Details of the Target

General Information of Target

Target ID LDTP10472
Target Name DDB1- and CUL4-associated factor 5 (DCAF5)
Gene Name DCAF5
Gene ID 8816
Synonyms
BCRG2; KIAA1824; WDR22; DDB1- and CUL4-associated factor 5; Breakpoint cluster region protein 2; BCRP2; WD repeat-containing protein 22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAWKSWTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLE
PIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKD
DIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYF
FSASEEVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLY
ELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLL
MDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIV
FDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQ
EQIEESKEQQEPSSGGSVVPTVQEPKDVLEKKKD
Target Bioclass
Enzyme
Function
Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1.
Uniprot ID
Q96JK2
Ensemble ID
ENST00000341516.10
HGNC ID
HGNC:20224

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.P602S .
IGROV1 SNV: p.R381C DBIA    Probe Info 
LU65 SNV: p.C711F .
MDAMB436 SNV: p.S600I DBIA    Probe Info 
MEWO SNV: p.P795S .
NALM6 SNV: p.R467H DBIA    Probe Info 
NCIH2172 SNV: p.E748Ter .
RKN SNV: p.E475Ter DBIA    Probe Info 
SNU1 SNV: p.W666R DBIA    Probe Info 
WM1552C SNV: p.S223F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C884(0.97); C890(0.97); C812(0.91); C883(0.87)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C829(11.53)  LDD0372  [7]
 LDCM0214  AC1 HEK-293T C286(0.96); C884(1.04); C890(1.04)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C280(1.21); C503(1.41); C884(1.03); C890(1.03)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C280(1.06); C286(0.97); C368(1.31); C884(1.01)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C280(0.86); C286(0.93); C368(1.17); C884(0.99)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C280(0.95); C286(0.94); C368(1.27); C884(0.99)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C280(1.45); C286(0.99); C368(1.48); C884(0.96)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C280(1.14); C286(1.09); C368(1.18); C884(1.78)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C280(1.15); C286(0.98); C368(1.00); C884(0.96)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C280(1.11); C286(0.76); C368(0.96); C884(0.81)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C280(1.17); C286(1.08); C368(1.53); C884(1.12)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C280(1.13); C286(0.89); C368(0.96); C884(1.22)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C280(0.85); C286(0.95); C368(1.24); C884(0.86)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C280(1.00); C503(0.92); C884(1.08); C890(1.08)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C280(0.91); C286(1.37); C368(1.70); C884(0.97)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C280(1.37); C286(1.82); C368(2.52); C884(0.92)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C280(1.42); C286(1.54); C368(1.90); C884(0.93)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C286(0.99); C368(0.92); C503(0.82); C884(0.93)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C286(0.90); C368(0.89); C503(1.21); C884(0.88)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C286(1.03); C368(1.04); C503(0.89); C884(0.78)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C286(1.30); C368(1.07); C503(0.85); C884(0.62)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C286(1.17); C368(1.06); C503(0.87); C884(1.26)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C286(0.94); C368(1.21); C503(0.87); C884(0.72)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C286(1.24); C368(1.10); C503(1.01); C884(1.00)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C280(0.88); C503(1.23); C884(0.77); C890(0.77)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C286(1.20); C368(1.23); C503(0.73); C884(0.83)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C286(1.27); C368(1.39); C503(0.79); C884(1.33)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C286(1.47); C368(1.59); C503(0.93); C884(0.98)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C286(1.62); C368(1.25); C503(1.04); C884(0.84)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C286(1.13); C368(1.20); C503(1.01); C884(1.12)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C286(1.48); C368(1.50); C503(1.01); C884(1.69)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C286(1.80); C368(1.66); C503(1.26); C884(1.73)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C286(2.11); C368(1.75); C503(1.39); C884(1.02)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C286(0.95); C368(0.96); C884(1.42); C890(1.42)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C286(1.03); C368(1.11); C884(1.78); C890(1.78)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C286(1.08); C368(1.20); C884(1.32); C890(1.32)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C286(0.89); C368(1.04); C884(1.46); C890(1.46)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C286(1.10); C368(1.30); C884(1.89); C890(1.89)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C286(1.32); C368(1.51); C884(1.17); C890(1.17)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C286(1.12); C368(1.02); C884(1.28); C890(1.28)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C286(1.24); C368(1.40); C884(0.88); C890(0.88)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C286(1.38); C368(1.29); C884(1.31); C890(1.31)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C286(1.58); C368(1.56); C884(1.22); C890(1.22)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C286(1.88); C368(1.81); C884(1.17); C890(1.17)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C286(1.38); C368(1.39); C884(1.19); C890(1.19)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C280(1.12); C503(1.51); C884(1.98); C890(1.98)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C286(1.27); C368(1.45); C884(1.08); C890(1.08)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C286(1.55); C368(1.54); C884(1.28); C890(1.28)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C286(1.29); C368(1.09); C884(1.19); C890(1.19)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C286(0.94); C368(1.04); C884(0.70)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C286(1.65); C368(1.22); C884(0.90)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C286(1.24); C368(1.44); C884(1.06)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C286(1.44); C368(1.43); C884(0.82)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C286(1.17); C368(1.30); C884(0.87