Details of the Target

General Information of Target

Target ID LDTP07334
Target Name Zinc finger protein 57 (ZNF57)
Gene Name ZNF57
Gene ID 126295
Synonyms
ZNF424; Zinc finger protein 57; Zinc finger protein 424
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFRNLASVDDGTQFKANGSVSLQDM
YGQEKSKEQTIPNFTGNNSCAYTLEKNCEGYGTEDHHKNLRNHMVDRFCTHNEGNQYGEA
IHQMPDLTLHKKVSAGEKPYECTKCRTVFTHLSSLKRHVKSHCGRKAPPGEECKQACICP
SHLHSHGRTDTEEKPYKCQACGQTFQHPRYLSHHVKTHTAEKTYKCEQCRMAFNGFASFT
RHVRTHTKDRPYKCQECGRAFIYPSTFQRHMTTHTGEKPYKCQHCGKAFTYPQAFQRHEK
THTGEKPYECKQCGKTFSWSETLRVHMRIHTGDKLYKCEHCGKAFTSSRSFQGHLRTHTG
EKPYECKQCGKAFTWSSTFREHVRIHTQEQLYKCEQCGKAFTSSRSFRGHLRTHTGEKPY
ECKQCGKTFTWSSTFREHVRIHTQEQLHKCEHCGKAFTSSRAFQGHLRMHTGEKPYECKQ
CGKTFTWSSTLHNHVRMHTGEKPHKCKQCGMSFKWHSSFRNHLRMHTGQKSHECQSYSKA
FSCQVILSKTSESTH
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q68EA5
Ensemble ID
ENST00000306908.10
HGNC ID
HGNC:13125

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C310(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C80(0.77)  LDD0533  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C310(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C310(2.25)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C534(1.15)  LDD1507  [3]
 LDCM0216  AC100 HCT 116 C80(0.77)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C80(1.00)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C80(0.96)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C80(0.99)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C80(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C80(0.83)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C80(0.90)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C80(0.91)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C80(0.84)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C80(0.99)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C80(0.98)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C80(1.18)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C80(1.24)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C80(0.85)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C80(0.83)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C80(0.97)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C80(0.85)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C80(0.86)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C80(0.91)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C80(0.86)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C534(1.00)  LDD1510  [3]
 LDCM0238  AC120 HCT 116 C80(1.18)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C80(0.76)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C80(0.83)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C80(1.00)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C80(0.70)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C80(0.91)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C80(0.76)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C80(0.72)  LDD0562  [2]
 LDCM0276  AC17 HCT 116 C80(0.82)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C80(0.81)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C80(0.94)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C80(1.11)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C80(0.91)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C80(0.99)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C80(0.90)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C80(1.02)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C534(0.95)  LDD1524  [3]
 LDCM0288  AC28 HEK-293T C534(1.24)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C534(1.04)  LDD1528  [3]
 LDCM0294  AC33 HEK-293T C534(0.84)  LDD1533  [3]
 LDCM0297  AC36 HEK-293T C534(1.05)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C534(0.95)  LDD1537  [3]
 LDCM0301  AC4 HEK-293T C534(0.81)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C534(1.00)  LDD1542  [3]
 LDCM0306  AC44 HEK-293T C534(1.07)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C534(0.96)  LDD1546  [3]
 LDCM0311  AC49 HEK-293T C534(0.98)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C534(0.94)  LDD1551  [3]
 LDCM0315  AC52 HEK-293T C534(0.94)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C534(1.00)  LDD1555  [3]
 LDCM0320  AC57 HCT 116 C80(0.94)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C80(0.96)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C80(1.12)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C80(0.95)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C80(0.75)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C80(0.85)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C80(0.90)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C80(1.18)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C80(0.92)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C80(1.00)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C80(0.99)  LDD0648  [2]
 LDCM0365  AC98 HCT 116 C80(1.12)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C80(0.90)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C534(0.95)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C534(0.84)  LDD1570  [3]
 LDCM0367  CL1 HCT 116 C80(1.15)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C80(0.90)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C173(0.91)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C534(0.86)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C173(0.94)  LDD1577  [3]
 LDCM0374  CL105 HCT 116 C80(0.84)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C80(0.77)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C80(0.74)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C80(0.76)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C80(1.15)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C80(1.08)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C80(0.91)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C80(0.78)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C173(1.03)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C534(1.19)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C173(1.05)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C534(1.05)  LDD1592  [3]
 LDCM0390  CL12 HCT 116 C80(1.00)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C173(1.08)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C534(1.20)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C173(0.92)  LDD1599  [3]
 LDCM0396  CL125 HCT 116 C80(0.90)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C80(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C80(0.90)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C80(0.65)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C80(1.10)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C80(1.04)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C80(1.02)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C173(0.97)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C534(0.94)  LDD1608  [3]
 LDCM0407  CL2 HCT 116 C80(1.33)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C534(1.10)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C534(0.84)  LDD1613  [3]
 LDCM0414  CL26 HEK-293T C534(0.82)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C173(0.92)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C534(0.96)  LDD1621  [3]
 LDCM0418  CL3 HCT 116 C80(0.99)  LDD0735  [2]
 LDCM0420  CL31 HCT 116 C80(0.84)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C80(0.98)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C80(1.00)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C80(1.08)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C80(1.24)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C80(1.31)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C80(1.25)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C80(1.15)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C80(0.95)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C80(1.28)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C80(1.32)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C80(1.65)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C80(1.31)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C80(1.16)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C80(0.92)  LDD0752  [2]
 LDCM0440  CL5 HCT 116 C80(0.97)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C534(0.77)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C173(0.91)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C534(1.08)  LDD1647  [3]
 LDCM0447  CL56 HEK-293T C534(0.87)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C534(1.16)  LDD1651  [3]
 LDCM0451  CL6 HCT 116 C80(0.96)  LDD0768  [2]
 LDCM0454  CL62 HEK-293T C534(0.82)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C173(0.96)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C534(0.83)  LDD1660  [3]
 LDCM0460  CL68 HEK-293T C534(1.01)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C534(0.94)  LDD1664  [3]
 LDCM0462  CL7 HCT 116 C80(0.88)  LDD0779  [2]
 LDCM0467  CL74 HEK-293T C534(0.88)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C173(1.12)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C534(0.77)  LDD1673  [3]
 LDCM0473  CL8 HCT 116 C80(1.67)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C534(0.95)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C534(0.92)  LDD1678  [3]
 LDCM0480  CL86 HEK-293T C534(0.93)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C173(0.83)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C534(0.95)  LDD1686  [3]
 LDCM0484  CL9 HCT 116 C80(1.17)  LDD0801  [2]
 LDCM0487  CL92 HEK-293T C534(0.88)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C534(0.92)  LDD1691  [3]
 LDCM0493  CL98 HEK-293T C534(1.07)  LDD1696  [3]
 LDCM0427  Fragment51 HCT 116 C80(2.88)  LDD0744  [2]
 LDCM0022  KB02 A2058 C88(1.52)  LDD2253  [4]
 LDCM0023  KB03 A2058 C88(1.40)  LDD2670  [4]
 LDCM0024  KB05 SK-MEL-28 C88(1.92); C534(1.85)  LDD3427  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Progranulin (GRN) Granulin family P28799
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Calcium-binding protein 2 (CABP2) . Q9NPB3
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840