Details of the Target

General Information of Target

Target ID LDTP05684
Target Name Hyaluronidase-2 (HYAL2)
Gene Name HYAL2
Gene ID 8692
Synonyms
LUCA2; Hyaluronidase-2; Hyal-2; EC 3.2.1.35; Hyaluronoglucosaminidase-2; Lung carcinoma protein 2; LuCa-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF
DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY
IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE
FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAW
LWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSR
RLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSW
ATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDH
LQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 56 family
Subcellular location
Cell membrane
Function
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Uniprot ID
Q12891
Ensemble ID
ENST00000357750.9
HGNC ID
HGNC:5321

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K148(1.46)  LDD3494  [1]
BTD
 Probe Info  		C370(1.00)  LDD2127  [2]
DBIA
 Probe Info  		C429(1.52); C438(1.52); C227(1.05); C427(1.52)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		C370(0.00); C227(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C429(1.52); C438(1.52); C227(1.05); C427(1.52)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C227(1.20)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C227(1.04)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C227(0.99)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C227(0.84)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C227(1.22)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C227(1.42)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C227(0.93)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C227(1.10)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C227(1.18)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C227(0.99)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C227(0.75)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C227(0.79)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C227(0.92)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C227(0.71)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C227(0.78)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C227(1.06)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C227(0.83)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C227(0.85)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C227(0.93)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C227(1.00)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C227(1.07)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C227(1.09)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C227(0.93)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C227(0.90)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C227(1.02)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C227(1.04)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C227(0.96)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C227(0.93)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C227(0.95)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C227(0.96)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C227(1.16)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C227(0.91)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C227(1.04)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C227(1.01)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C227(1.20)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C227(0.65)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C227(0.70)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C227(1.02)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C227(0.72)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C227(0.73)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C227(0.87)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C227(1.15)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C227(0.71)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C227(0.82)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C227(0.73)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C227(1.00)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C227(0.92)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C227(0.78)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C227(0.94)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C227(0.90)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C227(1.21)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C227(1.13)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C227(1.40)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C227(1.21); C429(1.28); C438(1.28); C427(1.28)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C227(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C227(1.17)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C227(1.01)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C227(1.09)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C227(1.45)  LDD0601  [3]
 LDCM0290  AC3 HCT 116 C227(1.06); C429(1.59); C438(1.59); C427(1.59)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C370(1.21)  LDD1530  [6]
 LDCM0296  AC35 HCT 116 C227(0.85)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C227(0.86)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C227(1.00)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C227(0.82)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C227(0.98)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C227(1.30); C429(1.64); C438(1.64); C427(1.64)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C227(1.12)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C227(0.94)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C227(1.22)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C227(1.05)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C227(1.01)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C227(1.00)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C429(1.06); C438(1.06); C227(1.29)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C429(0.89); C438(0.89); C227(1.29)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C429(0.85); C438(0.85); C227(1.05)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C429(0.73); C438(0.73); C227(1.16)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C227(1.21); C429(1.38); C438(1.38); C427(1.38)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C429(0.89); C438(0.89); C227(1.10)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C227(1.17); C429(1.28); C438(1.28)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C429(0.98); C438(0.98); C227(1.02)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C227(1.13); C429(1.20); C438(1.20)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C429(0.97); C438(0.97); C227(1.20)