)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C286(1.36); C368(1.34); C884(1.20)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C286(0.90); C368(1.11); C884(2.11)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C280(1.19); C503(1.47); C884(1.11); C890(1.11)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C286(1.00); C368(1.23); C884(0.73)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C286(1.45); C368(1.18); C884(1.02)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C286(1.15); C368(1.28); C884(1.10)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C286(1.08); C368(1.51); C884(1.02)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C286(0.96); C368(1.01); C884(0.71)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C286(1.24); C368(1.14); C884(1.02)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C286(1.42); C368(2.02); C884(0.82)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C286(1.80); C368(1.90); C884(0.62)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C280(1.26); C286(1.33); C503(0.71)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C280(1.15); C286(1.15); C503(0.75)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C280(1.04); C286(1.15); C503(0.81)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C286(1.21); C884(1.12); C890(1.12)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C280(1.38); C286(1.32); C503(0.74)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C280(1.27); C286(1.19); C503(0.82)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C280(1.18); C286(1.42); C503(0.80)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C280(1.35); C286(1.65); C503(0.65)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C280(1.17); C286(1.07); C503(0.89)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C280(0.87); C368(0.87)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C280(1.05); C368(0.91)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C280(0.68); C368(1.01)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C280(1.40); C368(1.86)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C280(1.03); C368(1.01)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C286(1.03); C884(1.09); C890(1.09)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C280(0.96); C368(1.02)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C280(0.90); C368(1.12)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C280(1.10); C368(0.92)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C280(0.89); C368(0.87)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C280(0.99); C368(0.83)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C884(0.81); C890(0.81)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C884(0.82); C890(0.82)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C884(0.84); C890(0.84)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C884(1.06); C890(1.06)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C884(1.49); C890(1.49)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C286(1.00); C884(1.05); C890(1.05)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C884(0.77); C890(0.77)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C884(0.83); C890(0.83)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C884(1.11); C890(1.11)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C884(1.08); C890(1.08)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C884(0.97); C890(0.97)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C884(1.05); C890(1.05)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C280(0.93); C286(0.93); C368(1.35); C884(0.51)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C280(1.03); C286(0.96); C368(1.57); C884(0.71)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C280(1.10); C286(1.15); C368(1.26); C884(0.71)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C280(0.98); C286(1.01); C368(1.29); C884(0.64)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C286(1.39); C884(1.14); C890(1.14)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C280(0.94); C286(1.19); C368(1.20); C884(0.61)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C280(1.00); C286(1.24); C368(1.52); C884(0.72)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C280(1.02); C286(1.40); C368(1.46); C884(0.75)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C280(0.86); C286(1.11); C368(1.29); C884(0.76)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C280(1.05); C286(1.31); C368(1.49); C884(0.70)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C280(1.06); C286(1.35); C368(1.49); C884(0.88)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C280(1.08); C286(1.20); C368(1.69); C884(0.63)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C286(1.05); C368(0.97); C884(0.96); C890(0.72)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C286(1.14); C368(0.99); C884(1.25); C890(1.43)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C286(1.01); C368(0.89); C884(0.94); C890(0.88)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C280(0.89); C503(1.51); C884(1.00); C890(1.00)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C286(0.99); C368(1.78); C884(1.07); C890(0.99)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C286(1.33); C368(1.17); C884(0.98); C890(0.85)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C286(1.10); C368(1.18); C884(1.01); C890(1.07)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C286(1.35); C368(1.18); C884(1.06); C890(0.99)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C286(1.22); C368(0.91); C884(0.99); C890(0.84)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C286(1.23); C368(1.09); C884(1.10); C890(1.24)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C286(1.11); C368(0.90); C884(1.70); C890(1.63)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C286(1.19); C368(0.99); C884(0.95); C890(0.95)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C280(1.05); C286(1.19); C884(1.06); C890(1.25)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C280(0.99); C286(0.77); C884(1.51); C890(1.66)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C280(0.88); C503(1.35); C884(0.71); C890(0.71)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C280(1.09); C286(0.76); C884(0.97); C890(1.13)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C280(1.31); C286(0.82); C884(1.06); C890(1.33)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C280(1.18); C286(0.99); C884(1.21); C890(1.15)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C280(1.15); C286(0.64); C884(1.10); C890(1.24)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C280(1.27); C286