Details of the Target

General Information of Target

Target ID LDTP10814
Target Name BTB/POZ domain-containing protein KCTD15 (KCTD15)
Gene Name KCTD15
Gene ID 79047
Synonyms
BTB/POZ domain-containing protein KCTD15; Potassium channel tetramerization domain-containing protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDTEDAA
AHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGPVPAAMSSMEEIQVELQCA
DLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSS
KWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKY
QPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAK
GFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPS
ASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSG
YNRLQSGTTSATQPSETFMPQRTPSLISGIPTPPSLPGNSKMEAYGGQLGSFPTSQFQYV
MQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQS
TLLCSSPSNGAFGERQYLPSGMEHSMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVH
MV
Target Bioclass
Other
Subcellular location
Nucleus
Function During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain.
Uniprot ID
Q96SI1
Ensemble ID
ENST00000284006.10
HGNC ID
HGNC:23297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.P272L .
HCT15 SNV: p.E280D .
IGR1 SNV: p.L143P .
KMCH1 SNV: p.T271S .
KP4 SNV: p.R172H .
MELJUSO Substitution: p.V230I DBIA    Probe Info 
REH SNV: p.P268R; p.Q269E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.47  LDD0403  [1]
DBIA
 Probe Info  		C225(1.57)  LDD3343  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [3]
1d-yne
 Probe Info  		N.A.  LDD0356  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C166(1.74); C168(1.30); C262(0.85)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C166(1.08)  LDD0813  [7]
 LDCM0216  AC100 HEK-293T C166(1.05); C168(1.05)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C166(1.16); C168(1.16)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C166(0.88); C168(0.88)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C166(1.12); C168(1.12)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C166(0.92); C168(0.92)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C166(1.19); C168(1.19)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C166(1.06); C168(1.06)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C166(0.98); C168(0.98)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C166(0.92); C168(0.92)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C166(1.04); C168(1.04)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C166(1.05)  LDD0824  [7]
 LDCM0227  AC110 HEK-293T C166(1.07); C168(1.07)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C166(0.90); C168(0.90)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C166(0.98); C168(0.98)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C166(1.01); C262(1.04)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C166(1.06); C262(1.22)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C166(0.98); C262(1.75)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C166(0.95); C262(1.23)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C166(1.03); C262(1.71)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C166(1.03); C262(1.10)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C166(0.98); C262(1.46)  LDD0834  [7]
 LDCM0237  AC12 HEK-293T C166(1.06)  LDD0835  [7]
 LDCM0238  AC120 HEK-293T C166(1.06); C262(1.07)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C166(0.99); C262(1.54)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C166(1.09); C262(1.09)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C166(1.07); C262(1.27)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C166(0.88); C262(1.21)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C166(1.04); C262(0.93)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C166(1.33); C262(1.31)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C166(1.52); C262(1.49)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C166(0.91); C168(0.91)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C166(0.80); C168(0.80)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C166(0.90); C168(0.90)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C166(0.90); C168(0.90)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C166(0.72); C168(0.72)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C166(1.11); C168(1.11)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C166(0.90); C168(0.90)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C166(1.22); C168(1.22)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C166(1.00); C168(1.00)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C166(0.96); C168(0.96)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C166(0.87); C168(0.87)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C166(0.77); C168(0.77)  LDD0856  [7]
 LDCM0259  AC14 HEK-293T C166(1.03)  LDD0857  [7]
 LDCM0260  AC140 HEK-293T C166(1.14); C168(1.14)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C166(1.06); C168(1.06)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C166(0.79); C168(0.79)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C166(1.02); C168(1.04)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C166(1.06); C168(0.94)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C166(0.99); C168(0.84)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C166(1.08); C168(0.98)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C166(1.09); C168(0.83)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C166(0.99); C168(0.93)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C166(1.03); C168(1.03)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C166(1.07)  LDD0868  [7]
 LDCM0271  AC150 HEK-293T C166(0.99); C168(0.87)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C166(1.02); C168(0.94)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C166(1.05); C168(1.05)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C166(0.99); C168(0.91)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C166(1.04); C168(0.99)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C166(0.98); C168(0.96)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C166(1.11); C168(0.85)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C166(1.18); C168(0.97)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C166(1.03); C262(0.98)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C166(1.03); C262(0.87)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C166(0.98); C262(0.90)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C166(1.26); C168(1.61); C262(1.03)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C166(0.95); C262(1.07)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C166(1.07); C262(1.11)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C166(0.98); C262(0.90)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C166(0.87); C262(0.71)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C166(1.03); C262(0.80)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C202(1.04); C166(1.14)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C202(0.93); C166(0.98)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C202(1.13)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C202(1.07); C166(0.92)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C202(0.99); C166(1.05)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C166(1.10); C168(1.31); C262(1.06)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C202(1.07)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C202(0.97); C166(0.86)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C202(1.15); C166(0.98)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C202(1.23); C166(1.02)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C202(1.01); C166(1.05)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C166(0.96); C168(1.05)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C166(0.98); C168(1.22)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C166(1.09); C168(1.28)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C166(0.95); C168(1.09)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C166(1.42); C168(1.62)  LDD0898  [7]
