Details of the Target

General Information of Target

Target ID LDTP11587
Target Name INO80 complex subunit B (INO80B)
Gene Name INO80B
Gene ID 83444
Synonyms
HMGA1L4; PAPA1; ZNHIT4; INO80 complex subunit B; High mobility group AT-hook 1-like 4; IES2 homolog; hIes2; PAP-1-associated protein 1; PAPA-1; Zinc finger HIT domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGI
SDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPG
VVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERAR
LAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDDDEYNR
PLDPNSDDEKITRLLKKHKPSNLALVSPCGGGAGDAL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Induces growth and cell cycle arrests at the G1 phase of the cell cycle.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Uniprot ID
Q9C086
Ensemble ID
ENST00000233331.12
HGNC ID
HGNC:13324

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C203(1.67)  LDD2227  [1]
AHL-Pu-1
 Probe Info  		C203(2.24)  LDD0170  [2]
DBIA
 Probe Info  		C309(0.73); C314(0.73); C330(1.07); C334(1.07)  LDD0533  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C203(2.24)  LDD0170  [2]
 LDCM0214  AC1 HEK-293T C309(0.93); C314(1.30); C334(1.68)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C309(0.98); C314(0.98)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C309(0.73); C314(0.73); C330(1.07); C334(1.07)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C309(0.85); C314(0.85); C330(1.15); C334(1.15)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C309(0.77); C314(0.77); C330(0.85); C334(0.85)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C309(1.16); C314(1.16); C330(0.98); C334(0.98)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C309(0.76); C314(0.76); C330(0.84); C334(0.84)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C309(1.45); C314(1.45); C330(1.25); C334(1.25)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C309(1.00); C314(1.00); C330(1.46); C334(1.46)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C309(1.18); C314(1.03); C330(1.06); C334(1.06)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C309(0.88); C314(0.84); C330(1.12); C334(1.12)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C309(0.75); C314(0.78); C330(0.86); C334(0.86)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C309(0.92); C314(0.92)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C309(0.83); C314(0.93); C330(0.94); C334(0.94)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C309(0.87); C314(0.85); C330(1.06); C334(1.06)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C309(0.98); C314(0.91); C330(1.35); C334(1.35)  LDD0546  [3]
 LDCM0237  AC12 HEK-293T C309(1.05); C314(1.05)  LDD0835  [3]
 LDCM0246  AC128 HCT 116 C309(1.10); C314(1.10); C330(0.50); C334(0.50)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C309(1.17); C314(1.17); C330(0.68); C334(0.68)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C309(1.12); C314(1.12); C330(0.73); C334(0.73)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C309(1.17); C314(1.17); C330(0.66); C334(0.66)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C309(1.06); C314(1.06); C330(0.92); C334(0.92)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C309(1.01); C314(1.01); C330(0.73); C334(0.73)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C309(1.31); C314(1.31); C330(0.66); C334(0.66)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C309(1.14); C314(1.14); C330(0.77); C334(0.77)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C309(0.99); C314(0.99); C330(0.77); C334(0.77)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C309(0.91); C314(0.91); C330(0.71); C334(0.71)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C309(1.19); C314(1.19); C330(0.66); C334(0.66)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C309(1.15); C314(1.15); C330(0.92); C334(0.92)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C309(1.12); C314(1.12)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C309(1.13); C314(1.13); C330(1.02); C334(1.02)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C309(1.31); C314(1.31); C330(0.78); C334(0.78)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C309(0.96); C314(0.96); C330(0.73); C334(0.73)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C309(1.08); C314(1.08)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C309(1.32); C314(1.32)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C314(1.18); C309(1.25)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C314(1.41); C309(1.48)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C314(1.38); C309(1.44)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C314(1.63); C309(1.75)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C314(1.53); C309(1.64)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C309(1.17); C314(1.17)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C314(1.03); C309(1.06)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C309(1.29); C314(1.30)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C314(1.43); C309(1.46)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C314(1.93); C309(2.04)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C309(1.60); C314(1.60)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C309(1.59); C314(1.56)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C309(1.15); C314(1.16)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C309(1.50); C314(1.54)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C309(0.57); C314(0.57); C330(0.98); C334(0.98)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C309(0.82); C314(0.82); C330(0.98); C334(0.98)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C309(0.55); C314(0.55); C330(0.97); C334(0.97)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C309(0.90); C314(1.09); C334(1.28)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C309(0.46); C314(0.46); C330(0.69); C334(0.69)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C309(0.68); C314(0.68); C330(0.74); C334(0.74)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C309(0.51); C314(0.51); C330(0.93); C334(0.93)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C309(0.50); C314(0.50); C330(0.76); C334(0.76)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