Details of the Target

General Information of Target

Target ID LDTP09214
Target Name Neurobeachin (NBEA)
Gene Name NBEA
Gene ID 26960
Synonyms
BCL8B; KIAA1544; LYST2; Neurobeachin; Lysosomal-trafficking regulator 2; Protein BCL8B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASEKPGPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGM
INPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITC
MTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVD
MLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSA
AAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCL
IVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHV
NTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKS
ESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQD
VKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVA
MQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILF
NPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSS
GITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIH
DVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKR
KVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQ
NPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLG
YINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAK
MYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPV
STDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPET
LVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLP
NSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTS
SIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSI
ISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQF
SPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVH
NTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMA
MVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHG
SSKPQEVPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQA
QFLALAVVYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHP
SLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEE
QVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKG
INVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPP
GSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGA
TSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQ
ELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVR
VANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLK
QKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIE
YGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQL
IAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRY
LLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLY
KSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNF
RDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFL
NANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEV
VVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHY
LTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK
DQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPG
YSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDK
SFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHII
GDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGP
ENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTG
GDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHY
EHQNRY
Target Bioclass
Other
Family
WD repeat neurobeachin family
Subcellular location
Cytoplasm
Function Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins.
Uniprot ID
Q8NFP9
Ensemble ID
ENST00000400445.8
HGNC ID
HGNC:7648

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y1018(38.19)  LDD3495  [1]
DBIA
 Probe Info  		C457(2.25)  LDD3312  [2]
NAIA_5
 Probe Info  		C238(20.00)  LDD2227  [3]
AHL-Pu-1
 Probe Info  		C315(2.12)  LDD0168  [4]
CY-1
 Probe Info  		N.A.  LDD0246  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C315(2.12)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C315(2.84)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C369(0.96)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C315(0.80); C369(1.11)  LDD0813  [7]
 LDCM0216  AC100 HEK-293T C369(0.78)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C369(1.11)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C369(0.86)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C369(0.96)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C369(1.10)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C369(0.58)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C369(0.72)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C369(0.75)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C369(0.50)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C369(0.57)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C315(0.81); C369(0.70)  LDD0824  [7]
 LDCM0227  AC110 HEK-293T C369(0.77)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C369(0.86)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C369(0.55)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C369(1.02)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C369(1.08)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C369(1.23)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C369(1.16)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C369(1.17)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C369(0.83)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C369(1.15)  LDD0834  [7]
 LDCM0237  AC12 HEK-293T C315(0.82); C369(0.96)  LDD0835  [7]
 LDCM0238  AC120 HEK-293T C369(1.01)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C369(1.10)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C369(1.14)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C369(1.08)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C369(1.07)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C369(1.02)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C369(1.04)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C369(0.90)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C369(0.84)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C369(1.04)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C369(0.93)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C369(1.10)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C369(1.07)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C369(1.08)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C369(1.00)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C369(0.89)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C369(1.80)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C369(1.05)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C369(0.89)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C369(1.06)  LDD0856  [7]
 LDCM0259  AC14 HEK-293T C315(0.77); C369(0.86)  LDD0857  [7]
 LDCM0260  AC140 HEK-293T C369(1.09)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C369(1.38)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C369(0.97)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C315(1.54); C369(0.89)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C315(0.87); C369(1.07)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C315(0.94); C369(1.01)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C315(1.02); C369(1.01)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C315(0.65); C369(1.01)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C315(0.96); C369(1.43)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C315(1.00); C369(0.88)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C315(0.71); C369(0.96)  LDD0868  [7]