 LDCM0301  AC4 HEK-293T C166(1.16); C168(1.26); C262(1.09)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C166(0.96); C168(1.19)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C166(1.14); C168(1.39)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C166(0.97); C168(1.25)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C166(0.98); C168(1.21)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C166(1.16); C168(1.20)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C166(1.18); C168(1.36)  LDD0905  [7]
 LDCM0308  AC46 HEK-293T C166(0.88)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C166(0.96)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C166(0.91)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C166(0.97)  LDD0909  [7]
 LDCM0312  AC5 HEK-293T C166(1.01); C168(1.12); C262(1.05)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C166(0.87)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C166(0.75)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C166(0.71)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C166(0.80)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C166(0.78)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C166(0.93)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C166(0.87)  LDD0917  [7]
 LDCM0320  AC57 HEK-293T C166(0.94); C168(0.92)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C166(0.94); C168(0.92)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C166(0.91); C168(0.95)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C166(1.19)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C166(1.60); C168(1.11)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C166(1.02); C168(1.10)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C166(0.90); C168(0.99)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C166(0.77); C168(0.82)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C166(0.83); C168(0.87)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C166(1.00); C168(1.11)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C166(0.92); C168(0.96)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C166(0.89); C168(0.92)  LDD0929  [7]
 LDCM0332  AC68 HEK-293T C166(0.93); C168(0.93)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C166(0.97); C168(0.97)  LDD0931  [7]
 LDCM0334  AC7 HEK-293T C166(0.99)  LDD0932  [7]
 LDCM0335  AC70 HEK-293T C166(1.04); C168(1.04)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C166(1.06); C168(1.06)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C166(0.99); C168(0.99)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C166(1.07); C168(1.07)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C166(1.28); C168(1.28)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C166(0.92); C168(0.92)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C166(0.91); C168(0.91)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C166(0.89); C168(0.89)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C166(0.94); C168(0.94)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C166(1.13); C168(1.13)  LDD0942  [7]
 LDCM0345  AC8 HEK-293T C166(0.95)  LDD0943  [7]
 LDCM0346  AC80 HEK-293T C166(0.89); C168(0.89)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C166(0.92); C168(0.92)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C166(0.94); C168(0.94)  LDD0946  [7]
 LDCM0349  AC83 HEK-293T C166(0.97); C168(0.89)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C166(0.75); C168(0.72)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C166(0.92); C168(0.97)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C166(0.95); C168(0.85)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C166(0.82); C168(0.87)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C166(0.91); C168(0.92)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C166(0.89); C168(0.78)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C166(0.93); C168(0.96)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C166(1.00); C168(0.99)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C166(0.80); C168(0.73)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C166(0.87); C168(0.95)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C166(0.98); C168(0.94)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C166(0.98); C168(1.02)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C166(0.88); C168(0.94)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C166(1.09); C168(0.94)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C166(1.23); C168(1.23)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C166(0.91); C168(0.91)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C166(1.04)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C166(0.98)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C166(0.97)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 13.47  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C166(1.06); C168(1.06)  LDD2171  [7]
 LDCM0367  CL1 HEK-293T C166(1.21); C168(1.36); C262(1.26)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C166(0.98); C168(0.81); C262(1.00)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C166(1.08); C168(1.20); C262(0.87)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C166(0.97)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C166(0.95)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C166(1.01)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C166(1.13)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C166(1.01); C262(0.77)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C166(1.00); C262(0.82)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C166(1.15); C262(0.83)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C166(1.12); C262(1.06)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C166(1.08); C262(0.73)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C166(1.05); C168(1.00); C262(0.94)  LDD0977  [7]
 LDCM0380  CL110 HEK-293T C166(1.00); C262(0.97)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C166(0.93); C262(0.81)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C202(1.06)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C202(1.10); C166(1.06)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C202(0.89); C166(0.96)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C202(0.99); C166(0.98)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C202(1.11)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C166(1.00); C168(1.14)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C166(1.09); C168(1.38)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C166(1.19); C168(1.61)  LDD0987  [7]
 LDCM0390  CL12 HEK-293T C166(0.93); C168(0.83); C262(1.08)  LDD0988  [7]
 LDCM0391  CL120 HEK-293T C166(1.07); C168(1.32)  LDD0989  [7]
 LDCM0392  CL121 HEK-293T C166(0.93)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C166(0.88)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C166(0.99)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C166(0.85)  LDD0993  [7]
