Details of the Target

General Information of Target

Target ID LDTP10805
Target Name Cyclin-L2 (CCNL2)
Gene Name CCNL2
Gene ID 81669
Synonyms
Cyclin-L2; Paneth cell-enhanced expression protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLCSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSC
ADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGD
MHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGV
DPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQH
QAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKAL
AVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVL
RHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRR
EILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGE
GTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGP
RGQDPVSSPCG
Target Bioclass
Other
Family
Cyclin family, Cyclin L subfamily
Subcellular location
Nucleus speckle
Function Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.
Uniprot ID
Q96S94
Ensemble ID
ENST00000400809.8
HGNC ID
HGNC:20570

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 SNV: p.S13A DBIA    Probe Info 
CHL1 SNV: p.D39N DBIA    Probe Info 
DU145 SNV: p.F235L DBIA    Probe Info 
FUOV1 SNV: p.L281V DBIA    Probe Info 
MELHO SNV: p.V144I DBIA    Probe Info 
MFE319 SNV: p.Y501H .
OVISE SNV: p.N221D DBIA    Probe Info 
SNGM Deletion: p.R434AfsTer93 DBIA    Probe Info 
TE4 SNV: p.S390C DBIA    Probe Info 
TOV21G SNV: p.A2E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C190(3.13)  LDD1701  [1]
DBIA
 Probe Info  		C82(1.06)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C52(0.00); C82(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C52(0.00); C82(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C82(0.00); C190(0.00); C52(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C82(1.06)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C52(0.97)  LDD1508  [5]
 LDCM0216  AC100 HEK-293T C82(0.73)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C82(0.99)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C82(0.99)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C82(0.64)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C82(0.89)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C82(1.07)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C82(1.03)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C82(0.88)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C82(1.14)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C82(0.91)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C52(0.98); C82(0.96)  LDD1509  [5]
 LDCM0227  AC110 HEK-293T C82(0.35)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C82(0.18)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C82(0.29)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C82(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C82(0.82)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C82(0.77)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C82(0.79)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C82(0.88)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C82(0.84)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C82(0.84)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C52(0.91); C82(0.87)  LDD1510  [5]
 LDCM0238  AC120 HCT 116 C82(0.77)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C82(0.91)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C82(0.69)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C82(1.01)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C82(0.72)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C82(0.81)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C82(0.80)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C82(0.83)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C82(1.05)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C82(1.11)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C82(0.94)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C82(1.14)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C82(1.03)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C82(1.08)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C82(0.89)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C82(0.96)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C82(0.98)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C82(1.00)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C82(0.93)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C82(0.96)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C52(0.96)  LDD1512  [5]
 LDCM0260  AC140 HCT 116 C82(0.97)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C82(1.00)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C82(1.23)  LDD0579  [2]
 LDCM0263  AC143 HEK-293T C82(1.41)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C82(0.73)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C82(0.69)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C82(0.84)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C82(0.73)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C82(0.86)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C82(1.08)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C52(1.08); C82(1.00)  LDD1513  [5]
 LDCM0271  AC150 HEK-293T C82(1.01)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C82(0.92)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C82(1.01)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C82(0.94)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C82(0.87)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C82(1.17)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C82(0.68)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C82(0.57)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C52(0.97); C82(0.86)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C52(0.98)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C52(1.14); C82(0.98)  LDD1517  [5]
 LDCM0279  AC2 HCT 116 C82(0.88)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C52(0.96); C82(1.02)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C52(1.00); C82(1.09)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C52(1.02)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C52(1.03); C82(1.06)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C52(1.01)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C52(0.90); C82(1.04)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C52(0.95)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C52(0.95); C82(1.03)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C52(0.95); C82(0.86)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C52(1.03); C82(1.03)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C82(0.94)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C52(0.98)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C52(0.91); C82(0.90)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C52(0.98)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C52(1.01); C82(1.14)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C52(0.97)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C52(0.87); C82(1.10)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C52(0.94); C82(0.88)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C52(1.04); C82(1.25)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C52(0.99)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C52(0.95); C82(1.01)  LDD1539  [5]
 LDCM0301  AC4 HCT 116 C82(0.91)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C52(0.97)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C52(0.95); C82(0.92)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C52(0.97)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C52(0.98); C82(0.92)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C52(0.96); C82(0.93)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C52(1.02); C82(1.00)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C52(1.00)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C52(1.08); C82(1.05)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C52(1.12)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C52(0.96); C82(0.97)  LDD1550  [5]
 LDCM0312  AC5 HCT 116 C82(0.98)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C52(1.02)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C52(0.92); C82(1.01)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C52(0.96); C82(0.84)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C52(1.04); C82(0.82)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C52(1.01)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C52(1.01); C82(1.03)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C52(1.05)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C52(1.07); C82(0.93)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C52(0.88)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C52(1.02); C82(1.13)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C52(1.04)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C52(0.96); C82(0.94)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C52(1.03); C82(1.08)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C52(1.00)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C52(1.02); C82(1.07)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C52(1.08)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C52(0.99); C82(1.09)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C52(1.01)  LDD1569  [5]
