Details of the Target

General Information of Target

Target ID LDTP07666
Target Name Protein O-glucosyltransferase 2 (POGLUT2)
Gene Name POGLUT2
Gene ID 79070
Synonyms
EP58; KDELC1; Protein O-glucosyltransferase 2; EC 2.4.1.-; Endoplasmic reticulum resident protein 58; ER protein 58; ERp58; KDEL motif-containing protein 1; Protein O-xylosyltransferase POGLUT2; EC 2.4.2.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFGTLLLYCFFLATVPALAETGGERQLSPEKSEIWGPGLKADVVLPARYFYIQAVDTSGN
KFTSSPGEKVFQVKVSAPEEQFTRVGVQVLDRKDGSFIVRYRMYASYKNLKVEIKFQGQH
VAKSPYILKGPVYHENCDCPLQDSAAWLREMNCPETIAQIQRDLAHFPAVDPEKIAVEIP
KRFGQRQSLCHYTLKDNKVYIKTHGEHVGFRIFMDAILLSLTRKVKMPDVELFVNLGDWP
LEKKKSNSNIHPIFSWCGSTDSKDIVMPTYDLTDSVLETMGRVSLDMMSVQANTGPPWES
KNSTAVWRGRDSRKERLELVKLSRKHPELIDAAFTNFFFFKHDENLYGPIVKHISFFDFF
KHKYQINIDGTVAAYRLPYLLVGDSVVLKQDSIYYEHFYNELQPWKHYIPVKSNLSDLLE
KLKWAKDHDEEAKKIAKAGQEFARNNLMGDDIFCYYFKLFQEYANLQVSEPQIREGMKRV
EPQTEDDLFPCTCHRKKTKDEL
Target Bioclass
Enzyme
Family
KDELC family
Subcellular location
Endoplasmic reticulum lumen
Function
Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway.
Uniprot ID
Q6UW63
Ensemble ID
ENST00000376004.5
HGNC ID
HGNC:19350

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K195(10.00)  LDD0275  [1]
Acrolein
 Probe Info  		C257(0.00); H204(0.00)  LDD0222  [2]
DBIA
 Probe Info  		C491(1.09); C493(1.09)  LDD0533  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
JW-RF-010
 Probe Info  		C493(0.00); C491(0.00)  LDD0026  [7]
TFBX
 Probe Info  		C491(0.00); C493(0.00)  LDD0027  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C153(1.07); C257(1.07); C454(0.93); C139(1.25)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C257(0.69)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C491(1.09); C493(1.09)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C491(0.92); C493(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C491(1.09); C493(1.09)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C491(0.76); C493(0.76)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C491(0.65); C493(0.65)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C491(0.62); C493(0.62)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C491(0.80); C493(0.80)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C491(0.50); C493(0.50)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C491(1.14); C493(1.14)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C491(0.98); C493(0.98)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C257(1.25)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C491(0.72); C493(0.72)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C491(0.80); C493(0.80)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C491(0.82); C493(0.82)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C491(1.05); C493(1.05)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C491(0.89); C493(0.76)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C491(0.95); C493(0.81)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C491(1.02); C493(0.97)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C491(0.89); C493(1.33)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C491(1.05); C493(1.17)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C491(0.92); C493(1.04)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C257(0.89)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C491(0.88); C493(0.85)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C491(1.03); C493(1.24)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C491(0.81); C493(0.75)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C491(0.79); C493(1.09)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C491(1.07); C493(0.98)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C491(0.92); C493(0.76)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C491(0.99); C493(0.82)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C491(0.98); C493(0.97)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C491(0.36); C493(0.36)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C491(0.80); C493(0.80)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C491(0.75); C493(0.75)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C491(1.57); C493(1.57)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C491(0.96); C493(0.96)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C491(0.66); C493(0.66)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C491(0.80); C493(0.80)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C491(0.69); C493(0.69)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C491(0.67); C493(0.67)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C491(0.78); C493(0.78)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C491(0.71); C493(0.71)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C491(1.11); C493(1.11)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C257(1.11)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C491(0.74); C493(0.74)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C491(0.86); C493(0.86)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C491(1.15); C493(1.15)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C491(1.31); C493(1.31)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C491(0.97); C493(0.97)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C491(0.76); C493(0.76)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C491(1.33); C493(1.33)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C491(0.86); C493(0.86)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C491(0.23); C493(0.23)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C491(0.67); C493(0.67)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C257(1.16)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C491(1.28); C493(1.28)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C491(1.23); C493(1.23)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C491(0.55); C493(0.55)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C491(0.18); C493(0.18)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C491(1.17); C493(1.17)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C491(2.61); C493(2.61)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C491(1.13); C493(1.13)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C491(1.05); C493(1.05)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C137(0.99)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C137(0.82)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C137(0.96)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C190(1.03); C153(1.10); C454(0.98); C139(1.14)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C137(0.97)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C137(0.92)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C137(1.01)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C137(0.98)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C137(0.97)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C153(1.05); C257(1.04); C454(1.27); C139(1.30)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C190(1.08); C153(1.09); C454(1.08); C139(0.96)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C190(1.01); C153(1.10); C257(0.93); C454(0.99)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C190(1.06); C153(1.02); C257(0.97)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C190(1.07); C153(1.02); C257(1.11); C139(1.05)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C190(0.91); C153(1.04); C257(1.00); C454(0.82)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C190(1.12); C153(1.05); C257(1.06); C454(1.07)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C190(1.17); C153(1.08); C257(1.16); C139(0.98)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C190