Details of the Target

General Information of Target

Target ID LDTP11420
Target Name Oxysterol-binding protein-related protein 1 (OSBPL1A)
Gene Name OSBPL1A
Gene ID 114876
Synonyms
ORP1; OSBP8; OSBPL1; OSBPL1B; Oxysterol-binding protein-related protein 1; ORP-1; OSBP-related protein 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLV
PQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYA
SQETFGCLESAAPRDGSSLEDRPCNPL
Target Bioclass
Other
Family
OSBP family
Subcellular location
Late endosome
Function
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.
Uniprot ID
Q9BXW6
Ensemble ID
ENST00000319481.8
HGNC ID
HGNC:16398

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.V684L DBIA    Probe Info 
FADU SNV: p.R87G DBIA    Probe Info 
HCT116 Deletion: p.K894NfsTer71
SNV: p.H651Y		 .
IM95 Deletion: p.K894NfsTer71 DBIA    Probe Info 
JURKAT Deletion: p.K894NfsTer71 .
KYSE30 SNV: p.E698Q DBIA    Probe Info 
NUGC3 SNV: p.T3I DBIA    Probe Info 
PEO1 SNV: p.R901K DBIA    Probe Info 
SF295 SNV: p.L67M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C369(1.07)  LDD2099  [2]
HHS-475
 Probe Info  		Y57(0.61)  LDD0264  [3]
DBIA
 Probe Info  		C520(1.14); C297(1.12)  LDD0078  [4]
IA-alkyne
 Probe Info  		C39(0.00); C303(0.00); C556(0.00); C739(0.00)  LDD0165  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C245
 Probe Info  		6.11  LDD1918  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C297(2.12); C303(1.04); C412(0.75); C418(0.75)  LDD1093  [4]
 LDCM0215  AC10 HEK-293T C520(1.11)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C297(0.57); C520(1.00)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C297(0.53); C520(1.11)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C297(0.68); C520(0.99)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C297(0.67); C520(1.11)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C297(0.92); C520(1.05)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C297(0.57); C520(1.09)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C297(0.36); C520(1.20)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C297(0.44); C520(1.04)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C297(0.57); C520(1.05)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C297(0.66); C520(0.94)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C520(1.35)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C297(0.50); C520(1.16)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C297(0.69); C520(1.07)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C297(0.78); C520(0.99)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C297(0.87)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C297(0.92)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C297(0.77)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C297(0.79)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C297(1.03)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C297(1.03)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C297(0.89)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C520(1.02)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C297(1.04)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C297(1.10)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C297(1.06)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C297(1.06)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C297(1.23)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C297(1.05)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C297(1.19)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C297(1.32)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C369(1.49); C520(0.94)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C369(1.23); C520(1.01)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C369(1.33); C520(0.90)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C369(1.20); C520(0.88)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C369(1.63); C520(1.02)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C369(1.26); C520(0.92)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C369(1.55); C520(0.90)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C369(1.42); C520(0.93)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C369(1.99); C520(1.15)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C369(2.21); C520(0.97)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C369(1.39); C520(0.92)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C369(1.12); C520(1.10)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C520(1.28)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C369(1.51); C520(1.05)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C369(1.94); C520(0.98)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C369(1.79); C520(1.03)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C520(0.85)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C520(0.96)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C520(0.92)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C520(0.94)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C520(0.75)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C520(0.76)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C520(0.92)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C520(1.16)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C520(0.77)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C520(0.90)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C520(0.95)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C520(0.90)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C520(0.78)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C520(1.02)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C520(0.91)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C520(0.82)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C297(0.84)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C297(0.90)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C297(0.91)  LDD0876  [4]
 LDCM0279  AC2 PaTu 8988t C297(1.63); C303(1.09); C412(0.71); C418(0.71)  LDD1158  [4]
 LDCM0280  AC20 HEK-293T C297(0.79)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C297(0.71)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C297(0.76)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C297(0.69)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C297(0.76)  LDD0882  [4]
 LDCM0285  AC25 PaTu 8988t C297(0.79); C412(1.06); C418(1.06); C520(1.22)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C297(0.90); C412(0.80); C418(0.80); C520(1.55)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C297(1.11); C412(0.89); C418(0.89); C520(1.66)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C297(1.19); C412(0.87); C418(0.87); C520(2.23)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C297(1.26); C412(0.83); C418(0.83); C520(1.50)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C297(1.56); C303(1.17); C412(0.71); C418(0.71)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C297(1.08); C412(1.18); C418(1.18); C520(1.40)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C297(0.94); C412(0.93); C418(0.93); C520(1.36)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C297(1.15); C412(0.89); C418(0.89); C520(1.87)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C297(1.14); C412(1.09); C418(1.09); C520(2.29)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C297(1.67); C412(1.30); C418(1.30); C520(1.35)  LDD1174  [4]
 LDCM0296  AC35 HEK-293T C297(1.19); C520(0.89)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C297(1.11); C520(0.96)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C297(1.65); C520(0.91)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C297(1.24); C520(1.18)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C297(0.90); C520(1.46)  LDD0898  [4]
