Details of the Target

General Information of Target

Target ID LDTP10819
Target Name Zinc finger protein 587 (ZNF587)
Gene Name ZNF587
Gene ID 84914
Synonyms
Zinc finger protein 587
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q96SQ5
Ensemble ID
ENST00000339656.8
HGNC ID
HGNC:30955

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.S523G .
NCIH1793 SNV: p.Q427R .
PEO1 SNV: p.G526E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C366(10.06)  LDD1703  [1]
DBIA
 Probe Info  		C366(0.96); C214(0.91)  LDD0078  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C214(0.72); C366(1.09)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C214(0.96); C366(0.99)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C366(0.88)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C366(1.04)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C366(0.91)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C366(1.01)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C366(0.93)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C366(0.86)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C366(0.95)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C366(0.90)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C366(0.89)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C366(0.87)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C214(1.27); C366(1.12)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C366(0.93)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C366(0.93)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C366(0.90)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C214(0.54); C366(0.97)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C214(0.47); C366(0.94)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C214(1.92); C366(1.07)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C214(0.69); C366(1.11)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C214(0.51); C366(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C214(0.47); C366(1.00)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C214(0.52); C366(1.03)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C214(1.00); C366(0.90)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C214(0.69); C366(0.93)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C214(0.50); C366(0.86)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C214(0.49); C366(1.04)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C214(0.38); C366(0.74)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C214(0.46); C366(0.91)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C214(0.43); C366(0.96)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C214(0.33); C366(0.95)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C214(0.50); C366(0.88)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C366(0.85)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C366(1.17)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C366(1.12)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C366(0.96)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C366(1.01)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C366(1.28)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C366(1.13)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C366(1.23)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C366(1.71)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C366(1.02)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C366(1.21)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C366(1.14)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C214(0.91); C366(0.90)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C366(1.14)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C366(1.25)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C366(1.24)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C366(1.06)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C366(1.05)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C366(1.08)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C366(0.93)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C366(0.95)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C366(0.98)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C366(1.16)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C214(0.80); C366(0.85)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C366(1.24)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C366(1.01)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C366(0.93)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C366(1.05)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C366(1.03)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C366(1.05)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C366(0.91)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C366(0.87)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C214(0.64); C366(1.25)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C214(0.92); C366(1.28)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C214(0.54); C366(1.25)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C214(0.66); C366(1.07)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C214(0.84); C366(1.20)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C214(0.50); C366(1.55)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C214(0.50); C366(1.19)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C214(0.54); C366(1.44)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C214(0.79); C366(1.32)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C366(1.23)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C366(1.25)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C366(0.90)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C366(0.86)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C366(0.87)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C214(0.72); C366(1.10)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C366(0.81)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C366(1.08)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C366(1.28)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C366(0.93)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C366(1.09)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C366(1.15)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C366(1.42)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C366(1.69)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C366(1.54)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C366(1.84)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C214(0.62); C366(0.95)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C366(1.87)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C366(1.54)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C366(1.51)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C366(1.38)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C366(2.22)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C366(1.78)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C214(1.29); C366(1.12)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C214(1.35); C366(1.23)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C214(1.22); C366(0.98)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C214(1.12); C366(1.19)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C214(0.75); C366(0.99)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C214(1.17); C366(1.08)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C214(1.45); C366(1.06)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C214(1.42); C366(1.21)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C214(1.13); C366(1.18)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C214(1.47); C366(1.30)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C214(1.38); C366(1.29)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C214(1.35); C366(1.18)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C366(1.07)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C366(1.08)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C366(1.06)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C366(0.88); C214(0.99)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C366(1.20)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C366(1.05)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C366(1.17)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C366(1.39)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C366(1.59)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C366(1.14)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C366(1.11)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C366(1.28)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C366(1.06)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C366(1.12)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C366(0.89); C214(1.00)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C366(1.25)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C366(1.24)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C366(1.43)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C366(1.20)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C366(1.64)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C366(1.53)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C366(1.57)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C366(1.35)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C366(1.27)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C366(1.22)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C366(0.95); C214(1.13)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C366(1.55)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C366(1.37)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C366(1.85)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C366(1.14)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C366(1.15)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C366(1.27)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C366(1.06)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C366(1.15)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C366(0.91)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C366(1.22)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C366(1.26)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C366(1.22)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C366(1.30)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C366(1.18)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C366(1.34)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C366(1.10)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C366(1.43)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C366(1.33)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C366(1.04)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C366(0.96)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C214(1.03); C366(0.94)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C366(1.09); C214(1.16)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C214(0.80); C366(0.99)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C366(0.96); C214(0.91)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C214(0.49); C366(1.04)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C214(0.27); C366(1.06)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C214(0.86); C366(1.11)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C214(0.84); C366(0.89)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C214(0.80); C366(1.15)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C366(0.83); C214(0.97)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C366(0.91); C214(0.92)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C214(1.08); C366(1.26)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C214(0.90); C366(1.62)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C214(0.79); C366(1.54)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C214(0.67); C366(1.23)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C214(0.66); C366(1.49)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C214(0.32); C366(1.89)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C214(0.54); C366(1.30)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C214(0.63); C366(1.52)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C366(1.42)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C366(1.02)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C366(1.07)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C366(1.01)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C366(0.97)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C366(1.26)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C366(2.16)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C366(1.37)  LDD1268  [2]
