Details of the Target

General Information of Target

Target ID LDTP12047
Target Name Gem-associated protein 7 (GEMIN7)
Gene Name GEMIN7
Gene ID 79760
Synonyms
Gem-associated protein 7; Gemin-7; SIP3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAESPTEEAATAGAGAAGPGASSVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGS
GLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMF
VVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPN
FYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNY
NECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDP
FGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV
Target Bioclass
Other
Family
Gemin-7 family
Subcellular location
Nucleus, nucleoplasm
Function
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.
Uniprot ID
Q9H840
Ensemble ID
ENST00000270257.9
HGNC ID
HGNC:20045
ChEMBL ID
CHEMBL4105841

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C44(1.65)  LDD3323  [1]
AHL-Pu-1
 Probe Info  		C44(2.18)  LDD0168  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
JW-RF-010
 Probe Info  		C44(0.00); C121(0.00)  LDD0026  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0176  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C44(2.18)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C44(3.14)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C121(0.83)  LDD0812  [10]
 LDCM0215  AC10 HEK-293T C121(0.92)  LDD0813  [10]
 LDCM0216  AC100 HEK-293T C121(1.32)  LDD0814  [10]
 LDCM0217  AC101 HEK-293T C121(0.94)  LDD0815  [10]
 LDCM0218  AC102 HEK-293T C121(1.11)  LDD0816  [10]
 LDCM0219  AC103 HEK-293T C121(1.33)  LDD0817  [10]
 LDCM0220  AC104 HEK-293T C121(1.26)  LDD0818  [10]
 LDCM0221  AC105 HEK-293T C121(1.00)  LDD0819  [10]
 LDCM0222  AC106 HEK-293T C121(0.77)  LDD0820  [10]
 LDCM0223  AC107 HEK-293T C121(1.13)  LDD0821  [10]
 LDCM0224  AC108 HEK-293T C121(1.05)  LDD0822  [10]
 LDCM0225  AC109 HEK-293T C121(0.92)  LDD0823  [10]
 LDCM0226  AC11 HEK-293T C121(0.94)  LDD0824  [10]
 LDCM0227  AC110 HEK-293T C121(2.31)  LDD0825  [10]
 LDCM0228  AC111 HEK-293T C121(3.46)  LDD0826  [10]
 LDCM0229  AC112 HEK-293T C121(2.71)  LDD0827  [10]
 LDCM0230  AC113 HEK-293T C121(1.00)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C121(1.29)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C121(1.23)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C121(1.29)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C121(1.36)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C121(1.30)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C121(1.84)  LDD0834  [10]
 LDCM0237  AC12 HEK-293T C121(1.10)  LDD0835  [10]
 LDCM0238  AC120 HEK-293T C121(1.56)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C121(2.07)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C121(2.29)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C121(2.02)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C121(1.51)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C121(2.33)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C121(3.36)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C121(3.30)  LDD0843  [10]
 LDCM0259  AC14 HEK-293T C121(0.99)  LDD0857  [10]
 LDCM0263  AC143 HEK-293T C121(1.04)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C121(1.69)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C121(1.22)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C121(1.21)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C121(1.39)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C121(0.80)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C121(0.83)  LDD0867  [10]
 LDCM0270  AC15 HEK-293T C121(1.11)  LDD0868  [10]
 LDCM0271  AC150 HEK-293T C121(1.07)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C121(1.37)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C121(1.00)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C121(1.12)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C121(1.09)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C121(1.10)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C121(1.25)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C121(2.37)  LDD2165  [10]
 LDCM0276  AC17 HEK-293T C121(1.64)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C121(1.47)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C121(1.32)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C121(0.96)  LDD0877  [10]
 LDCM0280  AC20 HEK-293T C121(1.67)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C121(1.37)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C121(1.72)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C121(2.05)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C121(1.39)  LDD0882  [10]
 LDCM0285  AC25 HEK-293T C121(1.36)  LDD0883  [10]
 LDCM0286  AC26 HEK-293T C121(1.54)  LDD0884  [10]
 LDCM0287  AC27 HEK-293T C121(1.33)  LDD0885  [10]
 LDCM0288  AC28 HEK-293T C121(1.25)  LDD0886  [10]
 LDCM0289  AC29 HEK-293T C121(1.68)  LDD0887  [10]
 LDCM0290  AC3 HEK-293T C121(0.75)  LDD0888  [10]
 LDCM0291  AC30 HEK-293T C121(1.54)  LDD0889  [10]
 LDCM0292  AC31 HEK-293T C121(1.40)  LDD0890  [10]
 LDCM0293  AC32 HEK-293T C121(1.59)  LDD0891  [10]
 LDCM0294  AC33 HEK-293T C121(1.55)  LDD0892  [10]
 LDCM0295  AC34 HEK-293T C121(1.59)  LDD0893  [10]
 LDCM0296  AC35 HEK-293T C121(0.63)  LDD0894  [10]
 LDCM0297  AC36 HEK-293T C121(0.83)  LDD0895  [10]
 LDCM0298  AC37 HEK-293T C121(0.92)  LDD0896  [10]
 LDCM0299  AC38 HEK-293T C121(0.92)  LDD0897  [10]
 LDCM0300  AC39 HEK-293T C121(0.82)  LDD0898  [10]
 LDCM0301  AC4 HEK-293T C121(0.77)  LDD0899  [10]
 LDCM0302  AC40 HEK-293T C121(1.03)  LDD0900  [10]
 LDCM0303  AC41 HEK-293T C121(0.89)  LDD0901  [10]
 LDCM0304  AC42 HEK-293T C121(1.06)  LDD0902  [10]
 LDCM0305  AC43 HEK-293T C121(1.03)  LDD0903  [10]
 LDCM0306  AC44 HEK-293T C121(0.97)  LDD0904  [10]
 LDCM0307  AC45 HEK-293T C121(0.82)  LDD0905  [10]
 LDCM0308  AC46 HEK-293T C121(0.77)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C121(0.90)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C121(0.94)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C121(1.19)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C121(1.01)  LDD0910  [10]
 LDCM0313  AC50 HEK-293T C121(1.19)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C121(1.17)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C121(1.33)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C121(1.12)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C121(1.22)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C121(1.08)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C121(1.09)  LDD0917  [10]
