Details of the Target

General Information of Target

Target ID LDTP06537
Target Name Transcription initiation factor TFIID subunit 12 (TAF12)
Gene Name TAF12
Gene ID 6883
Synonyms
TAF15; TAF2J; TAFII20; Transcription initiation factor TFIID subunit 12; Transcription initiation factor TFIID 20/15 kDa subunits; TAFII-20/TAFII-15; TAFII20/TAFII15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTK
KKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHL
ERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK
Target Bioclass
Other
Family
TAF12 family
Subcellular location
Nucleus
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex .
Uniprot ID
Q16514
Ensemble ID
ENST00000263974.4
HGNC ID
HGNC:11545

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LOXIMVI SNV: p.K160R .
MOLT4 SNV: p.A88V IA-alkyne    Probe Info 
SNGM SNV: p.Y139C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C143(0.96)  LDD2108  [1]
DBIA
 Probe Info  		C143(1.94)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C143(0.97)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C143(0.72)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C143(1.00)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C143(0.91)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C143(0.78)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C143(0.92)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C143(0.90)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C143(1.02)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C143(0.71)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C143(0.58)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C143(0.60)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C143(0.68)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C143(0.64)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C143(0.68)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C143(0.65)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C143(0.63)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C143(1.19)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C143(1.00)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C143(1.09)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C143(0.97)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C143(0.96)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C143(0.97)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C143(1.14)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C143(0.62)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C143(1.14)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C143(1.36)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C143(1.09)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C143(1.04)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C143(1.33)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C143(1.47)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C143(1.19)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C143(1.02)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C143(0.95)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C143(1.48)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C143(1.18)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C143(1.06)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C143(1.36)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C143(1.14)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C143(0.98)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C143(1.37)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C143(0.94)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C143(1.18)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C143(1.20)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C143(1.02)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C143(0.64)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C143(1.09)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C143(1.06)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C143(1.27)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C143(1.10)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C143(0.98)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C143(1.18)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C143(1.21)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C143(0.88)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C143(1.01)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C143(0.91)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C143(0.57)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C143(0.86)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C143(1.05)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C143(0.91)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C143(1.00)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C143(0.89)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C143(1.07)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C143(1.23)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C143(0.84)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C143(0.91)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C143(1.09)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C143(1.02)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C143(1.04)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C143(1.23)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C143(1.26)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C143(1.16)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C143(1.12)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C143(1.10)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C143(1.03)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C143(1.06)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C143(0.95)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C143(1.08)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C143(0.99)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C143(1.09)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C143(1.00)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C143(1.14)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C143(0.96)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C143(0.92)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C143(1.03)  LDD1534  [11]
 LDCM0296  AC35 HCT 116 C143(0.86)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C143(0.90)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C143(0.92)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C143(0.80)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C143(0.90)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C143(0.91)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C143(1.00)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C143(1.03)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C143(0.89)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C143(0.92)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C143(0.99)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C143(1.33)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C143(0.98)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C143(0.89)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C143(0.85)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C143(0.94)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C143(0.90)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C143(0.98)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C143(0.99)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C143(0.95)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C143(0.95)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C143(0.96)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C143(0.94)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C143(0.92)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C143(0.99)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C143(1.11)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C143(0.89)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C143(1.05)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C143(0.97)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C143(0.98)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C143(1.03)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C143(1.06)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C143(1.03)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C143(0.97)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C143(0.88)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C143(0.82)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C143(0.71)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C143(0.61)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C143(1.04)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C143(0.80)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C143(0.75)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C143(0.83)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C143(0.94)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C143(0.73)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C143(0.67)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C143(0.77)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C143(0.57)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C143(0.57)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C143(0.62)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C143(0.92)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C143(0.74)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C143(0.52)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C143(0.64)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C143(0.87)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C143(1.44)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C143(1.03)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C143(1.23)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C143(1.10)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C143(1.15)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C143(1.28)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C143(1.06)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C143(0.75)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C143(0.91)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C143(0.86)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C143(0.84)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C143(0.79)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C143(0.73)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C143(0.72)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C143(0.90)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C143(0.90)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C143(0.63)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C143(0.85)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C143(0.68)  LDD0873  [2]
