Details of the Target

General Information of Target

Target ID LDTP07234
Target Name BRO1 domain-containing protein BROX (BROX)
Gene Name BROX
Gene ID 148362
Synonyms
BROFTI; C1orf58; BRO1 domain-containing protein BROX; BRO1 domain- and CAAX motif-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTHWFHRNPLKATAPVSFNYYGVVTGPSASKICNDLRSSRARLLELFTDLSCNPEMMKNA
ADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSAQQDAVFELISMGFNVAL
WYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHLPKLITPAEKGRDLESRLI
EAYVIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHTLSSLEPAYSAKWRK
YLHLKMCFYTAYAYCYHGETLLASDKCGEAIRSLQEAEKLYAKAEALCKEYGETKGPGPT
VKPSGHLFFRKLGNLVKNTLEKCQRENGFIYFQKIPTEAPQLELKANYGLVEPIPFEFPP
TSVQWTPETLAAFDLTKRPKDDSTKPKPEEEVKPVKEPDIKPQKDTGCYIS
Target Bioclass
Other
Family
BROX family
Subcellular location
Nucleus membrane
Function
Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane.
Uniprot ID
Q5VW32
Ensemble ID
ENST00000340934.10
HGNC ID
HGNC:26512

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.L96F .
HCT15 SNV: p.R7M .
SUDHL6 SNV: p.E81D .
SW948 SNV: p.K58R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C52(1.98)  LDD3312  [1]
BTD
 Probe Info  		C323(1.88)  LDD1700  [2]
Acrolein
 Probe Info  		N.A.  LDD0223  [3]
ATP probe
 Probe Info  		K283(0.00); K141(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
IPM
 Probe Info  		C288(0.00); C33(0.00)  LDD0147  [7]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
TFBX
 Probe Info  		C288(0.00); C267(0.00)  LDD0148  [7]
1c-yne
 Probe Info  		N.A.  LDD0228  [8]
NAIA_5
 Probe Info  		C323(0.00); C52(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		K31(0.00); Y21(0.00)  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		16.38  LDD0471  [11]
FFF probe4
 Probe Info  		7.46  LDD0466  [11]
STS-2
 Probe Info  		3.33  LDD0139  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C323(0.63)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C323(1.26); C33(0.94)  LDD2152  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C323(0.49)  LDD2132  [2]
 LDCM0214  AC1 HEK-293T C52(0.97)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C52(0.99)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C52(0.94)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C52(0.85)  LDD1510  [13]
 LDCM0270  AC15 HEK-293T C52(1.00)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C52(1.02)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C52(0.93)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C52(0.97)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C52(0.97)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C52(0.88)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C52(0.89)  LDD1520  [13]
 LDCM0283  AC23 HEK-293T C52(1.01)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C52(0.91)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C52(0.94)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C52(0.95)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C52(0.95)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C52(1.04)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C52(1.08)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C52(1.01)  LDD1529  [13]
 LDCM0292  AC31 HEK-293T C52(0.88)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C52(1.20)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C52(1.03)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C52(0.93)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C52(0.99)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C52(0.95)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C52(1.04)  LDD1537  [13]
 LDCM0300  AC39 HEK-293T C52(1.05)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C52(0.97)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C52(1.01)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C52(0.96)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C52(0.99)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C52(1.02)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C52(1.00)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C52(0.95)  LDD1546  [13]
 LDCM0309  AC47 HEK-293T C52(1.10)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C52(1.13)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C52(1.01)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C52(1.01)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C52(1.02)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C52(0.91)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C52(0.94)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C52(0.88)  LDD1555  [13]
 LDCM0318  AC55 HEK-293T C52(1.00)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C52(0.96)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C52(0.98)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C52(0.99)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C52(0.95)  LDD1561  [13]
 LDCM0324  AC60 HEK-293T C52(0.91)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C52(1.06)  LDD1564  [13]
 LDCM0327  AC63 HEK-293T C52(1.02)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C52(1.09)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C52(1.10)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C52(0.97)  LDD1569  [13]
 LDCM0545  Acetamide MDA-MB-231 C323(0.29)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C323(0.98)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C52(0.99)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C52(1.04)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C52(1.21)  LDD1514  [13]
 LDCM0498  BS-3668 MDA-MB-231 C323(0.36)  LDD2091  [2]
 LDCM0632  CL-Sc Hep-G2 C288(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C52(0.94)  LDD1571  [13]
 LDCM0369  CL100 HEK-293T C52(0.89)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C52(0.91)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C52(0.87)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C52(0.86)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C52(0.76)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C52(0.94)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C52(1.00)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C52(1.00)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C52(0.92)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C52(0.87)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C52(1.14)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C52(0.91)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C52(0.99)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C52(1.13)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C52(0.94)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C52(0.92)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C52(0.82)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C52(0.92)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C52(0.90)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C52(0.94)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C52(0.78)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C52(0.91)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C52(0.83)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C52(0.96)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C52(1.02)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C52(0.91)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C52(0.95)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C52(1.00)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C52(1.05)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C52(1.04)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C52(1.03)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C52(0.86)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C52(0.99)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C52(0.85)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C52(0.97)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C52(1.04)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C52(0.95)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C52(1.00)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C52(1.00)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C52(0.93)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C52(0.83)  LDD1613  [13]
