Details of the Target

General Information of Target

Target ID LDTP08301
Target Name Protein Hook homolog 3 (HOOK3)
Gene Name HOOK3
Gene ID 84376
Synonyms
Protein Hook homolog 3; h-hook3; hHK3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNR
IKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ
LILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKK
TTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPA
GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLK
DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK
ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL
KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLN
QEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED
SVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQM
EERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM
EEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR
Target Bioclass
Other
Family
Hook family
Subcellular location
Cytoplasm, cytoskeleton
Function
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.; (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking.
Uniprot ID
Q86VS8
Ensemble ID
ENST00000307602.9
HGNC ID
HGNC:23576

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K312(6.62); K326(10.00); K372(10.00); K649(9.32)  LDD0277  [1]
DBIA
 Probe Info  		C58(1.45)  LDD3332  [2]
BTD
 Probe Info  		C272(0.88)  LDD2093  [3]
HHS-475
 Probe Info  		Y323(8.44)  LDD0264  [4]
HHS-465
 Probe Info  		Y323(10.00)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0223  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IPM
 Probe Info  		N.A.  LDD2156  [10]
W1
 Probe Info  		E557(0.00); E561(0.00)  LDD0236  [11]
AOyne
 Probe Info  		13.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C272(0.55)  LDD2112  [3]
 LDCM0214  AC1 PaTu 8988t C125(1.33); C129(1.33)  LDD1093  [14]
 LDCM0215  AC10 HEK-293T C129(1.17)  LDD0813  [14]
 LDCM0226  AC11 HEK-293T C129(0.92)  LDD0824  [14]
 LDCM0230  AC113 PaTu 8988t C125(1.14); C129(1.14)  LDD1109  [14]
 LDCM0231  AC114 PaTu 8988t C125(1.23); C129(1.23)  LDD1110  [14]
 LDCM0232  AC115 PaTu 8988t C125(1.11); C129(1.11)  LDD1111  [14]
 LDCM0233  AC116 PaTu 8988t C125(1.05); C129(1.05)  LDD1112  [14]
 LDCM0234  AC117 PaTu 8988t C125(1.11); C129(1.11)  LDD1113  [14]
 LDCM0235  AC118 PaTu 8988t C125(0.97); C129(0.97)  LDD1114  [14]
 LDCM0236  AC119 PaTu 8988t C125(1.11); C129(1.11)  LDD1115  [14]
 LDCM0237  AC12 HEK-293T C129(0.89)  LDD0835  [14]
 LDCM0238  AC120 PaTu 8988t C125(1.30); C129(1.30)  LDD1117  [14]
 LDCM0239  AC121 PaTu 8988t C125(1.39); C129(1.39)  LDD1118  [14]
 LDCM0240  AC122 PaTu 8988t C125(1.11); C129(1.11)  LDD1119  [14]