 LDCM0390  CL12 HCT 116 C214(0.40); C366(1.02)  LDD0707  [2]
 LDCM0391  CL120 PaTu 8988t C366(1.20)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C214(1.29); C366(1.04)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C214(1.16); C366(1.10)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C214(1.18); C366(0.95)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C214(1.14); C366(0.86)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C366(1.19)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C366(1.18)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C366(1.34)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C366(1.05)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C214(0.26); C366(0.94)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C214(0.32); C366(1.07)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C214(0.35); C366(1.37)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C214(0.92); C366(1.01)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C214(1.14); C366(1.19)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C366(1.08); C214(1.17)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C366(0.92); C214(1.06)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C214(0.71); C366(0.96)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C214(0.82); C366(1.16)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C214(0.76); C366(1.33)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C214(0.88); C366(1.23)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C214(0.73); C366(1.17)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C214(1.13); C366(0.99)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C214(0.96); C366(1.16)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C214(0.87); C366(1.19)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C214(1.16); C366(1.09)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C214(0.57); C366(1.13)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C214(1.35); C366(0.99)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C214(0.50); C366(0.90)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C214(0.93); C366(1.01)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C214(0.75); C366(1.02)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C186(1.08)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C186(0.71)  LDD1626  [4]
 LDCM0429  CL4 HCT 116 C214(0.43); C366(0.84)  LDD0746  [2]
 LDCM0431  CL41 HEK-293T C186(1.10)  LDD1635  [4]
 LDCM0434  CL44 HEK-293T C186(0.82)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C186(1.07)  LDD1639  [4]
 LDCM0436  CL46 HCT 116 C366(1.03)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C366(0.86)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C366(1.03)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C366(0.98)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C214(0.28); C366(0.80)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C366(0.90)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C366(0.95)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C366(1.25)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C366(0.88)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C366(0.91)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C366(0.80)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C366(0.80)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C366(0.91)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C366(1.04)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C366(0.78)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C214(0.30); C366(1.05)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C366(0.88)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C366(0.97)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C366(0.67)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C366(0.91)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C366(1.25)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C366(1.04)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C366(0.88)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C366(1.02)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C366(0.77)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C366(0.86)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C214(0.27); C366(0.95)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C366(1.30)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C366(0.66)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C366(0.88)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C366(0.77)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C366(1.09)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C366(0.93)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C366(0.86)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C366(1.00)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C366(0.94)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C214(0.40); C366(1.93)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C366(0.95)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C366(0.85)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C366(0.96)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C366(0.83)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C366(0.94)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C366(0.98)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C366(0.93)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C366(0.95)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C366(1.15)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C366(0.92)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C214(0.37); C366(0.95)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C366(1.04)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C214(0.78); C366(1.12)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C214(0.44); C366(1.06)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C214(0.59); C366(0.91)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C214(1.03); C366(1.14)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C214(0.68); C366(1.61)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C214(0.58); C366(1.09)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C214(0.60); C366(1.12)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C214(0.56); C366(1.23)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C214(0.69); C366(0.99)  LDD0811  [2]
 LDCM0468  Fragment33 HEK-293T C366(0.90)  LDD1066  [2]
 LDCM0022  KB02 HCT 116 C366(5.34)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C366(1.57)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C366(1.34)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C214(1.26); C366(0.98)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-trimethyltransferase SMYD5 (SMYD5) Class V-like SAM-binding methyltransferase superfamily Q6GMV2
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Putative ATP-dependent RNA helicase DHX57 (DHX57) DEAD box helicase family Q6P158
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Phospholipid scramblase 1 (PLSCR1) Phospholipid scramblase family O15162
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM36 (TRIM36) TRIM/RBCC family Q9NQ86
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
MyoD family inhibitor (MDFI) MDFI family Q99750
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) . Q9HD26
Transcription factor
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Cysteine/serine-rich nuclear protein 1 (CSRNP1) AXUD1 family Q96S65
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger and BTB domain-containing protein 43 (ZBTB43) Krueppel C2H2-type zinc-finger protein family O43298
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 286A (ZNF286A) Krueppel C2H2-type zinc-finger protein family Q9HBT8
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 547 (ZNF547) Krueppel C2H2-type zinc-finger protein family Q8IVP9
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Pre-B-cell leukemia transcription factor 2 (PBX2) TALE/PBX homeobox family P40425
Homeobox protein MOX-2 (MEOX2) . P50222
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Myogenic factor 5 (MYF5) . P13349
Transcription factor 4 (TCF4) . P15884
Transcription factor SOX-13 (SOX13) . Q9UN79
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 63 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ankyrin repeat and SOCS box protein 15 (ASB15) Ankyrin SOCS box (ASB) family Q8WXK1
Ankyrin repeat and SOCS box protein 6 (ASB6) Ankyrin SOCS box (ASB) family Q9NWX5
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-10 (KRTAP10-10) KRTAP type 10 family P60014
Keratin-associated protein 10-11 (KRTAP10-11) KRTAP type 10 family P60412
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-3 (KRTAP2-3) KRTAP type 2 family P0C7H8
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Protein LDOC1 (LDOC1) LDOC1 family O95751
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NKAP-like protein (NKAPL) NKAP family Q5M9Q1
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Syntaxin-11 (STX11) Syntaxin family O75558
Teneurin-4 (TENM4) Tenascin family Q6N022
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Axin-2 (AXIN2) . Q9Y2T1
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Brorin (VWC2) . Q2TAL6
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Follistatin (FST) . P19883
Four and a half LIM domains protein 3 (FHL3) . Q13643
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Heat shock factor 2-binding protein (HSF2BP) . O75031
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
KATNB1-like protein 1 (KATNBL1) . Q9H079
Keratinocyte proline-rich protein (KPRP) . Q5T749
LRP2-binding protein (LRP2BP) . Q9P2M1
Mitochondrial coiled-coil domain protein 1 (MCCD1) . P59942
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Protein inscuteable homolog (INSC) . Q1MX18
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TNF receptor-associated factor 1 (TRAF1) . Q13077
Uncharacterized protein C17orf50 (C17orf50) . Q8WW18

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402