Details of the Target

General Information of Target

Target ID LDTP08960
Target Name ER membrane protein complex subunit 1 (EMC1)
Gene Name EMC1
Gene ID 23065
Synonyms
KIAA0090; ER membrane protein complex subunit 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAEWASRFWLWATLLIPAAAVYEDQVGKFDWRQQYVGKVKFASLEFSPGSKKLVVATEK
NVIAALNSRTGEILWRHVDKGTAEGAVDAMLLHGQDVITVSNGGRIMRSWETNIGGLNWE
ITLDSGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIHYQMVYS
YGSGVVWALGVVPFSHVNIVKFNVEDGEIVQQVRVSTPWLQHLSGACGVVDEAVLVCPDP
SSRSLQTLALETEWELRQIPLQSLDLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSPSHY
ALLQYHYGTLSLLKNFPQTALVSFATTGEKTVAAVMACRNEVQKSSSSEDGSMGSFSEKS
SSKDSLACFNQTYTINLYLVETGRRLLDTTITFSLEQSGTRPERLYIQVFLKKDDSVGYR
ALVQTEDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKADGL
LGMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEINIDTLARDEFNLQKMMVMVT
ASGKLFGIESSSGTILWKQYLPNVKPDSSFKLMVQRTTAHFPHPPQCTLLVKDKESGMSS
LYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLR
QLHELAPSIFFYLVDAEQGRLCGYRLRKDLTTELSWELTIPPEVQRIVKVKGKRSSEHVH
SQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKAKG
PVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPQLPQVLQQSYIF
PSSISAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSP
DVQIHAERFINYNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDY
DYVLISSVLFGLVFATMITKRLAQVKLLNRAWR
Target Bioclass
Transporter and channel
Family
EMC1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Uniprot ID
Q8N766
Ensemble ID
ENST00000375199.7
HGNC ID
HGNC:28957