(0.94); C153(1.00); C257(1.01); C454(1.45)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C153(0.97); C257(1.03); C454(1.25); C139(1.22)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C190(0.94); C153(1.07); C454(0.98); C139(1.09)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C190(0.99); C153(1.04); C257(0.99); C454(1.03)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C190(1.06); C153(1.02); C257(0.97)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C190(1.13); C153(1.02); C257(1.07); C139(0.99)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C190(1.13); C153(0.99); C257(1.03); C454(1.06)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C190(1.02); C153(1.05); C257(1.13); C139(1.03)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C190(1.03); C153(0.98); C257(0.92)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C190(1.10); C153(0.94); C257(1.21); C454(1.22)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C153(1.08); C257(1.03); C454(1.19); C139(1.60)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C190(0.92); C153(1.16); C454(1.07); C139(0.95)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C190(0.96); C153(1.07); C257(1.01); C454(0.98)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C190(0.91); C153(1.11); C257(1.05)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C190(1.04); C153(1.02); C257(1.14); C139(1.16)  LDD1546  [8]
 LDCM0308  AC46 HCT 116 C491(1.13); C493(1.13)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C491(1.12); C493(1.12)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C491(1.29); C493(1.29)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C491(0.44); C493(0.44)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C190(1.07); C153(1.02); C257(1.13); C139(0.91)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C491(0.52); C493(0.52)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C491(2.35); C493(2.35)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C491(1.21); C493(1.21)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C491(0.87); C493(0.87)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C491(0.72); C493(0.72)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C491(0.50); C493(0.50)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C491(0.35); C493(0.35)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C491(0.73); C493(0.73)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C491(0.70); C493(0.70)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C491(0.48); C493(0.48)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C257(0.82)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C491(0.63); C493(0.63)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C491(0.69); C493(0.69)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C491(0.32); C493(0.32)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C491(0.77); C493(0.77)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C491(0.39); C493(0.39)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C491(0.35); C493(0.35)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C491(0.41); C493(0.41)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C491(0.08); C493(0.08)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C257(1.18)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C257(0.85)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C257(0.90)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C257(0.65)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C257(0.64)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C257(1.28)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C257(1.37)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C257(0.88)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C257(0.49)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C257(0.82)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C257(2.23)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C257(0.79)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C257(0.63)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C257(0.86)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C257(0.75)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C257(0.72)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C257(0.78)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C491(0.61); C493(0.61)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C491(0.68); C493(0.68)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C491(0.91); C493(0.91)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C491(1.25); C493(1.25)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C491(1.13); C493(1.13)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C491(1.09); C493(1.09)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C491(0.81); C493(0.81)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C491(1.21); C493(1.21)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C491(0.80); C493(0.80)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C491(0.77); C493(0.77)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C491(1.01); C493(1.01)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C491(1.00); C493(1.00)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C491(1.09); C493(1.09)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C491(1.12); C493(1.12)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C491(0.82); C493(0.82)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C491(0.21); C493(0.21)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C491(1.22); C493(1.22)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C257(0.73)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C257(0.97)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C257(0.76)  LDD0873  [3]
 LDCM0108  Chloroacetamide HeLa C257(0.00); H204(0.00)  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C257(0.89)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C257(1.90)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C190(0.64); C153(0.99); C454(1.08); C139(1.05)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C257(1.40)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C257(0.65)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C257(1.12)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C257(0.81)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C137(0.91)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C137(1.04)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C137(0.82)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C137(0.93)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C137(0.97)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C257(0.92)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C137(0.95)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C137(0.89)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C190(0.90); C153(0.96); C454(1.21); C139(1.31)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C190(0.85); C153(1.03); C257(1.06); C454(1.00)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C190(1.20); C153(1.01); C454(0.84); C139(0.90)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C190(0.98); C153(1.11); C257(1.08); C454(0.98)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C190(0.71); C153(1.06); C454(1.17); C139(1.20)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C190(0.91); C153(1.01); C257(1.06); C454(1.16)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C190(1.15); C153(0.95); C454(1.33); C139(0.82)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C190(0.94); C153(1.01); C257(0.99); C454(1.14)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C257(0.95)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C190(1.00); C153(1.08); C454(1.23); C139(0.98)  LDD1595  [8]
