Details of the Target

General Information of Target

Target ID LDTP11407
Target Name AP-1 complex subunit mu-1 (AP1M1)
Gene Name AP1M1
Gene ID 8907
Synonyms
CLTNM; AP-1 complex subunit mu-1; AP-mu chain family member mu1A; Adaptor protein complex AP-1 subunit mu-1; Adaptor-related protein complex 1 subunit mu-1; Clathrin assembly protein complex 1 mu-1 medium chain 1; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu-adaptin 1; Mu1A-adaptin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
QSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLSLNSGW
ILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVR
SKTEDHEEAGPLPTKVNLAHSEI
Target Bioclass
Transporter and channel
Family
Adaptor complexes medium subunit family
Subcellular location
Golgi apparatus
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Uniprot ID
Q9BXS5
Ensemble ID
ENST00000291439.8
HGNC ID
HGNC:13667

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R211H .
HEC1B SNV: p.P35S; p.R303W .
JURKAT SNV: p.K96E .
MFE319 Deletion: p.V55SfsTer182 .
NCIH1793 SNV: p.Q240Ter .
RKO Deletion: p.V55SfsTer182 .
SKNAS SNV: p.L9R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.25  LDD0402  [1]
TH211
 Probe Info  		Y384(15.13)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
Probe 1
 Probe Info  		Y134(18.52); Y411(87.39); Y418(4.77)  LDD3495  [4]
BTD
 Probe Info  		C241(1.22)  LDD2092  [5]
IA-alkyne
 Probe Info  		C241(20.00)  LDD0371  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
DBIA
 Probe Info  		C76(0.85)  LDD1492  [8]
ATP probe
 Probe Info  		K237(0.00); K229(0.00); K326(0.00)  LDD0199  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [13]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C160
 Probe Info  		12.91  LDD1840  [14]
STS-1
 Probe Info  		N.A.  LDD0137  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C241(20.00)  LDD0371  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C241(9.74)  LDD0372  [6]
 LDCM0214  AC1 HEK-293T C76(0.89)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C76(1.21)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C76(0.91)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C76(0.95)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C76(0.96)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C76(0.90)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C76(1.00)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C76(0.83)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C76(0.77)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C76(0.71)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C76(0.96)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C76(0.76)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C76(0.99)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C76(0.80)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C76(0.85)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C76(0.89)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C76(0.90)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C76(0.85)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C76(0.95)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C76(0.78)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C76(0.87)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C76(0.87)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C76(0.82)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C76(0.94)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C76(0.88)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C76(0.86)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C76(0.96)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C76(0.82)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C76(0.71)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C76(0.90)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C76(0.91)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C76(0.86)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C76(0.86)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C76(0.98)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C76(0.86)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C76(0.98)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C76(0.91)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C76(0.74)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C76(0.89)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C76(0.98)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C76(1.01)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C76(1.00)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C76(0.79)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C76(1.06)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C76(0.88)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C76(0.92)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C76(0.81)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C76(0.97)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C76(0.87)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C76(0.90)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C76(1.05)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C76(1.05)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C76(0.93)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C76(0.89)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C76(0.99)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C76(0.89)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C76(1.06)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C76(1.04)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C76(1.06)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C76(0.87)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C76(0.82)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C76(0.82)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C76(0.99)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C76(0.95)  LDD1514  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C76(0.57)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C76(2.30)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C76(1.13)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C76(0.94)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C76(1.11)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C76(0.96)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C76(0.99)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C76(0.90)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C76(1.16)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C76(0.91)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C76(1.09)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C76(0.89)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C76(1.81)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C76(1.29)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C76(0.95)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C76(1.23)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C76(0.85)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C76(0.97)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C76(1.01)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C76(1.07)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C76(1.05)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C76(1.03)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C76(0.90)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C76(1.25)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C76(0.99)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C76(1.08)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C76(1.21)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C76(1.81)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C76(1.06)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C76(1.19)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C76(1.34)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C76(1.04)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C76(1.07)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C76(1.00)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C76(1.06)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C76(1.01)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C76(1.08)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C76(1.14)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C76(1.08)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C76(0.99)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C76(1.13)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C76(1.37)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C76(1.15)