Details of the Target

General Information of Target

Target ID LDTP11387
Target Name Ion channel TACAN (TMEM120A)
Gene Name TMEM120A
Gene ID 83862
Synonyms
TACAN; TMPIT; Ion channel TACAN; Transmembrane protein 120A; Transmembrane protein induced by tumor necrosis factor alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVLGRVLLWLQLCALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLV
QEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRS
GDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLA
VFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACH
SALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRL
READTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAG
LAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELP
LPRRLSLVPKAAADSTSHSYFVNPLFAGAEAEA
Target Bioclass
Transporter and channel
Family
TMEM120 family
Subcellular location
Cell membrane
Function Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli. May also be required for efficient adipogenesis.
Uniprot ID
Q9BXJ8
Ensemble ID
ENST00000493111.7
HGNC ID
HGNC:21697

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L93I DBIA    Probe Info 
HDMYZ SNV: p.L279F .
KASUMI2 Insertion: p.L272PfsTer18
SNV: p.A64T		 .
LS123 SNV: p.G114E .
MFE296 SNV: p.V307M DBIA    Probe Info 
P31FUJ SNV: p.L259P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K66(10.00)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
BTD
 Probe Info  		C47(0.98)  LDD2125  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
DBIA
 Probe Info  		C47(0.90)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C12(0.00); C68(0.00)  LDD0162  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
NAIA_5
 Probe Info  		C68(0.00); C47(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C47(0.90)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C47(0.85); C68(1.08)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C47(1.16)  LDD1509  [10]
 LDCM0230  AC113 HCT 116 C47(1.00)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C47(1.01)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C47(0.95)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C47(1.11)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C47(0.95)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C47(1.13)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C47(1.06)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C47(0.99)  LDD1510  [10]
 LDCM0238  AC120 HCT 116 C47(0.97)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C47(0.91)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C47(0.99)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C47(0.84)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C47(0.94)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C47(0.95)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C47(1.11)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C47(0.88)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C47(0.96)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C47(1.00)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C47(1.34)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C47(1.10)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C47(0.94)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C47(0.93)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C47(0.94)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C47(0.91)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C47(0.92)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C47(0.87)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C47(0.75)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C47(1.02)  LDD1137  [5]
 LDCM0259  AC14 HEK-293T C47(0.99); C68(0.87)  LDD1512  [10]
 LDCM0260  AC140 PaTu 8988t C47(0.88)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C47(1.02)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C47(1.00)  LDD1141  [5]
 LDCM0270  AC15 HEK-293T C47(1.07)  LDD1513  [10]
 LDCM0276  AC17 PaTu 8988t C47(1.74)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C47(0.72)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C47(0.71)  LDD1157  [5]
 LDCM0279  AC2 HCT 116 C47(0.86)  LDD0596  [5]
 LDCM0280  AC20 PaTu 8988t C47(0.70)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C47(0.94)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C47(0.50)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C47(0.65)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C47(0.59)  LDD1163  [5]
 LDCM0285  AC25 PaTu 8988t C47(1.13)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C47(0.99)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C47(0.94)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C47(0.83)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C47(0.95)  LDD1168  [5]
 LDCM0290  AC3 HCT 116 C47(0.89)  LDD0607  [5]
 LDCM0291  AC30 PaTu 8988t C47(1.07)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C47(1.31)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C47(0.94)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C47(0.94)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C47(0.76)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C47(0.80)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C47(0.72)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C47(0.73)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C47(0.85)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C47(0.69)  LDD1179  [5]
 LDCM0301  AC4 HCT 116 C47(0.94)  LDD0618  [5]
 LDCM0302  AC40 PaTu 8988t C47(0.74)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C47(1.21)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C47(1.10)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C47(1.12)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C47(0.71)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C47(0.83)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C47(0.94); C68(0.94)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C47(1.04)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C47(1.06)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C47(0.91)  LDD1550  [10]
 LDCM0312  AC5 HCT 116 C47(0.79)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C47(0.93); C68(0.96)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C47(1.10)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C47(0.96)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C47(1.07)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C47(0.95); C68(0.99)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C47(0.96)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C47(1.05)  LDD1558  [10]
 LDCM0320  AC57 PaTu 8988t C47(0.30)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C47(0.20)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C47(0.36)  LDD1201  [5]
 LDCM0323  AC6 HEK-293T C47(0.98); C68(1.00)  LDD1562  [10]
 LDCM0324  AC60 PaTu 8988t C47(0.21)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C47(0.24)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C47(0.38)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C47(0.29)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C47(0.30)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C47(0.64)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C47(0.39)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C47(0.41)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C47(0.96)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C47(1.19)  LDD1212  [5]
 LDCM0334  AC7 HEK-293T C47(1.07)  LDD1568  [10]
 LDCM0335  AC70 PaTu 8988t C47(1.19)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C47(1.07)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C47(1.80)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C47(1.12)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C47(0.82)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C47(0.96)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C47(1.27)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C47(1.09)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C47(1.47)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C47(1.01)  LDD1223  [5]
 LDCM0345  AC8 HEK-293T C47(0.93)  LDD1569  [10]
 LDCM0346  AC80 PaTu 8988t C47(1.46)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C47(1.21)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C47(1.47)  LDD1227  [5]
 LDCM0248  AKOS034007472 HEK-293T C47(1.02)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C47(0.89)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C47(0.97)  LDD1514  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 PaTu 8988t C47(0.92)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C47(0.88)  LDD1247  [5]
