Details of the Target

General Information of Target

Target ID LDTP07186
Target Name Protein DDI1 homolog 2 (DDI2)
Gene Name DDI2
Gene ID 84301
Synonyms
Protein DDI1 homolog 2; EC 3.4.23.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRS
LASYGLKDGDVVILRQKENADPRPPVQFPNLPRIDFSSIAVPGTSSPRQRQPPGTQQSHS
SPGEITSSPQGLDNPALLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQ
DRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINC
KVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQ
IEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQTTFLPEGELPE
CARLAYGAGREDVRPEEIADQELAEALQKSAEDAERQKP
Target Bioclass
Enzyme
Family
DDI1 family
Subcellular location
Cytoplasm, cytosol
Function
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.
Uniprot ID
Q5TDH0
Ensemble ID
ENST00000480945.6
HGNC ID
HGNC:24578

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.P135A DBIA    Probe Info 
C4II SNV: p.T351I DBIA    Probe Info 
HEC1 SNV: p.A222T DBIA    Probe Info 
NCIH358 SNV: p.I334F DBIA    Probe Info 
OVK18 SNV: p.A362V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.55  LDD0402  [1]
DBIA
 Probe Info  		C361(2.44)  LDD3312  [2]
BTD
 Probe Info  		C332(0.23)  LDD2124  [3]
AHL-Pu-1
 Probe Info  		C361(3.02)  LDD0172  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
5E-2FA
 Probe Info  		H147(0.00); H119(0.00)  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C332(0.00); C361(0.00); C34(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C308(0.00); C34(0.00); C361(0.00); C332(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C34(0.00); C332(0.00); C361(0.00); C308(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C361(3.02)  LDD0172  [4]
 LDCM0214  AC1 HEK-293T C332(0.83); C361(0.95)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C332(0.95); C361(0.90)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C332(0.91); C361(1.05)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C332(0.95); C361(1.06)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C332(0.96); C361(1.01)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C332(0.99); C361(1.03)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C332(0.96); C361(1.02)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C332(0.95); C361(0.90)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C332(0.81); C361(0.89)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C332(1.06); C361(1.00)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C332(0.84); C361(0.96)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C361(0.98)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C332(0.88); C361(1.04)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C332(0.95); C361(1.01)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C332(1.00); C361(1.03)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C332(0.96); C361(0.96)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C332(0.99); C361(1.02)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C332(0.92); C361(1.05)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C332(0.92); C361(0.92)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C361(1.04)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C332(0.94); C361(1.10)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C332(0.86); C361(1.04)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C332(1.02); C361(1.02)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C332(0.95); C361(1.03)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C332(0.86); C361(1.06)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C332(0.95); C361(1.02)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C332(0.99); C361(0.99)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C332(0.82); C361(0.94)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C361(1.03)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C332(0.84); C361(1.10)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C332(0.93); C361(1.01)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C332(1.00); C361(0.97)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C332(0.89); C361(1.03)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C332(0.92); C361(1.07)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C332(0.98); C361(0.91)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C332(0.97); C361(1.04)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C332(0.86); C361(0.94)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C361(1.08)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C332(0.87); C361(1.14)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C332(0.93); C361(1.08)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C332(0.97); C361(1.04)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C332(1.00); C361(1.00)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C361(1.06)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C332(0.96); C361(1.00)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C332(0.97); C361(1.08)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C332(0.88); C361(1.04)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C361(1.04)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C332(0.89); C361(0.97)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C332(1.02); C361(1.00)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C332(0.78); C361(0.95)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C332(1.07); C361(0.92)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C332(0.98); C361(1.11)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C332(0.89); C361(1.03)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C332(0.91); C361(0.91)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C332(0.98); C361(0.89)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C361(1.02)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C332(0.81); C361(1.07)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C332(0.87); C361(0.96)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C332(0.97); C361(0.95)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C332(0.92); C361(1.16)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C332(1.05); C361(1.06)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C361(0.99)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C332(1.01); C361(1.03)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C332(0.90); C361(0.95)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 10.86  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C332(0.90); C361(1.08)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C332(1.20); C361(1.45)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C332(0.91); C361(0.92)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C332(0.87); C361(0.93)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C361(0.84)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C361(1.03)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C332(0.94); C361(0.98)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C332(0.88); C361(0.90)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C361(0.91)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C361(0.98)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C332(0.89); C361(0.87)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C332(0.86); C361(0.90)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C332(1.33); C361(1.57)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C361(0.79)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C361(0.79)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C332(0.92); C361(0.93)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C332(0.83); C361(1.12)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C361(0.81)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C361(0.99)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C332(1.03); C361(0.97)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C332(0.75); C361(1.11)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C361(1.10)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C361(1.14)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C332(1.00); C361(1.09)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C332(0.96); C361(0.89)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C332(0.82); C361(0.98)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C361(0.98)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C361(0.77)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C332(0.87); C361(0.74)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C332(0.78); C361(1.10)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C361(0.94)