Details of the Target

General Information of Target

Target ID LDTP09134
Target Name Putative RNA-binding protein 15B (RBM15B)
Gene Name RBM15B
Gene ID 29890
Synonyms
OTT3; Putative RNA-binding protein 15B; One-twenty two protein 3; HsOTT3; HuOTT3; RNA-binding motif protein 15B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRQSERDSSPSGRGSSSSAKRPREREREAEAGGRRAAHKASGGAKHPVPARARDKPRGS
GSGGGGHRDGRGTGDANHRASSGRSSGSGAGGGGRGGKASGDPGASGMSPRASPLPPPPP
PPGAEPACPGSSAAAPEYKTLLISSLSPALPAEHLEDRLFHQFKRFGEISLRLSHTPELG
RVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYLRGGGGSSRRSSSSSAAASTPP
PGPPAPADPLGYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSR
ERALDYYGLYDDRGRPYGYPAVCEEDLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKY
GIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRL
WVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLGG
PDRRLRVDFAKAEETRYPQQYQPSPLPVHYELLTDGYTRHRNLDADLVRDRTPPHLLYSD
RDRTFLEGDWTSPSKSSDRRNSLEGYSRSVRSRSGERWGADGDRGLPKPWEERRKRRSLS
SDRGRTTHSPYEERSRTKGSGQQSERGSDRTPERSRKENHSSEGTKESSSNSLSNSRHGA
EERGHHHHHHEAADSSHGKKARDSERNHRTTEAEPKPLEEPKHETKKLKNLSEYAQTLQL
GWNGLLVLKNSCFPTSMHILEGDQGVISSLLKDHTSGSKLTQLKIAQRLRLDQPKLDEVT
RRIKQGSPNGYAVLLATQATPSGLGTEGMPTVEPGLQRRLLRNLVSYLKQKQAAGVISLP
VGGSKGRDGTGMLYAFPPCDFSQQYLQSALRTLGKLEEEHMVIVIVRDTA
Target Bioclass
Other
Family
RRM Spen family
Subcellular location
Nucleus, nucleoplasm
Function
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.
Uniprot ID
Q8NDT2
Ensemble ID
ENST00000563281.2
HGNC ID
HGNC:24303

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.49  LDD0402  [1]
STPyne
 Probe Info  		K164(0.58)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C128(3.70)  LDD0171  [3]
DBIA
 Probe Info  		C859(2.48)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C128(3.70)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C859(0.96)  LDD0812  [4]
 LDCM0215  AC10 PaTu 8988t C859(1.05)  LDD1094  [4]
 LDCM0216  AC100 HEK-293T C859(0.83)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C859(1.04)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C859(1.25)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C859(0.93)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C859(0.84)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C859(1.12)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C859(0.77)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C859(1.46)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C859(1.39)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C859(1.08)  LDD0823  [4]
 LDCM0226  AC11 PaTu 8988t C859(1.05)  LDD1105  [4]
 LDCM0227  AC110 HEK-293T C859(0.94)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C859(0.61)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C859(0.95)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C323(1.08); C859(0.83)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C323(0.75); C859(0.85)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C323(0.94); C859(1.19)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C323(1.01); C859(0.96)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C323(0.93); C859(0.85)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C323(0.98); C859(0.98)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C323(1.07); C859(0.97)  LDD0834  [4]
 LDCM0237  AC12 PaTu 8988t C859(1.14)  LDD1116  [4]
 LDCM0238  AC120 HEK-293T C323(0.82); C859(0.80)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C323(0.96); C859(0.99)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C323(0.95); C859(0.81)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C323(0.90); C859(0.83)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C323(0.99); C859(1.04)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C323(1.02); C859(0.86)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C323(0.77); C859(0.63)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C323(0.91); C859(0.69)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C859(0.49)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C859(0.53)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C859(0.54)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C859(0.89)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C859(0.63)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C859(0.70)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C859(0.80)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C859(0.46)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C859(0.60)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C859(0.58)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C859(0.43)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C859(0.58)  LDD0856  [4]
 LDCM0259  AC14 PaTu 8988t C859(0.79)  LDD1138  [4]
 LDCM0260  AC140 HEK-293T C859(0.58)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C859(0.54)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C859(0.69)  LDD0860  [4]
 LDCM0263  AC143 PaTu 8988t C323(1.48); C859(1.46)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C323(1.38); C859(0.72)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C323(1.09); C859(0.82)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C323(0.93); C859(0.86)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C323(1.55); C859(0.98)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C323(1.69); C859(0.81)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C323(1.67); C859(0.85)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C859(1.00)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C323(1.70); C859(1.04)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C323(1.49); C859(1.51)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C323(0.98); C859(0.97)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C323(1.29); C859(1.18)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C323(1.37); C859(1.08)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C323(1.41); C859(1.21)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C323(1.54); C859(0.96)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C323(1.03); C859(1.01)  LDD2169  [4]
 LDCM0276  AC17 HEK-293T C323(1.05); C859(0.83)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C323(1.29); C859(1.13)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C323(1.16); C859(1.02)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C859(1.08)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C323(0.75); C859(0.55)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C323(0.57); C859(0.37)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C323(0.75); C859(0.60)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C323(1.39); C859(1.00)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C323(1.06); C859(1.16)  LDD0882  [4]
 LDCM0285  AC25 PaTu 8988t C859(0.97)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C859(1.15)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C859(1.21)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C859(1.37)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C859(1.23)  LDD1168  [4]
 LDCM0290  AC3 HEK-293T C859(1.15)  LDD0888  [4]
 LDCM0291  AC30 PaTu 8988t C859(1.24)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C859(0.97)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C859(1.24)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C859(1.22)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C859(1.45)  LDD1174  [4]
