Details of the Target

General Information of Target

Target ID LDTP12059
Target Name Bromodomain-containing protein 9 (BRD9)
Gene Name BRD9
Gene ID 65980
Synonyms
Bromodomain-containing protein 9; Rhabdomyosarcoma antigen MU-RMS-40.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPY
PMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWR
CCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHL
LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVH
FSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN
TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGA
GARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD
ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG
GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV
DAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL
EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA
RVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAG
AGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK
GKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQ
TVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT
GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR).
TTD ID
T46216
Uniprot ID
Q9H8M2
DrugMap ID
TTR7L5Y
Ensemble ID
ENST00000467963.6
HGNC ID
HGNC:25818
ChEMBL ID
CHEMBL3108640

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C288(2.64)  LDD0171  [1]
DBIA
 Probe Info  		C279(1.58); C288(1.58)  LDD1093  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
photo_BS
 Probe Info  		2.10  LDD0412  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C288(2.64)  LDD0171  [1]
 LDCM0214  AC1 PaTu 8988t C279(1.58); C288(1.58)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C279(1.31); C288(1.31)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C279(1.39); C288(1.39)  LDD1105  [2]
 LDCM0230  AC113 PaTu 8988t C279(1.36); C288(1.36)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C279(0.81); C288(0.81)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C279(0.81); C288(0.81)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C279(0.73); C288(0.73)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C279(0.86); C288(0.86)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C279(0.71); C288(0.71)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C279(0.83); C288(0.83)  LDD1115  [2]
 LDCM0237  AC12 PaTu 8988t C279(1.15); C288(1.15)  LDD1116  [2]
 LDCM0238  AC120 PaTu 8988t C279(0.92); C288(0.92)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C279(0.82); C288(0.82)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C279(0.87); C288(0.87)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C279(1.04); C288(1.04)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C279(0.89); C288(0.89)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C279(1.35); C288(1.35)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C279(0.79); C288(0.79)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C279(0.86); C288(0.86)  LDD1124  [2]
 LDCM0246  AC128 PaTu 8988t C279(0.91); C288(0.91)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C279(0.94); C288(0.94)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C279(1.00); C288(1.00)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C279(1.31); C288(1.31)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C279(0.90); C288(0.90)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C279(1.06); C288(1.06)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C279(0.91); C288(0.91)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C279(0.95); C288(0.95)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C279(0.87); C288(0.87)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C279(0.84); C288(0.84)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C279(1.24); C288(1.24)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C279(0.82); C288(0.82)  LDD1137  [2]
 LDCM0259  AC14 PaTu 8988t C279(1.31); C288(1.31)  LDD1138  [2]
 LDCM0260  AC140 PaTu 8988t C279(1.10); C288(1.10)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C279(1.05); C288(1.05)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C279(1.11); C288(1.11)  LDD1141  [2]
 LDCM0263  AC143 PaTu 8988t C279(0.84); C288(0.84)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C279(0.66); C288(0.66)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C279(0.87); C288(0.87)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C279(0.75); C288(0.75)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C279(0.51); C288(0.51)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C279(1.12); C288(1.12)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C279(1.00); C288(1.00)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C279(0.96); C288(0.96)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C279(0.69); C288(0.69)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C279(0.81); C288(0.81)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C279(0.72); C288(0.72)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C279(0.83); C288(0.83)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C279(1.05); C288(1.05)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C279(0.83); C288(0.83)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C279(0.59); C288(0.59)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C279(0.80); C288(0.80)  LDD2169  [2]
 LDCM0276  AC17 HEK-293T C421(1.01); C101(0.92)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C421(1.26)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C421(0.95)  LDD1517  [9]
 LDCM0279  AC2 PaTu 8988t C279(1.16); C288(1.16)  LDD1158  [2]
 LDCM0280  AC20 HEK-293T C421(0.98)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C421(1.04)  LDD1520  [9]
 LDCM0284  AC24 HEK-293T C421(1.01); C101(0.83)  LDD1523  [9]
 LDCM0285  AC25 PaTu 8988t C279(0.60); C288(0.60)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C279(0.70); C288(0.70)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C279(0.64); C288(0.64)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C279(0.68); C288(0.68)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C279(0.56); C288(0.56)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C279(1.41); C288(1.41)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C279(0.87); C288(0.87)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C279(0.58); C288(0.58)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C279(0.96); C288(0.96)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C279(0.89); C288(0.89)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C279(0.99); C288(0.99)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C421(0.81)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C421(1.04)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C421(1.16)  LDD1537  [9]
