Details of the Target

General Information of Target

Target ID LDTP07752
Target Name Dual serine/threonine and tyrosine protein kinase (DSTYK)
Gene Name DSTYK
Gene ID 25778
Synonyms
KIAA0472; RIP5; RIPK5; SGK496; Dual serine/threonine and tyrosine protein kinase; EC 2.7.12.1; Dusty protein kinase; Dusty PK; RIP-homologous kinase; Receptor-interacting serine/threonine-protein kinase 5; Sugen kinase 496; SgK496
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN
HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD
CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH
QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL
VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER
SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK
ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI
VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL
ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM
LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF
AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR
GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY
NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL
KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY
ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG
IVQPMLQGIMNRLCKSNSEQPNRGLDDST
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular location
Cytoplasm
Function
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
Uniprot ID
Q6XUX3
Ensemble ID
ENST00000367161.7
HGNC ID
HGNC:29043
ChEMBL ID
CHEMBL1908386

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.Q160E .
HCT116 Deletion: p.G661AfsTer41
SNV: p.V666A		 .
HEC1 SNV: p.L745R .
HEC1B SNV: p.L745R .
HT115 SNV: p.K50T .
ICC4 SNV: p.Y157N .
IGR1 Insertion: p.L861HfsTer19 DBIA    Probe Info 
LNCaP clone FGC SNV: p.G891D .
MCC13 SNV: p.P686L .
NUGC3 SNV: p.L384M .
OAW42 SNV: p.S845F .
PATU8988T SNV: p.S703P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C855(20.00)  LDD2227  [1]
AHL-Pu-1
 Probe Info  		C320(2.94)  LDD0171  [2]
DBIA
 Probe Info  		C669(0.93); C678(0.93)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		13.60  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C320(2.94)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C586(0.85); C669(0.82); C678(1.29)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C586(1.13); C669(1.29); C678(2.02)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C586(0.91); C669(0.91)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C586(0.82); C669(0.82)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C586(0.92); C669(0.92)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C586(0.80); C669(0.80)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C586(0.87); C669(0.87)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C586(1.06); C669(1.06)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C586(0.96); C669(0.96)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C586(0.87); C669(0.87)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C586(0.86); C669(0.86)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C586(1.07); C669(1.07)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C586(1.13); C669(1.15); C678(1.36)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C586(0.86); C669(0.86)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C586(1.05); C669(1.05)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C586(0.91); C669(0.91)  LDD0827  [3]
 LDCM0230  AC113 PaTu 8988t C669(0.85); C678(0.85)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C669(0.71); C678(0.71)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C669(0.77); C678(0.77)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C669(0.67); C678(0.67)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C669(0.74); C678(0.74)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C669(0.86); C678(0.86)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C669(0.99); C678(0.99)  LDD1115  [3]
 LDCM0237  AC12 HEK-293T C586(0.87); C669(0.95); C678(1.42)  LDD0835  [3]
 LDCM0238  AC120 PaTu 8988t C669(0.80); C678(0.80)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C669(0.77); C678(0.77)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C669(0.90); C678(0.90)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C669(0.94); C678(0.94)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C669(1.01); C678(1.01)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C669(0.98); C678(0.98)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C669(0.79); C678(0.79)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C669(0.85); C678(0.85)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C586(1.26)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C586(0.97)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C586(0.84)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C586(0.70)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C586(0.75)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C586(0.66)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C586(0.71)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C586(0.75)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C586(0.73)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C586(0.71)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C586(0.65)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C586(0.72)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C586(0.88); C669(1.04); C678(1.99)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C586(0.82)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C586(0.77)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C586(0.93)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C586(1.09); C669(1.04)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C586(0.69); C669(1.08)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C586(0.96); C669(1.32)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C586(0.96); C669(1.14)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C586(0.96); C669(1.35)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C586(0.82); C669(0.98)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C586(0.76); C669(0.91)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C586(0.89); C669(1.05); C678(1.78)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C586(0.73); C669(1.00)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C586(1.10); C669(1.17)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C586(0.77); C669(0.93)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C586(0.86); C669(0.99)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C586(1.16); C669(1.21)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C586(0.74); C669(0.92)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C586(0.92); C669(1.12)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C586(0.80); C669(1.14)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C586(0.81); C669(0.65); C678(0.99)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C586(0.82); C669(0.54); C678(0.92)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C586(0.76); C669(0.65); C678(0.96)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C586(0.78); C669(0.82); C678(1.14)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C586(0.73); C669(0.64); C678(1.05)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C586(0.75); C669(0.75); C678(0.90)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C586(0.66); C669(0.51); C678(1.13)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C586(0.73); C669(0.64); C678(1.00)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C586(0.71); C669(0.77); C678(1.00)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C586(0.80); C669(0.80); C678(0.76)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C586(0.65); C669(0.65); C678(0.71)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C586(0.52); C669(0.52); C678(0.88)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C586(2.44); C669(2.44); C678(0.84)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C586(0.62); C669(0.62); C678(1.14)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C586(0.98); C669(0.89); C678(1.09)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C586(0.58); C669(0.58); C678(1.16)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C586(0.72); C669(0.72); C678(1.30)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C586(0.88); C669(0.88); C678(0.67)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C586(0.66); C669(0.66); C678(0.87)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C586(0.55); C669(0.55); C678(0.79)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C669(1.03); C678(1.03)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C669(1.08); C678(1.08)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C669(0.94); C678(0.94)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C669(1.04); C678(1.04)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C669(1.18); C678(1.18)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C586(1.08); C669(0.97); C678(1.51)  LDD0899  [3]
