Details of the Target

General Information of Target

Target ID LDTP11913
Target Name tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (OSGEPL1)
Gene Name OSGEPL1
Gene ID 64172
Synonyms
GCP1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; EC 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; t(6)A synthase; O-sialoglycoprotein endopeptidase-like protein 1; OSGEP-like protein 1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALTTLGAPRAHTMPGTYAP
STTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVNLRNFSYGQTSLD
RLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQK
LACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLT
DFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDIL
QLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQ
GLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDE
QLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVSESSPHMAPVLAVVATFP
VLILWL
Target Bioclass
Enzyme
Family
KAE1 / TsaD family
Subcellular location
Mitochondrion
Function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. {|HAMAP-Rule:MF_03179}.
Uniprot ID
Q9H4B0
Ensemble ID
ENST00000264151.10
HGNC ID
HGNC:23075

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.P144R DBIA    Probe Info 
HUH28 SNV: p.M219I DBIA    Probe Info 
SNU449 Insertion: p.S107KfsTer2 DBIA    Probe Info 
SSP25 SNV: p.P144R DBIA    Probe Info 
TE11 SNV: p.C175Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.16  LDD0402  [1]
STPyne
 Probe Info  		K230(0.76)  LDD0277  [2]
BTD
 Probe Info  		C390(0.81)  LDD2118  [3]
AHL-Pu-1
 Probe Info  		C249(5.58)  LDD0170  [4]
DBIA
 Probe Info  		C390(2.58)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C249(0.00); C295(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C308(0.00); C249(0.00); C216(0.00)  LDD0165  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
IPM
 Probe Info  		N.A.  LDD0147  [8]
NPM
 Probe Info  		N.A.  LDD0016  [10]
TFBX
 Probe Info  		C216(0.00); C308(0.00); C390(0.00)  LDD0148  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C249(5.58)  LDD0170  [4]
 LDCM0214  AC1 HEK-293T C216(1.37)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C216(1.05); C390(0.96); C249(1.14); C295(1.05)  LDD1508  [13]
 LDCM0216  AC100 HEK-293T C216(1.11); C346(1.05)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C216(0.72); C346(1.10)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C216(0.75); C346(1.13)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C216(1.12); C346(1.13)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C216(0.95); C346(1.07)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C216(0.61); C346(1.02)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C216(0.61); C346(0.95)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C216(0.72); C346(1.01)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C216(0.73); C346(0.97)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C216(1.21); C346(1.09)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C216(0.91); C390(0.94); C249(1.02); C295(0.96)  LDD1509  [13]
 LDCM0227  AC110 HEK-293T C216(1.42); C346(1.18)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C216(2.17); C346(1.44)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C216(1.44); C346(1.18)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C216(1.22); C350(0.79)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C216(1.11); C350(0.83)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C216(1.16); C350(0.75)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C216(1.43); C350(0.85)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C216(1.35); C350(0.76)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C216(1.68); C350(0.91)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C216(1.99); C350(0.84)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C216(1.09); C390(0.97); C249(1.06); C295(0.93)  LDD1510  [13]
 LDCM0238  AC120 HEK-293T C216(1.48); C350(0.82)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C216(1.35); C350(0.78)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C216(1.47); C350(0.85)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C216(2.13); C350(0.78)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C216(1.50); C350(0.80)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C216(1.54); C350(0.80)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C216(1.99); C350(0.94)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C216(3.18); C350(0.91)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C350(0.85)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C350(0.76)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C350(0.78)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C350(0.75)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C350(0.81)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C350(0.85)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C350(0.88)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C350(0.86)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C350(0.87)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C350(0.89)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C350(0.84)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C350(0.86)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C216(1.02); C390(1.03); C249(1.13); C356(0.90)  LDD1512  [13]
 LDCM0260  AC140 HEK-293T C350(0.76)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C350(0.79)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C350(0.83)  LDD0860  [5]
 LDCM0270  AC15 HEK-293T C390(0.94); C249(1.14); C295(0.87); C356(1.15)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C350(1.02)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C350(1.06)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C350(1.09)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C216(1.40)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C350(1.27)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C350(1.12)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C350(1.10)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C350(0.97)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C350(1.00)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C216(0.91); C390(1.00); C249(0.92); C295(0.95)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C216(1.01); C390(0.97); C249(1.01); C295(0.98)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C216(0.81); C390(1.01); C249(1.05); C295(0.99)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C216(1.08); C390(0.98); C249(0.99); C295(1.03)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C216(1.04); C390(0.97); C249(1.06); C295(0.97)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C216(1.40)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C216(1.02); C390(1.06); C249(1.02); C356(0.89)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C390(0.99); C249(0.99); C295(0.99); C356(1.02)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C216(0.93); C390(0.95); C249(1.09); C295(1.03)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C216(1.08); C390(0.94); C249(0.93); C295(1.01)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C216(1.03); C390(0.93); C249(1.15); C295(1.02)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C346(1.25)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C346(1.07)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C346(1.18)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C346(1.25)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C346(1.26)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C216(1.30)