 LDCM0320  AC57 HEK-293T C121(1.32)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C121(1.10)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C121(1.14)  LDD0920  [10]
 LDCM0323  AC6 HEK-293T C121(1.36)  LDD0921  [10]
 LDCM0324  AC60 HEK-293T C121(1.05)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C121(1.58)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C121(0.90)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C121(1.14)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C121(1.10)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C121(1.39)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C121(1.15)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C121(1.47)  LDD0929  [10]
 LDCM0332  AC68 HEK-293T C121(0.96)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C121(1.06)  LDD0931  [10]
 LDCM0334  AC7 HEK-293T C121(1.16)  LDD0932  [10]
 LDCM0335  AC70 HEK-293T C121(1.23)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C121(1.05)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C121(0.97)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C121(1.03)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C121(1.07)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C121(1.13)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C121(0.96)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C121(1.13)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C121(1.09)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C121(1.08)  LDD0942  [10]
 LDCM0345  AC8 HEK-293T C121(1.88)  LDD0943  [10]
 LDCM0346  AC80 HEK-293T C121(1.30)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C121(1.26)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C121(2.00)  LDD0946  [10]
 LDCM0349  AC83 HEK-293T C121(0.71)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C121(1.08)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C121(1.09)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C121(0.88)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C121(1.05)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C121(1.23)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C121(1.30)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C121(1.35)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C121(0.91)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C121(1.26)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C121(1.32)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C121(1.11)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C121(1.20)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C121(1.14)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C121(2.97)  LDD0962  [10]
 LDCM0365  AC98 HEK-293T C121(0.92)  LDD0963  [10]
 LDCM0366  AC99 HEK-293T C121(1.05)  LDD0964  [10]
 LDCM0248  AKOS034007472 HEK-293T C121(0.95)  LDD0846  [10]
 LDCM0356  AKOS034007680 HEK-293T C121(1.24)  LDD0954  [10]
 LDCM0275  AKOS034007705 HEK-293T C121(1.28)  LDD0873  [10]
 LDCM0632  CL-Sc Hep-G2 C44(1.43)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C44(1.26); C121(0.88)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C44(1.37)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C121(1.01)  LDD0967  [10]
 LDCM0370  CL101 HEK-293T C121(1.79)  LDD0968  [10]
 LDCM0371  CL102 HEK-293T C121(1.37)  LDD0969  [10]
 LDCM0372  CL103 HEK-293T C121(1.53)  LDD0970  [10]
 LDCM0373  CL104 HEK-293T C121(1.40)  LDD0971  [10]
 LDCM0374  CL105 HEK-293T C121(1.39)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C121(1.25)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C121(1.33)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C121(1.11)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C121(1.21)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C44(1.12)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C121(1.30)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C121(1.42)  LDD0979  [10]
 LDCM0382  CL112 HEK-293T C121(1.80)  LDD0980  [10]
 LDCM0383  CL113 HEK-293T C121(1.68)  LDD0981  [10]
 LDCM0384  CL114 HEK-293T C121(2.39)  LDD0982  [10]
 LDCM0385  CL115 HEK-293T C121(1.76)  LDD0983  [10]
 LDCM0386  CL116 HEK-293T C121(2.02)  LDD0984  [10]
 LDCM0387  CL117 HEK-293T C121(0.77)  LDD0985  [10]
 LDCM0388  CL118 HEK-293T C121(0.76)  LDD0986  [10]
 LDCM0389  CL119 HEK-293T C121(0.96)  LDD0987  [10]
 LDCM0390  CL12 HEK-293T C44(1.07)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C121(0.99)  LDD0989  [10]
 LDCM0392  CL121 HEK-293T C121(1.21)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C121(1.08)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C121(0.93)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C121(1.20)  LDD0993  [10]
 LDCM0396  CL125 HEK-293T C121(1.25)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C121(0.98)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C121(1.16)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C121(1.17)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C44(1.18); C121(1.20)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C44(1.03); C121(1.17)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C44(1.24); C121(0.98)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C44(0.97); C121(1.23)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C44(1.23); C121(0.96)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C44(1.18); C121(1.23)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C44(1.13); C121(0.92)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C44(0.95); C121(0.97)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C44(1.03); C121(0.97)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C44(1.08); C121(1.04)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C44(1.62)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C44(1.20)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C44(1.04)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C44(0.98); C121(1.00)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C44(0.81); C121(1.03)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C44(1.09); C121(1.27)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C44(0.98); C121(1.13)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C44(1.11); C121(1.05)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C44(1.30); C121(1.04)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C44(0.98); C121(1.13)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C121(1.71)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C121(1.53)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C121(1.48)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C121(1.14)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C121(1.56)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C121(1.07)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C121(1.24)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C121(2.60)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C44(1.21); C121(1.11)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C121(1.26)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C121(1.91)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C121(1.85)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C121(1.79)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C121(1.41)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C121(1.84)  LDD1033  [10]