 LDCM0301  AC4 PaTu 8988t C279(1.02); C288(1.02)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C421(0.97); C101(0.97)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C421(1.77); C101(0.84)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C421(0.72)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C421(0.94)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C421(1.08)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C421(1.00)  LDD1546  [9]
 LDCM0308  AC46 PaTu 8988t C279(1.22); C288(1.22)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C279(1.03); C288(1.03)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C279(0.94); C288(0.94)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C279(1.33); C288(1.33)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C279(1.47); C288(1.47)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C279(1.21); C288(1.21)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C279(0.57); C288(0.57)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C279(1.17); C288(1.17)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C279(1.40); C288(1.40)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C279(1.18); C288(1.18)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C279(0.99); C288(0.99)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C279(1.34); C288(1.34)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C279(0.98); C288(0.98)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C279(1.03); C288(1.03)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C279(0.73); C288(0.73)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C279(1.76); C288(1.76)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C279(0.66); C288(0.66)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C279(1.02); C288(1.02)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C279(0.88); C288(0.88)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C279(1.07); C288(1.07)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C279(1.17); C288(1.17)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C279(0.79); C288(0.79)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C279(1.07); C288(1.07)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C279(0.61); C288(0.61)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C279(1.08); C288(1.08)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C279(0.87); C288(0.87)  LDD1212  [2]
 LDCM0334  AC7 PaTu 8988t C279(1.45); C288(1.45)  LDD1213  [2]
 LDCM0335  AC70 PaTu 8988t C279(1.09); C288(1.09)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C279(1.17); C288(1.17)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C279(1.22); C288(1.22)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C279(0.94); C288(0.94)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C279(0.97); C288(0.97)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C279(0.86); C288(0.86)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C279(1.03); C288(1.03)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C279(0.92); C288(0.92)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C279(0.83); C288(0.83)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C279(0.98); C288(0.98)  LDD1223  [2]
 LDCM0345  AC8 PaTu 8988t C279(1.01); C288(1.01)  LDD1224  [2]
 LDCM0346  AC80 PaTu 8988t C279(1.03); C288(1.03)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C279(1.11); C288(1.11)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C279(1.40); C288(1.40)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C279(0.60); C288(0.60)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C279(0.69); C288(0.69)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C279(0.66); C288(0.66)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C279(0.57); C288(0.57)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C279(0.56); C288(0.56)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C279(0.59); C288(0.59)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C279(0.75); C288(0.75)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C279(0.60); C288(0.60)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C279(0.48); C288(0.48)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C279(0.54); C288(0.54)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C279(0.59); C288(0.59)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C279(0.78); C288(0.78)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C279(0.69); C288(0.69)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C279(0.54); C288(0.54)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C279(0.54); C288(0.54)  LDD1243  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C279(1.30); C288(1.30)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C279(1.33); C288(1.33)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C279(1.23); C288(1.23)  LDD1154  [2]
 LDCM0160  Bromosprine HEK-293T 2.10  LDD0412  [8]
 LDCM0367  CL1 HEK-293T C421(1.16)  LDD1571  [9]
 LDCM0369  CL100 PaTu 8988t C279(1.26); C288(1.26)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C279(1.34); C288(1.34)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C279(1.42); C288(1.42)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C279(1.38); C288(1.38)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C279(1.51); C288(1.51)  LDD1252  [2]
 LDCM0374  CL105 HEK-293T C421(1.10)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C101(0.80)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C101(0.75)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C421(0.93)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C421(1.06)  LDD1582  [9]
 LDCM0380  CL110 HEK-293T C101(0.88)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C101(0.90)  LDD1585  [9]
 LDCM0382  CL112 PaTu 8988t C279(0.94); C288(0.94)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C279(0.49); C288(0.49)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C279(0.62); C288(0.62)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C279(0.69); C288(0.69)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C279(0.58); C288(0.58)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C421(1.19)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C101(1.00)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C101(0.65)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C421(1.43); C101(1.17)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C421(0.91)  LDD1595  [9]
 LDCM0392  CL121 PaTu 8988t C279(1.02); C288(1.02)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C279(1.19); C288(1.19)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C279(1.10); C288(1.10)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C279(1.31); C288(1.31)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C279(1.00); C288(1.00)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C279(0.81); C288(0.81)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C279(0.76); C288(0.76)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C279(1.16); C288(1.16)  LDD1278  [2]