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C361(1.04)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C332(0.95); C361(0.92)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C332(0.89); C361(1.05)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C361(0.99)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C361(0.94)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C332(1.05); C361(1.07)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C332(1.04); C361(0.78)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C332(1.08); C361(1.12)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C332(1.03); C361(1.15)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C361(0.99)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C332(1.47); C361(1.50)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C361(1.00)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C332(1.66); C361(1.40)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C332(1.42); C361(1.63)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C332(1.17); C361(1.34)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C332(0.85); C361(0.85)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C361(1.06)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C361(0.97)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C332(0.89); C361(0.95)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C332(1.07); C361(1.04)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C361(1.03)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C332(1.04); C361(1.04)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C332(1.05); C361(1.09)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C332(1.17); C361(1.17)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C361(0.98)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C332(1.36); C361(1.31)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C332(1.30); C361(1.87)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C332(1.21); C361(1.13)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C332(0.77); C361(1.04)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C361(0.85)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C332(1.07); C361(0.78)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C332(1.02); C361(0.86)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C332(0.97); C361(0.91)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C332(1.05); C361(0.97)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C332(1.09); C361(1.23)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C332(1.27); C361(1.29)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C361(0.95)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C332(1.39); C361(1.40)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C332(1.07); C361(1.55)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C332(1.08); C361(1.12)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C332(0.78); C361(1.00)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C332(1.12); C361(1.08)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C361(0.80)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C332(1.01); C361(0.99)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C332(1.05); C361(1.13)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C332(1.03); C361(0.74)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C332(1.13); C361(1.08)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C332(1.05); C361(1.24)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C361(1.03)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C332(1.21); C361(1.43)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C332(1.09); C361(1.56)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C332(0.96); C361(1.02)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C332(1.09); C361(1.07)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C332(0.79); C361(1.12)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C361(0.99)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C361(1.08)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C332(1.09); C361(0.60)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C332(1.04); C361(1.06)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C332(1.01); C361(0.92)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C332(1.00); C361(1.10)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C332(1.12); C361(1.34)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C361(1.10)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C332(0.98); C361(1.04)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C332(1.32); C361(1.33)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C332(1.33); C361(1.56)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C332(1.18); C361(1.10)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C332(0.94); C361(0.96)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C361(1.05)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C332(1.00); C361(1.08)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C332(0.94); C361(0.61)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C332(1.05); C361(1.04)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C332(1.10); C361(1.10)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C332(0.80); C361(1.09)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C332(1.13); C361(1.33)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C361(1.00)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C332(1.36); C361(1.28)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C332(1.11); C361(1.28)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C332(1.09); C361(1.02)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C332(0.74); C361(1.08)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C361(0.88)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C361(0.88)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C332(0.92); C361(1.06)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C332(0.89); C361(1.05)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C361(1.09)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C332(0.88); C361(0.80)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C332(0.98); C361(1.02)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C332(0.80); C361(1.13)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C361(1.09)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C332(1.11); C361(1.29)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C332(1.01); C361(1.17)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C332(0.92); C361(0.98)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C332(0.85); C361(0.82)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C361(0.87)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C361(0.91)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C361(0.86)  LDD1698  [12]
 LDCM0625  F8 Ramos C34(1.46)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C34(1.96)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C34(2.89)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C34(1.07)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C34(0.78)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C34(0.61)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C34(0.88)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C34(0.92)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C34(0.65)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C34(2.13)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C34(0.77)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C34(2.17)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C34(2.30)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C34(1.25)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C361(0.92)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C34(2.00)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C34(0.82)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C361(0.93)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C34(2.37)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C34(1.57)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C34(0.67)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C34(0.58)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C361(1.11)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C361(1.16)  LDD1497  [12]
 LDCM0024  KB05 HMCB C361(2.44)  LDD3312  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C332(0.23)  LDD2124  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C332(0.12)  LDD2151  [3]
 LDCM0131  RA190 MM1.R C361(1.07)  LDD0304  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.