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C429(0.88); C438(0.88); C227(1.28)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C429(0.99); C438(0.99); C227(1.16)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C227(0.95); C429(1.04); C438(1.04); C427(1.60)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C429(1.17); C438(1.17); C227(1.31); C427(1.76)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C227(0.91); C429(1.35); C438(1.35); C427(1.85)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C227(1.19)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C227(0.77); C427(1.98); C429(10.99); C438(10.99)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C227(0.77); C429(1.03); C438(1.03); C427(1.57)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C227(0.75); C429(1.26); C438(1.26); C427(2.09)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C227(0.91); C429(1.11); C438(1.11); C427(1.58)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C227(0.91); C429(1.05); C438(1.05); C427(1.39)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C227(1.05); C429(1.32); C438(1.32); C427(1.90)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C227(0.98); C429(1.56); C438(1.56); C427(2.03)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C227(0.76); C429(0.82); C438(0.82); C427(1.18)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C429(1.13); C438(1.19); C427(1.19); C227(1.25)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C227(1.11); C438(1.17); C427(1.17); C429(1.18)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C227(1.11)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C438(0.94); C427(0.94); C429(0.99); C227(1.22)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C429(1.14); C227(1.21); C438(1.24); C427(1.24)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C429(0.95); C438(0.97); C427(0.97); C227(1.24)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C438(0.89); C427(0.89); C429(0.92); C227(1.24)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C429(0.88); C438(0.96); C427(0.96); C227(1.25)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C438(0.80); C427(0.80); C429(0.81); C227(1.48)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C227(1.16); C438(1.26); C427(1.26); C429(1.29)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C438(1.25); C427(1.25); C429(1.27); C227(1.27)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C438(1.29); C427(1.29); C429(1.31); C227(1.31)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C438(1.05); C427(1.05); C429(1.06); C227(1.41)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C227(1.01)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C227(1.04); C438(1.04); C427(1.04); C429(1.05)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C429(0.89); C438(0.92); C427(0.92); C227(1.04)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C429(0.55); C438(0.59); C427(0.59); C227(1.06)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C227(1.05); C429(1.88); C438(1.88); C427(1.88)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C227(1.14); C429(1.38); C438(1.38); C427(1.38)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C227(1.22); C429(1.30); C438(1.30); C427(1.30)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C227(1.03); C429(1.29); C438(1.29); C427(1.29)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C429(1.12); C438(1.12); C427(1.12); C227(1.20)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C429(1.03); C438(1.03); C427(1.03); C227(1.05)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C227(1.10); C429(1.59); C438(1.59); C427(1.59)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C227(1.57); C429(2.76); C438(2.76); C427(2.76)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C227(0.94); C429(1.67); C438(1.67); C427(1.67)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C227(1.20); C429(1.23); C438(1.23); C427(1.23)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C429(1.20); C438(1.20); C427(1.20); C227(1.28)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C429(0.89); C438(0.89); C427(0.89); C227(1.37)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C227(1.17); C429(1.26); C438(1.26); C427(1.26)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C227(1.29); C429(1.81); C438(1.81); C427(1.81)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C227(1.24); C429(1.27); C438(1.27); C427(1.27)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C227(1.02)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C227(1.11)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C227(1.26)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C427(1.11); C429(1.11); C438(1.11)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C227(1.04)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C227(0.93)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C227(1.11); C429(1.33); C438(1.33); C427(1.33)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C227(1.24)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C227(1.09)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C227(1.04)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C227(1.07)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C227(0.80)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C227(0.93)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C227(0.94)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C227(1.07)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C227(1.10)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C227(1.16)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C227(1.11)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C227(1.03)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C370(1.13)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C370(0.94)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C370(1.04)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C370(1.14)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C370(0.93)  LDD1590  [6]
