Details of the Target

General Information of Target

Target ID LDTP11880
Target Name Lysine-specific demethylase 4C (KDM4C)
Gene Name KDM4C
Gene ID 23081
Synonyms
GASC1; JHDM3C; JMJD2C; KIAA0780; Lysine-specific demethylase 4C; EC 1.14.11.66; Gene amplified in squamous cell carcinoma 1 protein; GASC-1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C; [histone H3]-trimethyl-L-lysine(9) demethylase 4C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMSMLGGLQRYFRVILLLLLALTLLLLAGFLHSDLELDTPLFGGQAEGPPVTNIMFLKTH
KTASSTVLNILYRFAETHNLSVALPAGSRVHLGYPWLFLARYVEGVGSQQRFNIMCNHLR
FNLPQVQKVMPNDTFYFSILRNPVFQLESSFIYYKTYAPAFRGAPSLDAFLASPRTFYND
SRHLRNVYAKNNMWFDFGFDPNAQCEEGYVRARIAEVERRFRLVLIAEHLDESLVLLRRR
LRWALDDVVAFRLNSRSARSVARLSPETRERARSWCALDWRLYEHFNRTLWAQLRAELGP
RRLRGEVERLRARRRELASLCLQDGGALKNHTQIRDPRLRPYQSGKADILGYNLRPGLDN
QTLGVCQRLVMPELQYMARLYALQFPEKPLKNIPFLGA
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
JHDM3 histone demethylase family
Subcellular location
Nucleus
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
TTD ID
T73863
Uniprot ID
Q9H3R0
DrugMap ID
TTV8CRH
Ensemble ID
ENST00000381306.7
HGNC ID
HGNC:17071
ChEMBL ID
CHEMBL6175

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 SNV: p.H837N DBIA    Probe Info 
COLO792 SNV: p.R786Ter .
HCC15 SNV: p.P653R DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.L505R .
MELJUSO SNV: p.A369S .
NCIH1792 SNV: p.E528K .
NCIH2286 SNV: p.Q75H .
NCIH23 Deletion: p.E495_G522del .
OVK18 SNV: p.A781T .
OVKATE SNV: p.Y341C .
PF382 SNV: p.R552K DBIA    Probe Info 
RKO SNV: p.W210C .
RL952 SNV: p.C738R .
SNU1 SNV: p.A376V .
SNU478 SNV: p.E462K .
VCAP SNV: p.N704T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C375(8.18)  LDD1704  [1]
DBIA
 Probe Info  		C236(1.02)  LDD0533  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C236(0.95)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C236(1.02)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C236(0.92)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C236(1.06)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C236(0.86)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C236(0.93)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C236(0.99)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C236(1.00)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C236(0.83)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C236(1.00)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C236(1.03)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C236(0.83)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C236(1.02)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C236(0.96)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C236(0.82)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C236(1.05)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C236(0.94)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C236(1.17)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C236(0.82)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C236(1.21)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C236(0.99)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C236(1.14)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C236(1.04)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C236(1.05)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C236(1.37)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C236(1.19)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C236(1.35)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C236(1.08)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C236(1.03)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C236(1.17)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C236(1.28)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C236(1.19)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C236(1.31)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C236(1.35)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C236(1.14)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C236(1.35)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C236(1.26)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C236(1.07)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C236(1.33)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C236(1.16)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C236(1.22)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C236(1.09)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C236(1.04)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C236(1.01)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C236(1.05)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C236(1.18)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C236(1.07)  LDD0579  [2]
 LDCM0263  AC143 HEK-293T C236(1.06)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C236(0.94)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C236(1.02)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C236(1.01)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C236(1.04)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C236(1.12)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C236(0.99)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C236(0.97)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C236(1.00)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C236(0.95)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C236(1.00)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C236(1.04)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C236(0.96)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C236(1.01)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C236(1.24)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C236(1.32)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C236(1.04)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C236(0.96)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C236(1.10)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C236(0.91)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C236(0.91)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C236(0.88)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C236(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C236(0.99)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C236(0.99)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C236(0.93)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C236(1.12)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C236(0.91)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C236(1.04)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C236(0.98)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C236(0.80)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C236(0.93)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C236(1.00)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C236(0.99)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C236(0.98)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C236(0.81)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C236(0.90)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C236(1.09)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C236(0.78)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C60(0.84)  LDD1540  [5]