 LDCM0302  AC40 PaTu 8988t C669(1.23); C678(1.23)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C669(1.17); C678(1.17)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C669(1.12); C678(1.12)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C669(1.04); C678(1.04)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C669(1.10); C678(1.10)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C669(1.06); C678(1.06)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C586(1.34); C669(1.34)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C586(0.95); C669(0.95)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C586(1.21); C669(1.21)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C586(1.09); C669(1.09)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C586(0.76); C669(0.74); C678(1.01)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C586(1.02); C669(1.02)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C586(0.78); C669(0.78)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C586(0.81); C669(0.81)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C586(1.07); C669(1.07)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C586(0.75); C669(0.75)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C586(0.93); C669(0.93)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C586(0.91); C669(0.91)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C586(1.03); C669(1.00); C678(1.07)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C586(0.96); C669(0.92); C678(0.79)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C586(0.83); C669(0.87); C678(0.92)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C586(0.96); C669(0.96); C678(1.29)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C586(1.08); C669(0.95); C678(0.88)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C586(0.83); C669(0.91); C678(0.88)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C586(0.93); C669(0.87); C678(0.87)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C586(0.85); C669(0.91); C678(0.83)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C586(0.81); C669(0.82); C678(0.82)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C586(0.73); C669(0.86); C678(0.95)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C586(0.86); C669(0.93); C678(0.80)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C586(0.75); C669(0.91); C678(0.83)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C586(0.92); C669(0.97); C678(0.78)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C586(0.97); C669(0.97); C678(0.86)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C586(0.87); C669(0.96); C678(1.37)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C586(0.97); C669(1.04); C678(0.96)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C586(0.86); C669(0.95); C678(0.75)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C586(1.22); C669(1.15); C678(0.88)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C586(0.82); C669(1.02); C678(0.92)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C586(2.37); C669(1.70); C678(0.81)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C586(0.84); C669(1.02); C678(0.89)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C586(0.89); C669(0.93); C678(0.79)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C586(1.03); C669(1.02); C678(0.76)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C586(0.98); C669(0.95); C678(0.79)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C586(1.59); C669(1.28); C678(0.74)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C586(0.71); C669(0.84); C678(1.32)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C586(0.85); C669(0.96); C678(0.81)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C586(0.90); C669(0.97); C678(0.78)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C586(0.61); C669(0.76); C678(0.78)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C586(1.80)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C586(0.92)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C586(1.11)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C586(1.15)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C586(1.56)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C586(1.06)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C586(1.26)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C586(1.00)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C586(0.68)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C586(1.14)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C586(0.69)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C586(0.82)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C586(1.17)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C586(0.97)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C586(1.39)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C586(1.24); C669(1.24)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C586(0.85); C669(0.85)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C586(1.07); C669(1.03); C678(1.28)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C586(0.77); C669(1.00); C678(2.61)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C586(0.75); C669(0.99); C678(1.52)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C669(0.93); C678(0.93)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C855(20.00)  LDD2227  [1]
 LDCM0367  CL1 HEK-293T C586(1.00); C669(0.93)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C586(0.99); C669(1.48)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C586(0.87); C669(0.83); C678(1.42)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C586(0.93); C669(0.95); C678(1.82)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C586(0.89); C669(0.92); C678(1.73)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C586(1.05); C669(1.20); C678(1.33)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C586(0.79); C669(1.00); C678(3.07)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C586(0.76); C669(0.92); C678(1.02)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C586(0.72); C669(0.70); C678(0.95)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C586(0.57); C669(0.51); C678(0.89)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C586(0.91); C669(0.87); C678(1.00)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C586(0.93); C669(0.98); C678(0.99)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C586(0.85); C669(1.09)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C586(0.79); C669(0.68); C678(1.21)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C586(0.75); C669(0.89); C678(0.98)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C586(0.46); C669(0.46); C678(0.88)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C586(0.68); C669(0.68); C678(1.18)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C586(2.41); C669(2.41); C678(0.96)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C586(0.88); C669(0.88); C678(1.21)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C586(0.69); C669(0.69); C678(0.96)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C669(1.03); C678(1.03)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C669(0.99); C678(0.99)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C669(1.03); C678(1.03)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C586(0.87); C669(0.84)  LDD0988  [3]