 LDCM0301  AC4 PaTu 8988t C297(1.36); C303(1.17); C412(0.76); C418(0.76)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C297(1.32); C520(1.11)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C297(1.28); C520(0.97)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C297(1.71); C520(0.92)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C297(1.56); C520(1.05)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C297(1.31); C520(1.11)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C297(1.41); C520(1.04)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C369(1.14)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C369(1.34)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C369(1.35)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C369(1.38)  LDD0909  [4]
 LDCM0312  AC5 PaTu 8988t C297(2.23); C303(1.04); C412(0.79); C418(0.79)  LDD1191  [4]
 LDCM0313  AC50 HEK-293T C369(1.52)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C369(1.73)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C369(1.41)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C369(1.57)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C369(1.61)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C369(1.45)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C369(1.21)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C297(1.02); C369(0.62)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C297(1.05); C369(0.91)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C297(1.03); C369(0.82)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C520(0.98)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C297(0.88); C369(0.76)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C297(1.63); C369(0.86)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C297(1.34); C369(1.20)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C297(1.47); C369(1.12)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C297(1.14); C369(0.97)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C297(1.53); C369(0.88)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C297(1.38); C369(1.02)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C297(1.42); C369(0.74)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C297(0.90); C369(0.69); C520(0.87)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C297(1.01); C369(1.16); C520(1.19)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C520(1.03)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C297(1.08); C369(1.26); C520(1.16)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C297(0.98); C369(0.94); C520(1.10)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C297(1.14); C369(1.04); C520(1.20)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C297(0.78); C369(0.75); C520(1.16)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C297(0.73); C369(1.03); C520(0.89)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C297(0.79); C369(0.54); C520(0.84)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C297(0.90); C369(1.02); C520(0.74)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C297(0.90); C369(1.31); C520(0.92)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C297(1.11); C369(0.98); C520(0.78)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C297(0.78); C369(0.84); C520(0.86)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C520(0.98)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C297(1.01); C369(0.73); C520(0.90)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C297(0.87); C369(1.03); C520(0.89)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C297(1.29); C369(1.13); C520(1.10)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C369(0.88); C520(0.87)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C369(0.88); C520(1.31)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C369(0.60); C520(1.00)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C369(0.75); C520(1.13)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C369(0.86); C520(1.11)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C369(0.59); C520(1.16)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C369(0.90); C520(1.16)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C369(0.89); C520(1.14)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C369(1.12); C520(0.93)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C369(0.67); C520(1.01)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C369(0.97); C520(0.96)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C369(0.66); C520(1.08)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C369(0.85); C520(0.93)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C369(1.14); C520(0.91)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C369(0.85); C520(1.02)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C297(0.55); C520(0.88)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C297(0.65); C520(0.92)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C520(1.17)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C520(1.16)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C520(1.13)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 12.26  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C520(1.14); C297(1.12)  LDD0078  [4]
 LDCM0367  CL1 HEK-293T C297(0.63)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C297(0.68)  LDD0966  [4]
 LDCM0369  CL100 PaTu 8988t C297(1.19); C303(1.04); C412(0.74); C418(0.74)  LDD1248  [4]
 LDCM0370  CL101 HEK-293T C520(1.32)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C520(0.99)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C520(1.13)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C520(1.05)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C297(0.78)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C297(0.88)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C297(0.76)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C297(0.90)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C297(0.73)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C297(0.65)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C297(1.00)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C297(0.73)  LDD0979  [4]
 LDCM0382  CL112 PaTu 8988t C297(0.92); C412(1.08); C418(1.08); C520(1.39)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C297(0.84); C412(1.01); C418(1.01); C520(1.39)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C297(1.04); C412(1.14); C418(1.14); C520(1.24)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C297(0.94); C412(1.05); C418(1.05); C520(1.15)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C297(0.94); C412(0.77); C418(0.77); C520(1.45)  LDD1265  [4]
