Details of the Target

General Information of Target

Target ID LDTP08609
Target Name Kelch-like protein 7 (KLHL7)
Gene Name KLHL7
Gene ID 55975
Synonyms
Kelch-like protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRV
VLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA
ANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD
EFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISK
NFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGG
SQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKD
SWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQR
CSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVK
DKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG
RLGHILEYNTETDKWVANSKVRAFPVTSCLICVVDTCGANEETLET
Target Bioclass
Other
Subcellular location
Nucleus
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
Uniprot ID
Q8IXQ5
Ensemble ID
ENST00000322275.9
HGNC ID
HGNC:15646

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L137M DBIA    Probe Info 
EGI1 SNV: p.M34K DBIA    Probe Info 
HT115 SNV: p.R562C .
MCC13 SNV: p.R562C .
MFE319 SNV: p.V207I DBIA    Probe Info 
PF382 SNV: p.H58R .
RL952 SNV: p.R562C DBIA    Probe Info 
SNU449 SNV: p.K383N DBIA    Probe Info 
SW756 SNV: p.L375I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0229  [1]
DBIA
 Probe Info  		C133(0.92)  LDD0532  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C331(0.00); C306(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C331(0.00); C306(0.00)  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		C158(0.00); C44(0.00)  LDD2156  [5]
AOyne
 Probe Info  		13.70  LDD0443  [6]
NAIA_5
 Probe Info  		C572(0.00); C331(0.00); C435(0.00); C421(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C306(1.05); C133(0.92); C259(1.10); C44(1.13)  LDD1507  [8]
 LDCM0215  AC10 HCT 116 C133(0.92)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C306(1.07)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C306(1.06)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C306(1.07)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C306(1.04)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C306(1.07)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C306(0.94)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C306(1.22)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C306(1.18)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C306(1.25)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C306(1.14)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C133(0.88)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C306(0.97)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C306(0.52)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C306(0.75)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C306(1.03); C465(1.01)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C306(0.96); C465(1.01)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C306(1.11); C465(0.96)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C306(0.92); C465(1.11)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C306(1.09); C465(1.12)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C306(0.94); C465(1.23)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C306(0.99); C465(1.28)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C133(1.07)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C306(0.99); C465(1.28)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C306(0.97); C465(1.12)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C306(1.03); C465(1.35)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C306(1.01); C465(1.46)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C306(0.96); C465(1.20)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C306(0.88); C465(1.51)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C306(0.83); C465(1.77)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C306(0.65); C465(1.92)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C146(0.73); C306(1.20); C465(1.02)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C146(0.86); C306(1.22); C465(1.12)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C146(0.83); C306(1.21); C465(1.24)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C146(0.60); C306(1.00); C465(1.10)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C146(1.07); C306(1.11); C465(1.09)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C146(0.65); C306(1.09); C465(1.55)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C146(0.77); C306(1.07); C465(1.55)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C146(0.68); C306(1.07); C465(1.60)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C146(0.61); C306(1.07); C465(1.64)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C146(0.69); C306(1.07); C465(1.77)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C146(0.61); C306(1.02); C465(2.16)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C146(0.81); C306(1.02); C465(1.66)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C133(1.04)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C146(0.70); C306(1.11); C465(1.53)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C146(0.75); C306(0.99); C465(1.87)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C146(0.83); C306(1.08); C465(1.42)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C306(1.05)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C306(0.84)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C306(0.92)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C306(0.82)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C306(0.83)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C306(0.80)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C306(0.96)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C133(1.01)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C306(0.96)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C306(0.83)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C306(0.96)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C306(0.89)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C306(0.97)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C306(0.91)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C306(0.74)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C306(0.64)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C133(0.80)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C133(0.91)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C133(0.84)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C306(0.96); C133(0.97); C259(1.02); C44(0.89)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C133(0.88)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C133(0.76)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C133(0.91)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C133(0.79)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C133(0.84)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C133(0.73)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C133(0.62)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C133(0.83)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C133(0.80)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C133(0.73)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C306(1.06); C133(0.89); C259(0.93); C44(0.94)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C133(0.76)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C133(1.01)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C133(0.71)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C133(1.01)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C133(0.82)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C306(1.11)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C306(1.10)