Details of the Target

General Information of Target

Target ID LDTP11305
Target Name TIMELESS-interacting protein (TIPIN)
Gene Name TIPIN
Gene ID 54962
Synonyms
TIMELESS-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCGLQYQKKTLRPRCILGV
TQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISI
TGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFGESVKGYGEVTRRGRRQHVRF
TEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGSGEYDFRYIFVEIESYPRRTIII
EDNRSQDD
Target Bioclass
Other
Family
CSM3 family
Subcellular location
Cytoplasm
Function
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
Uniprot ID
Q9BVW5
Ensemble ID
ENST00000261881.9
HGNC ID
HGNC:30750

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K134(0.66)  LDD0274  [2]
STPyne
 Probe Info  		K87(8.19)  LDD0277  [2]
BTD
 Probe Info  		C139(0.70)  LDD2098  [3]
DBIA
 Probe Info  		C139(0.98)  LDD0547  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		14.60  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C139(0.98)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C139(0.96)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C139(1.12)  LDD1509  [9]
 LDCM0230  AC113 HCT 116 C139(0.98)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C139(1.03)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C139(0.99)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C139(1.11)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C139(1.08)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C139(1.08)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C139(1.35)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C139(0.94)  LDD1510  [9]
 LDCM0238  AC120 HCT 116 C139(0.75)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C139(0.82)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C139(1.22)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C139(0.75)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C139(1.11)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C139(0.91)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C139(0.91)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C139(1.08)  LDD0562  [4]
 LDCM0259  AC14 HEK-293T C139(1.04)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C139(0.97)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C139(0.99)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C139(0.98)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C139(1.02)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C139(0.98)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C139(0.99)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C139(1.02); C264(0.98)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C139(1.01)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C139(1.00)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C139(0.98); C264(1.03)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C139(0.98)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C139(1.05)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C139(1.04)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C139(0.98)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C139(1.02); C264(1.02)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C139(1.03)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C139(0.99)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C139(1.05)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C139(0.97); C264(1.34)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C139(1.00)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C139(0.95)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C139(1.05)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C139(0.91)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C139(0.96); C264(1.01)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C139(1.00)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C139(0.98)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C139(0.97)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C139(0.99); C264(1.37)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C139(1.00)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C139(0.96)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C139(0.95)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C139(0.92)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C139(1.00); C264(1.01)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C139(0.88)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C139(0.98)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C139(0.95); C264(1.20)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C139(0.97)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C139(0.95); C264(1.10)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C139(0.97)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C139(0.96)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C139(0.99)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C139(0.94); C264(1.16)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C139(1.07)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C139(1.00)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C139(0.97); C264(1.16)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C139(1.42)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C139(1.26)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C139(0.89)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C139(0.93)  LDD1562  [9]
 LDCM0324  AC60 HCT 116 C139(1.56)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C139(1.06)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C139(1.16)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C139(1.64)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C139(1.30)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C139(1.81)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C139(1.19)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C139(1.23)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C139(0.90)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C139(0.81)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C139(1.01)  LDD1568  [9]
 LDCM0335  AC70 HCT 116 C139(1.18)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C139(1.04)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C139(1.30)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C139(1.28)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C139(0.92)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C139(1.20)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C139(0.98)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C139(0.72)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C139(1.02)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C139(0.99)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C139(0.97); C264(1.35)  LDD1569  [9]
 LDCM0346  AC80 HCT 116 C139(0.91)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C139(1.04)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C139(0.95)  LDD0665  [4]
 LDCM0248  AKOS034007472 HEK-293T C139(0.96); C264(1.08)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C139(0.96)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C139(0.96); C264(1.13)  LDD1514  [9]
 LDCM0367  CL1 HCT 116 C139(0.81)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C139(0.90)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C139(0.97); C264(0.95)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C139(0.96)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C139(1.03)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C139(1.00)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C139(0.98); C264(0.91)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C139(0.94)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C139(1.06)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C139(1.05)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C139(1.02); C264(0.81)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C139(1.01)  LDD1582  [9]