 LDCM0302  AC40 HCT 116 C236(0.81)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C236(0.72)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C236(1.14)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C236(0.92)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C236(0.92)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C236(0.92)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C236(1.12)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C236(1.38)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C236(1.15)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C236(1.01)  LDD0909  [2]
 LDCM0313  AC50 HEK-293T C236(1.10)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C236(1.09)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C236(1.06)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C236(1.03)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C236(0.98)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C236(1.08)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C236(1.06)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C236(1.08)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C236(1.21)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C236(1.35)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C236(0.87)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C236(1.08)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C236(0.95)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C236(1.05)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C236(1.05)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C236(1.04)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C236(1.26)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C236(1.18)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C236(0.97)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C236(0.86)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C236(0.98)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C236(0.89)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C236(0.92)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C236(1.10)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C236(1.01)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C236(0.88)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C236(0.97)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C236(0.87)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C236(0.95)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C236(0.94)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C236(0.80)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C236(0.97)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C236(0.87)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C236(0.90)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C236(0.82)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C236(0.78)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C824(0.76); C827(0.76)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C824(0.71); C827(0.71)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C824(0.51); C827(0.51)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C824(0.73); C827(0.73)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C824(0.59); C827(0.59)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C824(0.64); C827(0.64)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C824(0.52); C827(0.52)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C824(0.50); C827(0.50)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C824(0.59); C827(0.59)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C824(0.53); C827(0.53)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C824(0.54); C827(0.54)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C824(0.49); C827(0.49)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C824(0.60); C827(0.60)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C824(0.63); C827(0.63)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C824(0.87); C827(0.87)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C236(0.73)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C236(0.89)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C236(1.10)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C236(0.92)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C236(0.98)  LDD0873  [2]
 LDCM0367  CL1 PaTu 8988t C236(0.88)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C236(1.11)  LDD1247  [2]
 LDCM0370  CL101 HEK-293T C236(0.84)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C236(1.05)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C236(0.90)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C236(0.92)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C236(0.99)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C236(0.86)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C236(0.86)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C236(1.05)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C236(0.93)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C236(0.85)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C236(1.07)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C236(0.73)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C236(0.87)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C236(0.90)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C236(1.38)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C236(1.03)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C236(1.02)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C236(0.85)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C236(0.80)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C236(0.91)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C236(0.89)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C236(0.74)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C236(1.08)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C236(1.02)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C236(1.08)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C236(1.03)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C236(1.28)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C236(0.95)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C236(1.00)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C236(1.18)  LDD0716  [2]