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C306(0.95)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C306(0.86)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C306(0.79)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C306(0.86); C133(1.03); C259(0.99); C44(1.03)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C306(1.14)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C306(0.99)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C306(0.88)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C306(1.13)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C306(0.94)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C306(0.88)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C306(1.02)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C306(1.06)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C306(1.01)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C306(1.02)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C306(1.03); C133(0.95); C259(1.21); C44(1.01)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C306(1.08)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C306(1.08)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C306(1.13)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C306(0.90)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C306(1.04)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C306(0.90)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C306(0.84)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C306(0.98)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C306(1.03)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C306(1.10)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C133(0.89)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C306(0.85)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C306(1.04)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C306(1.04)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C306(1.11)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C306(0.92)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C306(1.04)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C306(1.08)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C306(1.15)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C465(1.03)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C465(1.09)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C133(0.99)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C465(1.29)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C465(1.20)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C465(1.34)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C465(1.29)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C465(1.60)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C465(1.30)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C465(1.34)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C465(1.48)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C465(1.34)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C465(1.24)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C133(0.93)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C465(1.57)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C465(1.47)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C465(1.84)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C133(0.65)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C133(0.64)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C133(0.63)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C133(0.81)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C133(0.92)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C133(0.77)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C133(0.76)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C133(0.88)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C133(0.67)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C133(0.65)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C133(0.70)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C133(0.66)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C133(0.89)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C133(0.72)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C133(0.65)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C306(1.16)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C306(1.08)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C133(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C133(0.98)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C133(0.96)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C306(1.13); C133(0.93); C259(0.99)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C306(1.32); C133(0.50); C259(1.09); C44(1.44)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C306(0.87); C133(0.99); C259(0.86); C44(1.02)  LDD1573  [8]
 LDCM0370  CL101 HCT 116 C133(1.00)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C133(1.06)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C133(0.94)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C133(0.96)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C133(0.78)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C133(0.73)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C133(0.81)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C133(0.91)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C133(0.77)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C306(1.05); C133(0.83); C259(1.00); C44(0.89)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C133(0.75)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C133(0.77)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C133(1.10)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C133(0.62)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C133(0.58)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C133(0.97)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C133(0.99)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C306(0.81)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C306(0.89)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C306(0.90)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C306(1.23); C133(0.89); C259(1.05); C354(0.91)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C306(0.86)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C306(0.86)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C306(0.83)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C306(1.11)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C306(0.97)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C306(0.99)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C306(0.92)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C306(1.08)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C306(0.88)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C306(0.84); C133(1.00); C259(1.09)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C306(1.39); C133(1.03); C259(1.03); C44(0.97)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C306(1.32); C133(0.93); C259(1.12); C44(1.12)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C306(0.99); C133(1.12); C259(0.97); C44(1.02)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C306(1.09); C133(0.91); C259(1.12); C44(1.26)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C306(1.27); C133(1.17); C259(1.07); C44(1.07)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C306(1.01); C133(0.96); C259(1.09); C44(1.04)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C306(1.06); C133(1.00); C259(1.09); C44(0.99)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C306(1.02); C133(0.93); C259(1.00); C44(1.07)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C306(1.14); C133(1.04); C259(1.08); C44(0