 LDCM0365  AC98 HEK-293T C82(0.95)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C82(1.65)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C52(1.02); C82(0.95)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C52(0.93); C82(1.10)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C52(1.01)  LDD1514  [5]
 LDCM0367  CL1 HCT 116 C82(1.13)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C82(1.05)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C82(0.89)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C52(1.00)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C52(0.88)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C52(1.07)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C52(1.02); C82(0.72)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C52(0.93)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C52(0.99)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C52(0.98)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C52(0.94); C82(0.79)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C52(0.94)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C82(1.05)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C52(0.93)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C52(0.92)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C52(0.92); C82(0.66)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C52(1.03)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C52(0.93)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C52(1.13)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C52(0.94); C82(0.78)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C52(1.00)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C52(1.06)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C52(1.07)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C82(1.10)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C52(0.91); C82(0.88)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C52(0.96)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C52(0.90)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C52(0.94)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C52(0.90); C82(0.82)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C52(1.06)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C52(0.93)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C52(1.02)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C52(1.04); C82(0.78)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C82(0.94)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C82(0.99)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C82(1.07)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C52(1.02); C82(0.82)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C52(0.95); C82(1.03)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C52(1.12)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C52(1.10); C82(1.02)  LDD1610  [5]
 LDCM0407  CL2 HCT 116 C82(1.14)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C52(1.12); C82(1.01)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C52(1.11); C82(1.24)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C52(1.07)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C52(1.10); C82(1.20)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C52(1.08)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C52(1.02)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C52(0.92)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C52(1.00)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C52(0.94); C82(0.91)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C52(0.97); C82(0.81)  LDD1621  [5]
 LDCM0418  CL3 HCT 116 C82(0.89)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C52(1.01)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C52(1.04); C82(1.07)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C52(1.13); C82(0.87)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C52(0.97); C82(1.02)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C52(1.04)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C52(1.10); C82(1.05)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C52(0.98)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C52(1.06)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C52(0.93)  LDD1632  [5]
 LDCM0429  CL4 HCT 116 C82(1.04)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C52(1.00); C82(0.84)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C52(0.99); C82(1.17)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C52(0.95)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C52(0.95); C82(1.07)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C52(0.97); C82(0.97)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C52(0.97); C82(1.07)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C82(0.57)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C82(0.69)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C82(0.57)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C82(0.63)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C82(1.17)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C82(0.41)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C82(0.63)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C82(0.92)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C82(0.89)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C82(0.51)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C82(0.61)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C82(0.70)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C82(0.64)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C82(0.70)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C82(0.45)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C82(0.99)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C82(0.46)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C82(1.15)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C82(1.04)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C82(1.01)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C82(0.98)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C82(1.02)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C82(1.07)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C82(1.13)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C82(1.17)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C82(0.70)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C82(1.03)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C82(1.01)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C82(0.86)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C82(0.99)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C82(1.16)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C82(1.00)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C52(1.10); C82(0.79)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C52(0.87); C82(1.08)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C52(0.99)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C52(0.96); C82(1.19)  LDD1675  [5]
 LDCM0473  CL8 HCT 116 C82(1.19)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C52(1.05); C82(0.89)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C52(1.01); C82(1.06)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C52(1.01)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C52(1.04); C82(1.09)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C52(1.00)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C52(1.07)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C52(1.02)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C52(0.96)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C52(1.02); C82(0.78)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C52(0.94); C82(1.00)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C82(1.09)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C52(0.87)  LDD1688  [5]
 LDCM0486  CL91 HCT 116 C82(0.85)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C82(0.85)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C82(1.02)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C82(0.93)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C82(0.80)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C82(0.83)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C82(0.76)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C82(0.80)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C82(0.88)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C52(1.08)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C190(1.71)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C82(0.98)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C52(1.02)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C52(1.04)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C52(1.05)  LDD1497  [5]
 LDCM0024  KB05 COLO792 C195(2.08)  LDD3310  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
Emerin (EMD) . P50402
Melanoma-associated antigen B2 (MAGEB2) . O15479

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840