 LDCM0400  CL13 PaTu 8988t C236(0.76)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C236(0.74)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C236(1.03)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C236(0.95)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C236(1.08)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C236(0.78)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C236(0.94)  LDD1004  [2]
 LDCM0407  CL2 PaTu 8988t C236(0.69)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C236(1.01)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C236(0.97)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C236(0.89)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C236(0.93)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C236(1.30)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C236(1.01)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C236(0.91)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C236(0.96)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C236(1.02)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C236(1.13)  LDD1015  [2]
 LDCM0418  CL3 PaTu 8988t C236(0.66)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C236(1.03)  LDD1017  [2]
 LDCM0421  CL32 HEK-293T C60(0.70)  LDD1625  [5]
 LDCM0426  CL37 HEK-293T C60(0.91)  LDD1630  [5]
 LDCM0429  CL4 PaTu 8988t C236(0.74)  LDD1308  [2]
 LDCM0434  CL44 HEK-293T C60(0.68)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C236(0.77); C824(0.69); C827(0.69)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C236(0.91); C824(0.76); C827(0.76)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C236(0.89); C824(0.90); C827(0.90)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C236(1.14); C824(0.83); C827(0.83)  LDD1037  [2]
 LDCM0440  CL5 PaTu 8988t C236(0.86)  LDD1319  [2]
 LDCM0441  CL50 HEK-293T C236(1.04); C824(0.86); C827(0.86)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C236(1.00); C824(0.99); C827(0.99)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C236(0.97); C824(1.08); C827(1.08)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C236(1.01); C824(1.09); C827(1.09)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C236(1.01); C824(0.87); C827(0.87)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C236(0.83); C824(0.79); C827(0.79)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C236(0.97); C824(0.79); C827(0.79)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C236(0.99); C824(1.06); C827(1.06)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C236(1.02); C824(0.85); C827(0.85)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C236(0.89); C824(0.70); C827(0.70)  LDD1048  [2]
 LDCM0451  CL6 PaTu 8988t C236(0.75)  LDD1330  [2]
 LDCM0452  CL60 HEK-293T C236(1.12); C824(0.74); C827(0.74)  LDD1050  [2]
 LDCM0453  CL61 PaTu 8988t C236(1.19)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C236(0.83)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C236(0.68)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C236(0.69)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C236(1.05)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C236(1.20)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C236(0.81)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C236(0.81)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C236(0.80)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C236(0.68)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C236(0.86)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C236(0.86)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C236(0.90)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C236(0.80)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C236(1.02)  LDD1346  [2]
 LDCM0469  CL76 HEK-293T C824(0.83); C827(0.83)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C824(0.76); C827(0.76)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C824(0.71); C827(0.71)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C824(0.61); C827(0.61)  LDD1070  [2]
 LDCM0473  CL8 PaTu 8988t C236(0.73)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C824(0.71); C827(0.71)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C824(0.66); C827(0.66)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C824(0.77); C827(0.77)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C824(1.19); C827(1.19)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C824(0.70); C827(0.70)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C824(0.81); C827(0.81)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C824(0.63); C827(0.63)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C824(0.76); C827(0.76)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C824(0.68); C827(0.68)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C824(0.75); C827(0.75)  LDD1081  [2]
 LDCM0484  CL9 PaTu 8988t C236(1.00)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C824(1.28); C827(1.28)  LDD1083  [2]
 LDCM0487  CL92 HEK-293T C60(1.12)  LDD1690  [5]
 LDCM0492  CL97 HEK-293T C60(1.58)  LDD1695  [5]
 LDCM0468  Fragment33 PaTu 8988t C236(0.62)  LDD1347  [2]
 LDCM0022  KB02 T cell-activated C375(8.18)  LDD1704  [1]
 LDCM0023  KB03 697 C800(1.79)  LDD2662  [6]
 LDCM0024  KB05 MEWO C477(2.90)  LDD3319  [6]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iox1 Small molecular drug D0X5US
Patented
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flavonoid Derivative 6 Small molecular drug D0S8AZ
Hydroxamate Analog 1 Small molecular drug D0MJ4L
Pmid25468267-compound-46 Small molecular drug D09NCT
Pmid25468267-compound-47 Small molecular drug D0L5RA
Pmid25468267-compound-55 Small molecular drug D0U3KT
Pmid25468267-compound-56 Small molecular drug D07CYB
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 1 Small molecular drug D04KUD
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 2 Small molecular drug D0UQ2R
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 3 Small molecular drug D0RP4W
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 4 Small molecular drug D02FWO
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 5 Small molecular drug D0BK5N
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 6 Small molecular drug D0Z2YB
Pyrido[1,2-a]Indole-1.-carboxylic Acid Analog 7 Small molecular drug D0Q5IR

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840