 LDCM0241  AC123 PaTu 8988t C125(0.99); C129(0.99)  LDD1120  [14]
 LDCM0242  AC124 PaTu 8988t C125(1.20); C129(1.20)  LDD1121  [14]
 LDCM0243  AC125 PaTu 8988t C125(0.90); C129(0.90)  LDD1122  [14]
 LDCM0244  AC126 PaTu 8988t C125(1.10); C129(1.10)  LDD1123  [14]
 LDCM0245  AC127 PaTu 8988t C125(1.06); C129(1.06)  LDD1124  [14]
 LDCM0246  AC128 HEK-293T C129(1.14)  LDD0844  [14]
 LDCM0247  AC129 HEK-293T C129(1.05)  LDD0845  [14]
 LDCM0249  AC130 HEK-293T C129(1.09)  LDD0847  [14]
 LDCM0250  AC131 HEK-293T C129(1.10)  LDD0848  [14]
 LDCM0251  AC132 HEK-293T C129(1.14)  LDD0849  [14]
 LDCM0252  AC133 HEK-293T C129(1.04)  LDD0850  [14]
 LDCM0253  AC134 HEK-293T C129(0.94)  LDD0851  [14]
 LDCM0254  AC135 HEK-293T C129(1.02)  LDD0852  [14]
 LDCM0255  AC136 HEK-293T C129(1.11)  LDD0853  [14]
 LDCM0256  AC137 HEK-293T C129(1.10)  LDD0854  [14]
 LDCM0257  AC138 HEK-293T C129(1.16)  LDD0855  [14]
 LDCM0258  AC139 HEK-293T C129(1.18)  LDD0856  [14]
 LDCM0259  AC14 HEK-293T C129(1.13)  LDD0857  [14]
 LDCM0260  AC140 HEK-293T C129(1.06)  LDD0858  [14]
 LDCM0261  AC141 HEK-293T C129(1.16)  LDD0859  [14]
 LDCM0262  AC142 HEK-293T C129(1.06)  LDD0860  [14]
 LDCM0263  AC143 HEK-293T C129(1.14)  LDD0861  [14]
 LDCM0264  AC144 HEK-293T C129(1.39)  LDD0862  [14]
 LDCM0265  AC145 HEK-293T C129(1.36)  LDD0863  [14]
 LDCM0266  AC146 HEK-293T C129(1.36)  LDD0864  [14]
 LDCM0267  AC147 HEK-293T C129(1.54)  LDD0865  [14]
 LDCM0268  AC148 HEK-293T C129(1.38)  LDD0866  [14]
 LDCM0269  AC149 HEK-293T C129(1.11)  LDD0867  [14]
 LDCM0270  AC15 HEK-293T C129(1.06)  LDD0868  [14]
 LDCM0271  AC150 HEK-293T C129(1.37)  LDD0869  [14]
 LDCM0272  AC151 HEK-293T C129(1.31)  LDD0870  [14]
 LDCM0273  AC152 HEK-293T C129(1.33)  LDD0871  [14]
 LDCM0274  AC153 HEK-293T C129(1.37)  LDD0872  [14]
 LDCM0621  AC154 HEK-293T C129(1.23)  LDD2162  [14]
 LDCM0622  AC155 HEK-293T C129(1.33)  LDD2163  [14]
 LDCM0623  AC156 HEK-293T C129(1.56)  LDD2164  [14]
 LDCM0624  AC157 HEK-293T C129(2.04)  LDD2165  [14]
 LDCM0276  AC17 HEK-293T C129(0.94)  LDD0874  [14]
 LDCM0277  AC18 HEK-293T C129(0.91)  LDD0875  [14]
 LDCM0278  AC19 HEK-293T C129(0.95)  LDD0876  [14]
 LDCM0279  AC2 PaTu 8988t C125(1.08); C129(1.08)  LDD1158  [14]
 LDCM0280  AC20 HEK-293T C129(1.01)  LDD0878  [14]
 LDCM0281  AC21 HEK-293T C129(0.99)  LDD0879  [14]
 LDCM0282  AC22 HEK-293T C129(0.92)  LDD0880  [14]
 LDCM0283  AC23 HEK-293T C129(0.88)  LDD0881  [14]
 LDCM0284  AC24 HEK-293T C129(0.97)  LDD0882  [14]
 LDCM0285  AC25 HEK-293T C129(0.84)  LDD0883  [14]
 LDCM0286  AC26 HEK-293T C129(0.78)  LDD0884  [14]
 LDCM0287  AC27 HEK-293T C129(0.79)  LDD0885  [14]
