Details of the Target

General Information of Target

Target ID LDTP09191
Target Name Nesprin-1 (SYNE1)
Gene Name SYNE1
Gene ID 23345
Synonyms
C6orf98; KIAA0796; KIAA1262; KIAA1756; MYNE1; Nesprin-1; Enaptin; KASH domain-containing protein 1; KASH1; Myocyte nuclear envelope protein 1; Myne-1; Nuclear envelope spectrin repeat protein 1; Synaptic nuclear envelope protein 1; Syne-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS
IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA
KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE
DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP
GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM
KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR
AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD
QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL
QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE
VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM
NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL
SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE
EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV
LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ
IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL
RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL
HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL
IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI
STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA
QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE
KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST
LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE
QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT
MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI
VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN
LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV
NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS
PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE
QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ
VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV
ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE
SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK
KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD
KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK
VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH
SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM
AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD
LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK
KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ
ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ
SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF
EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR
GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV
KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ
RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL
QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ
FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL
SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT
QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH
KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN
KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK
LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV
SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL
WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI
HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ
QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA
ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA
KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV
HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL
RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA
RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW
YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE
GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH
VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ
SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT
QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI
CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR
ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS
ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT
KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW
DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH
LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA
QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL
VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ
ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN
LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL
TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI
ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF
RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE
QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS
WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI
QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA
LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS
TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT
AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV
ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV
KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ
DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ
ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL
AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT
DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS
KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID
SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE
LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE
DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEGAHRE
IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE
VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR
SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL
QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM
AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK
ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME
AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ
RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE
LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE
SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ
AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE
ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK
ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI
IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD
LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET
QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE
NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT
NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN
AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE
KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI
NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL
LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK
IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD
KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE
CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED
RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS
AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP
SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI
SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF
QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS
QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS
YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK
GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA
YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME
SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG
KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE
EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW
RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK
KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL
RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH
NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH
DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS
IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK
ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES
LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE
EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL
QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID
SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN
RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR
GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG
LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Target Bioclass
Other
Family
Nesprin family
Subcellular location
Nucleus outer membrane; Golgi apparatus
Function
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
Uniprot ID
Q8NF91
Ensemble ID
ENST00000367253.8
HGNC ID
HGNC:17089

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.E4393D; p.D6890E .
A549 SNV: p.D8246G .
AN3CA SNV: p.S1722T; p.A2401V; p.R2435L; p.L2918F; p.Q4112Ter; p.Q4492R; p.H8241R .
AU565 SNV: p.Q3063L; p.D4750H; p.E7841Ter .
C32 SNV: p.Q4056Ter .
CAL148 SNV: p.Q2400H; p.E5905D .
CAL27 SNV: p.Q4801K .
CAL72 SNV: p.I7283M .
CCK81 SNV: p.T2659A .
CCSW1 SNV: p.C7033Y; p.L7539V DBIA    Probe Info 
CMK SNV: p.T1474I .
COLO320 Insertion: p.R8212_L8213insPP
SNV: p.S1376T		 .
COLO678 SNV: p.W526C
Substitution: p.A4070K		 .
COLO792 SNV: p.E2712K DBIA    Probe Info 
DANG SNV: p.R1537Ter; p.Q7058E .
EFO21 Deletion: p.R6577GfsTer5 .
EFO27 SNV: p.A5138S; p.E5164K .
ETK1 SNV: p.I7809V DBIA    Probe Info 
FADU Deletion: p.P2054LfsTer7
SNV: p.Q6823K		 .
G415 SNV: p.W2639R DBIA    Probe Info 
HCC1395 SNV: p.E5203K .
HCT116 SNV: p.N2736K DBIA    Probe Info 
HCT15 SNV: p.Q1633H; p.E3812Ter; p.S7152P .
HEC1B SNV: p.L7768F .
HEPG2 SNV: p.G1674V .
HGC27 SNV: p.E1313K .
HSC3 SNV: p.E1397D; p.S5581N .
HT115 SNV: p.M824I; p.S2719R; p.R3070Ter; p.E3844Ter; p.A5299T; p.E6535K; p.K7043N; p.L7121V; p.F7454C .
HT1376 SNV: p.S1370I .
IGR1 SNV: p.S153F; p.P956S DBIA    Probe Info 
IGROV1 SNV: p.A632V; p.R1835C .
IM95 Deletion: .
Insertion: p.E3789GfsTer4		 .
IPC298 SNV: p.H3869Y .
Ishikawa (Heraklio) 02 ER SNV: p.G1232R; p.G7377E DBIA    Probe Info 
JURKAT SNV: p.A5299T
Substitution: p.S6857F		 .
KARPAS299 SNV: p.V4348M .