 LDCM0400  CL13 HEK-293T C421(1.21)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C101(0.91)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C101(0.71)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C421(1.34)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C421(1.74); C101(1.10)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C421(1.28)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C421(1.25)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C101(0.96)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C421(1.08)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C421(1.35)  LDD1613  [9]
 LDCM0412  CL24 HEK-293T C421(1.21); C101(1.01)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C421(1.31)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C101(0.87)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C101(0.74)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C421(1.14)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C421(1.40); C101(1.40)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C101(0.96)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C421(1.09)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C421(0.95)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C421(0.96)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C421(1.40)  LDD1626  [9]
 LDCM0425  CL36 HEK-293T C421(1.20); C101(1.29)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C421(0.98)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C101(0.59)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C421(1.26)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C421(0.93)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C421(0.92); C101(0.85)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C421(0.94)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C421(0.97)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C421(0.99)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C421(0.96)  LDD1639  [9]
 LDCM0436  CL46 PaTu 8988t C279(0.80); C288(0.80)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C279(0.89); C288(0.89)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C279(1.19); C288(1.19)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C279(1.00); C288(1.00)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C421(0.91); C101(1.10)  LDD1644  [9]
 LDCM0441  CL50 PaTu 8988t C279(0.88); C288(0.88)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C279(1.63); C288(1.63)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C279(1.14); C288(1.14)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C279(1.12); C288(1.12)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C279(0.98); C288(0.98)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C279(1.08); C288(1.08)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C279(1.01); C288(1.01)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C279(1.06); C288(1.06)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C279(0.72); C288(0.72)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C279(0.74); C288(0.74)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C421(1.07)  LDD1654  [9]
 LDCM0452  CL60 PaTu 8988t C279(0.84); C288(0.84)  LDD1331  [2]
 LDCM0453  CL61 HEK-293T C421(1.09)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C101(1.00)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C101(0.86)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C421(1.24)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C421(1.05); C101(1.41)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C421(1.27)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C421(1.00)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C421(1.15)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C421(1.16)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C421(1.13)  LDD1665  [9]
 LDCM0465  CL72 HEK-293T C421(1.45); C101(1.02)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C421(1.10)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C101(0.99)  LDD1670  [9]
 LDCM0469  CL76 PaTu 8988t C279(0.96); C288(0.96)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C279(1.19); C288(1.19)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C279(0.97); C288(0.97)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C279(1.20); C288(1.20)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C421(1.43)  LDD1676  [9]
 LDCM0474  CL80 PaTu 8988t C279(1.18); C288(1.18)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C279(2.00); C288(2.00)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C279(1.53); C288(1.53)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C279(1.00); C288(1.00)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C279(1.26); C288(1.26)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C279(1.12); C288(1.12)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C279(1.08); C288(1.08)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C279(1.32); C288(1.32)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C279(1.70); C288(1.70)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C279(1.69); C288(1.69)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C421(1.22)  LDD1687  [9]
 LDCM0485  CL90 PaTu 8988t C279(2.09); C288(2.09)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C279(1.05); C288(1.05)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C279(1.89); C288(1.89)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C279(1.08); C288(1.08)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C279(1.55); C288(1.55)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C279(2.35); C288(2.35)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C279(1.58); C288(1.58)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C279(1.31); C288(1.31)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C279(1.32); C288(1.32)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C279(1.27); C288(1.27)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C101(0.82)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C101(0.83)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C101(0.89)  LDD1631  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliogenesis-associated TTC17-interacting protein (CATIP) CATIP family Q7Z7H3

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bi 7273 Small molecular drug DVZ6M1
I-brd9 Small molecular drug D0N5BI
Lp99 Small molecular drug D08LXU

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells. J Am Chem Soc. 2019 Jul 24;141(29):11497-11505. doi: 10.1021/jacs.9b02738. Epub 2019 Jul 9.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402