Details of the Target

General Information of Target

Target ID LDTP08703
Target Name Netrin receptor UNC5B (UNC5B)
Gene Name UNC5B
Gene ID 219699
Synonyms
P53RDL1; UNC5H2; Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1; p53RDL1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV
KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL
FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV
PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT
VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP
VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL
SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG
FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL
KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD
PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV
LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP
CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT
PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY
HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC
SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA
SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
Target Bioclass
Immunoglobulin
Family
Unc-5 family
Subcellular location
Cell membrane
Function
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Uniprot ID
Q8IZJ1
Ensemble ID
ENST00000335350.10
HGNC ID
HGNC:12568

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 Substitution: p.A10L .
CCK81 SNV: p.Y377C .
COLO320 SNV: p.S786R .
COLO678 SNV: p.H320P .
COLO792 SNV: p.V505I .
DU145 SNV: p.S259Y .
HCT15 SNV: p.P541T .
IGROV1 SNV: p.T849A .
REH Substitution: p.A10L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		7.07  LDD0318  [1]
DBIA
 Probe Info  		C551(1.10)  LDD0531  [2]
IPM
 Probe Info  		C867(0.00); C551(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C551(1.10)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C551(0.59)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C551(0.60)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C551(0.62)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C551(0.86)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C551(1.15)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C551(0.66)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C551(0.88)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C551(1.01)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C551(1.12)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C551(0.94)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C551(1.30)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C551(0.91)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C551(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C551(0.74)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C867(0.79); C551(0.90); C716(1.10); C705(1.06)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C867(1.04); C551(1.53); C716(1.06); C705(1.28)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C867(0.99); C551(1.05); C716(0.94); C705(0.94)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C867(0.96); C551(1.05); C716(1.07); C625(1.19)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C867(1.06); C551(0.97); C716(0.99); C705(0.99)  LDD1528  [4]
 LDCM0290  AC3 HCT 116 C551(1.13)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C867(0.95); C551(1.03); C716(1.00); C705(0.91)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C867(0.95); C551(0.83); C716(1.04); C705(1.04)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C867(0.89); C551(0.88); C716(0.94); C705(0.85)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C867(0.80); C551(1.27); C716(1.10); C705(0.98)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C867(0.92); C551(0.79); C716(1.04); C705(0.98)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C867(0.96); C551(0.95); C716(1.07); C705(0.90)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C867(0.98); C551(0.83); C716(1.08); C625(0.97)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C867(1.04); C551(0.96); C716(1.06); C705(0.95)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C867(0.90); C551(0.88); C716(1.04); C705(0.92)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C867(0.90); C551(0.92); C716(1.07); C705(0.98)  LDD1539  [4]
 LDCM0301  AC4 HCT 116 C551(0.83)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C867(1.00); C551(0.82); C716(0.94); C705(0.95)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C867(0.81); C551(0.89); C716(1.02); C705(1.04)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C867(0.94); C551(0.90); C716(0.98); C705(1.03)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C867(1.05); C551(0.99); C716(1.08); C705(1.18)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C867(0.98); C551(0.95); C716(0.98); C625(1.16)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C867(0.99); C551(0.94); C716(0.95); C705(1.09)  LDD1546  [4]
 LDCM0308  AC46 HCT 116 C551(1.20)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C551(1.10)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C551(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C551(0.95)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C551(1.17)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C551(0.91)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C551(0.95)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C551(0.88)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C551(0.75)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C551(0.87)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C551(0.73)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C551(0.87)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C867(0.83); C551(1.02); C716(1.04); C705(1.17)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C867(0.99); C551(0.97); C716(1.00); C705(1.06)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C867(0.98); C551(1.18); C716(0.97); C705(1.15)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C551(1.06)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C867(1.03); C551(0.95); C716(1.09); C625(1.16)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C867(1.11); C551(0.96); C716(1.02); C705(1.00)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C867(1.06); C551(0.91); C716(0.93); C705(1.01)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C867(1.06); C551(1.01); C716(1.13); C705(1.14)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C867(0.94); C551(0.85); C716(0.93); C705(0.97)  LDD1567  [4]
 LDCM0332  AC68 HCT 116 C551(1.00)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C551(1.03)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C551(0.75)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C551(0.87)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C551(1.10)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C551(0.96)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C551(1.20)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C551(1.48)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C551(1.11)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C551(0.96)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C551(1.31)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C551(1.10)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C551(1.16)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C551(0.97)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C551(0.97)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C551(0.67)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C551(1.10)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C551(0.81)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C551(0.88)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C551(1.11)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C551(0.95)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C551(0.67)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C551(1.12)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C551(1.03)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C551(0.62)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C551(0.65)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C551(1.05)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C551(1.19)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C551(1.81)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C551(1.32)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C551(1.01)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C551(1.15)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C551(0.77)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C551(1.12)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C551(0.99)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C867(0.95); C551(1.74); C716(0.98); C625(1.01)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C867(1.04); C551(1.02); C716(1.03); C705(0.97)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C867(1.01); C551(0.93); C716(1.04); C705(1.14)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C867(1.11); C551(1.15); C716(0.98); C625(1.16)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C867(0.90); C551(0.82); C716(1.02); C625(0.93)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C867(0.98); C551(1.07); C716(0.99); C705(1.14)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C867(1.01); C551(0.80); C716(1.00); C705(1.03)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C867(0.98); C551(0.91); C716(1.05); C625(0.98)  LDD1593  [4]