KMCH1 SNV: p.P8699A DBIA    Probe Info 
KMS11 SNV: p.H4930Y; p.R7495G .
KMS12BM SNV: p.A1630G .
KPL1 SNV: p.M6190I .
KURAMOCHI SNV: p.N2029S .
KYSE150 SNV: p.D616V .
KYSE30 SNV: p.R6087G; p.M8374I .
LNCaP clone FGC SNV: p.A7268V .
LS123 SNV: p.D8190H .
MCC13 SNV: p.W1461Ter DBIA    Probe Info 
MCC26 SNV: p.K5439E DBIA    Probe Info 
MDAMB453 Deletion: p.A592LfsTer8 .
MEWO SNV: p.G2688R; p.G5610E DBIA    Probe Info 
MFE319 Insertion: p.C7678MfsTer2
SNV: p.Y510C;p.S1762F		 .
MINO SNV: p.K6435R .
MKN1 SNV: p.G1149E .
NB4 SNV: p.M4027I; p.D8725H .
NCIH146 SNV: p.Y5532F .
NCIH1793 SNV: p.L4687V; p.E5826A DBIA    Probe Info 
NCIH2170 SNV: p.R221L .
NCIH2172 SNV: p.L7947P DBIA    Probe Info 
NCIH2291 SNV: p.E8057Ter .
NCIH446 SNV: p.V4123D; p.A4986S .
NCIH716 SNV: p.E6091K .
NCIN87 SNV: p.S1244A .
NUGC3 SNV: p.G8793D .
OVK18 Deletion: p.M5377WfsTer10 .
P31FUJ SNV: p.E1405D .
REH SNV: p.Q1566K .
RKO Deletion: .
SNV: p.P734L;p.Q1553R;p.N1621H;p.K6658R;p.C8552Ter		 .
RPMI8226 SNV: p.S5932F .
SH4 SNV: p.H8494Y .
SKMEL28 SNV: p.E5326K DBIA    Probe Info 
SKMM2 SNV: p.R2062L DBIA    Probe Info 
SNGM SNV: p.A1110S DBIA    Probe Info 
SNU1 SNV: p.Q7867Ter DBIA    Probe Info 
SSP25 SNV: p.I7809V DBIA    Probe Info 
SUPT1 Insertion: p.E6198GfsTer6
SNV: p.I298V;p.K2127E		 .
SW620 SNV: p.E6322K; p.G7350E .
SW756 SNV: p.R4334S DBIA    Probe Info 
SW837 SNV: p.R317I; p.S6853F .
TCCSUP SNV: p.L4278F .
TE10 SNV: p.D3897E; p.P5292R .
TOV21G SNV: p.E366V; p.G7681Ter .
WM2664 SNV: p.I1753V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C8617(2.15); C7334(2.94); C3225(2.98)  LDD0170  [2]
DBIA
 Probe Info  		C8196(0.62)  LDD0533  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C8535(0.00); C8380(0.00); C8196(0.00); C8076(0.00)  LDD0165  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
IPM
 Probe Info  		C8703(0.00); C6415(0.00)  LDD2156  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
W1
 Probe Info  		D8519(0.00); D8522(0.00)  LDD0236  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C8617(2.15); C7334(2.94); C3225(2.98)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C8703(5.64); C8617(3.62); C7334(3.18); C4436(2.83)  LDD0171  [2]
 LDCM0214  AC1 PaTu 8988t C861(0.99); C865(0.99)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C8196(1.29); C861(1.01); C865(1.01)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C8196(0.62)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C8196(0.59)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C8196(0.47)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C8196(0.77)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C8196(0.49)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C8196(0.62)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C8196(1.03)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C8196(0.68)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C8196(0.52)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C8196(0.58)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C8196(0.76); C861(1.06); C865(1.06)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C8196(0.72)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C8196(0.70)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C8196(0.59)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C861(0.79); C865(0.79)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C861(1.12); C865(1.12)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C861(1.26); C865(1.26)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C861(0.87); C865(0.87)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C861(1.08); C865(1.08)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C861(0.92); C865(0.92)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C861(0.87); C865(0.87)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C8196(0.82); C861(0.96); C865(0.96)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C861(1.04); C865(1.04)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C861(1.00); C865(1.00)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C861(0.88); C865(0.88)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C861(0.82); C865(0.82)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C861(0.87); C865(0.87)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C861(0.88); C865(0.88)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C861(0.95); C865(0.95)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C861(0.94); C865(0.94)  LDD1124  [3]
 LDCM0259  AC14 PaTu 8988t C8196(0.82); C861(0.99); C865(0.99)  LDD1138  [3]
 LDCM0263  AC143 HCT 116 C8196(0.70)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C8196(0.72)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C8196(0.51)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C8196(1.18)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C8196(0.71)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C8196(0.92)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C8196(0.77)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C8196(0.98); C861(1.04); C865(1.04)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C8196(0.71)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C8196(1.23)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C8196(0.77)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C8196(0.72)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C8196(0.71)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C8196(1.29)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C8196(0.74)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C8196(0.65)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C8196(0.60)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C8196(0.57)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C8196(0.66)  LDD0595  [3]
 LDCM0279  AC2 PaTu 8988t C861(0.80); C865(0.80)  LDD1158  [3]
 LDCM0280  AC20 HCT 116 C8196(0.63)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C8196(0.46)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C8196(0.62)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C8196(0.58)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C8196(0.55)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C8196(0.84)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C8196(1.14)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C8196(1.09)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C8196(0.59)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C8196(0.75)  LDD0606  [3]
 LDCM0290  AC3 PaTu 8988t C861(0.98); C865(0.98)  LDD1169  [3]