 LDCM0632  CL-Sc Hep-G2 C143(1.26); C143(0.63)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C143(0.90)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C143(0.92)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C143(1.10)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C143(1.25)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C143(1.25)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C143(1.01)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C143(0.87)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C143(1.30)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C143(1.79)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C143(1.20)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C143(0.97)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C143(1.05)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C143(0.97)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C143(0.78)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C143(1.13)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C143(1.07)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C143(0.96)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C143(0.97)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C143(0.96)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C143(1.07)  LDD1590  [11]
 LDCM0387  CL117 HCT 116 C143(0.80)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C143(0.84)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C143(0.90)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C143(1.02)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C143(1.04)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C143(1.00)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C143(0.93)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C143(0.86)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C143(1.11)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C143(1.05)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C143(1.36)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C143(1.26)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C143(1.22)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C143(1.05)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C143(0.92)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C143(0.87)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C143(1.18)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C143(0.94)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C143(0.98)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C143(1.08)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C143(1.02)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C143(0.97)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C143(0.91)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C143(1.13)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C143(0.98)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C143(1.02)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C143(0.96)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C143(0.97)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C143(0.92)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C143(1.05)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C143(0.97)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C143(0.91)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C143(0.99)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C143(1.16)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C143(0.89)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C143(0.93)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C143(1.01)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C143(1.06)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C143(0.94)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C143(0.96)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C143(0.97)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C143(1.10)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C143(1.03)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C143(0.97)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C143(1.04)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C143(1.05)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C143(1.03)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C143(0.97)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C143(1.07)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C143(1.09)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C143(0.85)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C143(0.79)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C143(0.96)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C143(0.82)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C143(0.85)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C143(0.85)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C143(0.78)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C143(0.74)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C143(0.81)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C143(0.73)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C143(0.74)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C143(0.73)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C143(0.85)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C143(1.04)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C143(0.84)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C143(0.97)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C143(0.95)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C143(0.92)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C143(1.02)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C143(0.95)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C143(1.06)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C143(1.10)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C143(1.02)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C143(0.97)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C143(0.97)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C143(1.12)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C143(1.04)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C143(0.92)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C143(0.95)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C143(0.94)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C143(1.13)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C143(0.91)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C143(1.00)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C143(1.00)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C143(0.91)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C143(0.97)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C143(0.85)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C143(1.08)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C143(0.95)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C143(0.93)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C143(1.02)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C143(0.89)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C143(0.93)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C143(1.10)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C143(0.92)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C143(0.93)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C143(0.99)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C143(1.06)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C143(0.98)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C143(0.86)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C143(1.10)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C143(1.16)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C143(0.90)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C143(0.97)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C143(0.96)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C143(0.97)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C143(0.92)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C143(1.89)  LDD1702  [1]
 LDCM0625  F8 Ramos C143(1.26)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C143(1.64)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C143(0.60)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C143(0.95)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C143(0.66)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C143(0.70)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C143(1.11)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C143(0.83)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C143(1.19)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C143(0.92)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C143(0.43)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C143(1.02)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C143(0.70)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C143(1.55)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C143(0.93)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C143(0.86)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C143(0.78)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C143(0.94)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C143(0.92)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C143(0.97)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C143(0.99)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C143(1.05)  LDD2188  [12]
 LDCM0022  KB02 HCT 116 C143(1.94)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C143(1.31)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C143(1.50)  LDD0082  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C143(0.96)  LDD2108  [1]
 LDCM0628  OTUB2-COV-1 HEK-293T C143(0.70)  LDD2207  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C) . Q15572
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TATA-box-binding protein (TBP) TBP family P20226
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) CAMP-dependent kinase regulatory chain family P31323
Transcription initiation factor TFIID subunit 4 (TAF4) TAF4 family O00268

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.