Details of the Target

General Information of Target

Target ID LDTP08176
Target Name Serologically defined colon cancer antigen 8 (SDCCAG8)
Gene Name SDCCAG8
Gene ID 10806
Synonyms
CCCAP; NPHP10; Serologically defined colon cancer antigen 8; Antigen NY-CO-8; Centrosomal colon cancer autoantigen protein; hCCCAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNED
ARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVH
TINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLD
ASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE
SQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV
HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ
CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA
QVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRA
KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQ
EKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLK
EECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMK
QRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function
Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis.
Uniprot ID
Q86SQ7
Ensemble ID
ENST00000366541.8
HGNC ID
HGNC:10671

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.T617PfsTer5 .
AGS SNV: p.K683M DBIA    Probe Info 
CHL1 Insertion: p.A372GfsTer24 .
COLO678 Insertion: p.A372GfsTer8 .
COLO800 Insertion: p.A372GfsTer25 DBIA    Probe Info 
HKGZCC SNV: p.Q512L .
HT SNV: p.E158G .
KMCH1 SNV: p.L270I DBIA    Probe Info 
LNCaP clone FGC SNV: p.S100T .
LS123 Insertion: p.Q371_A372insGGGG .
MELJUSO Insertion: p.Q371_A372insGGG DBIA    Probe Info 
MEWO Insertion: p.A372GfsTer24
SNV: p.P101L		 .
MFE319 SNV: p.L687F .
NCIH358 Insertion: p.A372GfsTer24 .
OAW42 SNV: p.K227R .
OVCAR5 Insertion: p.A372_E373insGGGG .
SUDHL6 SNV: p.D391N .
SW1116 Insertion: p.A372GfsTer24 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C283(4.80)  LDD0209  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
IPM
 Probe Info  		C34(0.00); C649(0.00); C236(0.00)  LDD2156  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
VSF
 Probe Info  		C603(0.00); C604(0.00)  LDD0007  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C283(1.08)  LDD0812  [7]
 LDCM0215  AC10 HCT 116 C283(1.10)  LDD0532  [7]
 LDCM0216  AC100 HEK-293T C283(1.05)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C283(1.09)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C283(1.17)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C283(1.23)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C283(1.06)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C283(0.96)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C283(1.12)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C283(1.20)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C283(1.04)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C283(0.98)  LDD0823  [7]
 LDCM0226  AC11 HCT 116 C283(1.13)  LDD0543  [7]
 LDCM0227  AC110 HEK-293T C283(1.26)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C283(1.48)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C283(1.26)  LDD0827  [7]
 LDCM0230  AC113 HCT 116 C283(0.95)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C283(0.93)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C283(0.94)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C283(0.90)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C283(0.93)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C283(1.04)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C283(1.13)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C283(1.02)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C283(1.16)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C283(0.93)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C283(1.02)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C283(1.17)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C283(0.99)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C283(1.00)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C283(0.97)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C283(1.00)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C283(0.97)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C283(1.18)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C283(1.17)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C283(1.04)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C283(1.50)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C283(1.26)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C283(1.38)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C283(1.23)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C283(1.37)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C283(1.38)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C283(1.61)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C283(1.68)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C283(0.89)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C283(1.77)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C283(1.69)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C283(1.28)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C283(0.80)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C283(1.07)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C283(0.76)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C283(0.92)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C283(0.72)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C283(0.56)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C283(0.87)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C283(0.91)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C283(0.68)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C283(1.02)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C283(0.58)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C283(0.67)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C283(0.64)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C283(0.87)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C283(0.62)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C283(0.63)  LDD2161  [7]
 LDCM0276  AC17 HEK-293T C283(0.93)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C283(0.93); C236(1.06)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C649(1.16); C283(1.05); C604(1.06)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C283(1.16)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C649(1.01); C283(0.98); C604(0.92)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C283(0.95); C604(0.96)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C649(0.93); C283(0.93); C236(0.77)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C283(0.93)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C283(0.87); C236(1.16)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C283(0.93)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C283(0.92); C236(0.95)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C649(1.02); C283(1.01); C604(1.00)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C649(1.09); C283(0.96); C604(0.87)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C283(0.96); C604(0.99)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C283(1.19)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C649(0.97); C283(0.95); C236(0.98)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C283(0.94)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C283(0.90); C236(0.74)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C283(0.81)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C283(0.91); C236(1.24)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C283(0.93)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C283(0.95)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C283(0.98)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C283(0.97)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C283(1.08)  LDD0898  [7]