 LDCM0291  AC30 HCT 116 C8196(0.88)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C8196(1.03)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C8196(0.85)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C8196(1.00)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C8196(0.93)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C8196(0.80)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C8196(1.38)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C8196(1.26)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C8196(1.04)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C8196(1.17)  LDD0617  [3]
 LDCM0301  AC4 PaTu 8988t C861(0.97); C865(0.97)  LDD1180  [3]
 LDCM0302  AC40 HCT 116 C8196(0.92)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C8196(1.13)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C8196(1.60)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C8196(1.12)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C8196(1.16)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C8196(1.32)  LDD0624  [3]
 LDCM0308  AC46 PaTu 8988t C8196(1.06); C861(0.87); C865(0.87)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C8196(1.13); C861(0.73); C865(0.73)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C8196(0.80); C861(0.62); C865(0.62)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C8196(1.37); C861(0.81); C865(0.81)  LDD1190  [3]
 LDCM0312  AC5 PaTu 8988t C861(0.96); C865(0.96)  LDD1191  [3]
 LDCM0313  AC50 PaTu 8988t C8196(1.15); C861(0.84); C865(0.84)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C8196(0.58); C861(0.70); C865(0.70)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C8196(1.54); C861(0.79); C865(0.79)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C8196(1.82); C861(0.84); C865(0.84)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C8196(1.12); C861(0.95); C865(0.95)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C8196(1.90); C861(0.85); C865(0.85)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C8196(1.53); C861(1.04); C865(1.04)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C8196(1.14)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C8196(1.35)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C8196(1.38)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C8196(0.67); C861(1.22); C865(1.22)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C8196(1.63)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C8196(1.54)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C8196(1.46)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C8196(1.20)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C8196(1.33)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C8196(1.49)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C8196(1.31)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C8196(1.35)  LDD0648  [3]
 LDCM0334  AC7 PaTu 8988t C8196(0.58); C861(1.11); C865(1.11)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C8196(0.78); C861(1.09); C865(1.09)  LDD1224  [3]
 LDCM0365  AC98 HCT 116 C8196(0.73)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C8196(0.56)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C8196(1.09); C861(1.18); C865(1.18)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C8196(0.74); C861(1.22); C865(1.22)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C8196(1.09); C861(1.22); C865(1.22)  LDD1154  [3]
 LDCM0367  CL1 PaTu 8988t C8196(0.65); C861(1.02); C865(1.02)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C8196(0.93); C861(0.85); C865(0.85)  LDD1247  [3]
 LDCM0369  CL100 PaTu 8988t C861(0.87); C865(0.87)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C8196(0.72); C861(1.16); C865(1.16)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C8196(0.76); C861(1.03); C865(1.03)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C8196(0.93); C861(1.20); C865(1.20)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C8196(0.83); C861(1.00); C865(1.00)  LDD1252  [3]
 LDCM0374  CL105 HCT 116 C8196(0.58)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C8196(0.58)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C8196(0.56)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C8196(0.63)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C8196(0.53)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C8196(0.64); C861(0.80); C865(0.80)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C8196(0.73)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C8196(0.49)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C8196(0.87)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C8196(1.05)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C8196(0.78)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C8196(0.95)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C8196(1.28)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C8196(1.21)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C8196(1.12)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C8196(1.19)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C8196(0.82); C861(0.78); C865(0.78)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C8196(1.10)  LDD0708  [3]
 LDCM0392  CL121 PaTu 8988t C8196(1.15); C861(0.77); C865(0.77)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C8196(1.29); C861(0.82); C865(0.82)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C8196(1.07); C861(1.05); C865(1.05)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C8196(1.36); C861(0.68); C865(0.68)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C8196(1.18)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C8196(1.12)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C8196(1.51)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C8196(1.48)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C8196(1.10); C861(0.70); C865(0.70)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C8196(0.88); C861(0.85); C865(0.85)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C8196(0.51); C861(0.75); C865(0.75)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C8196(0.86)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C8196(0.83)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C8196(1.04)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C8196(1.36)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C8196(0.83); C861(0.77); C865(0.77)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C8196(0.93)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C8196(1.02)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C8196(1.32)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C8196(0.98)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C8196(1.38)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C8196(0.97)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C8196(0.89)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C8196(1.14)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C8196(0.90)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C8196(1.01)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C8196(1.00); C861(0.72); C865(0.72)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C8196(0.83)  LDD0736  [3]
