Details of the Target

General Information of Target

Target ID LDTP05519
Target Name 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
Gene Name PDE4B
Gene ID 5142
Synonyms
DPDE4; 3',5'-cyclic-AMP phosphodiesterase 4B; EC 3.1.4.53; DPDE4; PDE32; cAMP-specific phosphodiesterase 4B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Subcellular location
Cytoplasm
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
TTD ID
T10265
Uniprot ID
Q07343
DrugMap ID
TTVIAT9
Ensemble ID
ENST00000329654.8
HGNC ID
HGNC:8781
ChEMBL ID
CHEMBL275

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.N668K .
HCT15 SNV: p.T81P .
HT115 SNV: p.L350I .
IGROV1 SNV: p.A356V .
LS513 SNV: p.S128N .
NCIH23 SNV: p.S654R DBIA    Probe Info 
NCIH661 SNV: p.R594W .
YSCCC Deletion: p.K731SfsTer27 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]
DBIA
 Probe Info  		C671(1.15)  LDD0532  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C671(1.15)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C671(1.05)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C671(1.12)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C671(1.32)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C671(1.20)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C671(1.21)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C671(1.30)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C671(1.30)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C671(1.18)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C671(0.89)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C671(1.19)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C671(1.38)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C671(1.03)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C671(1.09)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C671(1.09)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C671(1.00)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C671(0.91)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C671(1.24)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C671(2.40)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C671(1.24)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C671(1.57)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C671(1.71)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C671(2.24)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C671(1.75)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C671(1.29)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C671(1.80)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C671(0.87)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C671(1.71)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C671(2.02)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C671(1.71)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C671(2.67)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C671(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C671(0.96)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C671(1.10)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C671(1.78)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C671(1.14)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C671(1.14)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C671(0.99)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C671(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C671(1.09)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C671(1.22)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C671(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C671(1.24)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C671(1.12)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C671(1.33)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C671(1.24)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C671(1.23)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C671(1.04)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C671(1.37)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C671(1.01)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C671(1.09)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C671(0.80)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C671(0.82)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C671(0.87)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C671(1.06)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C671(0.93)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C671(0.80)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C671(0.91)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C671(0.95)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C671(1.31)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C671(0.84)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C671(0.78)  LDD0624  [2]
 LDCM0320  AC57 HCT 116 C671(2.16)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C671(1.57)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C671(2.28)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C671(0.55)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C671(2.73)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C671(1.46)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C671(2.00)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C671(1.84)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C671(1.99)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C671(2.28)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C671(2.17)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C671(2.68)  LDD0648  [2]
 LDCM0334  AC7 HCT 116 C671(0.93)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C671(0.55)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C671(1.16)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C671(1.28)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C671(1.24)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C671(1.15)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C671(1.29)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C671(1.30)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C671(1.20)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C671(1.38)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C671(1.05)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C671(1.20)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C671(1.25)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C671(1.19)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C671(1.19)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C671(1.27)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C671(1.22)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C671(1.20)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C671(0.98)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C671(1.13)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C671(0.89)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C671(1.90)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C671(0.79)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C671(0.78)  LDD0685  [2]
 LDCM0370  CL101 HCT 116 C671(1.06)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C671(0.84)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C671(0.71)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C671(1.16)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C671(1.26)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C671(1.76)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C671(1.79)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C671(1.71)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C671(1.60)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C671(0.82)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C671(1.63)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C671(1.28)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C671(0.94)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C671(1.26)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C671(1.12)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C671(1.15)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C671(0.95)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C671(1.11)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C671(0.99)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C671(0.92)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C671(0.78)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C671(1.05)  LDD0708  [2]