(1.05); C884(1.22); C890(1.29)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C280(1.35); C286(1.07); C884(1.15); C890(1.23)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C280(1.43); C286(1.57); C884(1.20); C890(1.37)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C280(1.33); C286(0.94); C884(1.21); C890(1.19)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C280(1.23); C286(0.83); C884(1.68); C890(1.95)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C280(1.01); C286(1.16); C884(1.81); C890(2.05)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C280(1.14); C503(1.23); C884(0.65); C890(0.65)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C280(1.42); C286(1.05); C884(1.24); C890(1.41)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C280(1.24); C286(1.13); C884(1.24); C890(1.48)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C280(1.35); C286(1.55); C884(1.53); C890(1.56)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C286(1.08); C368(1.06); C884(1.42); C890(1.42)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C286(1.32); C368(1.53); C884(1.29); C890(1.29)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C286(1.23); C368(1.27); C884(1.41); C890(1.41)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C286(1.09); C368(1.31); C884(1.53); C890(1.53)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C286(1.30); C368(1.18); C884(1.98); C890(1.98)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C286(1.21); C368(1.50); C884(1.63); C890(1.63)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C286(1.34); C368(1.30); C884(1.94); C890(1.94)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C286(1.21); C368(1.47); C884(2.21); C890(2.21)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C286(1.27); C368(1.16); C884(2.39); C890(2.39)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C286(1.28); C368(1.07); C884(1.54); C890(1.54)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C286(1.39); C368(1.44); C884(1.74); C890(1.74)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C286(1.62); C368(1.76); C884(1.72); C890(1.72)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C286(1.20); C368(1.22); C884(1.67); C890(1.67)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C286(1.19); C368(1.43); C884(2.21); C890(2.21)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C286(2.27); C368(1.78); C884(1.36); C890(1.36)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C280(1.07); C286(0.89); C368(1.14); C884(1.23)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C280(1.15); C286(1.00); C368(1.11); C884(1.28)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C280(1.30); C503(1.19); C884(1.17); C890(1.17)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C280(1.32); C503(1.57); C884(1.09); C890(1.09)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C280(1.17); C503(1.87); C884(2.05); C890(2.05)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C884(0.97); C890(0.97); C812(0.91); C883(0.87)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C829(0.65)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C286(1.39); C503(0.69)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C286(2.71); C503(0.79)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C286(1.21); C884(1.23); C890(1.23)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C280(1.52); C503(1.40); C884(1.11); C890(1.11)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C280(0.89); C503(1.44); C884(1.65); C890(1.65)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C280(0.94); C503(1.08); C884(0.64); C890(0.64)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C280(1.22); C503(1.27); C884(0.85); C890(0.85)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C280(0.96); C286(1.08); C503(0.95)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C280(1.24); C286(1.11); C503(0.69)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C280(1.08); C286(1.02); C503(0.80)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C280(1.31); C286(1.14); C503(0.82)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C280(1.13); C286(1.23); C503(0.93)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C286(2.52); C503(0.84)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C280(1.22); C286(1.25); C503(0.97)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C280(1.03); C286(1.22); C503(0.92)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C280(0.88); C368(0.82)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C280(0.82); C368(1.03)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C280(0.96); C368(1.38)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C280(1.06); C368(0.93)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C280(1.09); C368(1.25)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C884(1.07); C890(1.07)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C884(0.49); C890(0.49)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C884(0.57); C890(0.57)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C286(1.34); C503(0.64)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C884(0.60); C890(0.60)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C280(1.10); C286(1.28); C368(1.52); C884(0.60)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C280(1.19); C286(1.19); C368(1.28); C884(0.99)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C280(0.88); C286(1.03); C368(1.70); C884(0.85)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C280(0.93); C286(1.12); C368(1.35); C884(0.61)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C286(1.17); C368(0.98); C884(0.79); C890(0.75)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C286(1.13); C368(0.85); C884(0.88); C890(0.66)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C286(0.91); C368(0.98); C884(0.94); C890(0.95)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C286(1.06); C368(0.89); C884(1.10); C890(1.01)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C286(1.23); C503(0.72)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C286(1.48); C503(0.80)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C286(1.44); C503(0.83)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C286(1.13); C503(0.71)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C286(0.98); C503(0.86)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C286(1.45); C503(0.86)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C286(1.04); C503(0.91)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C286(1.22); C503(0.69)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C286(1.22); C503(1.07)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