 LDCM0288  AC28 HEK-293T C129(0.83)  LDD0886  [14]
 LDCM0289  AC29 HEK-293T C129(0.77)  LDD0887  [14]
 LDCM0290  AC3 PaTu 8988t C125(1.02); C129(1.02)  LDD1169  [14]
 LDCM0291  AC30 HEK-293T C129(0.75)  LDD0889  [14]
 LDCM0292  AC31 HEK-293T C129(0.74)  LDD0890  [14]
 LDCM0293  AC32 HEK-293T C129(0.80)  LDD0891  [14]
 LDCM0294  AC33 HEK-293T C129(0.74)  LDD0892  [14]
 LDCM0295  AC34 HEK-293T C129(0.73)  LDD0893  [14]
 LDCM0296  AC35 PaTu 8988t C125(1.35); C129(1.35)  LDD1175  [14]
 LDCM0297  AC36 PaTu 8988t C125(1.26); C129(1.26)  LDD1176  [14]
 LDCM0298  AC37 PaTu 8988t C125(1.20); C129(1.20)  LDD1177  [14]
 LDCM0299  AC38 PaTu 8988t C125(1.34); C129(1.34)  LDD1178  [14]
 LDCM0300  AC39 PaTu 8988t C125(1.36); C129(1.36)  LDD1179  [14]
 LDCM0301  AC4 PaTu 8988t C125(1.10); C129(1.10)  LDD1180  [14]
 LDCM0302  AC40 PaTu 8988t C125(1.33); C129(1.33)  LDD1181  [14]
 LDCM0303  AC41 PaTu 8988t C125(1.50); C129(1.50)  LDD1182  [14]
 LDCM0304  AC42 PaTu 8988t C125(1.65); C129(1.65)  LDD1183  [14]
 LDCM0305  AC43 PaTu 8988t C125(1.82); C129(1.82)  LDD1184  [14]
 LDCM0306  AC44 PaTu 8988t C125(1.82); C129(1.82)  LDD1185  [14]
 LDCM0307  AC45 PaTu 8988t C125(1.23); C129(1.23)  LDD1186  [14]
 LDCM0308  AC46 HEK-293T C129(1.13)  LDD0906  [14]
 LDCM0309  AC47 HEK-293T C129(1.17)  LDD0907  [14]
 LDCM0310  AC48 HEK-293T C129(1.06)  LDD0908  [14]
 LDCM0311  AC49 HEK-293T C129(0.99)  LDD0909  [14]
 LDCM0312  AC5 PaTu 8988t C125(1.25); C129(1.25)  LDD1191  [14]
 LDCM0313  AC50 HEK-293T C129(1.08)  LDD0911  [14]
 LDCM0314  AC51 HEK-293T C129(1.04)  LDD0912  [14]
 LDCM0315  AC52 HEK-293T C129(1.05)  LDD0913  [14]
 LDCM0316  AC53 HEK-293T C129(1.06)  LDD0914  [14]
 LDCM0317  AC54 HEK-293T C129(1.09)  LDD0915  [14]
 LDCM0318  AC55 HEK-293T C129(1.11)  LDD0916  [14]
 LDCM0319  AC56 HEK-293T C129(1.12)  LDD0917  [14]
 LDCM0320  AC57 HEK-293T C129(0.89)  LDD0918  [14]
 LDCM0321  AC58 HEK-293T C129(0.78)  LDD0919  [14]
 LDCM0322  AC59 HEK-293T C129(0.76)  LDD0920  [14]
 LDCM0323  AC6 HEK-293T C129(0.96)  LDD0921  [14]
 LDCM0324  AC60 HEK-293T C129(0.81)  LDD0922  [14]
 LDCM0325  AC61 HEK-293T C129(0.96)  LDD0923  [14]
 LDCM0326  AC62 HEK-293T C129(0.77)  LDD0924  [14]
 LDCM0327  AC63 HEK-293T C129(0.86)  LDD0925  [14]
 LDCM0328  AC64 HEK-293T C129(0.78)  LDD0926  [14]
 LDCM0329  AC65 HEK-293T C129(0.82)  LDD0927  [14]
 LDCM0330  AC66 HEK-293T C129(0.81)  LDD0928  [14]
 LDCM0331  AC67 HEK-293T C129(0.81)  LDD0929  [14]
 LDCM0332  AC68 PaTu 8988t C125(0.92); C129(0.92)  LDD1211  [14]
 LDCM0333  AC69 PaTu 8988t C125(0.93); C129(0.93)  LDD1212  [14]
 LDCM0334  AC7 HEK-293T C129(0.90)  LDD0932  [14]