 LDCM0296  AC35 HEK-293T C323(1.09)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C323(0.93)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C323(0.86)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C323(0.84)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C323(1.07)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C859(1.07)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C323(0.75)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C323(1.23)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C323(0.95)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C323(1.02)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C323(1.01)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C323(0.91)  LDD0905  [4]
 LDCM0308  AC46 PaTu 8988t C859(0.96)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C859(0.84)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C859(0.86)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C859(0.89)  LDD1190  [4]
 LDCM0312  AC5 HEK-293T C859(1.11)  LDD0910  [4]
 LDCM0313  AC50 PaTu 8988t C859(1.00)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C859(0.35)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C859(0.88)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C859(1.02)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C859(1.11)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C859(0.87)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C859(0.91)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C323(1.08); C128(0.89); C732(0.91); C859(1.01)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C323(0.87); C128(0.94); C732(0.90); C859(1.01)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C323(1.13); C128(0.98); C732(0.83); C859(1.12)  LDD1561  [10]
 LDCM0323  AC6 PaTu 8988t C859(0.96)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C323(1.09); C128(1.01); C732(1.06); C859(1.09)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C323(1.06); C128(0.94); C859(0.99)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C323(0.94); C128(0.97); C859(1.17); C470(1.22)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C323(0.97); C128(0.90); C732(0.94); C859(0.97)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C323(1.00); C128(1.02); C732(1.25); C859(0.93)  LDD1567  [10]
 LDCM0332  AC68 HEK-293T C859(1.22)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C859(1.10)  LDD0931  [4]
 LDCM0334  AC7 PaTu 8988t C859(1.00)  LDD1213  [4]
 LDCM0335  AC70 HEK-293T C859(0.88)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C859(1.04)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C859(1.14)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C859(0.79)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C859(0.73)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C859(1.12)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C859(0.96)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C859(0.97)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C859(0.82)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C859(0.92)  LDD0942  [4]
 LDCM0345  AC8 PaTu 8988t C859(0.96)  LDD1224  [4]
 LDCM0346  AC80 HEK-293T C859(0.94)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C859(1.58)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C859(0.81)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C323(1.08)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C323(0.86)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C323(0.91)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C323(1.27)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C323(1.04)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C323(1.19)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C323(1.07)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C323(0.88)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C323(0.99)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C323(0.83)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C323(1.01)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C323(1.10)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C323(0.90)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C323(0.85)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C323(1.22)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C859(0.87)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C859(1.06)  LDD0964  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C859(0.94)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C859(1.22)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C859(1.04)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C323(0.43)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C323(1.01); C128(1.00); C732(1.03); C859(1.04)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C323(0.98); C128(1.21); C859(1.13); C470(0.92)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C859(0.82)  LDD0967  [4]
 LDCM0370  CL101 PaTu 8988t C859(1.33)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C859(1.14)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C859(1.25)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C859(1.23)  LDD1252  [4]
 LDCM0374  CL105 HEK-293T C323(0.73); C859(0.69)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C323(0.67); C859(0.61)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C323(0.99); C859(0.93)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C323(0.99); C859(1.09)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C323(0.81); C859(0.76)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C323(0.95); C128(1.16); C732(1.04); C859(1.12)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C323(0.87); C859(0.68)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C323(0.87); C859(0.89)  LDD0979  [4]
 LDCM0382  CL112 PaTu 8988t C859(0.96)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C859(1.08)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C859(1.30)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C859(1.11)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C859(1.03)  LDD1265  [4]
 LDCM0387  CL117 HEK-293T C323(0.99)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C323(0.95)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C323(0.84)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C323(1.18); C128(1.06); C732(1.00); C859(1.05)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C323(1.22)  LDD0989  [4]
