Details of the Target

General Information of Target

Target ID LDTP07033
Target Name E3 ubiquitin-protein ligase RNFT1 (RNFT1)
Gene Name RNFT1
Gene ID 51136
Synonyms
E3 ubiquitin-protein ligase RNFT1; EC 2.3.2.27; Protein PTD016; RING finger and transmembrane domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLFLLSLPTPPSASGHERRQRPEAKTSGSEKKYLRAMQANRSQLHSPPGTGSSEDASTP
QCVHTRLTGEGSCPHSGDVHIQINSIPKECAENASSRNIRSGVHSCAHGCVHSRLRGHSH
SEARLTDDTAAESGDHGSSSFSEFRYLFKWLQKSLPYILILSVKLVMQHITGISLGIGLL
TTFMYANKSIVNQVFLRERSSKIQCAWLLVFLAGSSVLLYYTFHSQSLYYSLIFLNPTLD
HLSFWEVFWIVGITDFILKFFFMGLKCLILLVPSFIMPFKSKGYWYMLLEELCQYYRTFV
PIPVWFRYLISYGEFGNVTRWSLGILLALLYLILKLLEFFGHLRTFRQVLRIFFTQPSYG
VAASKRQCSDVDDICSICQAEFQKPILLICQHIFCEECMTLWFNREKTCPLCRTVISDHI
NKWKDGATSSHLQIY
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
Uniprot ID
Q5M7Z0
Ensemble ID
ENST00000305783.13
HGNC ID
HGNC:30206