 LDCM0391  CL120 PaTu 8988t C669(1.21); C678(1.21)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C586(0.93); C669(0.93)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C586(0.86); C669(0.86)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C586(1.42); C669(1.42)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C586(1.39); C669(1.39)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C586(1.14); C669(1.00); C678(1.05)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C586(1.09); C669(1.10); C678(1.01)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C586(1.15); C669(1.03); C678(0.93)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C586(1.00); C669(1.00); C678(0.93)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C586(0.92); C669(0.95)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C586(1.31); C669(1.27)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C586(0.83); C669(0.80)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C586(1.23); C669(1.13); C678(1.10)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C586(1.22); C669(1.11); C678(1.04)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C586(0.83); C669(0.99); C678(1.10)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C586(1.48); C669(1.27); C678(1.00)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C586(1.04); C669(1.01)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C586(1.21); C669(1.23); C678(1.17)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C586(1.43); C669(1.34); C678(1.27)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C586(1.13); C669(1.23); C678(1.25)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C586(1.04); C669(1.09); C678(1.11)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C586(0.97); C669(1.16); C678(1.28)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C586(1.01); C669(1.20); C678(1.41)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C586(2.34); C669(1.73); C678(1.12)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C586(1.79); C669(1.43); C678(1.15)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C586(1.12); C669(1.18); C678(1.32)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C586(0.95); C669(1.07); C678(1.16)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C586(1.47); C669(1.73)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C586(0.90); C669(1.07); C678(1.12)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C586(0.89); C669(0.89)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C586(1.68); C669(1.68)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C586(0.79); C669(0.79)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C586(1.18); C669(1.18)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C586(0.76); C669(0.76)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C586(1.93); C669(1.93)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C586(1.47); C669(1.47)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C586(0.89); C669(0.89)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C586(1.07); C669(1.16)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C586(0.82); C669(0.82)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C586(0.64); C669(0.64)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C586(0.65); C669(0.65)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C586(0.75); C669(0.75)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C586(1.21); C669(1.21)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C586(0.67); C669(0.67)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C669(0.75)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C669(1.00)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C669(0.83)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C669(1.17)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C586(0.78); C669(0.90)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C669(1.05)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C669(0.75)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C669(1.34)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C669(1.01)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C669(1.13)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C669(0.78)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C669(0.77)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C669(0.76)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C669(0.92)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C669(1.07)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C586(1.01); C669(0.99)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C669(1.19)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C586(0.81); C669(0.78)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C586(1.20); C669(1.18)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C586(0.79); C669(0.84)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C586(1.40); C669(1.20)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C586(0.75); C669(0.90)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C586(1.37); C669(1.49)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C586(0.94); C669(1.11)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C586(1.12); C669(1.30)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C586(1.37); C669(1.22)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C586(0.86); C669(1.02)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C586(1.20); C669(1.48)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C586(1.00); C669(1.13)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C586(1.14); C669(1.15)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C586(1.02); C669(1.10)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C586(0.85); C669(1.22)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C586(1.18); C669(1.11); C678(0.90)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C586(1.08); C669(1.26); C678(0.70)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C586(0.96); C669(1.01); C678(0.70)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C586(1.06); C669(1.05); C678(0.77)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C586(0.94); C669(0.83)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C586(0.95); C669(1.06); C678(0.87)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C586(1.58); C669(1.66); C678(0.73)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C586(1.65); C669(1.89); C678(0.91)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C586(1.11); C669(1.24); C678(1.18)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C586(0.84); C669(0.73); C678(0.88)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C586(0.82); C669(0.88); C678(0.64)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C586(0.79); C669(0.90); C678(0.72)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C586(1.31); C669(1.16); C678(0.86)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C586(0.95); C669(0.93); C678(0.96)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C586(1.22); C669(1.48); C678(0.79)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C586(0.98); C669(1.41)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C586(1.87); C669(1.91); C678(1.17)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C586(1.10); C669(1.05); C678(1.12)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C586(1.19); C669(0.91); C678(1.68)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C586(1.16); C669(1.09); C678(1.37)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C586(0.69); C669(0.73); C678(2.21)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C586(0.69); C669(0.68); C678(1.67)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C586(0.81); C669(0.77); C678(1.57)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C586(1.06); C669(0.92); C678(1.35)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C586(1.25); C669(1.14); C678(1.53)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C586(0.98); C669(0.85); C678(1.72)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C125(0.86); C93(1.29); C669(0.93)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C586(1.06); C669(1.24)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C586(1.16); C669(1.16)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C148(1.07)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C148(1.06)  LDD1497  [7]
 LDCM0024  KB05 UACC257 C586(5.51)  LDD3325  [8]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840