 LDCM0335  AC70 PaTu 8988t C125(0.90); C129(0.90)  LDD1214  [14]
 LDCM0336  AC71 PaTu 8988t C125(0.97); C129(0.97)  LDD1215  [14]
 LDCM0337  AC72 PaTu 8988t C125(0.97); C129(0.97)  LDD1216  [14]
 LDCM0338  AC73 PaTu 8988t C125(0.73); C129(0.73)  LDD1217  [14]
 LDCM0339  AC74 PaTu 8988t C125(1.02); C129(1.02)  LDD1218  [14]
 LDCM0340  AC75 PaTu 8988t C125(1.07); C129(1.07)  LDD1219  [14]
 LDCM0341  AC76 PaTu 8988t C125(0.92); C129(0.92)  LDD1220  [14]
 LDCM0342  AC77 PaTu 8988t C125(0.88); C129(0.88)  LDD1221  [14]
 LDCM0343  AC78 PaTu 8988t C125(0.95); C129(0.95)  LDD1222  [14]
 LDCM0344  AC79 PaTu 8988t C125(1.04); C129(1.04)  LDD1223  [14]
 LDCM0345  AC8 HEK-293T C129(0.90)  LDD0943  [14]
 LDCM0346  AC80 PaTu 8988t C125(1.04); C129(1.04)  LDD1225  [14]
 LDCM0347  AC81 PaTu 8988t C125(1.13); C129(1.13)  LDD1226  [14]
 LDCM0348  AC82 PaTu 8988t C125(1.24); C129(1.24)  LDD1227  [14]
 LDCM0349  AC83 HEK-293T C129(0.88)  LDD0947  [14]
 LDCM0350  AC84 HEK-293T C129(1.00)  LDD0948  [14]
 LDCM0351  AC85 HEK-293T C129(0.92)  LDD0949  [14]
 LDCM0352  AC86 HEK-293T C129(1.11)  LDD0950  [14]
 LDCM0353  AC87 HEK-293T C129(0.97)  LDD0951  [14]
 LDCM0354  AC88 HEK-293T C129(1.09)  LDD0952  [14]
 LDCM0355  AC89 HEK-293T C129(1.04)  LDD0953  [14]
 LDCM0357  AC90 HEK-293T C129(1.02)  LDD0955  [14]
 LDCM0358  AC91 HEK-293T C129(1.04)  LDD0956  [14]
 LDCM0359  AC92 HEK-293T C129(0.92)  LDD0957  [14]
 LDCM0360  AC93 HEK-293T C129(0.97)  LDD0958  [14]
 LDCM0361  AC94 HEK-293T C129(1.09)  LDD0959  [14]
 LDCM0362  AC95 HEK-293T C129(1.12)  LDD0960  [14]
 LDCM0363  AC96 HEK-293T C129(0.99)  LDD0961  [14]
 LDCM0364  AC97 HEK-293T C129(1.50)  LDD0962  [14]
 LDCM0248  AKOS034007472 HEK-293T C129(0.93)  LDD0846  [14]
 LDCM0356  AKOS034007680 HEK-293T C129(1.02)  LDD0954  [14]
 LDCM0275  AKOS034007705 HEK-293T C129(0.97)  LDD0873  [14]
 LDCM0367  CL1 PaTu 8988t C125(1.14); C129(1.14)  LDD1246  [14]
 LDCM0368  CL10 PaTu 8988t C125(1.36); C129(1.36)  LDD1247  [14]
 LDCM0369  CL100 PaTu 8988t C125(1.01); C129(1.01)  LDD1248  [14]
 LDCM0370  CL101 HEK-293T C129(0.91)  LDD0968  [14]
 LDCM0371  CL102 HEK-293T C129(1.05)  LDD0969  [14]
 LDCM0372  CL103 HEK-293T C129(0.93)  LDD0970  [14]
 LDCM0373  CL104 HEK-293T C129(0.89)  LDD0971  [14]
 LDCM0374  CL105 HEK-293T C129(0.92)  LDD0972  [14]
 LDCM0375  CL106 HEK-293T C129(0.99)  LDD0973  [14]
 LDCM0376  CL107 HEK-293T C129(0.96)  LDD0974  [14]
 LDCM0377  CL108 HEK-293T C129(0.99)  LDD0975  [14]
 LDCM0378  CL109 HEK-293T C129(0.90)  LDD0976  [14]
 LDCM0379  CL11 PaTu 8988t C125(1.11); C129(1.11)  LDD1258  [14]
 LDCM0380  CL110 HEK-293T C129(0.97)  LDD0978  [14]