 LDCM0411  CL23 HEK-293T C52(1.03)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C52(1.05)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C52(0.87)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C52(1.03)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C52(0.72)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C52(0.96)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C52(1.08)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C52(0.98)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C52(0.95)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C52(0.96)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C52(0.92)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C52(0.40)  LDD1626  [13]
 LDCM0424  CL35 HEK-293T C52(1.16)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C52(1.06)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C52(1.10)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C52(0.74)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C52(0.93)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C52(0.98)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C52(0.96)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C52(1.01)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C52(1.02)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C52(0.95)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C52(0.94)  LDD1639  [13]
 LDCM0437  CL47 HEK-293T C52(1.09)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C52(0.96)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C52(1.02)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C52(1.12)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C52(1.01)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C52(0.91)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C52(1.04)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C52(0.96)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C52(0.89)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C52(1.01)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C52(0.96)  LDD1651  [13]
 LDCM0450  CL59 HEK-293T C52(1.04)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C52(1.01)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C52(1.09)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C52(0.99)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C52(0.93)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C52(0.87)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C52(0.89)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C52(1.05)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C52(1.01)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C52(0.98)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C52(0.95)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C52(1.01)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C52(0.95)  LDD1665  [13]
 LDCM0464  CL71 HEK-293T C52(1.10)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C52(1.01)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C52(0.89)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C52(1.02)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C52(1.05)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C52(0.94)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C52(0.91)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C52(1.00)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C52(0.84)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C52(0.84)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C52(0.90)  LDD1678  [13]
 LDCM0477  CL83 HEK-293T C52(1.04)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C52(1.13)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C52(0.95)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C52(0.91)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C52(0.88)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C52(1.04)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C52(0.98)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C52(0.90)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C52(0.90)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C52(0.95)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C52(0.98)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C52(0.95)  LDD1691  [13]
 LDCM0490  CL95 HEK-293T C52(1.21)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C52(0.92)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C52(0.87)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C52(0.89)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C52(0.74)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C52(0.82)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C52(0.88)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C52(0.95)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C52(0.95)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C52(1.08)  LDD1497  [13]
 LDCM0024  KB05 HMCB C52(1.98)  LDD3312  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C323(0.42)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C323(0.51)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C323(0.88)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C323(0.36)  LDD2096  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C323(0.36)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C323(0.62)  LDD2099  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C33(1.32)  LDD2104  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C323(0.63)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C323(0.48)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C323(0.68)  LDD2111  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C323(0.42)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C323(0.67)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C323(0.67)  LDD2118  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C323(0.55)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C323(0.61)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C323(0.52)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C323(0.54)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C323(0.60)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C323(0.78)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C323(0.92); C33(0.91)  LDD2129  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C323(0.48)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C323(1.09)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C323(0.82)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C323(0.83)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C323(1.88)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C323(0.45)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C323(3.16)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C323(0.53)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C323(0.51)  LDD2148  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C323(0.65)  LDD2149  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C323(0.32)  LDD2150  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C323(0.62)  LDD2151  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Charged multivesicular body protein 4b (CHMP4B) SNF7 family Q9H444

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402