Details of the Target

General Information of Target

Target ID LDTP07678
Target Name Dehydrogenase/reductase SDR family member 11 (DHRS11)
Gene Name DHRS11
Gene ID 79154
Synonyms
SDR24C1; Dehydrogenase/reductase SDR family member 11; 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; EC 1.1.1.270; Estradiol 17-beta-dehydrogenase; EC 1.1.1.62; Short-chain dehydrogenase/reductase family 24C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGY
PGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNV
NVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGL
RQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVL
STPAHIQIGDIQMRPTEQVT
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Secreted
Function
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
Uniprot ID
Q6UWP2
Ensemble ID
ENST00000611337.4
HGNC ID
HGNC:28639

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.T169A .
KMCH1 SNV: p.Y133C DBIA    Probe Info 
NCIH2286 SNV: p.G109C .
NCIH716 SNV: p.Y60Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y166(6.95)  LDD0257  [1]
TH216
 Probe Info  		Y166(14.01)  LDD0259  [1]
DBIA
 Probe Info  		C195(1.76)  LDD3335  [2]
BTD
 Probe Info  		C41(0.58)  LDD2093  [3]
HHS-482
 Probe Info  		Y166(0.91)  LDD0285  [4]
IPM
 Probe Info  		C94(3.75)  LDD1701  [3]
HHS-465
 Probe Info  		Y166(9.32)  LDD2237  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C69(0.00); C55(0.00); C195(0.00); C226(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C195(0.00); C69(0.00); C55(0.00); C226(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C69(0.00); C195(0.00); C226(0.00)  LDD0037  [6]
NAIA_5
 Probe Info  		C41(0.00); C226(0.00); C55(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C226(0.92)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C226(1.33)  LDD1508  [8]
 LDCM0276  AC17 HEK-293T C226(0.98)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C226(0.98)  LDD1516  [8]
 LDCM0279  AC2 HEK-293T C226(0.98)  LDD1518  [8]
 LDCM0285  AC25 HEK-293T C226(1.02)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C226(1.06)  LDD1525  [8]
 LDCM0294  AC33 HEK-293T C226(1.12)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C226(0.94)  LDD1534  [8]
 LDCM0303  AC41 HEK-293T C226(1.08)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C226(1.12)  LDD1543  [8]
 LDCM0311  AC49 HEK-293T C226(1.13)  LDD1550  [8]
 LDCM0313  AC50 HEK-293T C226(1.07)  LDD1552  [8]
 LDCM0320  AC57 HEK-293T C226(0.93)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C226(1.03)  LDD1560  [8]
 LDCM0356  AKOS034007680 HEK-293T C226(1.09)  LDD1570  [8]
 LDCM0369  CL100 HEK-293T C226(1.18)  LDD1573  [8]
 LDCM0371  CL102 HEK-293T C226(1.14)  LDD1575  [8]
 LDCM0373  CL104 HEK-293T C226(0.99)  LDD1577  [8]
 LDCM0375  CL106 HEK-293T C226(1.19)  LDD1579  [8]
 LDCM0377  CL108 HEK-293T C226(0.89)  LDD1581  [8]
 LDCM0380  CL110 HEK-293T C226(1.04)  LDD1584  [8]
 LDCM0382  CL112 HEK-293T C226(1.29)  LDD1586  [8]
 LDCM0384  CL114 HEK-293T C226(1.48)  LDD1588  [8]
 LDCM0386  CL116 HEK-293T C226(1.17)  LDD1590  [8]
 LDCM0388  CL118 HEK-293T C226(1.02)  LDD1592  [8]
 LDCM0391  CL120 HEK-293T C226(1.01)  LDD1595  [8]
 LDCM0393  CL122 HEK-293T C226(0.92)  LDD1597  [8]
 LDCM0395  CL124 HEK-293T C226(1.26)  LDD1599  [8]
 LDCM0397  CL126 HEK-293T C226(0.98)  LDD1601  [8]
 LDCM0399  CL128 HEK-293T C226(0.91)  LDD1603  [8]
 LDCM0401  CL14 HEK-293T C226(1.12)  LDD1605  [8]
 LDCM0403  CL16 HEK-293T C226(0.90)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C226(0.97)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C226(1.09)  LDD1609  [8]
 LDCM0407  CL2 HEK-293T C226(0.94)  LDD1611  [8]
 LDCM0414  CL26 HEK-293T C226(1.05)  LDD1618  [8]
 LDCM0416  CL28 HEK-293T C226(1.10)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C226(0.85)  LDD1621  [8]
 LDCM0419  CL30 HEK-293T C226(1.03)  LDD1623  [8]
 LDCM0429  CL4 HEK-293T C226(1.03)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C226(1.09)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C226(1.21)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C226(1.05)  LDD1636  [8]
 LDCM0440  CL5 HEK-293T C226(0.86)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C226(1.09)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C226(0.93)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C226(1.17)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C226(1.17)  LDD1648  [8]
 LDCM0451  CL6 HEK-293T C226(1.14)  LDD1654  [8]
 LDCM0454  CL62 HEK-293T C226(1.03)  LDD1657  [8]
 LDCM0456  CL64 HEK-293T C226(1.16)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C226(1.17)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C226(1.86)  LDD1661  [8]
 LDCM0467  CL74 HEK-293T C226(0.88)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C226(1.07)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C226(1.02)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C226(1.05)  LDD1674  [8]
 LDCM0480  CL86 HEK-293T C226(1.12)  LDD1683  [8]
 LDCM0482  CL88 HEK-293T C226(1.18)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C226(0.85)  LDD1686  [8]
 LDCM0485  CL90 HEK-293T C226(1.36)  LDD1688  [8]
 LDCM0493  CL98 HEK-293T C226(1.26)  LDD1696  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C41(3.56); C55(1.80)  LDD1702  [3]
 LDCM0427  Fragment51 HEK-293T C226(1.09)  LDD1631  [8]
 LDCM0123  JWB131 DM93 Y166(0.91)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y166(0.42)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y166(1.20)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y166(2.69)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y166(1.13)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y166(0.54)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y166(0.17)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y166(0.82)  LDD0292  [4]
 LDCM0022  KB02 A204 C226(4.00)  LDD2252  [2]
 LDCM0023  KB03 MDA-MB-231 C94(3.75)  LDD1701  [3]
 LDCM0024  KB05 MONO-MAC-6 C195(1.76)  LDD3335  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C41(0.58)  LDD2093  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C41(0.79)  LDD2101  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C41(0.50)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C41(0.96)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C41(0.62)  LDD2115  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C41(0.67)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C41(0.59)  LDD2125  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C41(0.66)  LDD2133  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C41(0.86)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C41(0.49)  LDD2140  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C41(1.16)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disks large homolog 3 (DLG3) MAGUK family Q92796

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nicotinamide Adenine Dinucleotide Phosphate . DB03461

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402