 LDCM0381  CL111 HEK-293T C129(0.84)  LDD0979  [14]
 LDCM0382  CL112 HEK-293T C129(0.75)  LDD0980  [14]
 LDCM0383  CL113 HEK-293T C129(0.73)  LDD0981  [14]
 LDCM0384  CL114 HEK-293T C129(0.76)  LDD0982  [14]
 LDCM0385  CL115 HEK-293T C129(0.78)  LDD0983  [14]
 LDCM0386  CL116 HEK-293T C129(0.82)  LDD0984  [14]
 LDCM0387  CL117 PaTu 8988t C125(1.50); C129(1.50)  LDD1266  [14]
 LDCM0388  CL118 PaTu 8988t C125(1.26); C129(1.26)  LDD1267  [14]
 LDCM0389  CL119 PaTu 8988t C125(1.55); C129(1.55)  LDD1268  [14]
 LDCM0390  CL12 PaTu 8988t C125(1.09); C129(1.09)  LDD1269  [14]
 LDCM0391  CL120 PaTu 8988t C125(1.33); C129(1.33)  LDD1270  [14]
 LDCM0392  CL121 HEK-293T C129(0.98)  LDD0990  [14]
 LDCM0393  CL122 HEK-293T C129(1.08)  LDD0991  [14]
 LDCM0394  CL123 HEK-293T C129(0.97)  LDD0992  [14]
 LDCM0395  CL124 HEK-293T C129(1.08)  LDD0993  [14]
 LDCM0396  CL125 HEK-293T C129(0.83)  LDD0994  [14]
 LDCM0397  CL126 HEK-293T C129(0.87)  LDD0995  [14]
 LDCM0398  CL127 HEK-293T C129(0.90)  LDD0996  [14]
 LDCM0399  CL128 HEK-293T C129(0.82)  LDD0997  [14]
 LDCM0400  CL13 PaTu 8988t C125(1.74); C129(1.74)  LDD1279  [14]
 LDCM0401  CL14 PaTu 8988t C125(1.79); C129(1.79)  LDD1280  [14]
 LDCM0402  CL15 PaTu 8988t C125(1.13); C129(1.13)  LDD1281  [14]
 LDCM0403  CL16 HEK-293T C429(0.83); C129(1.08)  LDD1607  [15]
 LDCM0405  CL18 HEK-293T C429(1.29)  LDD1609  [15]
 LDCM0407  CL2 PaTu 8988t C125(1.16); C129(1.16)  LDD1286  [14]
 LDCM0408  CL20 HEK-293T C429(1.22)  LDD1612  [15]
 LDCM0411  CL23 HEK-293T C429(0.90)  LDD1615  [15]
 LDCM0414  CL26 HEK-293T C129(0.88)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C429(1.04)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C429(1.03); C129(0.89)  LDD1620  [15]
 LDCM0418  CL3 PaTu 8988t C125(1.05); C129(1.05)  LDD1297  [14]
 LDCM0419  CL30 HEK-293T C429(0.89)  LDD1623  [15]
 LDCM0420  CL31 PaTu 8988t C125(1.02); C129(1.03)  LDD1299  [14]
 LDCM0421  CL32 PaTu 8988t C125(1.08); C129(1.03)  LDD1300  [14]
 LDCM0422  CL33 PaTu 8988t C125(0.99); C129(0.98)  LDD1301  [14]
 LDCM0423  CL34 PaTu 8988t C125(1.44); C129(1.43)  LDD1302  [14]
 LDCM0424  CL35 PaTu 8988t C125(1.36); C129(1.40)  LDD1303  [14]
 LDCM0425  CL36 PaTu 8988t C125(0.71); C129(0.71)  LDD1304  [14]
 LDCM0426  CL37 PaTu 8988t C125(1.43); C129(1.40)  LDD1305  [14]
 LDCM0428  CL39 PaTu 8988t C125(1.17); C129(1.17)  LDD1307  [14]
 LDCM0429  CL4 PaTu 8988t C125(0.93); C129(0.93)  LDD1308  [14]
 LDCM0430  CL40 PaTu 8988t C125(1.05); C129(1.07)  LDD1309  [14]
 LDCM0431  CL41 PaTu 8988t C125(1.25); C129(1.23)  LDD1310  [14]
 LDCM0432  CL42 PaTu 8988t C125(1.46); C129(1.44)  LDD1311  [14]
