Details of the Target

General Information of Target

Target ID LDTP10258
Target Name F-box only protein 17 (FBXO17)
Gene Name FBXO17
Gene ID 115290
Synonyms
FBG4; FBX17; FBX26; FBXO26; F-box only protein 17; F-box only protein 26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEK
LPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSK
EMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSS
KFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVD
TRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEF
LSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFY
RTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFN
ENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTM
YGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKV
RDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQ
VKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDI
SEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ
Target Bioclass
Enzyme
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Uniprot ID
Q96EF6
Ensemble ID
ENST00000292852.9
HGNC ID
HGNC:18754

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.94  LDD0402  [1]
DBIA
 Probe Info  		C193(3.64); C195(3.64); C148(1.95); C156(1.95)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		C114(0.00); C193(0.00)  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C148(0.47); C114(0.72); C193(0.77); C195(0.77)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C148(0.63); C114(0.56)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C148(1.10); C114(1.01)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C148(1.33); C114(1.23)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C148(0.96); C114(1.10)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C148(1.16); C114(0.94)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C148(0.98); C114(0.91)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C148(1.33); C114(1.01)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C148(1.56); C114(1.23)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C148(1.15); C114(1.07)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C148(1.09); C114(1.07)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C148(1.23); C114(1.07)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C148(0.82); C114(0.64)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C148(1.35); C114(1.15)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C148(1.71); C114(1.28)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C148(1.35); C114(1.15)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C148(0.91); C114(1.07)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C148(0.85); C114(0.99)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C148(0.85); C114(1.10)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C148(0.76); C114(0.79)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C148(0.82); C114(0.99)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C148(0.74); C114(0.79)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C148(0.73); C114(0.85)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C148(0.56); C114(0.45)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C148(0.76); C114(0.88)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C148(0.82); C114(1.01)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C148(0.79); C114(1.03)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C148(0.82); C114(0.97)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C148(0.79); C114(0.91)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C148(0.82); C114(0.99)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C148(0.97); C114(1.08)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C148(1.10); C114(1.04)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C148(1.24); C114(1.13)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C148(1.07); C114(1.03)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C148(1.12); C114(0.93)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C148(0.99); C114(1.06)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C148(1.23); C114(1.11)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C148(1.13); C114(1.10)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C148(1.07); C114(1.00)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C148(1.14); C114(1.05)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C148(1.07); C114(1.04)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C148(1.27); C114(1.16)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C148(1.57); C114(1.24)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C148(1.24); C114(1.18)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C148(0.65); C114(0.55)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C148(1.23); C114(1.08)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C148(1.18); C114(1.15)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C148(1.20); C114(1.03)  LDD0860  [2]
 LDCM0263  AC143 PaTu 8988t C81(0.71); C148(1.10); C156(1.10); C94(0.90)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C81(0.98); C148(1.01); C156(1.11); C94(0.97)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C81(0.86); C148(1.17); C156(1.10); C94(0.93)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C81(0.78); C148(1.33); C156(1.19); C94(1.10)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C81(1.03); C148(1.23); C156(1.09); C94(0.99)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C81(0.81); C148(1.07); C156(1.06); C94(0.92)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C81(0.73); C148(1.10); C156(1.03); C94(0.88)  LDD1148  [2]
 LDCM0270  AC15 HEK-293T C148(0.59); C114(0.59)  LDD0868  [2]
 LDCM0271  AC150 PaTu 8988t C81(0.89); C148(1.10); C156(1.02); C94(0.87)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C81(0.91); C148(1.04); C156(0.96); C94(0.77)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C81(0.94); C148(1.26); C156(1.13); C94(0.78)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C81(0.74); C148(1.01); C156(0.97); C94(0.76)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C81(0.91); C148(0.98); C156(0.89); C94(0.83)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C81(0.89); C148(1.09); C156(0.99); C94(0.82)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C81(0.95); C148(1.17); C156(1.09); C94(0.86)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C81(1.19); C148(1.03); C156(0.91); C94(0.97)  LDD2169  [2]
 LDCM0276  AC17 HCT 116 C114(0.97)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C114(0.95)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C114(1.10)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C148(0.55); C114(0.79); C193(0.81); C195(0.81)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C114(1.08)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C114(1.33)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C114(1.03)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C114(1.16)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C114(1.28)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C114(1.25)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C114(1.25)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C114(1.17)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C114(1.13)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C114(1.45)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C148(0.80); C114(0.77); C193(0.92); C195(0.92)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C114(1.15)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C114(1.62)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C114(1.30)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C114(1.16)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C114(1.44)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C114(0.87)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C114(0.86)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C114(0.85)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C114(1.06)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C114(0.91)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C148(0.74); C114(0.98); C193(0.87); C195(0.87)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C114(0.91)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C114(0.88)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C114(1.02)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C114(0.96)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C114(0.87)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C114(0.84)  LDD0624  [2]