C309(0.41); C314(0.41); C330(0.87); C334(0.87)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C309(1.00); C314(1.00)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C309(1.18); C314(1.18)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C309(0.93); C314(0.93)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C309(1.00); C314(1.00)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C309(1.01); C314(1.01)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C309(0.89); C314(1.04); C334(1.18)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C309(1.11); C314(1.11)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C309(1.08); C314(1.08)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C309(1.22); C314(1.22)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C309(1.15); C314(1.15)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C309(1.04); C314(1.04)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C309(1.00); C314(0.93); C334(0.87)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C309(0.68); C314(0.78); C334(0.89)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C309(1.02); C314(0.98); C334(0.93)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C309(1.02); C314(1.00); C334(0.97)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C309(0.88); C314(0.97); C334(1.06)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C309(0.86); C314(1.02); C334(1.18)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C309(0.78); C314(0.87); C334(0.95)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C309(0.97); C314(0.97); C334(0.98)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C309(0.73); C314(0.87); C334(1.01)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C309(1.09); C314(1.07); C334(1.05)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C309(0.87); C314(0.93); C334(0.98)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C309(1.01); C314(1.00); C334(0.99)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C309(0.92); C314(0.92); C334(1.06)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C309(0.73); C314(0.73); C334(0.93)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C309(1.00); C314(1.00); C334(0.87)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C309(0.91); C314(0.91); C334(0.90)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C309(1.02); C314(1.18); C334(1.34)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C309(1.02); C314(1.02); C334(0.88)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C309(0.90); C314(0.90); C334(0.91)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C309(1.02); C314(1.02); C334(0.82)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C309(0.83); C314(0.83); C334(0.97)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C309(1.07); C314(1.07); C334(1.02)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C309(1.10); C314(1.10); C334(1.03)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C309(0.95); C314(0.95); C334(1.12)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C309(1.10); C314(1.10)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C309(1.01); C314(1.01)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C309(0.90); C314(0.90)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C309(1.01); C314(1.01)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C309(0.99); C314(0.99)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C309(1.13); C314(1.13)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C309(0.91); C314(0.91)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C309(1.02); C314(1.02)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C309(1.05); C314(1.05)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C309(0.74); C314(0.74)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C309(0.67); C314(0.67)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C309(0.74); C314(0.74)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C309(0.75); C314(0.75); C330(0.96); C334(0.96)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C309(0.83); C314(0.83); C330(1.14); C334(1.14)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C309(0.89); C314(0.89)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C309(0.86); C314(0.86); C330(1.13); C334(1.13)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C309(0.69); C314(0.69); C330(0.74); C334(0.74)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C309(0.84); C314(0.84); C330(1.44); C334(1.44)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C309(1.10); C314(1.10); C330(1.89); C334(1.89)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C309(1.14); C314(1.14); C330(1.74); C334(1.74)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C309(1.31); C314(1.31); C330(1.89); C334(1.89)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C309(0.79); C314(0.79); C330(1.27); C334(1.27)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C309(1.15); C314(1.15); C330(1.51); C334(1.51)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C309(0.97); C314(0.97); C330(1.14); C334(1.14)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C309(0.90); C314(0.90); C330(1.18); C334(1.18)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C309(0.85); C314(0.85)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C309(0.90); C314(0.90); C330(1.41); C334(1.41)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C309(0.77); C314(0.77); C330(0.91); C334(0.91)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C309(1.15); C314(1.15); C330(1.63); C334(1.63)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C309(1.73); C314(1.73); C334(1.76)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C334(1.38); C309(1.38); C314(1.38)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C334(1.21); C309(1.23); C314(1.23)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C309(1.34); C314(1.34); C334(1.45)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C334(0.98); C309(1.48); C314(1.48)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C334(1.00); C309(1.43); C314(1.43)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C334(1.43); C309(1.72); C314(1.72)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C334(1.03); C309(1.70); C314(1.70)