 LDCM0433  CL43 PaTu 8988t C125(1.68); C129(1.67)  LDD1312  [14]
 LDCM0434  CL44 PaTu 8988t C125(1.33); C129(1.27)  LDD1313  [14]
 LDCM0435  CL45 PaTu 8988t C125(1.13); C129(1.08)  LDD1314  [14]
 LDCM0436  CL46 PaTu 8988t C125(1.10); C129(1.09)  LDD1315  [14]
 LDCM0437  CL47 PaTu 8988t C125(1.06); C129(1.03)  LDD1316  [14]
 LDCM0438  CL48 PaTu 8988t C125(1.02); C129(1.05)  LDD1317  [14]
 LDCM0439  CL49 PaTu 8988t C125(1.06); C129(1.08)  LDD1318  [14]
 LDCM0440  CL5 PaTu 8988t C125(1.67); C129(1.67)  LDD1319  [14]
 LDCM0441  CL50 PaTu 8988t C125(1.18); C129(1.20)  LDD1320  [14]
 LDCM0442  CL51 PaTu 8988t C125(1.06); C129(1.07)  LDD1321  [14]
 LDCM0443  CL52 PaTu 8988t C125(1.12); C129(1.12)  LDD1322  [14]
 LDCM0444  CL53 PaTu 8988t C125(1.14); C129(1.20)  LDD1323  [14]
 LDCM0445  CL54 PaTu 8988t C125(1.06); C129(1.08)  LDD1324  [14]
 LDCM0446  CL55 PaTu 8988t C125(1.06); C129(1.09)  LDD1325  [14]
 LDCM0447  CL56 PaTu 8988t C125(0.76); C129(0.75)  LDD1326  [14]
 LDCM0448  CL57 PaTu 8988t C125(1.45); C129(1.44)  LDD1327  [14]
 LDCM0449  CL58 PaTu 8988t C125(1.17); C129(1.16)  LDD1328  [14]
 LDCM0450  CL59 PaTu 8988t C125(1.45); C129(1.47)  LDD1329  [14]
 LDCM0451  CL6 PaTu 8988t C125(1.33); C129(1.33)  LDD1330  [14]
 LDCM0452  CL60 PaTu 8988t C125(1.29); C129(1.28)  LDD1331  [14]
 LDCM0453  CL61 PaTu 8988t C125(1.05); C129(1.05)  LDD1332  [14]
 LDCM0454  CL62 PaTu 8988t C125(0.92); C129(0.92)  LDD1333  [14]
 LDCM0455  CL63 PaTu 8988t C125(0.94); C129(0.94)  LDD1334  [14]
 LDCM0456  CL64 PaTu 8988t C125(1.06); C129(1.06)  LDD1335  [14]
 LDCM0457  CL65 PaTu 8988t C125(1.07); C129(1.07)  LDD1336  [14]
 LDCM0458  CL66 PaTu 8988t C125(1.06); C129(1.06)  LDD1337  [14]
 LDCM0459  CL67 PaTu 8988t C125(1.50); C129(1.50)  LDD1338  [14]
 LDCM0460  CL68 PaTu 8988t C125(1.43); C129(1.43)  LDD1339  [14]
 LDCM0461  CL69 PaTu 8988t C125(1.26); C129(1.26)  LDD1340  [14]
 LDCM0462  CL7 PaTu 8988t C125(1.64); C129(1.64)  LDD1341  [14]
 LDCM0463  CL70 PaTu 8988t C125(1.16); C129(1.16)  LDD1342  [14]
 LDCM0464  CL71 PaTu 8988t C125(0.96); C129(0.96)  LDD1343  [14]
 LDCM0465  CL72 PaTu 8988t C125(1.04); C129(1.04)  LDD1344  [14]
 LDCM0466  CL73 PaTu 8988t C125(1.25); C129(1.25)  LDD1345  [14]
 LDCM0467  CL74 PaTu 8988t C125(0.91); C129(0.91)  LDD1346  [14]
 LDCM0469  CL76 HEK-293T C129(1.12)  LDD1067  [14]
 LDCM0470  CL77 HEK-293T C129(1.03)  LDD1068  [14]
 LDCM0471  CL78 HEK-293T C129(1.36)  LDD1069  [14]
 LDCM0472  CL79 HEK-293T C129(1.17)  LDD1070  [14]
 LDCM0473  CL8 PaTu 8988t C125(1.08); C129(1.08)  LDD1352  [14]
 LDCM0474  CL80 HEK-293T C129(1.29)  LDD1072  [14]