 LDCM0301  AC4 HEK-293T C283(1.13)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C283(1.01)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C283(0.99)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C283(0.98)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C283(1.05)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C283(1.22)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C283(0.95)  LDD0905  [7]
 LDCM0308  AC46 HEK-293T C283(1.08)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C283(0.81)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C283(0.90)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C283(1.08)  LDD0909  [7]
 LDCM0312  AC5 HEK-293T C283(1.24)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C283(0.87)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C283(0.98)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C283(0.79)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C283(1.11)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C283(0.95)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C283(1.00)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C283(0.88)  LDD0917  [7]
 LDCM0320  AC57 PaTu 8988t C283(1.02)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C283(0.90)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C283(0.81)  LDD1201  [7]
 LDCM0323  AC6 HCT 116 C283(1.19)  LDD0640  [7]
 LDCM0324  AC60 PaTu 8988t C283(0.89)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C283(0.90)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C283(0.95)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C283(1.01)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C283(1.07)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C283(0.86)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C283(0.89)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C283(0.88)  LDD1210  [7]
 LDCM0332  AC68 HEK-293T C283(1.03)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C283(1.04)  LDD0931  [7]
 LDCM0334  AC7 HCT 116 C283(1.26)  LDD0651  [7]
 LDCM0335  AC70 HEK-293T C283(1.16)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C283(1.00)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C283(1.02)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C283(1.31)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C283(1.31)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C283(1.00)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C283(1.08)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C283(1.02)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C283(1.05)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C283(1.05)  LDD0942  [7]
 LDCM0345  AC8 HCT 116 C283(1.20)  LDD0662  [7]
 LDCM0346  AC80 HEK-293T C283(1.02)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C283(1.21)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C283(1.23)  LDD0946  [7]
 LDCM0349  AC83 HEK-293T C283(1.05)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C283(1.08)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C283(1.04)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C283(1.02)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C283(1.09)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C283(1.23)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C283(1.25)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C283(1.05)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C283(0.96)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C283(1.08)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C283(1.06)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C283(1.22)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C283(1.17)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C283(1.09)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C283(1.15)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C283(1.14)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C283(1.02)  LDD0964  [7]
 LDCM0248  AKOS034007472 HCT 116 C283(0.99)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C283(0.88)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C283(1.28)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C649(1.09); C283(0.97); C604(1.08)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C649(0.61); C283(1.67); C236(0.66)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C283(1.19)  LDD0967  [7]
 LDCM0370  CL101 HCT 116 C283(1.30)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C283(3.60)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C283(1.26)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C283(1.22)  LDD0690  [7]
 LDCM0374  CL105 HEK-293T C649(1.02); C283(0.92); C604(1.14)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C649(0.94); C283(1.04)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C283(0.98)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C283(0.93)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C649(0.87); C283(0.92); C604(1.00)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C283(1.68)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C649(1.12); C283(1.05)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C283(0.98)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C283(0.96)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C649(1.12); C283(0.91); C604(0.94)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C649(1.26); C283(1.02)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C283(0.94)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C283(0.95)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C283(1.05)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C283(0.88)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C283(1.08)  LDD0987  [7]
 LDCM0390  CL12 HEK-293T C283(1.45); C236(0.77)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C283(1.07)  LDD0989  [7]
 LDCM0392  CL121 HEK-293T C283(1.27)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C283(0.95)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C283(1.18)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C283(1.13)  LDD0993  [7]
 LDCM0396  CL125 PaTu 8988t C283(0.95)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C283(0.94)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C283(0.95)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C283(0.95)  LDD1278  [7]
