Details of the Target

General Information of Target

Target ID LDTP05483
Target Name Aldehyde oxidase (AOX1)
Gene Name AOX1
Gene ID 316
Synonyms
AO; Aldehyde oxidase; EC 1.2.3.1; Aldehyde oxidase 1; Azaheterocycle hydroxylase; EC 1.17.3.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYN
PITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPG
MVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCC
LDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMAEKQSQRTRVFGSER
MMWFSPVTLKELLEFKFKYPQAPVIMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHA
YNGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHII
SRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSR
KWEFVSAFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKL
IGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPV
HYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYC
DDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAE
KFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPE
RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKY
IQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGE
DMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF
PNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEID
QTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGS
RAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETV
PNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVG
YFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAID
IGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSN
TLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
KMIPRDEPGSYVPWNVPI
Target Type
Successful
Target Bioclass
Enzyme
Family
Xanthine dehydrogenase family
Subcellular location
Cytoplasm
Function
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
TTD ID
T94444
Uniprot ID
Q06278
DrugMap ID
TT3MOS2
Ensemble ID
ENST00000374700.7
HGNC ID
HGNC:553
ChEMBL ID
CHEMBL3257

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C1103(2.72); C1315(8.13)  LDD1699  [1]
IPM
 Probe Info  		C149(0.00); C170(0.00); C171(0.00); C562(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C943(2.07)  LDD3340  [3]
WYneN
 Probe Info  		C377(0.00); C1103(0.00); C171(0.00)  LDD0021  [4]
WYneO
 Probe Info  		N.A.  LDD0022  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1315(0.32); C1103(0.32)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1315(0.71); C1103(0.51)  LDD2112  [1]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1103(0.98)  LDD2103  [1]
 LDCM0214  AC1 PaTu 8988t C171(1.72); C170(1.72)  LDD1093  [5]
 LDCM0215  AC10 PaTu 8988t C171(1.71); C460(1.15); C472(1.15); C170(1.71)  LDD1094  [5]
 LDCM0216  AC100 PaTu 8988t C171(0.97); C460(0.81); C472(0.81); C170(0.97)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C171(0.84); C460(1.15); C472(1.15); C170(0.84)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C171(0.82); C460(0.99); C472(0.99); C170(0.82)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C171(1.03); C460(0.88); C472(0.88); C170(1.03)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C171(0.79); C460(0.98); C472(0.98); C170(0.79)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C171(0.68); C460(0.85); C472(0.85); C170(0.68)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C171(0.96); C460(0.95); C472(0.95); C170(0.96)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C171(0.91); C460(0.96); C472(0.96); C170(0.91)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C171(0.97); C460(1.07); C472(1.07); C170(0.97)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C171(0.91); C460(1.17); C472(1.17); C170(0.91)  LDD1104  [5]
 LDCM0226  AC11 PaTu 8988t C171(1.70); C460(1.25); C472(1.25); C170(1.70)  LDD1105  [5]
 LDCM0227  AC110 PaTu 8988t C171(0.97); C460(0.86); C472(0.86); C170(0.97)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C171(1.07); C460(0.97); C472(0.97); C170(1.07)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C171(1.51); C460(0.98); C472(0.98); C170(1.51)  LDD1108  [5]
 LDCM0230  AC113 PaTu 8988t C171(0.69); C460(0.99); C472(0.99); C170(0.69)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C171(0.91); C460(1.20); C472(1.20); C170(0.91)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C171(0.70); C460(1.34); C472(1.34); C170(0.70)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C171(0.94); C460(1.17); C472(1.17); C170(0.94)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C171(0.70); C460(1.19); C472(1.19); C170(0.70)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C171(0.90); C460(0.83); C472(0.83); C170(0.90)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C171(0.88); C460(1.50); C472(1.50); C170(0.88)  LDD1115  [5]
 LDCM0237  AC12 PaTu 8988t C171(1.51); C460(1.21); C472(1.21); C170(1.51)  LDD1116  [5]
 LDCM0238  AC120 PaTu 8988t C171(0.78); C460(1.39); C472(1.39); C170(0.78)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C171(1.03); C460(1.39); C472(1.39); C170(1.03)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C171(0.81); C460(1.28); C472(1.28); C170(0.81)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C171(0.84); C460(0.97); C472(0.97); C170(0.84)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C171(1.07); C460(1.50); C472(1.50); C170(1.07)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C171(0.95); C460(1.05); C472(1.05); C170(0.95)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C171(0.84); C460(0.87); C472(0.87); C170(0.84)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C171(1.19); C460(1.28); C472(1.28); C170(1.19)  LDD1124  [5]
 LDCM0246  AC128 PaTu 8988t C171(1.12); C170(1.12)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C171(1.06); C170(1.06)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C171(0.97); C170(0.97)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C171(1.07); C170(1.07)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C171(1.17); C170(1.17)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C171(1.55); C170(1.55)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C171(1.24); C170(1.24)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C171(1.48); C170(1.48)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C171(1.52); C170(1.52)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C171(1.43); C170(1.43)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C171(1.14); C170(1.14)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C171(1.23); C170(1.23)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C171(1.63); C460(1.15); C472(1.15); C170(1.63)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C171(1.08); C170(1.08)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C171(1.18); C170(1.18)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C171(1.40); C170(1.40)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C171(2.98); C460(1.29); C472(1.29)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C171(2.01); C460(1.06); C472(1.06)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C171(1.12); C460(1.19); C472(1.19)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C171(1.67); C460(1.02); C472(1.02)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C171(2.23); C460(1.10); C472(1.10)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C171(1.51); C460(1.05); C472(1.05)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C171(3.28); C460(1.53); C472(1.53)  LDD1148  [5]