 LDCM0271  AC150 HEK-293T C315(1.09); C369(1.13)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C315(0.87); C369(1.10)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C315(0.97); C369(0.98)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C315(0.99); C369(1.21)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C315(1.10); C369(0.99)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C315(1.11); C369(1.23)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C315(0.67); C369(1.23)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C315(0.53); C369(1.03)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C369(0.37)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C369(0.30)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C369(0.40)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C369(1.31)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C369(0.60)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C369(0.43)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C369(0.58)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C369(0.74)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C369(0.53)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C369(0.55)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C369(1.40)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C369(1.23)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C369(1.99)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C369(1.09)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C369(1.18)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C369(0.93)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C369(1.28)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C369(0.74)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C369(0.92)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C369(0.79)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C315(1.00); C369(1.07)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C315(0.96); C369(0.80)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C315(1.05); C369(0.88)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C315(0.77); C369(0.95)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C315(0.99); C369(1.10)  LDD0898  [7]
 LDCM0301  AC4 HEK-293T C369(0.81)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C315(0.97); C369(0.80)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C315(0.87); C369(1.01)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C315(0.85); C369(1.02)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C315(0.75); C369(0.86)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C315(0.81); C369(1.05)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C315(0.76); C369(1.00)  LDD0905  [7]
 LDCM0308  AC46 HEK-293T C315(1.06)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C315(1.04)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C315(0.97)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C315(0.81)  LDD0909  [7]
 LDCM0312  AC5 HEK-293T C369(1.15)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C315(0.82)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C315(0.94)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C315(0.98)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C315(0.81)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C315(0.99)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C315(1.11)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C315(0.83)  LDD0917  [7]
 LDCM0320  AC57 HEK-293T C315(0.94); C369(0.96)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C315(1.04); C369(1.15)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C315(1.00); C369(1.07)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C315(0.92); C369(0.52)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C315(1.04); C369(1.02)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C315(1.25); C369(1.65)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C315(1.00); C369(1.77)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C315(1.31); C369(1.45)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C315(1.09); C369(1.42)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C315(1.31); C369(1.60)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C315(1.18); C369(1.43)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C315(1.20); C369(1.47)  LDD0929  [7]
 LDCM0332  AC68 HEK-293T C315(0.80); C369(0.99)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C315(0.99); C369(1.16)  LDD0931  [7]
 LDCM0334  AC7 HEK-293T C315(0.98); C369(0.89)  LDD0932  [7]
 LDCM0335  AC70 HEK-293T C315(0.80); C369(1.15)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C315(0.88); C369(1.03)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C315(0.93); C369(1.06)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C315(1.06); C369(1.07)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C315(0.79); C369(1.10)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C315(0.75); C369(1.11)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C315(0.68); C369(0.95)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C315(0.67); C369(1.31)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C315(0.63); C369(1.01)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C315(0.78); C369(1.33)  LDD0942  [7]
 LDCM0345  AC8 HEK-293T C315(1.11); C369(1.04)  LDD0943  [7]
 LDCM0346  AC80 HEK-293T C315(0.76); C369(1.01)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C315(0.65); C369(1.07)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C315(0.75); C369(1.36)  LDD0946  [7]
 LDCM0349  AC83 HEK-293T C315(0.82); C369(1.21)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C315(0.98); C369(1.21)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C315(0.92); C369(0.75)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C315(0.98); C369(0.81)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C315(0.86); C369(1.34)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C315(1.01); C369(0.73)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C315(0.84); C369(0.95)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C315(0.93); C369(0.87)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C315(0.60); C369(1.18)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C315(0.58); C369(1.04)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C315(0.68); C369(1.50)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C315(0.78); C369(1.05)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C315(0.63); C369(1.12)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C315(0.64); C369(1.22)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C315(0.61); C369(1.18)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C369(0.73)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C369(1.18)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C315(0.74); C369(1.00)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C315(0.80); C369(0.83)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C315(0.73); C369(0.82)  LDD0873  [7]
 LDCM0632  CL-Sc Hep-G2 C238(20.00)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C315(0.76)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C315(0.45)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C369(0.88)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C315(1.02); C369(0.71)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C315(0.73); C369(0.91)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C315(0.75); C369(0.77)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C315(0.98); C369(0.62)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C369(0.59)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C369(0.32)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C369(0.28)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C369(0.30)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C369(0.52)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C315(0.79)  LDD0977  [7]
 LDCM0380  CL110 HEK-293T C369(0.38)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C369(0.31)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C369(1.16)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C369(1.28)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C369(1.01)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C369(0.59)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C369(0.90)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C315(0.74); C369(0.96)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C315(0.86); C369(1.27)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C315(0.67); C369(1.12)  LDD0987  [7]