 LDCM0420  CL31 PaTu 8988t C861(0.99); C865(0.99)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C861(0.85); C865(0.85)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C861(0.78); C865(0.78)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C861(0.93); C865(0.93)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C861(0.80); C865(0.80)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C861(0.28); C865(0.28)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C861(1.14); C865(1.14)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C861(1.01); C865(1.01)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C8196(1.31); C861(0.75); C865(0.75)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C861(0.83); C865(0.83)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C861(0.92); C865(0.92)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C861(0.91); C865(0.91)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C861(0.92); C865(0.92)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C861(1.27); C865(1.27)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C861(0.81); C865(0.81)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C861(0.85); C865(0.85)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C861(0.60); C865(0.60)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C861(0.72); C865(0.72)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C861(0.81); C865(0.81)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C8196(0.98); C861(0.87); C865(0.87)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C861(0.69); C865(0.69)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C861(0.75); C865(0.75)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C861(0.64); C865(0.64)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C861(0.64); C865(0.64)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C861(0.72); C865(0.72)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C861(0.67); C865(0.67)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C861(0.31); C865(0.31)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C861(0.90); C865(0.90)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C861(0.68); C865(0.68)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C861(1.00); C865(1.00)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C8196(0.85); C861(0.72); C865(0.72)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C861(0.83); C865(0.83)  LDD1331  [3]
 LDCM0453  CL61 PaTu 8988t C861(1.11); C865(1.11)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C861(1.00); C865(1.00)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C861(0.92); C865(0.92)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C861(0.95); C865(0.95)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C861(0.90); C865(0.90)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C861(0.84); C865(0.84)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C861(0.90); C865(0.90)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C861(1.02); C865(1.02)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C861(0.95); C865(0.95)  LDD1340  [3]
 LDCM0462  CL7 PaTu 8988t C8196(1.03); C861(0.78); C865(0.78)  LDD1341  [3]
 LDCM0463  CL70 PaTu 8988t C861(1.05); C865(1.05)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C861(0.92); C865(0.92)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C861(1.34); C865(1.34)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C861(1.02); C865(1.02)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C861(1.15); C865(1.15)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C861(1.15); C865(1.15)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C861(0.99); C865(0.99)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C861(0.94); C865(0.94)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C861(1.00); C865(1.00)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C8196(0.70); C861(0.64); C865(0.64)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C861(1.30); C865(1.30)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C861(1.03); C865(1.03)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C861(1.00); C865(1.00)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C861(1.12); C865(1.12)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C861(0.97); C865(0.97)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C861(0.91); C865(0.91)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C861(0.89); C865(0.89)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C861(1.02); C865(1.02)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C861(1.12); C865(1.12)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C861(1.19); C865(1.19)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C8196(0.73); C861(0.70); C865(0.70)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C861(1.04); C865(1.04)  LDD1364  [3]
 LDCM0486  CL91 PaTu 8988t C861(0.85); C865(0.85)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C861(0.75); C865(0.75)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C861(0.84); C865(0.84)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C861(1.15); C865(1.15)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C861(0.91); C865(0.91)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C861(1.02); C865(1.02)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C861(0.81); C865(0.81)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C861(1.02); C865(1.02)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C861(0.80); C865(0.80)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C7251(0.87); C7984(1.01); C6415(1.02); C6090(1.16)  LDD1698  [12]
 LDCM0468  Fragment33 PaTu 8988t C861(1.00); C865(1.00)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C861(1.01); C865(1.01)  LDD1306  [3]
 LDCM0022  KB02 HEK-293T C8196(1.10); C7984(1.03); C6090(0.88); C8076(0.93)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C8196(1.04); C7984(1.00); C6090(0.90); C8076(1.03)  LDD1497  [12]
 LDCM0024  KB05 IGR37 C5304(2.26); C3994(3.66); C5598(2.63); C3677(4.80)  LDD3314  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SUN domain-containing protein 1 (SUN1) . O94901
SUN domain-containing protein 2 (SUN2) . Q9UH99
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Emerin (EMD) . P50402

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840