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C309(1.52); C314(1.52); C334(1.72)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C334(1.38); C309(1.70); C314(1.70)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C334(1.13); C309(1.44); C314(1.44)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C334(0.98); C309(1.03); C314(1.03)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C334(1.35); C309(1.67); C314(1.67)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C334(1.37); C309(1.38); C314(1.38)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C334(1.55); C309(1.63); C314(1.63)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C309(1.12); C314(1.12); C330(1.14); C334(1.14)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C309(0.64); C314(0.64); C330(0.96); C334(0.96)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C309(1.07); C314(1.07)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C309(1.01); C314(1.01)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C309(1.11); C314(1.11)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C309(1.27); C314(1.27); C330(1.10); C334(1.10)  LDD2171  [3]
 LDCM0632  CL-Sc Hep-G2 C203(1.67)  LDD2227  [1]
 LDCM0367  CL1 HEK-293T C309(0.83); C314(0.83)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C309(0.70); C314(0.70)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C309(0.77); C314(1.13); C334(1.49)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C309(1.03); C314(1.03)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C309(0.91); C314(0.91)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C309(0.81); C314(0.81)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C309(0.94); C314(0.94)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C309(0.55); C314(0.55); C330(0.82); C334(0.82)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C309(0.57); C314(0.57); C330(0.88); C334(0.88)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C309(0.56); C314(0.56); C330(0.90); C334(0.90)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C309(0.40); C314(0.40); C330(0.92); C334(0.92)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C309(0.68); C314(0.68); C330(1.07); C334(1.07)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C309(0.94); C314(0.94)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C309(0.64); C314(0.64); C330(0.85); C334(0.85)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C309(0.58); C314(0.58); C330(0.85); C334(0.85)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C309(1.07); C314(1.07)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C309(1.31); C314(1.31)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C309(1.01); C314(1.01)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C309(1.17); C314(1.17)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C309(1.22); C314(1.22)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C309(1.30); C314(1.06); C334(0.82)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C309(0.87); C314(0.84); C334(0.81)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C309(0.88); C314(0.94); C334(1.01)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C309(0.95); C314(0.95)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C309(0.85); C314(0.91); C334(0.97)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C309(0.98); C314(0.98); C334(0.98)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C309(0.88); C314(0.88); C334(0.98)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C309(0.60); C314(0.60); C334(0.86)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C309(0.94); C314(0.94); C334(1.01)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C309(0.97); C314(0.97)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C309(0.86); C314(0.86)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C309(0.79); C314(0.79)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C309(0.89); C314(0.89)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C309(1.14); C314(1.14)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C309(0.88); C314(0.88)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C309(0.87); C314(0.87)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C330(1.09); C334(1.09)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C330(0.92); C334(0.92)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C330(1.11); C334(1.11)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C330(1.09); C334(1.09)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C309(0.92); C314(0.92)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C330(1.64); C334(1.64)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C330(0.92); C334(0.92)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C330(1.11); C334(1.11)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C330(0.94); C334(0.94)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C330(1.47); C334(1.47)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C330(1.69); C334(1.69)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C330(0.95); C334(0.95)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C330(1.10); C334(1.10)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C330(1.81); C334(1.81)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C330(1.13); C334(1.13)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C309(0.90); C314(0.90)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C330(1.03); C334(1.03)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C309(1.09); C314(0.99)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C309(1.01); C314(1.10)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C309(0.90); C314(0.88)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C309(1.19); C314(1.21)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C309(1.11); C314(1.28)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C309(1.09); C314(1.11)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C309(0.98); C314(1.24)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C309(1.04); C314(1.10)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C309(1.06); C314(1.06)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C309(0.94); C314(1.01)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C309(1.08); C314(1.08)