Details of the Target

General Information of Target

Target ID LDTP07485
Target Name Pre-mRNA-processing factor 40 homolog B (PRPF40B)
Gene Name PRPF40B
Gene ID 25766
Synonyms
HYPC; Pre-mRNA-processing factor 40 homolog B; Huntingtin yeast partner C; Huntingtin-interacting protein C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGILPPMLPPMGAPPPLTQIPGMVP
PMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVW
EKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQSKESRWTRPKDLDDLEVLVKQEAAG
KQQQQLPQTLQPQPPQPQPDPPPVPPGPTPVPTGLLEPEPGGSEDCDVLEATQPLEQGFL
QQLEEGPSSSGQHQPQQEEEESKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQ
AMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKEEKEEARLRAKEAKQTLQHFLEQHERM
TSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDVLFFLAKKEKEQAKQLRRRNIQALKSI
LDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQNMDKEDALICFEEHIRALEREEEEERE
RARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYPAVSTDVRFANMLGQPGSTP
LDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVISFDKRAAALDAGNI
KLTFNSLLEKAEAREREREKEEARRMRRREAAFRSMLRQAVPALELGTAWEEVRERFVCD
SAFEQITLESERIRLFREFLQVLEQTECQHLHTKGRKHGRKGKKHHHKRSHSPSGSESEE
EELPPPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGSPSSHLLGADHGLRKAK
KPKKKTKKRRHKSNSPESETDPEEKAGKESDEKEQEQDKDRELQQAELPNRSPGFGIKKE
KTGWDTSESELSEGELERRRRTLLQQLDDHQ
Target Bioclass
Other
Family
PRPF40 family
Subcellular location
Nucleus speckle
Function May be involved in pre-mRNA splicing.
Uniprot ID
Q6NWY9
Ensemble ID
ENST00000261897.5
HGNC ID
HGNC:25031

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C463(0.08)  LDD2145  [2]
DBIA
 Probe Info  		C137(1.60)  LDD0080  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C137(0.79)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C137(0.96)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C137(1.02)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C137(1.21)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C137(1.05)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C137(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C137(1.11)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C137(1.02)  LDD1510  [4]
 LDCM0238  AC120 HCT 116 C137(1.16)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C137(0.80)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C137(0.85)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C137(0.89)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C137(0.87)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C137(0.98)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C137(1.11)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C137(0.98)  LDD0562  [3]
 LDCM0280  AC20 HEK-293T C137(0.87)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C137(1.17)  LDD1520  [4]
 LDCM0284  AC24 HEK-293T C137(1.06)  LDD1523  [4]
 LDCM0285  AC25 HCT 116 C137(0.93)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C137(0.88)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C137(0.77)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C137(0.85)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C137(0.92)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C137(0.96)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C137(1.04)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C137(0.88)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C137(1.18)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C137(1.27)  LDD0612  [3]
 LDCM0297  AC36 HEK-293T C137(0.83)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C137(1.05)  LDD1537  [4]
 LDCM0301  AC4 HEK-293T C137(1.11)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C137(1.16)  LDD1541  [4]
 LDCM0306  AC44 HEK-293T C137(1.18)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C137(1.13)  LDD1546  [4]
 LDCM0310  AC48 HEK-293T C137(1.00)  LDD1549  [4]
 LDCM0312  AC5 HEK-293T C137(1.19)  LDD1551  [4]
 LDCM0315  AC52 HEK-293T C137(0.96)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C137(1.02)  LDD1555  [4]
 LDCM0319  AC56 HEK-293T C137(1.04)  LDD1558  [4]
 LDCM0320  AC57 HCT 116 C137(1.14)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C137(1.12)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C137(1.28)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C137(1.21)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C137(1.06)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C137(1.15)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C137(1.04)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C137(1.24)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C137(1.17)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C137(1.22)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C137(1.03)  LDD0648  [3]
 LDCM0345  AC8 HEK-293T C137(0.96)  LDD1569  [4]
 LDCM0349  AC83 HCT 116 C137(1.10)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C137(1.22)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C137(1.23)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C137(1.19)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C137(1.04)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C137(1.22)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C137(1.26)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C137(1.06)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C137(1.06)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C137(1.22)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C137(1.23)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C137(1.17)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C137(1.21)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C137(1.20)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C137(1.27)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C137(1.12)  LDD1511  [4]
 LDCM0275  AKOS034007705 HEK-293T C137(1.07)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C137(0.89)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C137(1.02)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C137(0.98)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C137(0.93)  LDD1582  [4]
 LDCM0382  CL112 HCT 116 C137(1.20)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C137(0.78)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C137(1.12)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C137(1.47)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C137(0.98)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C137(1.06)  LDD1591  [4]
 LDCM0390  CL12 HEK-293T C137(0.96)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C137(0.94)  LDD1596  [4]
 LDCM0396  CL125 HCT 116 C137(0.94)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C137(0.92)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C137(0.91)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C137(1.16)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C137(0.95)  LDD1604  [4]
 LDCM0403  CL16 HCT 116 C137(0.91)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C137(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C137(1.09)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C137(0.99)  LDD0723  [3]
 LDCM0408  CL20 HCT 116 C137(1.14)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C137(1.18)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C137(1.48)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C137(0.96)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C137(1.17)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C137(1.13)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C137(1.00)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C137(0.99)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C137(1.09)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C137(1.17)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C137(1.03)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C137(1.09)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C137(1.06)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C137(1.42)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C137(1.33)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C137(1.18)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C137(1.41)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C137(1.23)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C137(1.57)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C137(1.17)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C137(1.28)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C137(1.54)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C137(1.41)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C137(1.36)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C137(1.49)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C137(0.73)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C137(0.73)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C137(0.69)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C137(0.80)  LDD0756  [3]
 LDCM0441  CL50 HCT 116 C137(0.71)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C137(0.73)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C137(0.75)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C137(0.72)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C137(0.72)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C137(0.66)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C137(0.87)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C137(0.91)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C137(0.72)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C137(0.78)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C137(0.87)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C137(1.08)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C137(1.16)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C137(1.27)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C137(1.54)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C137(1.33)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C137(1.90)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C137(1.60)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C137(1.45)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C137(1.05)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C137(1.21)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C137(1.49)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C137(1.29)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C137(1.34)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C137(1.38)  LDD0784  [3]
 LDCM0473  CL8 HEK-293T C137(0.84)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C137(0.99)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C137(1.23)  LDD1678  [4]
 LDCM0478  CL84 HEK-293T C137(1.04)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C137(0.98)  LDD1682  [4]
 LDCM0484  CL9 HEK-293T C137(1.14)  LDD1687  [4]
 LDCM0487  CL92 HEK-293T C137(1.28)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C137(1.14)  LDD1691  [4]
 LDCM0491  CL96 HEK-293T C137(0.94)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C137(0.73)  LDD1695  [4]
 LDCM0468  Fragment33 HCT 116 C137(1.34)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C137(1.46)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C137(1.60)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C137(1.29)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C137(1.23)  LDD0082  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C463(0.08)  LDD2145  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402