 LDCM0400  CL13 HEK-293T C649(1.14); C283(1.00); C604(1.11)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C649(1.13); C283(1.00)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C283(1.15)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C283(0.87)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C283(0.71)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C283(0.97)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C283(1.00)  LDD1004  [7]
 LDCM0407  CL2 HEK-293T C649(1.17); C283(1.01)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C283(0.92)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C283(0.99)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C283(0.90)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C283(0.93)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C283(0.82)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C283(0.78)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C283(0.84)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C283(0.96)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C283(1.00)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C283(1.01)  LDD1015  [7]
 LDCM0418  CL3 HEK-293T C283(1.07)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C283(0.91)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C649(0.50); C283(1.15); C604(1.21)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C649(1.15); C283(1.16); C604(1.08)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C283(1.72); C604(1.41)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C649(0.57); C283(1.40); C236(1.08)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C283(1.65)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C283(1.43); C236(0.74)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C649(1.11); C283(0.95); C604(0.89)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C283(1.03)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C283(1.04)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C283(0.91)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C283(0.97)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C283(1.14); C236(1.14)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C649(0.46); C283(1.10); C604(1.09)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C649(1.21); C283(1.20); C604(1.11)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C283(1.37); C604(1.47)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C649(0.63); C283(1.31); C236(0.70)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C283(1.65)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C283(1.73); C236(1.41)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C649(1.01); C283(0.93); C604(0.92)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C283(0.97)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C649(1.19); C283(0.98)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C283(0.98)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C283(0.95)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C283(1.11); C236(1.20)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C649(0.48); C283(1.19); C604(1.24)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C649(1.20); C283(1.15); C604(1.15)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C283(1.54); C604(1.48)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C649(0.64); C283(1.33); C236(0.97)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C283(1.49)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C283(0.94); C236(1.04)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C283(1.59); C236(0.85)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C649(1.26); C283(0.91); C604(0.92)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C649(1.07); C283(0.98)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C283(0.94)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C283(1.06)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C283(0.97)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C283(0.93); C236(0.98)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C649(0.64); C283(1.08); C604(1.13)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C649(1.17); C283(1.13); C604(1.19)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C283(1.30); C604(1.57)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C649(0.71); C283(1.15); C604(1.12)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C649(0.70); C283(1.20); C236(1.11)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C283(1.44)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C283(1.45); C236(0.96)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C649(1.13); C283(0.93); C604(0.95)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C649(1.12); C283(0.88)  LDD1670  [8]
 LDCM0469  CL76 PaTu 8988t C283(1.72)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C283(1.34)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C283(1.52)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C283(1.18)  LDD1351  [7]
 LDCM0473  CL8 HEK-293T C649(1.10); C283(1.51); C604(1.06)  LDD1676  [8]
 LDCM0474  CL80 PaTu 8988t C283(1.41)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C283(1.61)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C283(1.68)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C283(1.33)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C283(2.16)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C283(1.10)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C283(1.35)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C283(1.88)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C283(1.57)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C283(1.90)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C283(1.42); C604(1.37)  LDD1687  [8]
 LDCM0485  CL90 PaTu 8988t C283(2.01)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C283(1.06)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C283(0.93)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C283(1.03)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C283(1.19)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C283(1.22)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C283(1.08)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C283(1.14)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C283(1.19)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C283(1.15)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C283(0.99)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C283(1.01)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C649(1.08); C283(0.98)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C283(0.96); C276(0.93)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C283(4.80)  LDD0209  [1]
 LDCM0024  KB05 MONO-MAC-6 C276(1.39)  LDD3335  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 131 kDa (CEP131) CEP131 family Q9UPN4
Rab GTPase-binding effector protein 2 (RABEP2) Rabaptin family Q9H5N1

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840