C675(0.92); C676(0.92)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C675(0.85); C676(0.85)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C675(0.85); C676(0.85)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C675(0.90); C676(0.90)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C920(1.11)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C675(0.98); C676(0.98)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C675(0.98); C676(0.98)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C675(0.77); C676(0.77)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C675(0.95); C676(0.95)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C675(0.98); C676(0.98)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C675(0.99); C676(0.99)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C675(0.86); C676(0.86)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C675(0.93); C676(0.93)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C675(1.04); C676(1.04)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C675(1.04); C676(1.04)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C920(1.22)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C675(0.88); C676(0.88)  LDD0769  [9]
 LDCM0453  CL61 PaTu 8988t C675(1.01); C676(1.01)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C675(1.01); C676(1.01)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C675(0.97); C676(0.97)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C675(0.84); C676(0.84)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C675(0.84); C676(0.84)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C675(0.76); C676(0.76)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C675(0.76); C676(0.76)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C675(0.68); C676(0.68)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C675(0.86); C676(0.86)  LDD1340  [9]
 LDCM0462  CL7 HCT 116 C920(1.07)  LDD0779  [9]
 LDCM0463  CL70 PaTu 8988t C675(0.88); C676(0.88)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C675(1.16); C676(1.16)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C675(1.61); C676(1.61)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C675(0.91); C676(0.91)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C675(1.40); C676(1.40)  LDD1346  [9]
 LDCM0469  CL76 HEK-293T C1244(1.27); C1031(1.09); C536(1.32)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C1244(0.98); C1031(0.86); C675(1.08)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C1244(0.87); C1031(1.16); C561(0.89); C1268(1.12)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C1244(1.05); C1031(1.09)  LDD1675  [10]
 LDCM0473  CL8 HCT 116 C920(1.10)  LDD0790  [9]
 LDCM0474  CL80 HEK-293T C1244(0.96); C1031(1.12); C561(1.18)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C1244(1.04); C1031(1.03); C561(0.90)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C1244(0.99); C536(0.90); C1268(1.16)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C1244(0.67); C1031(0.94); C561(0.92); C536(0.91)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C1244(1.07); C1031(1.10); C1268(0.90); C675(1.12)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C1244(0.74); C1031(1.07); C675(1.02)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C1244(1.17); C1031(1.13); C561(0.87); C536(1.11)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C1244(1.28); C1031(0.97)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C1244(0.85); C1031(0.97); C536(1.28)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C1244(1.31); C1031(1.20); C675(1.06)  LDD1686  [10]
 LDCM0484  CL9 HCT 116 C920(1.10)  LDD0801  [9]
 LDCM0485  CL90 HEK-293T C1244(1.49); C1031(1.00); C561(1.60); C1268(0.98)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C675(1.73); C676(1.73)  LDD1084  [9]
 LDCM0487  CL92 HEK-293T C675(1.26); C676(1.26)  LDD1085  [9]
 LDCM0488  CL93 HEK-293T C675(1.26); C676(1.26)  LDD1086  [9]
 LDCM0489  CL94 HEK-293T C675(1.22); C676(1.22)  LDD1087  [9]
 LDCM0490  CL95 HEK-293T C675(1.14); C676(1.14)  LDD1088  [9]
 LDCM0491  CL96 HEK-293T C675(1.21); C676(1.21)  LDD1089  [9]
 LDCM0492  CL97 HEK-293T C675(1.36); C676(1.36)  LDD1090  [9]
 LDCM0493  CL98 HEK-293T C675(0.95); C676(0.95)  LDD1091  [9]
 LDCM0494  CL99 HEK-293T C675(0.91); C676(0.91)  LDD1092  [9]
 LDCM0495  E2913 HEK-293T C1244(0.89); C1031(0.97)  LDD1698  [10]
 LDCM0468  Fragment33 PaTu 8988t C675(1.08); C676(1.08)  LDD1347  [9]
 LDCM0427  Fragment51 HEK-293T C675(1.20); C676(1.20)  LDD1025  [9]
 LDCM0022  KB02 HEK-293T C1031(0.95); C1244(1.06); C675(1.03)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C1244(51.67)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C994(2.13)  LDD3310  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX5 (DDX5) DEAD box helicase family P17844
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 1 (SMAD1) Dwarfin/SMAD family Q15797
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FUS (FUS) RRM TET family P35637
Microprocessor complex subunit DGCR8 (DGCR8) . Q8WYQ5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840