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C76(1.67)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C76(1.41)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C76(1.40)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C76(0.94)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C76(1.00)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C76(0.73)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C76(1.14)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C76(0.95)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C76(1.22)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C76(1.29)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C76(1.12)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C76(1.24)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C76(1.14)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C76(1.82)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C76(1.54)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C76(1.14)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C76(1.12)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C76(0.92)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C76(1.15)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C76(1.63)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C76(1.02)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C76(1.06)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C76(1.03)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C76(0.98)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C76(1.53)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C76(1.43)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C76(1.23)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C76(1.41)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C76(0.90)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C76(1.00)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C76(1.16)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C76(1.03)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C76(0.92)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C76(1.35)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C76(1.03)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C76(1.10)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C76(0.99)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C76(1.72)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C76(1.39)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C76(1.09)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C76(1.32)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C76(0.89)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C76(1.05)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C76(0.89)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C76(0.86)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C76(0.92)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C76(1.02)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C76(1.02)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C76(1.25)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C76(1.65)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C76(0.95)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C76(1.25)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C76(1.45)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C76(1.16)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C76(0.83)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C76(1.16)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C76(0.99)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C76(1.15)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C76(0.77)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C76(0.88)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C76(2.10)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C76(0.97)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C76(1.05)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C76(1.20)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C76(1.12)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C76(1.18)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C76(1.05)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C76(1.07)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C76(0.97)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C76(1.09)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C76(1.12)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C76(1.23)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C76(1.00)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C76(1.00)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C76(1.40)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C76(1.20)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C76(1.20)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C76(1.22)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C76(1.27)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C76(1.01)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C76(1.15)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C76(1.08)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C76(0.77)  LDD1698  [8]
 LDCM0625  F8 Ramos C241(1.50)  LDD2187  [16]
 LDCM0573  Fragment11 Ramos C241(3.48)  LDD2190  [16]
 LDCM0576  Fragment14 Ramos C241(0.67)  LDD2193  [16]
 LDCM0586  Fragment28 Ramos C241(0.78)  LDD2198  [16]
 LDCM0468  Fragment33 HEK-293T C76(1.06)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C76(0.88)  LDD1631  [8]
 LDCM0569  Fragment7 Ramos C241(0.46)  LDD2186  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C76(0.85)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C76(1.04)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C76(1.37)  LDD1502  [8]
 LDCM0109  NEM HeLa H359(0.00); H140(0.00)  LDD0223  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C241(1.22)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C241(1.23)  LDD2093  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C241(1.03)  LDD2097  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
N-terminal EF-hand calcium-binding protein 1 (NECAB1) . Q8N987
Transcription factor
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Transcription factor ETV6 (ETV6) ETS family P41212
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger and BTB domain-containing protein 43 (ZBTB43) Krueppel C2H2-type zinc-finger protein family O43298
Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) Krueppel C2H2-type zinc-finger protein family Q9H4T2
Zinc finger protein 19 (ZNF19) Krueppel C2H2-type zinc-finger protein family P17023
Zinc finger protein 219 (ZNF219) Krueppel C2H2-type zinc-finger protein family Q9P2Y4
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 8 (ZNF8) Krueppel C2H2-type zinc-finger protein family P17098
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Transcriptional regulator protein Pur-beta (PURB) PUR DNA-binding protein family Q96QR8
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) . Q9HBZ2
Metal regulatory transcription factor 1 (MTF1) . Q14872
Myoblast determination protein 1 (MYOD1) . P15172
Oligodendrocyte transcription factor 3 (OLIG3) . Q7RTU3
THAP domain-containing protein 6 (THAP6) . Q8TBB0
Zinc finger and BTB domain-containing protein 3 (ZBTB3) . Q9H5J0
Zinc finger and BTB domain-containing protein 44 (ZBTB44) . Q8NCP5
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger protein 276 (ZNF276) . Q8N554
Other
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Protein FAM219B (FAM219B) FAM219 family Q5XKK7
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Protein Hook homolog 2 (HOOK2) Hook family Q96ED9
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Protein LDOC1 (LDOC1) LDOC1 family O95751
Protein LRATD2 (LRATD2) LRATD family Q96KN1
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
NF-kappa-B-activating protein (NKAP) NKAP family Q8N5F7
Midkine (MDK) Pleiotrophin family P21741
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
Axin-2 (AXIN2) . Q9Y2T1
Breast cancer anti-estrogen resistance protein 3 (BCAR3) . O75815
EVI5-like protein (EVI5L) . Q96CN4
Germinal center-associated signaling and motility protein (GCSAM) . Q8N6F7
Male-enhanced antigen 1 (MEA1) . Q16626
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
PRKCA-binding protein (PICK1) . Q9NRD5
Retinitis pigmentosa 9 protein (RP9) . Q8TA86
Syntenin-2 (SDCBP2) . Q9H190
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1
Zinc finger CCHC domain-containing protein 17 (ZCCHC17) . Q9NP64

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578