 LDCM0390  CL12 HCT 116 C551(0.76)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C867(1.03); C551(0.98); C716(1.06); C625(0.94)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C551(1.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C551(0.99)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C551(0.90)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C551(0.95)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C867(1.24); C551(0.96); C716(0.97); C705(1.11)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C867(1.14); C551(1.04); C716(1.05); C705(1.02)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C867(1.05); C551(1.15); C716(1.01); C625(1.20)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C867(1.07); C551(1.17); C716(1.05); C625(1.11)  LDD1603  [4]
 LDCM0400  CL13 HCT 116 C551(0.73)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C551(0.83)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C551(0.79)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C867(0.99); C551(1.08); C716(0.97); C625(1.05)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C867(0.96); C551(1.04); C716(1.06); C705(1.04)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C867(0.83); C551(0.99); C716(1.13); C705(1.05)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C867(0.94); C551(0.95); C716(1.04); C705(1.03)  LDD1610  [4]
 LDCM0407  CL2 HCT 116 C551(0.66)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C867(1.02); C551(1.18); C716(1.19); C625(1.03)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C867(1.13); C551(1.24); C716(1.21); C705(1.10)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C867(1.08); C551(1.14); C716(1.29); C705(0.99)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C867(0.93); C551(1.34); C716(1.29); C705(1.31)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C867(1.19); C551(1.06); C716(1.22); C705(0.93)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C867(1.16); C551(1.10); C716(1.13); C705(1.03)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C867(1.01); C551(0.91); C716(1.04); C705(1.06)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C867(0.99); C551(1.27); C716(1.06); C625(0.90)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C867(0.96); C551(0.94); C716(1.01); C625(0.97)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C867(0.87); C551(1.02); C716(1.08); C705(0.91)  LDD1621  [4]
 LDCM0418  CL3 HCT 116 C551(0.94)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C867(0.96); C551(0.92); C716(1.04); C705(1.09)  LDD1623  [4]
 LDCM0420  CL31 HCT 116 C551(0.99)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C551(1.01)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C551(0.99)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C551(1.17)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C551(1.04)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C551(0.93)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C551(1.02)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C551(1.09)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C551(0.75)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C551(0.84)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C551(1.10)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C551(0.94)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C551(1.14)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C551(1.05)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C551(1.05)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C867(1.01); C551(0.99); C716(1.21); C705(1.05)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C867(1.04); C551(0.93); C716(1.29); C705(1.05)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C867(0.97); C551(1.26); C716(1.15); C705(1.08)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C867(1.06); C551(0.88); C716(1.06); C705(1.17)  LDD1643  [4]
 LDCM0440  CL5 HCT 116 C551(0.93)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C867(1.03); C551(0.84); C716(1.02); C705(1.27)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C867(1.09); C551(0.84); C716(1.00); C625(0.88)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C867(0.90); C551(1.58); C716(1.03); C705(0.89)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C867(0.96); C551(0.88); C716(1.16); C705(1.06)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C867(0.82); C551(0.90); C716(1.07); C705(1.10)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C867(0.94); C551(1.16); C716(1.15); C625(0.89)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C867(1.04); C551(1.20); C716(1.07); C705(0.87)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C867(0.99); C551(0.94); C716(1.38); C705(1.07)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C867(1.03); C551(0.99); C716(1.29); C705(1.24)  LDD1653  [4]
 LDCM0451  CL6 HCT 116 C551(0.87)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C867(1.02); C551(1.18); C716(1.11); C705(0.93)  LDD1655  [4]
 LDCM0453  CL61 HCT 116 C551(1.14)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C551(1.10)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C551(0.98)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C551(1.03)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C551(0.96)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C551(0.93)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C551(0.74)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C551(0.71)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C551(0.80)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C551(0.84)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C551(0.74)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C551(0.79)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C551(0.68)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C551(0.69)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C551(0.60)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C867(0.99); C551(1.19); C716(1.03); C625(0.89)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C867(0.87); C551(1.42); C716(1.11); C705(0.84)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C867(0.90); C551(0.77); C716(0.94); C705(1.10)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C867(1.12); C551(1.14); C716(1.00); C705(0.78)  LDD1675  [4]
 LDCM0473  CL8 HCT 116 C551(0.88)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C867(0.97); C551(0.93); C716(1.03); C625(0.85)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C867(1.00); C551(1.05); C716(1.18); C705(1.01)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C867(1.01); C551(1.01); C716(1.09); C705(1.06)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C867(1.09); C551(1.13); C716(1.26); C705(1.17)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C867(1.01); C551(1.07); C716(1.16); C705(0.89)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C867(1.20); C551(0.93); C716(1.13); C705(1.15)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C867(1.10); C551(0.87); C716(1.09); C705(1.81)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C867(1.11); C551(1.44); C716(1.10); C625(1.35)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C867(1.13); C551(0.89); C716(1.08); C625(1.11)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C867(0.80); C551(1.24); C716(1.08); C705(1.09)  LDD1686  [4]
 LDCM0484  CL9 HCT 116 C551(0.86)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C867(1.25); C551(1.29); C716(1.18); C705(1.08)  LDD1688  [4]
 LDCM0486  CL91 HCT 116 C551(1.12)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C551(1.02)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C551(1.08)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C551(1.17)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C551(1.20)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C551(1.13)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C551(1.10)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C551(1.12)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C551(1.09)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C867(1.05); C551(0.96); C716(1.05); C625(1.13)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C551(1.07)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C551(0.98)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C867(1.02); C551(0.97); C625(1.05); C716(0.88)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C867(0.93); C551(1.01); C625(1.06); C716(1.02)  LDD1497  [4]
 LDCM0024  KB05 NCI-H1155 C867(3.09)  LDD3342  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Netrin-1 (NTN1) . O95631

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840