 LDCM0392  CL121 PaTu 8988t C859(0.78)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C859(1.03)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C859(1.50)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C859(0.94)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C323(1.06); C128(0.94); C732(0.84); C859(1.14)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C323(0.89); C128(1.08); C859(0.95); C470(0.98)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C323(1.01); C128(0.94); C732(0.81); C859(1.15)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C323(1.05); C128(0.97); C732(0.89); C859(0.96)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C323(0.93); C128(1.07); C732(0.88); C859(1.11)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C323(0.98); C128(1.07); C859(1.06); C470(1.34)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C323(0.94); C128(0.92); C732(1.08); C859(0.98)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C323(1.01); C128(1.03); C732(1.18); C859(0.99)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C323(1.07); C128(1.06); C732(0.85); C859(0.92)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C323(1.08); C128(1.04); C732(0.91); C859(0.94)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C323(1.16); C128(1.11); C732(1.06); C859(1.32)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C323(1.13); C128(1.06); C859(1.17); C470(1.12)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C323(1.13); C128(1.02); C732(1.01); C859(1.06)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C323(1.02); C128(1.13); C859(1.13)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C323(1.10); C128(1.02); C859(1.01); C470(1.13)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C323(0.90); C128(0.98); C732(1.07); C859(1.03)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C323(1.04); C128(1.15); C732(1.08); C859(1.03)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C323(0.89); C128(1.07); C732(0.76); C859(1.03)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C323(0.90); C128(0.97); C859(0.89); C470(1.09)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C323(0.92); C128(0.95); C732(1.17); C859(1.08)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C323(1.08); C128(0.93); C732(1.16); C859(0.77)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C323(0.91); C128(0.94); C732(0.92); C859(0.91)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C323(1.09); C128(0.99); C732(1.00); C859(1.39)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C323(1.02); C128(0.98); C732(1.02); C859(1.13)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C323(0.73)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C323(0.81)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C323(0.81)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C323(0.84)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C323(0.94)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C323(1.01)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C323(1.18)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C323(0.88)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C323(1.07); C128(1.03); C732(1.03); C859(0.86)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C323(0.80)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C323(0.85)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C323(0.88)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C323(0.91)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C323(0.83)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C323(1.14)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C323(0.71); C859(0.87)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C323(1.14); C859(0.80)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C323(1.03); C859(0.85)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C323(0.99); C859(0.91)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C323(1.15); C128(0.94); C732(0.95); C859(1.14)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C323(1.01); C859(0.63)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C323(1.24); C859(0.69)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C323(1.22); C859(0.94)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C323(1.04); C859(0.66)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C323(1.20); C859(0.68)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C323(1.37); C859(1.05)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C323(0.98); C859(0.79)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C323(1.02); C859(0.74)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C323(1.21); C859(0.74)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C323(0.91); C859(0.73)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C323(0.97); C128(1.09); C732(0.82); C859(1.06)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C323(1.32); C859(0.78)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C323(0.72)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C323(0.65)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C323(0.77)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C323(0.59)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C323(0.86)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C323(1.07)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C323(1.21)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C323(1.06)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C323(1.00)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C323(1.08); C128(1.08); C732(0.73); C859(1.20)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C323(0.90)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C323(0.81)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C323(0.97)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C323(1.06)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C323(1.11)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C323(0.72)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C323(0.73)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C323(0.72)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C323(0.81)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C323(0.89); C128(0.95); C732(1.18); C859(1.52)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C323(0.60)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C323(0.75)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C323(1.19)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C323(0.80)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C323(0.62)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C323(0.75)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C323(0.46)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C323(0.55)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C323(0.84)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C323(0.63)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C323(0.97); C128(1.02); C859(1.17)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C323(0.78)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C859(1.44)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C859(1.17)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C859(0.98)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C859(1.14)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C859(1.16)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C859(1.22)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C859(1.22)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C859(1.14)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C859(1.75)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C323(1.17); C128(1.05); C732(1.23); C859(1.12)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C323(0.62)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C323(0.85)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C859(2.48)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C859(20.00)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C859(1.04)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Neuron navigator 2 (NAV2) Nav/unc-53 family Q8IVL1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402