Details of the Target

General Information of Target

Target ID LDTP09379
Target Name 5'(3')-deoxyribonucleotidase, cytosolic type (NT5C)
Gene Name NT5C
Gene ID 30833
Synonyms
DNT1; UMPH2; 5'(3')-deoxyribonucleotidase, cytosolic type; EC 3.1.3.-; Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE
Target Bioclass
Enzyme
Family
5'(3')-deoxyribonucleotidase family
Subcellular location
Cytoplasm
Function Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Uniprot ID
Q8TCD5
Ensemble ID
ENST00000245552.7
HGNC ID
HGNC:17144
ChEMBL ID
CHEMBL3751653

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.E154D .
DU4475 SNV: p.V95F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C108(2.07)  LDD2144  [1]
DBIA
 Probe Info  		C165(1.27); C166(1.27)  LDD0080  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
1d-yne
 Probe Info  		N.A.  LDD0358  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C98(0.00); C108(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NHS
 Probe Info  		N.A.  LDD0010  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
Ox-W18
 Probe Info  		N.A.  LDD2175  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
NAIA_5
 Probe Info  		C98(0.00); C108(0.00)  LDD2223  [13]
HHS-475
 Probe Info  		Y65(1.72)  LDD2238  [14]
HHS-482
 Probe Info  		Y65(1.05)  LDD2239  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C98(1.13)  LDD1507  [15]
 LDCM0215  AC10 HCT 116 C166(0.76)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C166(0.72)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C166(0.94)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C166(0.90)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C166(0.89)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C166(0.78)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C166(0.79)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C166(0.86)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C166(0.73)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C166(0.94)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C166(0.86)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C166(0.91)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C166(0.77)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C166(0.74)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C166(0.87)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C166(1.04)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C166(0.92)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C166(0.91)  LDD0587  [2]
 LDCM0276  AC17 HEK-293T C98(1.20)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C108(0.80); C98(0.99); C165(0.91)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C108(0.84); C98(0.90); C166(0.73)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C108(1.22); C98(0.95); C165(1.17)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C108(1.08); C98(1.16); C166(0.96)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C108(1.02); C166(1.09)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C108(1.01); C98(1.08); C166(1.02)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C166(0.97)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C98(1.08); C166(1.09)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C98(1.09)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C108(1.09); C98(1.01); C165(1.02)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C108(1.17); C98(0.97); C166(0.99)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C108(1.02); C98(1.15); C166(0.81)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C108(1.02); C166(1.14)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C108(1.08); C98(0.96); C166(0.99)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C108(0.91); C98(1.05); C166(1.24)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C166(1.08)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C98(1.06); C166(0.92)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C98(1.17)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C108(1.17); C98(0.90); C165(1.07)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C108(0.91); C98(1.17); C166(0.93)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C108(1.31); C98(1.32); C166(1.09)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C108(1.32); C166(1.10)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C108(1.01); C98(1.04); C166(1.11)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C166(1.01)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C108(0.98); C98(1.34); C166(0.97)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C98(1.08); C166(0.90)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C98(1.16)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C108(0.82); C98(0.99); C165(1.02)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C108(1.08); C98(1.05); C166(0.88)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C108(1.29); C98(1.36); C166(0.97)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C108(1.04); C166(1.02)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C108(1.13); C98(0.92); C166(1.11)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C166(0.96)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C98(1.22); C166(0.97)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C98(1.19)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C108(1.16); C166(1.09)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C108(1.09); C98(0.89); C165(1.08)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C108(1.07); C98(1.12); C166(1.02)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C108(0.88); C98(1.31); C166(0.84)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C108(1.07); C166(1.09)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C108(1.37); C98(1.05); C166(1.06)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C166(0.94)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C98(1.13); C166(1.08)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C98(1.19)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C108(0.88); C98(0.91); C165(1.08)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C108(1.21); C98(1.23); C166(0.93)  LDD1561  [15]
 LDCM0323  AC6 HCT 116 C166(0.89)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C108(1.07); C98(0.97); C166(0.94)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C108(1.13); C166(1.15)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C108(1.20); C98(0.95); C166(1.03)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C166(1.05)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C98(1.08); C166(1.23)  LDD1567  [15]
 LDCM0332  AC68 HCT 116 C166(0.84)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C166(0.68)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C166(0.83)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C166(0.49)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C166(0.69)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C166(0.79)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C166(0.60)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C166(0.54)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C166(0.45)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C166(0.80)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C166(0.65)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C166(0.58)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C166(0.66)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C166(0.96)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C166(1.00)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C166(0.51)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C166(0.11)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C166(1.10)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C166(0.95)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C166(0.98)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C166(0.97)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C166(0.98)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C165(1.10); C166(1.10)  LDD2171  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C108(0.99); C98(0.98); C166(1.00)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C108(0.90); C98(0.79); C166(0.84)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C98(0.99)  LDD1573  [15]
