Details of the Target

General Information of Target

Target ID LDTP07190
Target Name Transcription factor Gibbin (AHDC1)
Gene Name AHDC1
Gene ID 27245
Synonyms
Transcription factor Gibbin; AT-hook DNA-binding motif-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPPASPPDKAFSTHAFSEN
PRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPVGDGSSSRRCWDNGRVNLRP
VVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPGDLQYSFFSSPSLANSIRSP
EERATPHAKSERPSHPLYEPEPEPRDSPQPGQGHSPGATAAATGLPPEPEPDSTDYSELA
DADILSELASLTCPEAQLLEAQALEPPSPEPEPQLLDPQPRFLDPQALEPLGEALELPPL
QPLADPLGLPGLALQALDTLPDSLESQLLDPQALDPLPKLLDVPGRRLEPQQPLGHCPLA
EPLRLDLCSPHGPPGPEGHPKYALRRTDRPKILCRRRKAGRGRKADAGPEGRLLPLPMPT
GLVAALAEPPPPPPPPPPALPGPGPVSVPELKPESSQTPVVSTRKGKCRGVRRMVVKMAK
IPVSLGRRNKTTYKVSSLSSSLSVEGKELGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMP
IILKRKRGRPPKNLLLGPGKPKEPAVVAAEAATVAAATMAMPEVKKRRRRKQKLASPQPS
YAADANDSKAEYSDVLAKLAFLNRQSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLH
RVQGFRRRGGKAGGFGGRGGGHAAKSARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTEL
GHPRKRGRGEVDAVTGKPKRKRRSRKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHH
GHPGGQAGRNCGFQGTEARAFASTGLESGASGRGSYYSTGAPSGQTELSQERQNLFTGYF
RSLLDSDDSSDLLDFALSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAV
GSSGAGADPSFQPVLSARQTFPPGRAASYGLTPAASDCRAAETFPKLVPPPSAMARSPTT
HPPANTYLPQYGGYGAGQSVFAPTKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGY
APPPTGGPCLPPSKASFFSSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATS
AASAASSSSSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPSFDCHVSEPN
VILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGGFRRANSEASSSEGQSSLSS
LEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPTSASAAASGY
PSKRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGD
SSMSPLPSQSRAFGVGERDPCDFIGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGKHF
PPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGHAAAA
QAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGTGLLADFLGRTEAACL
SAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVPRDSLLPLQ
DTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis. Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture. Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification.
Uniprot ID
Q5TGY3
Ensemble ID
ENST00000247087.10
HGNC ID
HGNC:25230