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.A363G .
TOV21G SNV: p.E18D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C73(2.74); C106(5.08)  LDD0171  [2]
DBIA
 Probe Info  		C368(1.08); C378(1.08)  LDD0532  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C73(2.74); C106(5.08)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C90(0.84); C73(1.06); C106(1.03)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C368(1.08); C378(1.08)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C368(0.53); C378(0.53)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C368(0.52); C378(0.52)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C368(0.59); C378(0.59)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C368(0.66); C378(0.66)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C368(0.56); C378(0.56)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C368(0.53); C378(0.53)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C368(0.57); C378(0.57)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C368(0.30); C378(0.51)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C368(1.13); C378(0.50)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C368(1.11); C378(0.73)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C368(1.16); C378(1.16)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C368(0.91); C378(0.53)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C368(1.11); C378(0.51)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C368(0.56); C378(0.67)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C368(1.07); C375(0.99)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C368(0.85); C375(0.99)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C368(1.09); C375(1.03)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C368(1.19); C375(0.92)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C368(1.18); C375(0.89)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C368(1.24); C375(0.93)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C368(1.36); C375(0.96)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C368(1.07); C378(1.07)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C368(1.09); C375(0.87)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C368(1.17); C375(0.92)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C368(1.07); C375(1.09)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C368(1.02); C375(0.99)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C368(1.05); C375(0.89)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C368(1.28); C375(0.91)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C368(1.00); C375(1.05)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C368(1.08); C375(1.12)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C368(0.88)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C368(0.96)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C368(1.29)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C368(0.70)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C368(1.08)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C368(1.19)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C368(1.15)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C368(0.98)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C368(1.17)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C368(0.98)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C368(1.18)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C368(0.83)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C368(1.23); C378(1.23)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C368(1.20)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C368(1.41)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C368(0.95)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C368(0.83)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C368(1.13)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C368(1.11)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C368(1.06)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C368(1.24)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C368(1.37)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C368(0.81)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C368(1.44); C378(1.44)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C368(1.42)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C368(1.40)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C368(1.55)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C368(1.38)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C368(0.82)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C368(1.37)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C368(1.41)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C368(0.94)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C368(1.01); C378(1.01)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C368(0.90); C378(0.90)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C368(0.91); C378(0.91)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C90(1.33); C62(1.00)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C368(1.02); C378(1.02)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C368(0.74); C378(0.74)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C368(0.91); C378(0.91)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C368(0.87); C378(0.87)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C368(1.27); C378(1.27)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C90(0.97); C73(1.10); C106(1.13)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C90(1.29); C62(1.05)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C90(1.20); C62(1.11)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C90(0.97)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C90(1.21); C62(1.08)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C90(1.46); C62(0.86)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C90(0.94); C62(0.97); C73(0.96); C110(1.10)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C90(1.07); C62(0.97); C73(1.24)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C90(1.01); C62(1.31); C110(1.83)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C90(1.05); C73(1.31); C106(1.26)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C90(1.42); C62(0.96)  LDD1534  [10]
 LDCM0296  AC35 HCT 116 C368(1.48); C378(1.48)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C368(1.55); C378(1.55)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C368(1.31); C378(1.31)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C368(1.46); C378(1.46)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C368(1.22); C378(1.22)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C90(0.98)  LDD1540  [10]
 LDCM0302  AC40 HCT 116 C368(1.45); C378(1.45)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C368(1.23); C378(1.23)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C368(1.06); C378(1.06)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C368(1.24); C378(1.24)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C368(1.17); C378(1.17)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C368(1.26); C378(1.26)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C368(0.98); C378(0.98)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C368(0.81); C378(0.81)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C368(0.67); C378(0.67)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C368(0.76); C378(0.76)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C90(1.00); C62(1.39)  LDD1551  [10]
 LDCM0313  AC50 HCT 116 C368(0.75); C378(0.75)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C368(0.65); C378(0.65)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C368(0.63); C378(0.63)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C368(0.51); C378(0.51)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C368(0.83); C378(0.83)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C368(0.80); C378(0.80)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C368(0.43); C378(0.43)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C368(0.90)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C368(0.83)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C368(0.42)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C368(1.41); C378(1.41)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C368(0.66)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C368(0.80)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C368(0.77)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C368(0.74)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C368(0.58)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C368(0.65)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C368(0.79)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C368(1.04)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C368(1.13)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C368(1.11)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C368(1.01); C378(1.01)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C368(1.50)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C368(1.10)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C368(1.03)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C368(1.24)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C368(2.19)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C368(2.06)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C368(1.82)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C368(1.66)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C368(1.28)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C368(1.39)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C368(1.12); C378(1.12)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C368(2.11)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C368(1.89)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C368(2.93)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C368(1.06); C378(1.06)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C368(1.11); C378(1.11)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C368(1.71); C378(1.71)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C368(1.26); C378(1.26)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C368(1.05); C378(1.05)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C368(0.79); C378(0.79)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C368(1.56); C378(1.56)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C368(1.41); C378(1.41)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C368(1.26); C378(1.26)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C368(1.43); C378(1.43)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C368(1.29); C378(1.29)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C368(1.90); C378(1.90)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C368(1.47); C378(1.47)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C368(1.99); C378(1.99)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C368(1.19); C378(1.19)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C368(0.52); C378(0.52)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C368(0.50); C378(0.50)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C368(1.20); C378(1.20)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C368(1.36); C378(1.36)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C368(1.46); C378(1.46)  LDD0592  [3]
 LDCM0632  CL-Sc Hep-G2 C62(1.11)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C368(0.71); C375(1.04)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C368(1.75); C375(0.92)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C90(0.89)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C368(1.44); C378(1.44)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C368(1.08); C378(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C368(0.89); C378(0.89)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C368(1.12); C378(1.12)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C368(0.83); C378(0.83)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C368(0.69); C378(0.69)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C368(0.76); C378(0.76)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C368(1.21); C378(1.21)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C368(1.14); C378(1.14)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C368(1.51); C375(0.76)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C368(0.83); C378(0.83)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C368(1.07); C378(1.07)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C90(1.02)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C90(1.03)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C90(1.19); C73(1.08)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C90(1.31)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C90(1.14)  LDD1590  [10]
 LDCM0387  CL117 HCT 116 C368(1.78); C378(1.78)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C368(1.38); C378(1.38)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C368(2.02); C378(2.02)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C368(1.24); C375(0.77)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C368(1.15); C378(1.15)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C368(0.76); C378(0.76)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C368(0.48); C378(0.48)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C368(0.46); C378(0.46)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C368(0.68); C378(0.68)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C368(0.94)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C368(0.66)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C368(0.69)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C368(0.78)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C368(1.47); C375(0.82)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C368(1.51); C375(0.69)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C368(1.89); C375(0.64)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C368(1.07); C378(1.07)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C368(0.88); C378(0.88)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C368(1.20); C378(1.20)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C368(1.06); C378(1.06)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C368(1.44); C375(0.82)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C368(1.06); C378(1.06)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C368(0.91); C378(0.91)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C368(0.96); C378(0.96)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C368(1.15); C378(1.15)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C368(1.56); C378(1.56)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C368(1.20); C378(1.20)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C368(1.56); C378(1.56)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C368(1.28); C378(1.28)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C368(1.78); C378(1.78)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C368(1.57); C378(1.57)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C368(0.94); C375(0.95)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C368(1.78); C378(1.78)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C368(1.16); C375(0.85)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C368(1.16); C375(0.78)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C368(1.08); C375(0.63)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C368(1.15); C375(0.89)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C368(1.25); C375(0.66)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C368(1.11); C375(0.72)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C368(0.98); C375(0.67)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C368(1.53); C375(0.72)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C368(1.33); C375(0.88)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C368(1.27); C375(0.66)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C368(1.54); C375(0.67)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C368(1.55); C375(0.64)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C368(1.34); C375(0.65)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C368(1.29); C375(0.69)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C368(1.57); C375(0.64)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C368(1.05); C378(1.05)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C368(0.93); C378(0.93)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C368(0.96); C378(0.96)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C368(1.40); C378(1.40)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C368(1.46); C375(0.87)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C368(1.08); C378(1.08)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C368(1.19); C378(1.19)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C368(1.16); C378(1.16)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C368(0.87); C378(0.87)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C368(0.91); C378(0.91)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C368(1.00); C378(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C368(0.94); C378(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C368(0.87); C378(0.87)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C368(1.30); C378(1.30)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C368(1.03); C378(1.03)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C368(1.38); C375(0.87)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C368(1.03); C378(1.03)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C368(0.87)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C368(1.23)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C368(1.01)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C368(0.81)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C368(1.21)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C368(0.83)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C368(1.15)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C368(1.55)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C368(1.36)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C368(1.26); C375(0.85)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C368(0.95)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C368(1.06)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C368(1.02)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C368(1.26)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C368(2.11)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C368(0.99)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C368(0.90)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C368(1.07)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C368(0.96)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C368(0.68)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C368(1.09)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C368(1.05)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C368(1.18)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C368(1.12)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C368(1.04)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C368(1.02)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C368(1.25)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C368(0.96)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C368(1.30)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C368(1.12)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C368(0.67)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C368(1.12)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C90(1.04); C62(0.79)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C90(1.36)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C90(0.94); C62(1.22)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C90(0.97); C62(1.00); C73(1.05); C110(0.88)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C90(1.00); C62(1.11); C73(0.92)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C90(1.08); C62(0.88); C110(0.74)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C90(1.04)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C90(1.10); C73(1.13)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C90(0.89)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C90(1.07)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C368(1.31)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C368(1.04); C375(0.84)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C62(1.15)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C62(1.24)  LDD1497  [10]
 LDCM0024  KB05 G361 C90(1.71)  LDD3311  [11]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840