 LDCM0369  CL100 HCT 116 C47(0.88)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C47(1.10)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C47(0.96); C68(0.98)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C47(0.90)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C47(1.02); C68(1.06)  LDD1577  [10]
 LDCM0374  CL105 PaTu 8988t C47(0.70)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C47(0.85)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C47(2.34)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C47(0.66)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C47(0.60)  LDD1257  [5]
 LDCM0379  CL11 PaTu 8988t C47(0.92)  LDD1258  [5]
 LDCM0380  CL110 PaTu 8988t C47(0.77)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C47(0.47)  LDD1260  [5]
 LDCM0382  CL112 PaTu 8988t C47(1.10)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C47(1.09)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C47(1.13)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C47(1.08)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C47(1.30)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C47(1.81)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C47(1.44)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C47(1.15)  LDD1268  [5]
 LDCM0390  CL12 PaTu 8988t C47(0.80)  LDD1269  [5]
 LDCM0391  CL120 PaTu 8988t C47(0.66)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C47(0.94)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C47(1.15); C68(0.99)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C47(1.16)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C47(0.92); C68(0.99)  LDD1599  [10]
 LDCM0396  CL125 PaTu 8988t C47(0.35)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C47(0.25)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C47(0.50)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C47(0.33)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C47(0.76)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C47(0.77)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C47(0.65)  LDD1281  [5]
 LDCM0403  CL16 HCT 116 C47(0.61)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C47(0.50)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C47(0.42)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C47(0.38)  LDD0723  [5]
 LDCM0407  CL2 PaTu 8988t C47(0.73)  LDD1286  [5]
 LDCM0408  CL20 HCT 116 C47(0.32)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C47(0.33)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C47(0.35)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C47(0.34)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C47(0.39)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C47(0.29)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C47(0.29)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C47(0.53)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C47(0.32)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C47(0.47)  LDD0734  [5]
 LDCM0418  CL3 PaTu 8988t C47(0.73)  LDD1297  [5]
 LDCM0419  CL30 HCT 116 C47(0.63)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C47(0.62)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C47(0.72)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C47(0.58)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C47(0.61)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C47(0.55)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C47(0.32)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C47(0.45)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C47(0.77)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C47(0.79)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C47(0.59)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C47(0.58)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C47(0.44)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C47(0.50)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C47(0.44)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C47(0.59)  LDD1314  [5]
 LDCM0436  CL46 HCT 116 C47(0.93)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C47(1.02)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C47(1.07)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C47(0.98)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C47(0.75)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C47(1.04)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C47(1.08)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C47(1.03)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C47(1.21)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C47(0.95)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C47(0.78)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C47(0.96)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C47(1.02)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C47(1.08)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C47(1.08)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C47(0.85)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C47(1.09)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C47(0.72)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C47(0.63)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C47(0.42)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C47(0.74)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C47(1.11)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C47(0.57)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C47(0.72)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C47(0.50)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C47(0.67)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C47(0.68)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C47(0.59)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C47(0.54)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C47(0.62)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C47(0.64)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C47(0.72)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C47(0.50)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C47(0.80)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C47(0.79)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C47(0.45)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C47(0.60)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C47(0.93)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C47(0.45)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C47(0.56)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C47(0.40)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C47(0.50)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C47(0.40)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C47(0.62)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C47(0.58)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C47(0.55)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C47(0.45)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C47(0.82)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C47(20.00)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C47(0.81)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C47(0.79)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C47(0.97)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C47(0.99)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C47(0.89)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C47(0.92)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C47(0.88)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C47(1.02)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C47(0.95)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C47(1.11)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C47(0.72)  LDD0785  [5]
 LDCM0427  Fragment51 PaTu 8988t C47(0.50)  LDD1306  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 HEK-293T C47(1.02); C68(1.02)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C47(0.98); C68(1.02)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C47(2.37)  LDD3310  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C47(0.98)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C47(0.93)  LDD2127  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C47(0.50)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C47(0.80)  LDD2144  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Dehydrogenase/reductase SDR family member 7 (DHRS7) Short-chain dehydrogenases/reductases (SDR) family Q9Y394
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Syntaxin-1A (STX1A) Syntaxin family Q16623
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Leptin receptor gene-related protein (LEPROT) OB-RGRP/VPS55 family O15243
ORM1-like protein 2 (ORMDL2) ORM family Q53FV1
Transmembrane protein 88 (TMEM88) TMEM88 family Q6PEY1
Tumor protein p63-regulated gene 1 protein (TPRG1) TPRG1 family Q6ZUI0
Bcl-2-interacting killer (BIK) . Q13323
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840