 LDCM0308  AC46 PaTu 8988t C195(1.17); C193(1.17); C81(0.88); C114(1.21)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C195(0.82); C193(0.82); C81(1.00); C114(0.89)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C195(1.17); C193(1.17); C81(0.86); C114(1.38)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C195(1.02); C193(1.02); C81(0.69); C114(1.36)  LDD1190  [2]
 LDCM0312  AC5 HEK-293T C148(0.52); C114(0.70); C193(0.93); C195(0.93)  LDD0910  [2]
 LDCM0313  AC50 PaTu 8988t C195(0.85); C193(0.85); C81(0.71); C114(0.96)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C195(0.28); C193(0.28); C81(0.64); C114(1.05)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C195(1.24); C193(1.24); C81(0.64); C114(1.52)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C195(1.24); C193(1.24); C81(0.63); C114(1.25)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C195(1.17); C193(1.17); C81(0.59); C114(1.19)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C195(1.06); C193(1.06); C81(1.15); C114(1.28)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C195(1.29); C193(1.29); C81(0.76); C114(1.12)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C148(1.37); C114(1.37)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C148(1.16); C114(1.16)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C148(1.21); C114(1.21)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C148(0.72); C114(0.64)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C148(1.32); C114(1.32)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C148(1.00); C114(1.00)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C148(1.29); C114(1.29)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C148(1.09); C114(1.09)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C148(1.21); C114(1.21)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C148(1.15); C114(1.15)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C148(1.15); C114(1.15)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C148(1.03); C114(1.03)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C148(0.91); C114(1.05)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C148(0.77); C114(0.95)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C148(0.81); C114(0.85)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C148(0.70); C114(0.83)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C148(0.77); C114(0.90)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C148(0.74); C114(0.88)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C148(0.81); C114(0.77)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C148(0.94); C114(1.09)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C148(0.67); C114(0.69)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C148(0.78); C114(0.91)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C148(0.77); C114(0.98)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C148(0.74); C114(0.84)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C148(0.84); C114(0.89)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C148(0.58); C114(0.55)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C148(0.61); C114(0.76)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C148(0.74); C114(0.88)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C148(0.62); C114(0.86)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C148(0.99); C114(1.16)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C148(0.73); C114(0.96)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C148(0.87); C114(1.04)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C148(1.62); C114(1.14)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C148(0.77); C114(0.88)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C148(0.93); C114(0.90)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C148(0.70); C114(0.95)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C148(0.73); C114(0.85)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C148(0.78); C114(0.87)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C148(0.68); C114(0.99)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C148(0.75); C114(0.89)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C148(0.85); C114(0.92)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C148(0.66); C114(0.91)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C148(0.45); C114(0.88)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C148(0.78); C114(0.91)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C148(1.16); C114(1.13)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C148(1.02); C114(1.08)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C148(0.60); C114(0.59)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C148(0.63); C114(0.56)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C148(0.51); C114(0.41)  LDD0873  [2]
 LDCM0156  Aniline NCI-H1299 11.73  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C114(1.17)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C114(0.92)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C148(0.40); C114(0.67); C193(0.68); C195(0.68)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C148(0.58); C114(0.57)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C148(0.59); C114(0.49)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C148(0.52); C114(0.43)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C148(0.52); C114(0.39)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C114(1.16)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C114(1.06)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C114(1.14)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C114(1.07)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C114(1.11)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C114(1.09)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C114(1.26)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C114(1.02)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C114(0.92)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C114(1.23)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C114(1.12)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C114(1.26)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C114(1.44)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C114(1.02)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C114(1.01)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C114(1.06)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C114(1.19)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C114(1.02)  LDD0708  [2]
 LDCM0392  CL121 PaTu 8988t C195(0.97); C193(0.97); C81(1.01); C114(1.53)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C195(1.03); C193(1.03); C81(0.87); C114(0.99)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C195(1.06); C193(1.06); C81(0.85); C114(1.38)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C195(0.99); C193(0.99); C81(0.71); C114(1.14)  LDD1274  [2]
 LDCM0396  CL125 HEK-293T C148(1.21); C114(1.21)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C148(1.15); C114(1.15)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C148(1.30); C114(1.30)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C148(1.37); C114(1.37)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C114(1.10)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C114(1.10)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C114(1.11)  LDD0719  [2]
 LDCM0403  CL16 PaTu 8988t C114(1.25); C148(0.82); C156(0.96); C94(0.85)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C114(1.16); C148(0.78); C156(0.85); C94(0.75)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C114(1.33); C148(0.70); C156(1.13); C94(0.75)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C114(1.15); C148(0.69); C156(0.95); C94(0.73)  LDD1285  [2]