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C346(1.06)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C346(1.22)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C346(1.13)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C346(1.35)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C346(1.26)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C346(1.17)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C346(1.71)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C346(1.27)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C346(1.54)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C346(1.40)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C216(1.27)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C346(1.26)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C346(1.28)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C346(1.26)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C346(1.25)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C346(1.38)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C346(1.66)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C346(1.77)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C346(0.93); C350(0.89)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C346(0.95); C350(0.93)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C346(0.91); C350(1.06)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C216(1.01); C390(0.96); C249(1.02); C356(0.87)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C346(0.76); C350(0.87)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C346(0.92); C350(1.05)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C346(1.15); C350(0.99)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C346(1.01); C350(0.96)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C346(0.89); C350(1.26)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C346(0.96); C350(1.14)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C346(0.91); C350(1.02)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C346(0.92); C350(0.99)  LDD0929  [5]
 LDCM0334  AC7 HEK-293T C390(0.92); C249(1.03); C295(0.88); C356(1.16)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C216(0.92); C390(0.94); C249(1.00); C295(0.99)  LDD1569  [13]
 LDCM0349  AC83 HEK-293T C350(0.97)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C350(1.03)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C350(1.06)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C350(1.13)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C350(1.02)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C350(0.99)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C350(1.13)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C350(1.11)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C350(0.98)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C350(1.10)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C350(1.31)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C350(0.93)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C350(0.97)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C350(1.57)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C350(1.28)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C216(0.74); C346(0.95)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C216(0.44); C346(1.07)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C216(1.14); C390(0.95); C249(0.98); C295(0.98)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C216(1.12); C390(0.95); C249(0.98); C295(0.95)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C216(0.91); C390(0.96); C249(1.06); C295(0.89)  LDD1514  [13]
 LDCM0102  BDHI 8 Jurkat C308(11.98)  LDD0204  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C216(0.93); C390(0.84); C249(1.11); C295(0.81)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C216(0.92); C390(1.01); C249(1.20); C356(0.84)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C216(1.49)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C216(1.02); C390(0.93); C249(1.07); C295(0.91)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C216(0.95); C390(0.97); C249(0.97); C295(1.13)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C390(0.88); C249(0.95); C295(0.94); C46(0.81)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C216(0.92); C390(0.94); C249(1.08); C295(1.15)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C350(0.99)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C350(1.04)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C350(1.19)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C350(1.04)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C350(1.09)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C390(0.89); C249(0.98); C295(1.03); C356(0.99)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C350(1.14)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C350(1.02)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C216(0.99); C390(0.94); C249(1.02); C295(0.98)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C216(1.06); C390(0.91); C249(0.99); C295(0.86)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C216(0.90); C390(0.98); C249(0.99); C295(1.00)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C390(0.87); C249(1.06); C295(0.94); C46(1.13)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C216(0.94); C390(0.94); C249(1.01); C295(1.01)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C346(1.06)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C346(1.03)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C346(1.19)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C216(1.01); C390(0.98); C249(1.12); C295(1.08)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C346(1.14)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C346(1.59)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C346(1.28)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C346(1.22)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C346(1.28)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C346(0.96); C350(0.94)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C346(0.92); C350(0.96)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C346(0.94); C350(1.08)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C346(0.98); C350(1.00)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C216(0.91); C390(0.84); C249(1.04); C295(1.15)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C216(1.03); C390(0.97); C249(1.08); C295(1.02)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C390(0.86); C249(0.93); C295(1.12); C46(0.95)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C346(0.92)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C346(0.82)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C346(0.94)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C346(1.02)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C216(1.01); C390(0.91); C249(1.02); C295(0.98)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C346(1.00)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C346(1.06)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C346(0.92)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C346(0.89)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C346(0.99)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C346(0.84)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C346(0.99)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C346(1.12)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C346(0.97)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C346(1.04)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