 LDCM0396  CL125 HCT 116 C671(1.49)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C671(1.12)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C671(1.28)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C671(1.85)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C671(0.89)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C671(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C671(0.80)  LDD0719  [2]
 LDCM0404  CL17 HCT 116 C671(1.32)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C671(1.19)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C671(1.08)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C671(0.68)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C671(1.10)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C671(1.43)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C671(1.03)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C671(1.07)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C671(0.97)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C671(1.14)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C671(1.09)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C671(1.05)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C671(1.07)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C671(0.96)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C671(0.57)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C671(1.07)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C671(1.03)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C671(1.26)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C671(1.08)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C671(1.17)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C671(1.09)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C671(1.18)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C671(1.12)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C671(1.36)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C671(0.87)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C671(1.09)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C671(0.79)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C671(0.84)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C671(1.04)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C671(0.84)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C671(0.96)  LDD0752  [2]
 LDCM0440  CL5 HCT 116 C671(0.91)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C671(0.90)  LDD0768  [2]
 LDCM0453  CL61 HCT 116 C671(0.80)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C671(0.78)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C671(1.05)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C671(0.94)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C671(0.89)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C671(0.96)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C671(1.49)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C671(0.88)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C671(1.00)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C671(0.93)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C671(0.86)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C671(1.11)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C671(1.02)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C671(1.03)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C671(0.95)  LDD0784  [2]
 LDCM0473  CL8 HCT 116 C671(0.88)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C671(0.83)  LDD0801  [2]
 LDCM0468  Fragment33 HCT 116 C671(0.96)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C671(1.00)  LDD0744  [2]
 LDCM0022  KB02 A204 C660(2.74)  LDD2252  [3]
 LDCM0023  KB03 A204 C660(3.80)  LDD2669  [3]
 LDCM0024  KB05 MOLM-13 C660(1.89)  LDD3333  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine Phosphate Small molecular drug DB00131
Amrinone Small molecular drug DB01427
Caffeine Small molecular drug DB00201
Crisaborole Small molecular drug DB05219
Dyphylline Small molecular drug DB00651
Enprofylline Small molecular drug DB00824
Iloprost Small molecular drug DB01088
Papaverine Small molecular drug DB01113
Theophylline Small molecular drug DB00277
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Denbufylline Small molecular drug D01XHG
Sotb07 . D06VFP
Phase 2
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Awd-12-281 Small molecular drug D0F4TV
Cc-1088 Small molecular drug D0U2DH
Ht-0712 Small molecular drug D07OCV
Lirimilast Small molecular drug D0F5IY
Mk-0873 Small molecular drug D0M7CB
Oglemilast Small molecular drug D0L8KJ
Piclamilast Small molecular drug D0Z2FB
Revamilast Small molecular drug D0X0PW
Tofimilast Small molecular drug D09TFB
An-2898 . D00JED
Gpd-1116 . D01XFZ
Ox-914 . D0RJ1W
Ta-7906 . D02POH
Phase 1
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk-356278 Small molecular drug D0K9DI
Ronomilast Small molecular drug D0O8JW
Ave-8112 . D01WZL
Mem-1414 . D03CWX
Investigative
Click To Hide/Show 42 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(R)-rolipram Small molecular drug D01RUN
(S)-rolipram Small molecular drug D02FZD
3-(2-bromophenyl)-2-thioxo-(1h )-quinazolin-4-one Small molecular drug D06PUS
8-(3-nitro-phenyl)-6-phenyl-[1,7]Naphthyridine Small molecular drug D02NKD
8-bromo-adenosine-5'-monophosphate Small molecular drug D0R5ZH
Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine Small molecular drug D09AUL
Benzyl-(2-phenyl-quinazolin-4-yl)-amine Small molecular drug D0J7GF
Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine Small molecular drug D01TOR
Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine Small molecular drug D0U8YQ
Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine Small molecular drug D02NWF
Ci-1044 Small molecular drug D0DL6J
Cilomilast Small molecular drug DB03849
Ibudilast Small molecular drug DB05266
Isobutylmethylxanthine Small molecular drug D0R6MT
Kf-66490 Small molecular drug D0E5VP
Kuraidin Small molecular drug D06GUJ
Kurarinol Small molecular drug D0W4ZU
L-454560 Small molecular drug D0JD4C
L-869298 Small molecular drug D0W7WV
Nitraquazone Small molecular drug D0V5BX
Rolipram Small molecular drug D0T5PO
Rolipram Small molecular drug DB01954
Rs-14491 Small molecular drug D0O3BL
Rs-25344 Small molecular drug D0P2HX
S,S-(2-hydroxyethyl)Thiocysteine Small molecular drug D0P7JE
Sophoflavescenol Small molecular drug D00QCL
Ss-(2-hydroxyethyl)Thiocysteine Small molecular drug DB04530
Theobromine Small molecular drug DB01412
Trapidil Small molecular drug DB09283
Ucb-101333-3 Small molecular drug D02ZPV
1-(2-chlorophenyl)-35-dimethyl-1h-pyrazole-4-carboxylic Acid Ethyl Ester . DB03807
1-ethyl-n-(Phenylmethyl)-4-(Tetrahydro-2h-pyran-4-ylamino)-1h-pyrazolo[34-b]Pyridine-5-carboxamide . DB06909
35-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic Acid Ethyl Ester . DB01959
4-[8-(3-nitrophenyl)-17-naphthyridin-6-yl]Benzoic Acid . DB08299
Al-59640 . D04BMR
Asp-3258 . D0N7HS
Cd-160130 . D0U4SS
Ch-3697 . D05YEL
Chf-5480 . D0K9PS
Ocid-2987 . D0S6MA
Tas-203 . D0S1HX
Zl-n-91 . D04JNC
Discontinued
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cdp840 Small molecular drug D0UG4T
Ci-1018 Small molecular drug D00DBE
D-22888 Small molecular drug D0R1QJ
D-4418 Small molecular drug D0K1OA
Filaminast Small molecular drug D0H9KW
Sch-351591 Small molecular drug D01FXD
Torbafylline Small molecular drug D0F7TV
Ym-976 Small molecular drug D0C7JT
Daxalipram . D0I0GM
Gw-3600 . D01QUF
Kw-4490 . D03ZVD
Las-37779 . D0V2CN
Nik-616 . D07UHY
Tjn-598 . D01OUA
V-11294a . D08SNX

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840