 LDCM0387  CL117 HCT 116 C227(1.02)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C227(0.93)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C227(0.98)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C227(1.15)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C227(0.94)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C227(1.18); C429(1.39); C438(1.39)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C429(0.93); C438(0.93); C227(1.08)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C429(0.85); C438(0.85); C227(1.28)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C429(0.91); C438(0.91); C227(1.26)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C429(0.89); C438(0.89); C227(0.94); C427(1.29)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C227(0.90); C429(1.08); C438(1.08); C427(1.51)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C227(0.85); C429(1.20); C438(1.20); C427(1.42)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C227(0.84); C429(1.04); C438(1.04); C427(1.43)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C227(0.92)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C227(1.25)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C227(0.95)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C429(0.88); C438(0.88); C427(0.88); C227(1.18)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C429(3.22); C438(3.22); C427(3.22)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C429(0.86); C438(0.86); C427(0.86)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C429(1.26); C438(1.26); C427(1.26)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C227(0.98)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C429(1.07); C438(1.07); C427(1.07)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C429(2.70); C438(2.70); C427(2.70)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C429(1.78); C438(1.78); C427(1.78)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C429(1.90); C438(1.90); C427(1.90)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C429(1.15); C438(1.15); C427(1.15)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C429(1.87); C438(1.87); C427(1.87)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C429(0.89); C438(0.89); C427(0.89)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C429(1.58); C438(1.58); C427(1.58)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C429(1.49); C438(1.49); C427(1.49)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C429(1.00); C438(1.00); C427(1.00)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C227(0.90)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C429(0.99); C438(0.99); C427(0.99)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C429(1.15); C438(1.15); C427(1.15)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C429(1.01); C438(1.01); C227(1.26); C427(1.01)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C429(1.32); C438(1.32); C227(1.57); C427(1.32)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C429(1.43); C438(1.43); C227(1.26); C427(1.43)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C429(1.17); C438(1.17); C227(1.31); C427(1.17)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C429(1.31); C438(1.31); C227(0.87); C427(1.31)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C429(1.75); C438(1.75); C227(1.26); C427(1.75)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C429(1.54); C438(1.54); C227(1.12); C427(1.54)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C227(0.95)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C429(1.86); C438(1.86); C227(1.05); C427(1.86)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C429(1.55); C438(1.55); C227(1.07); C427(1.55)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C429(0.98); C438(0.98); C227(0.90); C427(0.98)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C429(1.32); C438(1.32); C227(1.07); C427(1.32)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C429(1.14); C438(1.14); C227(1.14); C427(1.14)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C429(1.76); C438(1.76); C227(1.22); C427(1.76)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C370(1.16)  LDD1640  [6]
 LDCM0439  CL49 HEK-293T C370(0.89)  LDD1643  [6]
 LDCM0440  CL5 HCT 116 C227(0.76)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C370(1.03)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C370(1.15)  LDD1646  [6]
 LDCM0449  CL58 HEK-293T C370(1.40)  LDD1652  [6]
 LDCM0451  CL6 HCT 116 C227(0.92)  LDD0768  [3]
 LDCM0453  CL61 HEK-293T C227(1.19)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C227(1.01)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C227(0.84)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C227(0.88)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C227(1.04)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C227(0.93)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C227(1.04)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C227(1.27)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C227(0.90)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C227(1.00)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C227(1.19)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C227(1.03)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C227(1.26)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C227(1.22)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C227(1.47)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C370(0.89)  LDD1672  [6]
 LDCM0473  CL8 HCT 116 C227(0.72)  LDD0790  [3]
 LDCM0476  CL82 HEK-293T C370(1.51)  LDD1679  [6]
 LDCM0479  CL85 HEK-293T C370(0.85)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C370(1.12)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C370(1.07)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C370(0.94)  LDD1685  [6]
 LDCM0484  CL9 HCT 116 C227(0.95)  LDD0801  [3]
 LDCM0486  CL91 HCT 116 C429(1.42); C438(1.42); C227(1.05); C427(1.42)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C429(2.32); C438(2.32); C227(1.12); C427(2.32)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C429(1.81); C438(1.81); C227(1.03); C427(1.81)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C429(1.73); C438(1.73); C227(1.06); C427(1.73)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C429(1.61); C438(1.61); C227(1.05); C427(1.61)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C429(1.38); C438(1.38); C227(0.97); C427(1.38)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C429(1.67); C438(1.67); C227(0.99); C427(1.67)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C429(1.93); C438(1.93); C227(1.15); C427(1.93)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C429(1.15); C438(1.15); C227(1.13); C427(1.15)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C370(1.48)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C227(1.58)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C429(2.39); C438(2.39); C227(1.05); C427(2.39)  LDD0744  [3]
 LDCM0024  KB05 TGBC1TKB C370(1.69)  LDD3473  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C370(1.00)  LDD2127  [2]
 LDCM0021  THZ1 HCT 116 C427(1.11); C429(1.11); C438(1.11)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nitric oxide synthase 3 (NOS3) NOS family P29474
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Pellino family Q9HAT8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Four and a half LIM domains protein 3 (FHL3) . Q13643

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hyaluronic Acid Small molecular drug DB08818

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840