 LDCM0387  CL117 HEK-293T C297(1.11); C520(0.98)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C297(1.09); C520(0.96)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C297(1.46); C520(0.86)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C297(0.60)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C297(1.00); C520(1.12)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C369(1.44)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C369(1.37)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C369(0.91)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C369(1.23)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C297(1.07); C369(0.70)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C297(1.33); C369(1.28)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C297(1.05); C369(1.16)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C297(0.88); C369(1.04)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C297(0.53)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C297(0.81)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C297(0.59)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C297(0.83); C520(0.83)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C297(1.19); C520(0.70)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C297(1.22); C520(0.94)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C297(1.05); C520(0.78)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C297(0.81)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C297(1.15); C520(0.93)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C297(1.46); C520(0.97)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C297(1.62); C520(0.82)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C297(1.41); C520(0.69)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C297(1.11); C520(0.87)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C297(1.45); C520(0.67)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C297(1.18); C520(0.79)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C297(1.26); C520(0.82)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C297(1.16); C520(0.69)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C297(1.19); C520(0.88)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C297(0.52)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C297(1.84); C520(0.88)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C297(1.04)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C297(1.29)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C297(1.81)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C297(1.11)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C297(1.10)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C297(1.20)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C297(1.08)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C297(1.23)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C297(0.68)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C297(1.09)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C297(1.07)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C297(1.31)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C297(1.42)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C297(1.04)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C297(1.09)  LDD1033  [4]
 LDCM0436  CL46 PaTu 8988t C778(0.91); C303(0.95); C520(1.11)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C778(0.85); C303(0.89); C520(1.23)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C778(1.19); C303(1.01); C520(1.29)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C778(0.98); C303(1.10); C520(1.17)  LDD1318  [4]
 LDCM0440  CL5 HEK-293T C297(0.85)  LDD1038  [4]
 LDCM0441  CL50 PaTu 8988t C778(0.80); C303(0.92); C520(1.37)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C778(1.12); C303(1.00); C520(1.17)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C778(0.90); C303(0.97); C520(1.31)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C778(0.75); C303(0.67); C520(1.43)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C778(0.51); C303(1.32); C520(1.19)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C778(0.64); C303(1.41); C520(1.37)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C778(0.22); C303(0.16); C520(1.44)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C778(0.30); C303(0.71); C520(1.25)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C778(0.71); C303(1.00); C520(1.18)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C778(0.26); C303(0.87); C520(1.21)  LDD1329  [4]
 LDCM0451  CL6 HEK-293T C297(0.82)  LDD1049  [4]
 LDCM0452  CL60 PaTu 8988t C778(0.42); C303(1.00); C520(1.29)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C297(0.90)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C297(1.06)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C297(0.88)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C297(1.71)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C297(1.02)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C297(1.12)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C297(1.00)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C297(0.99)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C297(0.97)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C297(0.79)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C297(0.80)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C297(0.80)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C297(1.16)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C297(0.90)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C297(0.90)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C297(1.21)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C297(1.31)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C297(0.92)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C297(1.26)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C297(1.15)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C297(1.39)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C297(1.04)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C297(0.89)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C297(1.00)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C297(1.55)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C297(1.33)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C297(1.47)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C297(1.39)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C297(1.78)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C297(0.93)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C297(1.09)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C297(2.15)  LDD1083  [4]
 LDCM0486  CL91 PaTu 8988t C297(1.77); C303(1.26); C412(0.95); C418(0.95)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C297(1.83); C303(1.07); C412(0.81); C418(0.81)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C297(1.46); C303(1.12); C412(0.75); C418(0.75)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C297(3.12); C303(0.96); C412(0.82); C418(0.82)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C297(2.66); C303(0.90); C412(0.72); C418(0.72)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C297(1.37); C303(1.17); C412(0.91); C418(0.91)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C297(1.48); C303(1.13); C412(0.81); C418(0.81)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C297(2.00); C303(1.24); C412(0.73); C418(0.73)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C297(1.66); C303(1.32); C412(0.75); C418(0.75)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C520(0.83); C556(0.95); C769(0.93); C746(0.88)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C369(0.87)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C297(1.08)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C297(0.87)  LDD1025  [4]
 LDCM0116  HHS-0101 DM93 Y57(0.61)  LDD0264  [3]
 LDCM0120  HHS-0701 DM93 Y57(0.58)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C769(1.19); C297(2.39); C520(1.41); C556(1.03)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C769(1.73); C297(1.84); C520(1.10); C556(1.40)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C769(1.28); C297(1.26); C520(1.21); C556(1.08)  LDD0082  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C369(1.07)  LDD2099  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C369(1.05)  LDD2127  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C369(1.01)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-7a (RAB7A) Rab family P51149
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Motile sperm domain-containing protein 2 (MOSPD2) . Q8NHP6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402