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.G94Ter; p.I856T DBIA    Probe Info 
MFE319 SNV: p.T814A .
NCIH716 SNV: p.S858I .
SKOV3 SNV: p.L642F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.26  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
DBIA
 Probe Info  		C587(1.51); C338(3.02)  LDD3310  [4]
BTD
 Probe Info  		C338(1.52)  LDD1700  [5]
Acrolein
 Probe Info  		H905(0.00); H752(0.00)  LDD0227  [6]
ATP probe
 Probe Info  		K52(0.00); K53(0.00)  LDD0199  [7]
N1
 Probe Info  		N.A.  LDD0245  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
Ox-W18
 Probe Info  		W32(0.00); W75(0.00); W254(0.00)  LDD2175  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C388
 Probe Info  		37.01  LDD2047  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe15
 Probe Info  		6.50  LDD0478  [15]
FFF probe2
 Probe Info  		17.24  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
STS-1
 Probe Info  		N.A.  LDD0136  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
OEA-DA
 Probe Info  		13.46  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C338(0.31)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C933(0.90); C454(0.95); C587(1.02)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C933(1.00); C454(1.22); C587(1.01)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C933(1.08); C454(0.93); C587(1.09)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C933(0.93); C454(1.16)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C933(1.04); C454(1.00)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C933(1.18)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C933(1.20); C454(0.89); C587(0.96)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C933(1.06); C454(1.10); C587(1.07)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C933(0.95); C454(0.84); C587(0.92)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C933(1.06); C454(0.88); C587(1.08)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C933(1.06); C454(0.87)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C933(0.92); C454(0.89)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C933(1.00); C454(0.98)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C933(1.24)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C933(1.02); C454(0.98)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C933(1.15); C454(0.92); C587(0.98)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C933(0.96); C454(0.96); C587(1.03)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C933(1.00); C454(1.15); C587(0.99)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C933(0.92); C454(1.08)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C933(0.96); C454(0.99)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C933(0.97); C454(0.94); C587(1.04)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C933(1.02); C454(1.18)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C933(1.02)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C933(1.01); C454(0.88)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C933(1.03); C454(0.80); C587(0.99)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C933(1.03); C454(1.02); C587(1.16)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C933(1.04); C454(1.38); C587(1.08)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C933(0.95); C454(1.13)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C933(0.92); C454(0.94)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C933(1.01); C454(0.98)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C933(1.07)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C933(0.89); C454(1.32)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C933(0.91); C454(0.90)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C933(1.31); C454(0.84); C587(0.97)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C933(1.04); C454(1.12); C587(1.04)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C933(1.10); C454(1.12); C587(1.00)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C933(0.97); C454(1.16)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C933(0.99); C454(0.95)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C933(1.00); C454(1.13)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C933(1.03)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C933(1.11); C454(1.22)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C933(1.14); C454(0.99); C587(0.99)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C933(0.93); C454(0.99)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C933(1.09); C454(1.01); C587(1.09)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C933(1.12); C454(1.02); C587(1.08)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C933(0.88); C454(1.00)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C933(0.99); C454(0.94)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C933(1.00); C454(0.97)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C933(0.88)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C933(1.01); C454(0.88)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C933(1.05); C454(0.90); C587(1.01)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C933(1.03); C454(0.87); C587(1.00)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C933(1.17); C454(1.03); C587(1.03)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C933(1.01); C454(1.06)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C933(1.19); C454(1.10)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C933(1.05); C454(0.94)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C933(1.07); C454(1.13)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C933(0.97)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C933(1.01); C454(1.06)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C933(0.88)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C933(1.00); C454(1.14)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C933(1.03); C454(1.00)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C933(1.03); C454(0.91); C587(0.99)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C933(1.06); C454(1.02)  LDD1514  [18]
 LDCM0367  CL1 HEK-293T C933(0.86); C454(0.90)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C933(1.06); C454(1.01)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C933(0.95); C454(0.84); C587(0.96)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C933(0.94); C454(0.96)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C933(1.25)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C933(0.88); C454(1.01)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C933(0.92); C454(0.81); C587(1.08)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C933(0.85); C454(0.91)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C933(1.25)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C933(0.81); C454(0.98)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C933(0.94); C454(1.12); C587(1.09)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C933(1.01); C454(0.87)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C933(1.08)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C933(1.11)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C933(0.99); C454(0.97)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C933(1.01); C454(1.14); C587(1.05)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C933(0.98); C454(0.90)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C933(1.11)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C933(0.91); C454(1.06)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C933(0.96); C454(1.00); C587(1.13)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C933(1.07); C454(0.90)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C933(1.05)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C933(0.88); C454(1.11)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C933(1.03); C454(1.14)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C933(0.93); C454(0.94); C587(1.07)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C933(0.87); C454(0.98)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C933(1.09)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C933(0.82); C454(0.88)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C933(0.95); C454(0.98); C587(1.03)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C933(1.23); C454(1.01)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C933(1.01)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C933(0.96); C454(0.93)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C933(0.93); C454(1.10); C587(1.06)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C933(0.95); C454(0.79)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C933(1.25)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C933(0.64); C454(0.80)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C933(0.97); C454(0.96); C587(1.12)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C933(1.01); C454(0.90); C587(0.94)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C933(1.08); C454(1.57); C587(1.06)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C933(1.06); C454(0.95); C587(1.16)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C933(0.99)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C933(0.82); C454(1.10)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C933(0.86); C454(0.96)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C933(1.18); C454(1.20)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C933(1.19)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C933(1.22); C454(1.17)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C933(0.94); C454(0.94)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C933(0.96)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C933(1.00); C454(1.08)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C933(1.03); C454(0.87); C587(0.91)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C933(1.06); C454(1.03); C587(0.96)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C933(1.01); C454(1.02)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C933(0.99); C454(1.22); C587(1.04)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C933(1.08); C454(0.87); C587(1.08)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C933(0.81); C454(1.23)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C933(1.04); C454(0.94)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C933(1.18); C454(1.09)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C933(0.95)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C933(1.04); C454(1.06)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C933(0.95); C454(0.93)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C933(0.86); C454(0.86)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C933(0.93); C454(1.36); C587(1.01)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C933(0.96); C454(0.94); C587(1.01)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C933(0.98); C454(0.87); C587(1.03)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C933(1.06); C454(0.84); C587(1.13)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C933(0.99); C454(1.04); C587(1.03)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C933(0.98); C454(1.24)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C933(1.11); C454(0.73)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C933(1.04); C454(1.10)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C933(0.90)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C933(1.14); C454(1.03)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C933(1.04); C454(0.90)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C933(1.01); C454(1.04); C587(0.96)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C933(1.21)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C933(0.98); C454(0.79); C587(0.87)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C933(1.04); C454(0.75); C587(0.98)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C933(0.93); C454(1.30); C587(1.03)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C933(0.40); C454(1.24); C587(1.03)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C933(0.87); C454(1.10)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C933(0.93); C454(0.90)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C933(1.09); C454(1.18)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C933(0.98)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C933(1.00); C454(0.92); C587(1.04)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C933(0.99); C454(1.28)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C933(1.07); C454(0.89)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C933(1.12)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C933(1.04); C454(1.05)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C933(0.94); C454(1.00); C587(1.04)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C933(1.10); C454(1.06); C587(1.01)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C933(1.02); C454(1.22); C587(0.98)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C933(1.03); C454(1.03); C587(1.04)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C933(0.79); C454(0.97)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C933(0.98); C454(1.02)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C933(1.04); C454(1.19); C587(1.05)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C933(1.07); C454(1.04)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C933(1.02)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C933(1.05); C454(1.02)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C933(0.94); C454(0.95)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C933(0.95)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C933(1.02); C454(1.08); C587(1.04)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C933(0.91); C454(0.97); C587(0.95)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C933(1.04); C454(1.16); C587(1.04)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C933(1.17); C454(0.97); C587(1.07)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C933(1.12); C454(1.15)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C933(1.10); C454(1.18)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C933(0.99); C454(0.91)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C933(1.14); C454(1.27)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C933(0.91)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C933(1.02); C454(0.82)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C933(1.22); C454(1.07)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C933(1.30)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C933(0.92); C454(0.90)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C933(0.46); C454(1.03); C587(1.05)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C933(1.00); C454(0.90); C587(0.99)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C933(0.94); C454(0.96)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C933(1.05); C454(0.74); C587(1.01)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C933(1.03); C454(1.14); C587(1.04)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C933(0.97); C454(1.27)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C933(1.05); C454(1.03)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C933(1.07); C454(1.10)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C933(0.94)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C933(1.23); C454(1.28)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C933(0.83); C454(0.87)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C933(1.05)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C933(1.10); C454(0.95)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C933(0.95); C454(0.97)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C587(1.56); C338(1.30)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C933(0.94); C454(1.03)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C933(1.19)  LDD1631  [18]
 LDCM0022  KB02 HEK-293T C454(0.91); C587(1.02); C933(1.21)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C454(1.18); C587(1.01); C933(1.01)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C587(1.51); C338(3.02)  LDD3310  [4]
 LDCM0109  NEM HeLa H905(0.00); H752(0.00)  LDD0227  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C338(0.45)  LDD2099  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C338(0.68)  LDD2109  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C338(0.34)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C338(0.31)  LDD2125  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C338(0.89)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C338(1.51)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C338(0.35)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C338(1.52)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C338(0.45)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C338(1.03)  LDD2146  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402