 LDCM0370  CL101 HCT 116 C166(0.67)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C166(0.73)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C166(1.01)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C166(0.79)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C108(0.94); C98(0.82); C166(0.95)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C108(0.96)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C108(1.11); C98(1.01); C165(1.08)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C98(1.15)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C108(1.03); C98(1.37); C166(0.94)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C166(0.75)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C108(0.91)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C108(1.08); C98(0.86); C165(0.92)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C98(0.99)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C108(1.05); C98(1.04); C166(0.97)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C108(0.93)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C108(1.29); C98(1.03); C165(1.15)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C98(1.06)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C108(1.03); C98(1.04); C166(0.90)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C108(1.02)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C108(1.17); C98(1.19); C165(1.19)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C98(1.03); C166(1.08)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C98(1.10)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C108(1.03); C98(0.94); C166(1.01)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C108(1.04)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C108(1.06); C98(0.91); C165(0.86)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C98(1.11)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C108(1.05); C98(1.49); C166(0.92)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C108(1.08)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C108(1.23); C98(1.09); C165(1.03)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C98(1.16)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C108(0.84); C98(0.73); C166(1.07)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C108(0.90)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C108(1.15); C98(0.95); C165(0.94)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C98(1.07)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C98(0.87)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C108(0.78); C98(0.89); C165(1.30)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C108(0.89); C98(1.06); C166(0.85)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C108(0.92)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C108(1.21); C98(1.18); C166(0.83)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C108(1.07); C166(0.82)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C108(0.98); C98(0.96); C166(1.20)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C166(0.86)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C98(1.13); C166(1.12)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C108(0.89); C98(0.97); C166(0.92)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C108(0.99)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C108(1.28); C98(0.93); C165(1.00)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C98(0.99)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C98(0.94)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C108(1.13); C98(1.05); C165(1.02)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C108(0.94); C98(0.88); C165(1.17)  LDD1623  [15]
 LDCM0420  CL31 HCT 116 C166(0.70)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C166(0.71)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C166(0.75)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C166(0.76)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C166(0.93)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C166(0.90)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C166(0.98)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C166(0.82)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C98(1.09)  LDD1633  [15]
 LDCM0430  CL40 HCT 116 C166(1.01)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C166(0.90)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C166(1.58)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C166(0.81)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C166(0.78)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C166(0.55)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C108(1.09); C98(1.13); C166(0.99)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C166(0.81)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C98(0.89); C166(0.91)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C108(0.97); C98(1.71); C166(1.16)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C98(1.37)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C108(0.93)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C98(1.08)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C98(0.82)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C108(0.92); C98(0.80); C165(1.14)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C108(1.25); C98(0.99); C166(0.90)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C108(1.13); C98(1.05); C166(0.85)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C108(1.33); C166(0.96)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C108(1.29); C98(1.04); C166(1.19)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C166(0.83)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C108(0.75); C98(1.03); C165(1.01)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C98(0.94); C166(0.91)  LDD1655  [15]
 LDCM0453  CL61 HCT 116 C166(1.34)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C166(1.15)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C166(1.15)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C166(1.32)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C166(1.29)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C166(1.32)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C166(1.47)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C166(1.26)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C166(1.53)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C108(0.98); C98(1.16); C166(0.92)  LDD1665  [15]
 LDCM0463  CL70 HCT 116 C166(1.15)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C166(1.21)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C166(1.27)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C166(1.28)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C166(1.20)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C98(1.13)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C98(0.83)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C108(1.19); C98(0.96); C165(1.18)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C108(1.17); C98(1.08); C166(0.87)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C108(0.79); C98(0.91); C166(0.58)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C108(1.28); C98(1.15); C166(0.97)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C108(1.21); C166(1.10)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C108(1.26); C98(1.19); C166(1.01)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C166(0.86)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C98(1.08); C166(1.06)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C108(0.94); C98(1.14); C166(0.95)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C108(0.98)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C108(1.04); C98(0.92); C165(0.95)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C98(1.10)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C98(1.33)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C108(1.10); C166(0.91)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C108(0.77); C98(0.86); C165(1.00)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C108(1.07); C98(1.10); C166(0.93)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C108(1.19); C98(1.06); C166(0.79)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C108(1.36); C166(0.96)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C108(1.30); C98(0.96); C166(1.08)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C166(0.75)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C98(1.10); C166(0.86)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C108(0.87); C98(0.90); C166(0.81)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C108(0.93)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C108(1.11); C98(0.90); C165(1.03)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C108(1.24); C98(1.04); C165(1.10)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C166(1.42)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C166(0.96)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C165(1.27); C166(1.27)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C165(1.27); C166(1.27)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C165(1.25); C166(1.25)  LDD0082  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C108(2.07)  LDD2144  [1]
 LDCM0021  THZ1 HCT 116 C165(1.10); C166(1.10)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'(3')-deoxyribonucleotidase, cytosolic type (NT5C) 5'(3')-deoxyribonucleotidase family Q8TCD5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lamivudine Small molecular drug DB00709

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402