 LDCM0270  AC15 PaTu 8988t C171(1.90); C460(1.19); C472(1.19); C170(1.90)  LDD1149  [5]
 LDCM0271  AC150 PaTu 8988t C171(2.87); C460(1.35); C472(1.35)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C171(2.38); C460(1.28); C472(1.28)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C171(1.90); C460(1.16); C472(1.16)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C171(1.94); C460(1.12); C472(1.12)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C171(2.83); C460(1.36); C472(1.36)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C171(4.15); C460(1.32); C472(1.32)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C171(1.90); C460(1.04); C472(1.04)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C171(1.99); C460(1.33); C472(1.33)  LDD2169  [5]
 LDCM0279  AC2 PaTu 8988t C171(1.54); C170(1.54)  LDD1158  [5]
 LDCM0285  AC25 PaTu 8988t C171(0.77); C170(0.77)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C171(0.94); C170(0.94)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C171(1.07); C170(1.07)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C171(1.04); C170(1.04)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C171(0.95); C170(0.95)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C171(1.49); C170(1.49)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C171(0.99); C170(0.99)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C171(0.85); C170(0.85)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C171(0.94); C170(0.94)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C171(1.08); C170(1.08)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C171(1.28); C170(1.28)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C171(1.03); C170(1.03)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C171(1.20); C170(1.20)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C171(1.52); C170(1.52)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C171(1.54); C170(1.54)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C171(1.33); C170(1.33)  LDD1179  [5]
 LDCM0301  AC4 PaTu 8988t C171(1.25); C170(1.25)  LDD1180  [5]
 LDCM0302  AC40 PaTu 8988t C171(1.88); C170(1.88)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C171(1.35); C170(1.35)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C171(1.67); C170(1.67)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C171(1.26); C170(1.26)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C171(2.13); C170(2.13)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C171(1.63); C170(1.63)  LDD1186  [5]
 LDCM0308  AC46 PaTu 8988t C460(1.00); C472(1.00)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C460(0.93); C472(0.93)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C460(0.89); C472(0.89)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C460(1.01); C472(1.01)  LDD1190  [5]
 LDCM0312  AC5 PaTu 8988t C171(1.83); C170(1.83)  LDD1191  [5]
 LDCM0313  AC50 PaTu 8988t C460(0.94); C472(0.94)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C460(0.51); C472(0.51)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C460(0.89); C472(0.89)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C460(1.01); C472(1.01)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C460(0.80); C472(0.80)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C460(0.84); C472(0.84)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C460(0.81); C472(0.81)  LDD1198  [5]
 LDCM0323  AC6 PaTu 8988t C171(1.43); C460(1.16); C472(1.16); C170(1.43)  LDD1202  [5]
 LDCM0332  AC68 PaTu 8988t C171(0.94); C460(1.08); C472(1.08); C170(0.94)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C171(0.99); C460(0.86); C472(0.86); C170(0.99)  LDD1212  [5]
 LDCM0334  AC7 PaTu 8988t C171(1.01); C460(1.12); C472(1.12); C170(1.01)  LDD1213  [5]
 LDCM0335  AC70 PaTu 8988t C171(1.02); C460(1.04); C472(1.04); C170(1.02)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C171(0.97); C460(1.19); C472(1.19); C170(0.97)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C171(0.96); C460(0.96); C472(0.96); C170(0.96)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C171(0.91); C460(0.92); C472(0.92); C170(0.91)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C171(1.11); C460(1.05); C472(1.05); C170(1.11)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C171(1.01); C460(0.89); C472(0.89); C170(1.01)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C171(0.96); C460(0.79); C472(0.79); C170(0.96)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C171(0.93); C460(1.03); C472(1.03); C170(0.93)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C171(1.05); C460(1.03); C472(1.03); C170(1.05)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C171(1.16); C460(1.10); C472(1.10); C170(1.16)  LDD1223  [5]
 LDCM0345  AC8 PaTu 8988t C171(1.19); C460(1.00); C472(1.00); C170(1.19)  LDD1224  [5]
 LDCM0346  AC80 PaTu 8988t C171(1.19); C460(1.09); C472(1.09); C170(1.19)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C171(1.12); C460(1.03); C472(1.03); C170(1.12)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C171(1.19); C460(1.10); C472(1.10); C170(1.19)  LDD1227  [5]
 LDCM0365  AC98 PaTu 8988t C171(0.99); C460(0.83); C472(0.83); C170(0.99)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C171(0.73); C460(0.88); C472(0.88); C170(0.73)  LDD1245  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C1315(0.50); C1103(0.97)  LDD2113  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C171(2.06); C460(1.24); C472(1.24); C170(2.06)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C171(1.57); C460(0.95); C472(0.95); C170(1.57)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C171(1.67); C460(1.13); C472(1.13); C170(1.67)  LDD1154  [5]