 LDCM0390  CL12 HEK-293T C315(1.04)  LDD0988  [7]
 LDCM0391  CL120 HEK-293T C315(0.87); C369(1.08)  LDD0989  [7]
 LDCM0392  CL121 HEK-293T C315(1.08)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C315(0.93)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C315(1.02)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C315(0.77)  LDD0993  [7]
 LDCM0396  CL125 HEK-293T C315(0.99); C369(0.98)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C315(0.75); C369(1.02)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C315(0.87); C369(1.08)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C315(0.99); C369(0.99)  LDD0997  [7]
 LDCM0400  CL13 HEK-293T C315(0.94)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C315(1.25)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C315(1.22)  LDD1000  [7]
 LDCM0403  CL16 HEK-293T C315(0.84); C369(0.76)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C315(1.01); C369(1.00)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C315(0.92); C369(1.00)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C315(0.90); C369(0.79)  LDD1004  [7]
 LDCM0407  CL2 HEK-293T C315(1.11)  LDD1005  [7]
 LDCM0408  CL20 HEK-293T C315(0.99); C369(1.30)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C315(1.00); C369(1.39)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C315(0.85); C369(1.26)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C315(0.76); C369(1.79)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C315(0.81); C369(1.56)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C315(0.69); C369(1.05)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C315(0.64); C369(1.17)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C315(0.62); C369(1.06)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C315(0.66); C369(1.55)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C315(0.67); C369(1.23)  LDD1015  [7]
 LDCM0418  CL3 HEK-293T C315(0.64)  LDD1016  [7]
 LDCM0419  CL30 HEK-293T C315(0.55); C369(1.37)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C315(0.96)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C315(0.96)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C315(0.68)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C315(0.73)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C315(0.78)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C315(0.91)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C315(0.95)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C315(0.61)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C315(0.86)  LDD1027  [7]
 LDCM0430  CL40 HEK-293T C315(0.68)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C315(0.55)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C315(0.61)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C315(0.61)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C315(0.69)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C315(0.58)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C315(0.82); C369(0.62)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C315(0.89); C369(1.00)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C315(0.78); C369(1.00)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C315(0.88); C369(1.06)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C315(1.19)  LDD1038  [7]
 LDCM0441  CL50 HEK-293T C315(0.67); C369(1.09)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C315(0.80); C369(0.83)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C315(0.76); C369(0.73)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C315(0.75); C369(0.51)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C315(0.74); C369(0.96)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C315(0.86); C369(0.49)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C315(0.77); C369(0.83)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C315(0.78); C369(0.44)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C315(0.88); C369(0.50)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C315(0.85); C369(0.78)  LDD1048  [7]
 LDCM0451  CL6 HEK-293T C315(0.69)  LDD1049  [7]
 LDCM0452  CL60 HEK-293T C315(0.81); C369(1.44)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C315(0.98); C369(0.63)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C315(1.18); C369(0.56)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C315(1.20); C369(1.04)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C315(0.88); C369(0.62)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C315(1.59); C369(0.71)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C315(0.99); C369(1.20)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C315(1.41); C369(0.75)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C315(1.03); C369(1.26)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C315(0.75); C369(1.37)  LDD1059  [7]
 LDCM0462  CL7 HEK-293T C315(1.07)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C315(1.02); C369(0.85)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C315(0.99); C369(0.74)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C315(1.15); C369(1.43)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C315(0.96); C369(1.04)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C315(1.12); C369(0.65)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C315(1.04); C369(0.89)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C315(0.92); C369(0.71)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C315(1.13); C369(1.40)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C315(1.11); C369(1.42)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C315(0.76)  LDD1071  [7]
 LDCM0474  CL80 HEK-293T C315(1.15); C369(1.59)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C315(1.07); C369(1.51)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C315(0.96); C369(1.17)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C315(0.80); C369(0.72)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C315(0.94); C369(0.97)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C315(1.10); C369(1.25)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C315(1.19); C369(1.48)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C315(1.00); C369(1.00)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C315(1.13); C369(1.54)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C315(1.06); C369(1.18)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C315(0.73)  LDD1082  [7]
 LDCM0485  CL90 HEK-293T C315(0.90); C369(0.71)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C369(0.60)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C369(0.62)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C369(0.86)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C369(0.73)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C369(0.96)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C369(0.83)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C369(0.80)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C369(0.76)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C369(0.82)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C315(1.04); C2021(0.96); C369(0.91); C1760(1.01)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C315(1.35); C369(0.78)  LDD1066  [7]
 LDCM0427  Fragment51 HEK-293T C315(0.69)  LDD1025  [7]
 LDCM0022  KB02 HEK-293T C315(0.97); C369(0.77); C457(0.98); C282(1.03)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C315(1.03); C369(0.98); C457(0.98); C282(0.99)  LDD1497  [8]
 LDCM0024  KB05 HMCB C457(2.25)  LDD3312  [2]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402