 LDCM0475  CL81 HEK-293T C129(0.98)  LDD1073  [14]
 LDCM0476  CL82 HEK-293T C129(0.92)  LDD1074  [14]
 LDCM0477  CL83 HEK-293T C129(0.81)  LDD1075  [14]
 LDCM0478  CL84 HEK-293T C129(0.88)  LDD1076  [14]
 LDCM0479  CL85 HEK-293T C129(1.20)  LDD1077  [14]
 LDCM0480  CL86 HEK-293T C129(1.49)  LDD1078  [14]
 LDCM0481  CL87 HEK-293T C129(0.98)  LDD1079  [14]
 LDCM0482  CL88 HEK-293T C129(1.00)  LDD1080  [14]
 LDCM0483  CL89 HEK-293T C129(1.21)  LDD1081  [14]
 LDCM0484  CL9 PaTu 8988t C125(1.43); C129(1.43)  LDD1363  [14]
 LDCM0485  CL90 HEK-293T C129(0.88)  LDD1083  [14]
 LDCM0486  CL91 PaTu 8988t C125(1.07); C129(1.07)  LDD1365  [14]
 LDCM0487  CL92 PaTu 8988t C125(1.07); C129(1.07)  LDD1366  [14]
 LDCM0488  CL93 PaTu 8988t C125(1.10); C129(1.10)  LDD1367  [14]
 LDCM0489  CL94 PaTu 8988t C125(1.11); C129(1.11)  LDD1368  [14]
 LDCM0490  CL95 PaTu 8988t C125(1.09); C129(1.09)  LDD1369  [14]
 LDCM0491  CL96 PaTu 8988t C125(1.07); C129(1.07)  LDD1370  [14]
 LDCM0492  CL97 PaTu 8988t C125(1.14); C129(1.14)  LDD1371  [14]
 LDCM0493  CL98 PaTu 8988t C125(1.28); C129(1.28)  LDD1372  [14]
 LDCM0494  CL99 PaTu 8988t C125(1.07); C129(1.07)  LDD1373  [14]
 LDCM0495  E2913 HEK-293T C429(0.95)  LDD1698  [15]
 LDCM0468  Fragment33 PaTu 8988t C125(1.10); C129(1.10)  LDD1347  [14]
 LDCM0427  Fragment51 PaTu 8988t C125(1.18); C129(1.14)  LDD1306  [14]
 LDCM0116  HHS-0101 DM93 Y323(8.44)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y323(2.50)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y323(0.92)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y323(6.54)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y323(10.46)  LDD0268  [4]
 LDCM0022  KB02 FAP expression C58(1.38)  LDD2367  [2]
 LDCM0023  KB03 FAP expression C58(1.49)  LDD2784  [2]
 LDCM0024  KB05 MKN45 C58(1.45)  LDD3332  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C272(0.88)  LDD2093  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C272(0.33)  LDD2104  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C272(0.82)  LDD2109  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C272(0.66)  LDD2115  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C272(0.42)  LDD2122  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C272(0.22)  LDD2145  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C272(0.66)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Macrophage scavenger receptor types I and II (MSR1) . P21757
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Keratin, type I cytoskeletal 13 (KRT13) Intermediate filament family P13646
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402