 LDCM0369  CL100 PaTu 8988t C171(1.36); C170(1.36)  LDD1248  [5]
 LDCM0370  CL101 PaTu 8988t C171(1.35); C460(1.11); C472(1.11); C170(1.35)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C171(1.46); C460(1.27); C472(1.27); C170(1.46)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C171(2.33); C460(1.36); C472(1.36); C170(2.33)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C171(1.50); C460(1.16); C472(1.16); C170(1.50)  LDD1252  [5]
 LDCM0382  CL112 PaTu 8988t C171(0.98); C170(0.98)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C171(0.74); C170(0.74)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C171(1.05); C170(1.05)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C171(0.85); C170(0.85)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C171(0.90); C170(0.90)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C171(1.26); C170(1.26)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C171(1.54); C170(1.54)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C171(1.54); C170(1.54)  LDD1268  [5]
 LDCM0391  CL120 PaTu 8988t C171(1.20); C170(1.20)  LDD1270  [5]
 LDCM0392  CL121 PaTu 8988t C460(0.99); C472(0.99)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C460(0.88); C472(0.88)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C460(1.06); C472(1.06)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C460(0.97); C472(0.97)  LDD1274  [5]
 LDCM0420  CL31 PaTu 8988t C171(0.57)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C171(0.81)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C171(1.03)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C171(0.65)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C171(0.62)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C171(0.73)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C171(0.97)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C171(1.05)  LDD1307  [5]
 LDCM0430  CL40 PaTu 8988t C171(0.59)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C171(0.91)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C171(1.16)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C171(1.20)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C171(0.79)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C171(1.04)  LDD1314  [5]
 LDCM0486  CL91 PaTu 8988t C171(1.20); C170(1.20)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C171(1.73); C170(1.73)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C171(1.71); C170(1.71)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C171(1.82); C170(1.82)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C171(3.56); C170(3.56)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C171(1.72); C170(1.72)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C171(1.50); C170(1.50)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C171(1.79); C170(1.79)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C171(1.45); C170(1.45)  LDD1373  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C149(2.03); C170(1.58)  LDD1702  [1]
 LDCM0427  Fragment51 PaTu 8988t C171(0.72)  LDD1306  [5]
 LDCM0022  KB02 C-4-II C943(1.89)  LDD2282  [3]
 LDCM0023  KB03 MDA-MB-231 C1103(12.50); C171(2.88); C161(0.16)  LDD1701  [1]
 LDCM0024  KB05 NB1 C943(2.07)  LDD3340  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1315(0.84); C1103(1.00)  LDD2102  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1315(0.90); C1103(1.10)  LDD2092  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1315(1.23); C1103(1.48)  LDD2094  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1315(0.07); C1103(0.08)  LDD2096  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1103(0.76)  LDD2097  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1315(1.04); C1103(0.69)  LDD2098  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1315(0.24); C1103(0.41)  LDD2100  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1103(1.00); C171(0.89)  LDD2101  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1315(0.23); C1103(0.46)  LDD2104  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1315(2.67)  LDD2105  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1315(0.24)  LDD2108  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1315(0.60)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1315(0.35); C1103(0.35)  LDD2115  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1315(0.19); C1103(0.67)  LDD2116  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1315(0.48)  LDD2120  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1315(0.11)  LDD2122  [1]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1103(0.09)  LDD2124  [1]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1315(0.54)  LDD2128  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1103(0.97)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1103(0.50)  LDD2134  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1315(0.37)  LDD2141  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1103(0.86)  LDD2143  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1315(0.18)  LDD2145  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1315(0.61); C1103(0.38); C171(0.55)  LDD2148  [1]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1315(0.14); C1103(0.65)  LDD2149  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aldehyde oxidase (AOX1) Xanthine dehydrogenase family Q06278

The Drug(s) Related To This Target

Approved
Click To Hide/Show 19 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Allopurinol Small molecular drug DB00437
Aminocaproic Acid Small molecular drug DB00513
Brimonidine Small molecular drug DB00484
Capmatinib Small molecular drug DB11791
Cyclobenzaprine Small molecular drug DB00924
Famciclovir Small molecular drug DB00426
Favipiravir Small molecular drug DB12466
Idelalisib Small molecular drug DB09054
Isovanillin Small molecular drug D0E9CD
Lenvatinib Small molecular drug DB09078
Menadione Small molecular drug D03GET
Mercaptopurine Small molecular drug DB01033
Methotrexate Small molecular drug DB00563
Nadh Small molecular drug DB00157
Pyrazinamide Small molecular drug DB00339
Raloxifene Small molecular drug DB00481
Zaleplon Small molecular drug DB00962
Ziprasidone Small molecular drug DB00246
Zonisamide Small molecular drug DB00909
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Eniluracil Small molecular drug DB03516

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.