C286(1.57); C503(0.92)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C286(1.27); C503(0.90)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C286(1.51); C503(0.70)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C286(1.24); C503(0.71)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C286(1.22); C503(0.78)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C286(1.11); C503(0.80)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C286(1.28); C503(0.77)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C286(1.21); C503(0.72)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C286(1.50); C503(0.88)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C286(1.45); C503(0.62)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C286(1.64); C503(0.78)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C503(0.88)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C503(0.71)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C503(0.86)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C503(1.12)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C503(0.67)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C503(0.75)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C503(0.68)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C503(0.87)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C286(1.47); C503(0.88)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C503(0.82)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C503(0.83)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C503(0.95)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C503(0.88)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C503(0.78)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C503(0.96)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C280(1.17); C368(1.23)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C280(1.09); C368(1.09)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C280(0.97); C368(1.20)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C280(1.11); C368(1.31)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C286(1.53); C503(0.76)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C280(1.28); C368(1.70)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C280(1.00); C368(1.44)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C280(0.99); C368(0.92)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C280(0.91); C368(0.84)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C280(1.18); C368(1.31)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C280(0.95); C368(1.22)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C280(0.98); C368(1.04)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C280(1.02); C368(1.20)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C280(1.05); C368(1.17)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C280(1.13); C368(1.28)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C286(1.22); C503(0.81)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C280(1.38); C368(1.45)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C286(1.44); C503(0.94)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C286(1.34); C503(0.89)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C286(1.21); C503(0.85)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C286(0.96); C503(1.25)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C286(1.21); C503(1.15)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C286(1.05); C503(0.80)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C286(1.16); C503(1.08)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C286(1.12); C503(0.92)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C286(1.00); C503(1.06)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C286(1.35); C503(0.77)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C286(1.10); C503(1.15)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C286(1.25); C503(0.88)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C286(1.43); C503(0.88)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C286(1.14); C503(1.08)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C286(2.00); C503(1.00)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C286(0.94)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C286(1.08)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C286(0.89)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C286(1.05)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C286(0.92); C503(1.08)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C286(0.96)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C286(1.29)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C286(1.46)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C286(1.52)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C286(1.03)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C286(1.20)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C286(1.15)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C286(1.41)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C286(1.27)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C286(1.19)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C286(0.86); C503(1.45)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C286(1.12)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C286(1.15); C884(1.27); C890(1.27)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C286(1.21); C884(1.01); C890(1.01)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C286(1.18); C884(1.11); C890(1.11)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C286(1.39); C884(0.80); C890(0.80)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C286(1.49); C884(1.29); C890(1.29)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C286(1.18); C884(1.34); C890(1.34)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C286(1.22); C884(1.71); C890(1.71)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C286(1.17); C884(0.94); C890(0.94)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C286(1.07); C884(1.42); C890(1.42)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C711(1.11); C280(1.51); C829(1.17)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C286(1.68); C503(0.94)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C503(0.67)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C280(2.11)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C280(2.36)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C280(1.71)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA (cytosine-5)-methyltransferase 1 (DNMT1) C5-methyltransferase family P26358
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402