 LDCM0407  CL2 HCT 116 C114(0.78)  LDD0724  [2]
 LDCM0408  CL20 PaTu 8988t C114(1.42); C148(0.73); C156(0.96); C94(0.74)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C114(1.14); C148(0.94); C156(1.05); C94(0.76)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C114(1.25); C148(0.65); C156(1.09); C94(0.87)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C114(1.42); C148(0.81); C156(1.01); C94(0.76)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C114(1.22); C148(0.98); C156(1.10); C94(0.76)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C114(1.35); C148(0.90); C156(1.10); C94(0.82)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C114(1.34); C148(0.65); C156(0.91); C94(0.75)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C114(1.34); C148(0.77); C156(1.00); C94(0.74)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C114(1.25); C148(0.87); C156(1.09); C94(0.78)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C114(1.18); C148(0.95); C156(1.06); C94(0.79)  LDD1296  [2]
 LDCM0418  CL3 HCT 116 C114(1.00)  LDD0735  [2]
 LDCM0419  CL30 PaTu 8988t C114(1.29); C148(0.92); C156(1.23); C94(0.81)  LDD1298  [2]
 LDCM0420  CL31 HEK-293T C148(0.81); C114(0.81); C193(0.96); C195(0.96)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C148(0.74); C114(0.74); C193(1.26); C195(1.26)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C148(0.65); C114(0.65); C193(1.09); C195(1.09)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C148(0.85); C114(0.85); C193(1.32); C195(1.32)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C148(0.70); C114(0.70); C193(1.03); C195(1.03)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C148(0.68); C114(0.68); C193(0.89); C195(0.89)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C148(0.76); C114(0.76); C193(0.85); C195(0.85)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C148(0.73); C114(0.73); C193(1.08); C195(1.08)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C114(0.98)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C148(0.70); C114(0.70); C193(0.89); C195(0.89)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C148(0.70); C114(0.70); C193(0.93); C195(0.93)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C148(0.67); C114(0.67); C193(1.20); C195(1.20)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C148(0.71); C114(0.71); C193(0.90); C195(0.90)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C148(0.68); C114(0.68); C193(0.97); C195(0.97)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C148(0.73); C114(0.73); C193(0.85); C195(0.85)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C114(0.94)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C114(1.00)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C114(1.13)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C114(1.19)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C114(0.91)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C114(1.04)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C114(1.03)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C114(1.00)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C114(1.20)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C114(0.95)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C114(0.94)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C114(0.95)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C114(0.89)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C114(1.04)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C114(1.24)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C114(0.97)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C114(1.07)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C148(1.02); C193(0.88); C195(0.88)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C148(0.87); C193(0.99); C195(0.99)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C148(0.91); C193(1.05); C195(1.05)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C148(0.72); C193(1.04); C195(1.04)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C148(0.86); C193(1.06); C195(1.06)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C148(0.87); C193(1.34); C195(1.34)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C148(1.03); C193(1.08); C195(1.08)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C148(0.83); C193(1.00); C195(1.00)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C148(0.82); C193(1.09); C195(1.09)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C114(0.83)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C148(1.07); C193(0.93); C195(0.93)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C148(0.80); C193(1.02); C195(1.02)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C148(1.02); C193(1.19); C195(1.19)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C148(1.07); C193(1.01); C195(1.01)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C148(1.00); C193(1.07); C195(1.07)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C148(0.93); C114(0.93)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C148(0.76); C114(0.76)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C148(0.54); C114(0.54)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C148(0.57); C114(0.57)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C114(1.07)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C148(1.08); C114(1.08)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C148(0.87); C114(0.87)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C148(1.03); C114(1.03)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C148(1.05); C114(1.05)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C148(0.65); C114(0.65)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C148(0.55); C114(0.55)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C148(0.65); C114(0.65)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C148(0.74); C114(0.74)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C148(0.78); C114(0.78)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C148(1.12); C114(1.12)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C114(0.97)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C148(0.98); C114(0.98)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C148(0.84); C114(0.87); C193(0.92); C195(0.92)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C148(0.51); C114(0.65); C193(0.79); C195(0.79)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C148(0.53); C114(0.78); C193(0.94); C195(0.94)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C148(0.43); C114(0.67); C193(0.75); C195(0.75)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C148(0.49); C114(0.74); C193(0.91); C195(0.91)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C148(0.50); C114(0.59); C193(1.18); C195(1.18)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C148(0.53); C114(0.75); C193(1.14); C195(1.14)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C148(0.58); C114(0.73); C193(0.99); C195(0.99)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C148(0.56); C114(0.69); C193(0.74); C195(0.74)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C114(1.03); C94(0.97); C81(1.15)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C148(0.69); C193(1.05); C195(1.05)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C148(0.49); C114(0.49); C193(0.76); C195(0.76)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C193(3.64); C195(3.64); C148(1.95); C156(1.95)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C193(2.64); C195(2.64); C148(1.93); C156(1.93)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C193(2.73); C195(2.73); C148(2.17); C156(2.17)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 213 (ZNF213) Krueppel C2H2-type zinc-finger protein family O14771
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Borealin (CDCA8) Borealin family Q53HL2
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Stabilizer of axonemal microtubules 2 (SAXO2) FAM154 family Q658L1
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratinocyte proline-rich protein (KPRP) . Q5T749
Rab11 family-interacting protein 2 (RAB11FIP2) . Q7L804

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402