 LDCM0396  CL125 HEK-293T C166(0.91); C168(0.92)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C166(1.07); C168(1.10)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C166(0.89); C168(0.84)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C166(0.98); C168(0.87)  LDD0997  [7]
 LDCM0400  CL13 HEK-293T C166(1.02); C168(1.05); C262(1.20)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C166(0.93); C168(0.84); C262(0.94)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C166(1.00); C168(0.83); C262(1.20)  LDD1000  [7]
 LDCM0403  CL16 HEK-293T C166(1.09); C168(1.21); C262(0.92)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C166(0.89); C168(0.84); C262(0.80)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C166(1.06); C168(0.92); C262(0.80)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C166(1.21); C168(1.14); C262(1.05)  LDD1004  [7]
 LDCM0407  CL2 HEK-293T C166(0.94); C168(0.98); C262(0.80)  LDD1005  [7]
 LDCM0408  CL20 HEK-293T C166(1.07); C168(0.94); C262(0.81)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C166(1.18); C168(1.12); C262(0.82)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C166(1.15); C168(1.26); C262(0.79)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C166(1.03); C168(1.10); C262(0.89)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C166(0.95); C168(0.94); C262(0.91)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C166(1.10); C168(0.95); C262(0.86)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C166(1.05); C168(1.13); C262(0.72)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C166(1.29); C168(1.45); C262(0.85)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C166(1.09); C168(1.21); C262(0.74)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C166(1.03); C168(1.07); C262(0.86)  LDD1015  [7]
 LDCM0418  CL3 HEK-293T C166(0.96); C168(1.00); C262(0.97)  LDD1016  [7]
 LDCM0419  CL30 HEK-293T C166(1.10); C168(1.18); C262(0.87)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C166(0.94); C262(0.98)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C166(0.96); C262(0.82)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C166(1.10); C262(0.90)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C166(1.00); C262(1.03)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C166(0.87); C262(1.04)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C166(0.83); C262(0.80)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C166(0.85); C262(0.83)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C166(1.05); C262(0.88)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C166(1.36); C168(1.78); C262(1.02)  LDD1027  [7]
 LDCM0430  CL40 HEK-293T C166(0.87); C262(0.78)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C166(0.87); C262(0.88)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C166(0.87); C262(0.95)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C166(0.88); C262(0.85)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C166(0.93); C262(0.88)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C166(1.01); C262(0.84)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C166(0.90)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C166(0.93)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C166(1.00)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C166(1.00)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C166(0.96); C168(0.97); C262(0.76)  LDD1038  [7]
 LDCM0441  CL50 HEK-293T C166(1.03)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C166(0.96)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C166(1.02)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C166(1.12)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C166(1.02)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C166(0.92)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C166(0.89)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C166(1.06)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C166(1.04)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C166(0.93)  LDD1048  [7]
 LDCM0451  CL6 HEK-293T C166(1.12); C168(1.06); C262(1.07)  LDD1049  [7]
 LDCM0452  CL60 HEK-293T C166(0.99)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C166(0.91)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C166(0.78)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C166(0.92)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C166(1.14)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C166(0.86)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C166(0.78)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C166(0.80)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C166(0.67)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C166(0.88)  LDD1059  [7]
 LDCM0462  CL7 HEK-293T C166(0.95); C168(0.97); C262(0.89)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C166(0.88)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C166(0.83)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C166(0.74)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C166(0.72)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C166(0.76)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C166(0.95); C262(1.27)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C166(0.73); C262(1.70)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C166(0.61); C262(1.94)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C166(0.65); C262(1.39)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C168(1.64); C262(1.28)  LDD1071  [7]
 LDCM0474  CL80 HEK-293T C166(0.69); C262(1.66)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C166(0.64); C262(1.86)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C166(0.92); C262(1.14)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C166(0.83); C262(1.43)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C166(0.66); C262(1.44)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C166(0.57); C262(1.47)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C166(0.48); C262(2.51)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C166(0.63); C262(1.15)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C166(0.58); C262(1.45)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C166(0.65); C262(1.24)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C168(1.36); C262(1.25)  LDD1082  [7]
 LDCM0485  CL90 HEK-293T C166(0.88); C262(1.54)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C166(1.00); C168(1.01); C262(0.97)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C166(1.02); C168(1.02); C262(1.09)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C166(1.25); C168(1.59); C262(0.74)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C166(1.48); C168(1.89); C262(0.99)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C166(1.05); C168(1.09); C262(1.17)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C166(0.98); C168(0.95); C262(1.02)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C166(1.42); C168(1.84); C262(1.16)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C166(1.03); C168(1.20); C262(0.98)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C166(1.04); C168(1.13); C262(0.96)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C202(1.07); C166(0.98)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C166(0.82)  LDD1066  [7]
 LDCM0427  Fragment51 HEK-293T C166(0.83); C262(0.93)  LDD1025  [7]
 LDCM0022  KB02 HEK-293T C202(0.78)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C202(1.09)  LDD1497  [8]
 LDCM0024  KB05 NCI-H1299 C225(1.57)  LDD3343  [2]
 LDCM0021  THZ1 HCT 116 C166(1.06); C168(1.06)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
BTB/POZ domain-containing protein KCTD15 (KCTD15) . Q96SI1
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402