 LDCM0392  CL121 HCT 116 C491(1.06); C493(1.06)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C491(0.91); C493(0.91)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C491(0.87); C493(0.87)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C491(0.49); C493(0.49)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C491(0.81); C493(0.81)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C491(0.89); C493(0.89)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C491(0.99); C493(0.99)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C491(0.58); C493(0.58)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C257(0.69)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C257(0.57)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C257(0.86)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C257(1.45)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C257(1.24)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C257(1.32)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C257(1.17)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C257(0.78)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C257(1.55)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C257(1.59)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C257(1.89)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C257(1.60)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C257(1.40)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C257(1.57)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C257(1.70)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C257(1.53)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C257(1.84)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C257(2.11)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C257(0.51)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C257(1.94)  LDD1017  [3]
 LDCM0420  CL31 PaTu 8988t C454(1.10)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C454(1.03)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C454(0.91)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C454(0.89)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C454(0.84)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C454(0.86)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C454(0.55)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C454(0.82)  LDD1307  [3]
 LDCM0429  CL4 HEK-293T C257(0.69)  LDD1027  [3]
 LDCM0430  CL40 PaTu 8988t C454(1.05)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C454(0.72)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C454(0.38)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C454(0.23)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C454(0.75)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C454(0.98)  LDD1314  [3]
 LDCM0436  CL46 HEK-293T C257(0.58)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C257(0.70)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C257(1.07)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C257(0.56)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C257(0.69)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C257(1.10)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C257(1.00)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C257(0.66)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C257(0.70)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C257(1.12)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C257(1.23)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C257(0.87)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C257(0.57)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C257(1.22)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C257(0.85)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C257(0.63)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C257(0.85)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C257(1.71)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C257(1.58)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C257(0.79)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C257(1.20)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C257(1.36)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C257(1.27)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C257(0.95)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C257(1.10)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C257(2.02)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C257(0.64)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C257(1.07)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C257(1.30)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C257(0.92)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C257(1.87)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C257(2.12)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C190(0.91); C153(1.03); C454(1.20); C139(1.22)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C153(1.24); C257(1.05); C454(0.98); C139(1.33)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C190(0.91); C153(0.97); C454(1.01); C139(1.02)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C190(0.97); C153(1.08); C257(0.97); C454(1.07)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C257(0.85)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C190(0.86); C153(0.95); C257(0.95)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C190(0.91); C153(1.08); C257(1.10); C139(1.19)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C190(1.05); C153(1.10); C257(0.91); C454(0.86)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C190(0.96); C153(1.11); C257(1.22); C139(0.87)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C190(0.84); C153(1.00); C257(1.22); C454(0.87)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C190(0.70); C153(1.03); C257(0.93); C454(1.01)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C190(0.75); C153(0.98); C454(0.97); C139(0.90)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C190(0.82); C153(1.08); C257(0.88); C454(1.00)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C190(0.64); C153(1.14); C454(1.09); C139(1.23)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C153(1.11); C257(1.00); C454(1.05); C139(1.07)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C257(1.21)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C190(0.95); C153(2.32); C454(1.42); C139(1.98)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C190(0.77); C153(1.31); C257(0.79); C454(0.98)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C190(0.86); C153(1.12); C257(0.89)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C190(0.82); C153(1.15); C257(1.10); C139(1.11)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C190(1.02); C153(1.08); C257(1.00); C454(0.99)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C190(1.16); C153(1.27); C257(1.27); C139(1.56)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C190(0.70); C153(1.10); C257(0.99); C454(1.15)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C190(0.86); C153(1.09); C257(0.99); C454(1.17)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C190(1.08); C153(1.02); C454(0.95); C139(1.13)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C190(1.09); C153(1.05); C257(0.97); C454(0.99)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C190(1.21); C153(1.15); C257(1.04); C454(1.06)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C257(1.15)  LDD1066  [3]
 LDCM0427  Fragment51 PaTu 8988t C454(0.64)  LDD1306  [3]
 LDCM0022  KB02 HEK-293T C153(0.82); C454(0.97)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C153(0.96); C454(1.05)  LDD1497  [8]
 LDCM0024  KB05 OCUG-1 C153(1.66)  LDD3373  [9]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840