.99)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C306(1.01); C133(0.79); C259(1.13); C44(0.99)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C306(1.07); C133(0.97); C259(0.99); C44(0.87)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C306(1.26); C133(0.93); C259(1.07); C354(0.79)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C306(0.97); C133(0.96); C259(1.14)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C306(0.97); C133(1.17); C259(1.09); C44(0.86)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C306(0.86); C133(0.99); C259(0.98); C44(1.03)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C306(0.97); C133(0.93); C259(0.93); C44(1.10)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C306(1.22); C133(0.94); C259(1.02); C44(1.12)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C306(0.89); C133(0.90); C259(1.09); C44(1.07)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C306(1.12); C133(1.09); C259(1.02); C44(0.89)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C146(1.07); C306(0.88); C465(0.94)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C146(0.84); C306(0.84); C465(1.04)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C146(0.77); C306(0.73); C465(0.95)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C146(1.10); C306(0.78); C465(1.07)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C146(0.78); C306(0.77); C465(1.08)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C146(0.74); C306(0.84); C465(1.19)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C146(0.77); C306(0.78); C465(1.11)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C146(0.54); C306(0.79); C465(1.56)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C306(1.14); C133(0.96); C259(0.89); C44(1.05)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C146(0.65); C306(0.84); C465(1.16)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C146(0.54); C306(0.79); C465(1.45)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C146(0.62); C306(0.75); C465(1.73)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C146(0.54); C306(0.75); C465(1.60)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C146(0.75); C306(0.81); C465(1.18)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C146(0.57); C306(0.75); C465(1.37)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C146(1.17); C306(1.04); C465(1.10)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C146(1.02); C306(1.19); C465(1.00)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C146(1.20); C306(1.02); C465(0.98)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C146(1.37); C306(0.97); C465(1.25)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C306(1.08); C133(0.91); C259(1.16); C44(1.04)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C146(0.93); C306(0.94); C465(1.62)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C146(1.10); C306(1.07); C465(1.22)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C146(1.73); C306(1.14); C465(0.91)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C146(1.84); C306(1.15); C465(0.94)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C146(1.01); C306(1.18); C465(1.11)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C146(1.22); C306(1.24); C465(1.20)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C146(1.23); C306(1.35); C465(0.93)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C146(1.42); C306(1.27); C465(1.07)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C146(1.83); C306(1.32); C465(1.10)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C146(0.92); C306(1.13); C465(1.34)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C306(1.09); C133(1.13); C259(0.96); C44(0.56)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C146(0.88); C306(1.05); C465(1.62)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C306(0.90); C465(0.95)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C306(1.02); C465(1.16)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C306(1.20); C465(1.08)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C306(1.14); C465(1.07)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C306(1.19); C465(1.03)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C306(1.05); C465(1.18)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C306(1.15); C465(1.11)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C306(1.05); C465(1.09)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C306(1.20); C465(0.96)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C306(0.98); C133(0.90); C259(1.22); C44(1.13)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C306(1.42); C465(1.21)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C306(1.20); C465(1.10)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C306(0.98); C465(1.19)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C306(1.23); C465(1.34)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C306(1.17); C465(1.46)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C306(1.03)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C306(1.03)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C306(1.59)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C306(1.19)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C306(0.88); C133(0.90); C259(1.00); C44(1.68)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C306(1.10)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C306(1.04)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C306(0.81)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C306(0.76)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C306(1.15)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C306(1.19)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C306(1.72)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C306(1.03)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C306(1.03)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C306(1.02)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C306(1.00); C133(1.06); C259(1.05); C44(1.14)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C306(0.88)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C306(1.17); C133(1.04); C259(0.97); C44(0.99)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C306(0.95); C133(0.91); C259(0.99); C44(1.17)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C306(0.94); C133(1.10); C259(1.11); C44(1.28)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C306(1.09); C133(0.87); C259(1.12); C44(1.13)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C306(0.79); C133(0.90); C259(0.93); C44(1.10)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C306(1.07); C133(0.86); C259(1.15); C354(0.84)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C306(1.10); C133(0.89); C259(1.04)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C306(0.96); C133(1.00); C259(1.10); C44(1.00)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C306(0.85); C133(0.90); C259(0.96); C44(0.86)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C306(0.88); C133(0.88); C259(1.03); C44(0.82)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C306(1.07); C465(1.36)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C146(0.49); C306(0.78); C465(1.14)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C306(1.10); C259(1.07); C133(1.00)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C306(1.15); C259(0.94); C133(0.93)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C306(2.16)  LDD3310  [9]
 LDCM0109  NEM HeLa N.A.  LDD0229  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-3 (CUL3) Cullin family Q13618
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like protein 7 (KLHL7) . Q8IXQ5

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840