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y817(11.64)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C628(2.87)  LDD0171  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C791(1.03)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		C147(0.00); C689(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		C147(0.00); C1540(0.00); C791(0.00); C1499(0.00)  LDD0147  [7]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
NAIA_5
 Probe Info  		C689(0.00); C16(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C628(2.87)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C689(0.95)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C689(0.89)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C689(1.11)  LDD0543  [5]
 LDCM0230  AC113 HCT 116 C689(1.12)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C689(1.16)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C689(1.18)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C689(1.19)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C689(1.18)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C689(1.13)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C689(1.25)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C689(1.01)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C689(1.19)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C689(1.09)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C689(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C689(1.23)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C689(1.08)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C689(1.03)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C689(1.23)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C689(1.32)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C689(1.05)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C689(0.84)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C689(1.04)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C689(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C689(0.85)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C689(0.93)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C689(0.98)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C689(0.98)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C689(0.93)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C689(0.86)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C689(0.88)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C689(0.98)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C689(1.01)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C689(0.97)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C689(0.93)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C689(0.82)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C689(1.04)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C689(1.32)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C689(1.08)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C689(1.41)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C689(1.42)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C689(1.83)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C689(1.50)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C689(1.24)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C689(1.01)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C689(1.00)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C689(1.35)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C689(2.30)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C689(1.35)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C689(1.31)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C689(1.15)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C689(1.04)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C689(0.78)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C689(0.69)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C689(0.69)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C689(0.91)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C689(0.54)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C689(0.65)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C689(0.77)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C689(0.67)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C689(0.61)  LDD0601  [5]
 LDCM0285  AC25 PaTu 8988t C689(0.82)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C689(0.97)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C689(1.02)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C689(1.17)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C689(0.97)  LDD1168  [5]
 LDCM0290  AC3 HCT 116 C689(1.00)  LDD0607  [5]
 LDCM0291  AC30 PaTu 8988t C689(0.91)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C689(0.98)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C689(1.09)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C689(1.20)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C689(1.10)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C689(1.18)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C689(1.19)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C689(1.34)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C689(1.33)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C689(1.49)  LDD1179  [5]
 LDCM0301  AC4 HCT 116 C689(1.08)  LDD0618  [5]
 LDCM0302  AC40 PaTu 8988t C689(1.75)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C689(1.32)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C689(1.68)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C689(1.34)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C689(1.86)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C689(1.58)  LDD1186  [5]
 LDCM0310  AC48 HEK-293T C357(1.27)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C357(0.90)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C689(1.02)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C357(0.98)  LDD1552  [11]
 LDCM0315  AC52 HEK-293T C368(0.96)  LDD1554  [11]
 LDCM0319  AC56 HEK-293T C357(1.14)  LDD1558  [11]
 LDCM0320  AC57 HCT 116 C689(1.08)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C689(1.18)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C689(1.21)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C689(0.87)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C689(1.13)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C689(1.04)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C689(1.22)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C689(1.07)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C689(1.22)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C689(0.91)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C689(0.85)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C689(0.99)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C689(1.23)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C689(1.39)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C689(0.90)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C689(1.45)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C689(1.31)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C689(1.54)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C689(2.02)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C689(1.87)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C689(2.35)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C689(1.45)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C689(1.47)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C689(1.33)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C689(1.33)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C689(1.12)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C689(1.34)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C689(1.43)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C689(2.45)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C689(1.25)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C689(1.17)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C689(1.17)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C689(1.13)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C689(1.18)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C689(1.23)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C689(1.18)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C689(1.38)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C689(1.00)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C689(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C689(1.05)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C689(0.89)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C689(1.09)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C689(0.85)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C689(1.14)  LDD0681  [5]
 LDCM0248  AKOS034007472 HCT 116 C689(0.91)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C689(1.31)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C689(1.16)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C791(1.03)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C1402(2.53); C689(0.86); C1540(0.63)  LDD2227  [8]
 LDCM0369  CL100 HCT 116 C689(0.96)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C689(0.95)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C689(1.02)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C689(0.99)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C689(1.18)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C689(0.80)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C689(0.71)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C689(0.91)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C689(0.76)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C689(0.81)  LDD0695  [5]
 LDCM0380  CL110 HCT 116 C689(0.77)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C689(0.80)  LDD0698  [5]
 LDCM0382  CL112 PaTu 8988t C689(0.98)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C689(0.88)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C689(1.10)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C689(0.97)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C689(1.13)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C689(1.47)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C689(1.64)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C689(1.40)  LDD1268  [5]
 LDCM0390  CL12 HEK-293T C357(1.00)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C689(1.27)  LDD1270  [5]
 LDCM0393  CL122 HEK-293T C689(1.32)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C1422(1.10)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C689(1.30)  LDD1599  [11]
 LDCM0396  CL125 HCT 116 C689(0.97)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C689(0.93)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C689(1.00)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C689(1.22)  LDD0716  [5]
 LDCM0401  CL14 HEK-293T C689(1.23)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C1422(1.15)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C689(1.29)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C689(0.99)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C689(1.18)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C689(1.25)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C689(1.10)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C689(1.16)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C689(1.12)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C689(1.46)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C689(1.27)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C689(1.20)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C689(1.30)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C689(1.38)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C689(1.17)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C689(1.37)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C689(1.37)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C1422(1.00)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C689(1.31)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C689(1.12)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C689(1.17)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C689(2.18)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C689(1.34)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C689(1.28)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C689(1.38)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C689(1.43)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C689(1.63)  LDD1307  [5]
 LDCM0429  CL4 HEK-293T C689(1.15)  LDD1633  [11]
 LDCM0430  CL40 PaTu 8988t C689(1.17)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C689(1.37)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C689(1.33)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C689(1.44)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C689(1.41)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C689(1.71)  LDD1314  [5]
 LDCM0438  CL48 HEK-293T C357(1.15)  LDD1642  [11]
 LDCM0440  CL5 HEK-293T C357(0.90)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C689(1.21)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C689(1.12)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C357(0.93)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C357(0.98)  LDD1648  [11]
 LDCM0447  CL56 HEK-293T C368(0.98)  LDD1650  [11]
 LDCM0451  CL6 HEK-293T C357(1.13)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C357(1.15)  LDD1655  [11]
 LDCM0453  CL61 PaTu 8988t C689(1.11)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C689(1.06)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C689(1.12)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C689(1.29)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C689(1.10)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C689(1.22)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C689(1.28)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C689(1.67)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C689(1.65)  LDD1340  [5]
 LDCM0463  CL70 PaTu 8988t C689(1.34)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C689(1.16)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C689(1.05)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C689(1.75)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C689(1.43)  LDD1346  [5]
 LDCM0469  CL76 HEK-293T C689(1.23)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C357(1.07)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C357(1.03)  LDD1674  [11]
 LDCM0473  CL8 HEK-293T C368(0.84)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C368(0.96)  LDD1677  [11]
 LDCM0478  CL84 HEK-293T C357(1.18)  LDD1681  [11]
 LDCM0480  CL86 HEK-293T C689(1.02)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C1422(1.04)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C689(1.06)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C357(1.00)  LDD1686  [11]
 LDCM0485  CL90 HEK-293T C357(1.16)  LDD1688  [11]
 LDCM0486  CL91 HCT 116 C689(1.10)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C689(1.19)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C689(1.17)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C689(1.33)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C689(1.44)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C689(1.20)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C689(0.99)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C689(0.98)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C689(1.02)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C1099(0.32)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C1422(1.15)  LDD1698  [11]
 LDCM0468  Fragment33 PaTu 8988t C689(1.35)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C689(1.55)  LDD1306  [5]
 LDCM0022  KB02 T cell C147(7.48)  LDD1703  [12]
 LDCM0023  KB03 697 C1099(1.95); C628(1.44)  LDD2662  [13]
 LDCM0024  KB05 G361 C1402(3.38); C628(3.60)  LDD3311  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840