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C309(1.07); C314(1.27)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C309(1.06); C314(1.16)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C309(1.38); C314(1.70)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C309(1.02); C314(1.25)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C309(1.13); C314(1.13)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C309(1.18); C314(1.18)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C309(1.07); C314(1.07)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C309(0.84); C314(0.84)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C309(1.03); C314(1.03)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C309(0.93); C314(0.93)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C309(1.27); C314(1.27)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C309(1.14); C314(1.14)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C309(1.02); C314(1.02)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C309(1.20); C314(1.20)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C309(1.01); C314(1.01)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C309(0.98); C314(0.98)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C309(0.93); C314(0.93)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C309(1.37); C314(1.37)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C309(0.94); C314(0.94)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C309(0.97); C314(0.97)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C309(1.51); C314(1.51)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C330(1.60); C334(1.60)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C330(1.33); C334(1.33)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C330(1.24); C334(1.24)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C330(0.53); C334(0.53)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C330(0.90); C334(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C330(0.90); C334(0.90)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C330(1.45); C334(1.45)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C330(0.97); C334(0.97)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C330(1.44); C334(1.44)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C309(0.78); C314(0.78)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C330(1.00); C334(1.00)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C330(0.90); C334(0.90)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C330(1.11); C334(1.11)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C330(1.04); C334(1.04)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C330(1.17); C334(1.17)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C309(0.90); C314(0.77); C334(0.64)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C309(0.62); C314(0.74); C334(0.86)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C309(0.83); C314(0.73); C334(0.63)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C309(0.80); C314(0.78); C334(0.77)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C309(0.80)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C309(0.75); C314(0.70); C334(0.64)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C309(0.71); C314(0.74); C334(0.77)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C309(0.71); C314(0.83); C334(0.95)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C309(0.61); C314(0.74); C334(0.88)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C309(0.68); C314(0.66); C334(0.64)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C309(0.92); C314(0.78); C334(0.64)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C309(0.66); C314(0.60); C334(0.54)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C309(0.75); C314(0.82); C334(0.88)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C309(0.72); C314(0.85); C334(0.97)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C309(0.71); C314(0.70); C334(0.68)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C309(0.92)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C309(0.57); C314(0.65); C334(0.72)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C309(0.99); C314(1.10); C334(1.21)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C309(0.74); C314(1.07); C334(1.40)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C309(0.79); C314(1.03); C334(1.27)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C309(0.87); C314(1.06); C334(1.25)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C309(0.85); C314(1.28); C334(1.72)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C309(0.52); C314(0.92); C334(1.31)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C309(0.93); C314(1.09); C334(1.26)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C309(1.10); C314(1.18); C334(1.27)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C309(0.90); C314(0.96); C334(1.02)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C334(1.23)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C334(1.12)  LDD1702  [7]
 LDCM0468  Fragment33 HCT 116 C330(0.80); C334(0.80)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C309(1.21); C314(1.34)  LDD1025  [3]
 LDCM0022  KB02 22RV1 C203(0.67)  LDD2243  [8]
 LDCM0023  KB03 MDA-MB-231 C334(1.01)  LDD1701  [7]
 LDCM0024  KB05 MEWO C322(1.79)  LDD3319  [8]
 LDCM0021  THZ1 HCT 116 C309(1.27); C314(1.27); C330(1.10); C334(1.10)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Casein kinase II subunit beta (CSNK2B) Casein kinase 2 subunit beta family P67870
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
pre-mRNA splicing regulator USH1G (USH1G) . Q495M9
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Golgin-45 (BLZF1) . Q9H2G9
HMG domain-containing protein 4 (HMGXB4) . Q9UGU5
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Transcription factor SOX-13 (SOX13) . Q9UN79
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Heat shock factor 2-binding protein (HSF2BP) . O75031
Insulin-like growth factor-binding protein 2 (IGFBP2) . P18065
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
MORN repeat-containing protein 3 (MORN3) . Q6PF18
PRKCA-binding protein (PICK1) . Q9NRD5
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840