 LDCM0379  CL11 HCT 116 C139(0.88)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C139(1.10)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C139(1.01)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C139(0.95); C264(0.71)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C139(0.99)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C139(1.12)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C139(1.02)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C139(0.90); C264(0.81)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C139(0.96)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C139(1.00)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C139(0.97)  LDD1593  [9]
 LDCM0390  CL12 HCT 116 C139(1.04)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C139(0.94); C264(1.05)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C139(0.93)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C139(1.02)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C139(1.15)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C139(0.90); C264(1.02)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C139(1.20)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C139(1.67)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C139(1.15)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C139(0.83)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C139(0.95)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C139(1.02)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C139(0.96)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C139(0.81); C264(1.07)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C139(1.08)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C139(0.89)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C139(0.99)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C139(0.85)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C139(0.95)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C139(1.17); C264(1.26)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C139(0.99)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C139(0.96)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C139(0.97); C264(1.76)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C139(1.02)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C139(1.02)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C139(0.98)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C139(0.93); C264(0.96)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C139(0.97)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C139(1.04)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C139(1.01)  LDD1623  [9]
 LDCM0420  CL31 HCT 116 C139(1.05)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C139(0.94)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C139(1.02)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C139(0.95)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C139(1.11)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C139(1.12)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C139(1.02)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C139(1.20)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C139(0.82)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C139(1.13)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C139(0.99)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C139(0.99)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C139(1.18)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C139(1.07)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C139(1.08)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C139(1.11)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C139(1.03)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C139(1.14); C264(1.39)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C139(0.87)  LDD1643  [9]
 LDCM0440  CL5 HCT 116 C139(0.99)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C139(1.07)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C139(0.88); C264(1.39)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C139(1.29)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C139(1.04)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C139(1.09)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C139(0.95)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C139(1.03); C264(0.99)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C139(0.99)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C139(1.00)  LDD1653  [9]
 LDCM0451  CL6 HCT 116 C139(0.97)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C139(1.09); C264(1.77)  LDD1655  [9]
 LDCM0453  CL61 HCT 116 C139(1.18)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C139(1.03)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C139(1.21)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C139(1.34)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C139(1.26)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C139(1.18)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C139(1.00)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C139(0.94)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C139(1.14)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C139(0.94)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C139(0.93)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C139(1.08)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C139(1.34)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C139(1.17)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C139(1.17)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C139(0.86); C264(1.01)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C139(1.09)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C139(0.93)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C139(0.97)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C139(1.09)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C139(0.98)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C139(1.01); C264(1.40)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C139(0.92)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C139(1.04)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C139(1.06); C264(1.29)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C139(0.92)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C139(0.99)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C139(0.96)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C139(0.98); C264(0.85)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C139(0.98)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C139(0.92)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C139(1.34)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C139(0.94)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C139(1.01)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C139(1.12); C264(1.21)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C139(0.95)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C139(1.97)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C139(1.07); C264(1.07)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C139(0.99)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C139(0.98)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C139(0.99)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C139(0.93)  LDD1698  [9]
 LDCM0625  F8 Ramos C139(0.53)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C139(0.14)  LDD2190  [10]
 LDCM0576  Fragment14 Ramos C139(1.12)  LDD2193  [10]
 LDCM0586  Fragment28 Ramos C139(0.64)  LDD2198  [10]
 LDCM0468  Fragment33 HCT 116 C139(1.13)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C139(1.16)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C139(0.89); C264(0.84)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C139(1.00); C264(0.92)  LDD1497  [9]
 LDCM0024  KB05 NCI-H1299 C139(2.17)  LDD3343  [11]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C139(0.70)  LDD2098  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Replication protein A 32 kDa subunit (RPA2) Replication factor A protein 2 family P15927
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840