 LDCM0436  CL46 HEK-293T C121(1.73)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C121(1.85)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C121(1.32)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C121(1.17)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C44(1.12); C121(1.00)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C121(1.46)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C121(0.96)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C121(0.83)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C121(0.92)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C121(1.01)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C121(1.52)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C121(1.07)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C121(1.09)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C121(0.90)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C121(1.56)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C44(1.13); C121(1.18)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C121(1.91)  LDD1050  [10]
 LDCM0453  CL61 HEK-293T C121(2.82)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C121(1.10)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C121(2.01)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C121(0.90)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C121(1.10)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C121(0.99)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C121(0.87)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C121(0.84)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C121(0.91)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C44(1.05); C121(0.91)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C121(1.00)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C121(0.68)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C121(1.18)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C121(1.08)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C121(1.56)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C121(1.44)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C121(1.54)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C121(2.25)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C121(2.08)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C44(1.01); C121(1.17)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C121(1.58)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C121(1.34)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C121(0.86)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C121(1.19)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C121(2.33)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C121(2.01)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C121(2.20)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C121(2.47)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C121(1.69)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C121(1.77)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C44(0.94); C121(1.05)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C121(1.34)  LDD1083  [10]
 LDCM0486  CL91 HEK-293T C121(1.17)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C121(0.83)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C121(1.06)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C121(1.63)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C121(1.42)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C121(1.14)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C121(1.06)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C121(0.90)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C121(0.78)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C44(1.23); C121(1.01)  LDD1698  [11]
 LDCM0625  F8 Ramos C121(0.70); C44(1.33)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C121(0.77); C44(1.33)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C121(0.12)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C121(1.28); C44(1.04)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C121(0.89); C44(0.85)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C121(0.86); C44(0.89)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C121(0.75); C44(0.93)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C121(1.07); C44(1.00)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C121(1.23); C44(1.12)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C121(0.96); C44(1.89)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C121(0.86); C44(0.60)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C121(0.99); C44(1.39)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C121(1.13); C44(0.89)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C121(0.71); C44(1.95)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C121(1.35)  LDD1066  [10]
 LDCM0596  Fragment38 Ramos C121(0.74); C44(1.09)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C121(0.76); C44(0.72)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C121(1.14)  LDD1025  [10]
 LDCM0610  Fragment52 Ramos C121(0.88); C44(0.95)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C121(0.81); C44(0.89)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C121(0.86); C44(0.87)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C121(0.77); C44(0.82)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C44(1.04)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C44(1.10)  LDD1497  [11]
 LDCM0024  KB05 SKMEL24 C44(1.65)  LDD3323  [1]
 LDCM0628  OTUB2-COV-1 HEK-293T C44(0.76)  LDD2207  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine-threonine kinase receptor-associated protein (STRAP) WD repeat STRAP family Q9Y3F4
Gem-associated protein 6 (GEMIN6) . Q8WXD5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.