C390(0.81); C249(1.19); C295(0.96); C46(0.92)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C346(1.00)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C216(0.98); C390(1.03); C249(1.14); C295(0.99)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C216(0.94); C390(0.99); C249(1.01); C295(1.06)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C216(0.97); C390(0.99); C249(0.96); C295(0.92)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C216(0.95); C390(1.08); C249(1.10); C356(0.75)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C390(1.00); C249(0.97); C295(1.03); C356(1.03)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C216(0.91); C390(1.05); C249(0.98); C295(1.03)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C216(0.95); C390(0.94); C249(1.05); C295(0.87)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C390(0.85); C249(0.99); C295(0.86); C46(0.95)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C216(1.03); C390(0.95); C249(0.90); C295(1.04)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C216(0.96); C390(0.94); C249(1.08); C295(0.97)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C216(1.02); C390(1.03); C249(0.77); C295(1.51)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C216(1.00); C390(0.96); C249(0.99); C295(1.01)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C216(1.20); C390(0.98); C249(1.07); C295(0.90)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C216(1.08); C390(0.95); C249(1.03); C295(0.96)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C216(1.07); C390(1.01); C249(0.95); C295(1.09)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C216(0.94); C390(1.10); C249(1.00); C356(0.82)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C390(1.00); C249(1.00); C295(0.93); C356(0.99)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C216(0.82); C390(1.04); C249(0.99); C295(0.95)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C216(0.93); C390(0.86); C249(0.95); C295(0.89)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C216(1.12); C390(0.89); C249(0.85); C295(1.00)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C216(1.02); C390(0.92); C249(1.11); C295(1.03)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C216(1.11); C390(0.95); C249(1.11); C295(0.99)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C216(0.88); C390(0.97); C249(0.76); C295(2.09)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C216(0.88); C390(0.96); C249(1.15); C295(0.90)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C216(1.01); C390(0.92); C249(1.04); C295(1.00)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C216(1.09); C390(0.92); C249(1.07); C295(1.00)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C216(0.98); C390(0.87); C249(1.06); C295(1.02)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C216(0.89); C390(0.95); C249(1.22); C356(0.80)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C390(0.89); C249(1.13); C295(0.86); C356(1.16)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C216(0.93); C390(0.91); C249(0.97); C295(1.13)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C216(0.79); C390(0.97); C249(1.11); C295(1.00)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C216(1.57); C346(0.95)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C216(1.20); C346(1.00)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C216(1.47); C346(0.94)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C216(1.95); C346(0.82)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C216(1.53); C346(0.99)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C216(1.16); C346(0.98)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C216(1.31); C346(1.04)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C216(1.84); C346(1.07)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C216(1.45); C346(0.97)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C216(0.77); C390(0.91); C249(1.04); C295(0.97)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C216(1.41); C346(0.95)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C216(1.88); C346(0.96)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C216(1.38); C346(1.00)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C216(1.70); C346(1.09)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C216(2.07); C346(1.13)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C216(0.99); C390(0.98); C249(1.02); C295(1.04)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C216(0.98); C390(0.97); C249(0.70); C295(1.12)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C216(1.00); C390(0.94); C249(1.09); C295(1.00)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C216(0.78); C390(0.96); C249(1.08); C295(0.97)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C216(0.77); C390(0.90); C249(0.81); C295(1.49)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C216(1.05); C390(0.97); C249(1.07); C295(0.90)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C216(1.09); C390(0.96); C249(1.10); C295(1.06)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C216(0.99); C390(1.03); C249(1.01); C356(0.83)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C390(0.91); C249(1.03); C295(1.00); C356(1.03)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C216(0.85); C390(0.96); C249(0.96); C295(0.94)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C216(0.91); C390(0.86); C249(1.01); C295(0.88)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C216(0.97); C390(0.90); C249(0.93); C295(1.01)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C390(0.85); C249(1.04); C295(1.00); C46(1.09)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C216(0.97); C390(0.89); C249(0.96); C295(1.06)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C216(1.00); C390(0.87); C249(0.80); C295(0.99)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C216(0.94); C390(0.90); C249(1.05); C295(1.04)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C216(0.85); C390(0.92); C249(0.88); C295(1.06)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C216(0.78)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C216(1.40)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C216(1.11)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C216(1.37)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C216(1.70)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C216(1.34)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C216(1.12)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C216(1.66)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C216(1.21)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C390(0.87); C249(1.01); C295(0.92); C46(0.77)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C216(2.66)  LDD1702  [3]
 LDCM0625  F8 Ramos C390(3.25)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C216(9.36)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C216(0.93)  LDD2191  [15]
 LDCM0576  Fragment14 Ramos C216(0.34)  LDD2193  [15]
 LDCM0586  Fragment28 Ramos C390(1.13)  LDD2198  [15]
 LDCM0468  Fragment33 HEK-293T C216(1.86); C346(1.21)  LDD1066  [5]
 LDCM0566  Fragment4 Ramos C390(8.17)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C216(1.04); C390(0.97); C249(0.98); C295(0.94)  LDD1631  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C390(2.58)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C390(2.22)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C390(2.40)  LDD0082  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C390(0.81)  LDD2118  [3]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578