Details of the Target
General Information of Target
Target ID | LDTP05482 | |||||
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Target Name | Exosome complex component RRP45 (EXOSC9) | |||||
Gene Name | EXOSC9 | |||||
Gene ID | 5393 | |||||
Synonyms |
PMSCL1; Exosome complex component RRP45; Autoantigen PM/Scl 1; Exosome component 9; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; Polymyositis/scleroderma autoantigen 1; Polymyositis/scleroderma autoantigen 75 kDa; PM/Scl-75
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3D Structure | ||||||
Sequence |
MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVS
CELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTES LCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEER DPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGI MLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEK APIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEG GGDQAIILDGIKMDTGVEVSDIGSQDAPIILSDSEEEEMIILEPDKNPKKIRTQTTSAKQ EKAPSKKPVKRRKKKRAAN |
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Target Bioclass |
Enzyme
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Family |
RNase PH family
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Subcellular location |
Cytoplasm; Nucleus; Nucleus, nucleolus
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Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Target Site Mutations in Different Cell Lines
Cell line | Mutation details | Probe for labeling this protein in this cell | |||
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CCK81 | SNV: p.V222A | DBIA Probe Info | |||
KPNYN | Insertion: p.R162KfsTer3 | DBIA Probe Info | |||
NUGC3 | SNV: p.Q200K | DBIA Probe Info | |||
SKMEL2 | Deletion: p.F78LfsTer23 | DBIA Probe Info |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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m-APA Probe Info |
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11.23 | LDD0402 | [1] | |
STPyne Probe Info |
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K101(10.00); K297(10.00) | LDD0277 | [2] | |
Probe 1 Probe Info |
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Y30(17.81); Y175(12.63) | LDD3495 | [3] | |
BTD Probe Info |
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C9(1.03) | LDD1700 | [4] | |
DBIA Probe Info |
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C9(4.01) | LDD0209 | [5] | |
ATP probe Probe Info |
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K67(0.00); K2(0.00) | LDD0199 | [6] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C9(0.00); C158(0.00); C61(0.00); C46(0.00) | LDD0038 | [7] | |
IA-alkyne Probe Info |
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N.A. | LDD0032 | [8] | |
IPIAA_H Probe Info |
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N.A. | LDD0030 | [9] | |
IPIAA_L Probe Info |
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N.A. | LDD0031 | [9] | |
Lodoacetamide azide Probe Info |
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C232(0.00); C9(0.00); C46(0.00); C45(0.00) | LDD0037 | [7] | |
NAIA_4 Probe Info |
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N.A. | LDD2226 | [10] | |
TFBX Probe Info |
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C61(0.00); C9(0.00) | LDD0027 | [11] | |
WYneO Probe Info |
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N.A. | LDD0022 | [12] | |
Compound 10 Probe Info |
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N.A. | LDD2216 | [13] | |
Compound 11 Probe Info |
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N.A. | LDD2213 | [13] | |
ENE Probe Info |
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N.A. | LDD0006 | [12] | |
IPM Probe Info |
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N.A. | LDD0005 | [12] | |
VSF Probe Info |
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N.A. | LDD0007 | [12] | |
YN-1 Probe Info |
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N.A. | LDD0447 | [14] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [15] | |
Acrolein Probe Info |
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C61(0.00); C9(0.00); C232(0.00) | LDD0217 | [16] | |
Methacrolein Probe Info |
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C61(0.00); C9(0.00) | LDD0218 | [16] | |
W1 Probe Info |
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N.A. | LDD0236 | [17] | |
AOyne Probe Info |
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13.20 | LDD0443 | [18] | |
NAIA_5 Probe Info |
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C9(0.00); C61(0.00) | LDD2223 | [10] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
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LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C9(0.99) | LDD2142 | [4] |
LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C9(1.28) | LDD2112 | [4] |
LDCM0537 | 2-Cyano-N,N-dimethylacetamide | MDA-MB-231 | C9(1.05) | LDD2130 | [4] |
LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C9(0.94); C61(0.90) | LDD2117 | [4] |
LDCM0558 | 2-Cyano-N-phenylacetamide | MDA-MB-231 | C9(1.29) | LDD2152 | [4] |
LDCM0510 | 3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C9(1.00) | LDD2103 | [4] |
LDCM0214 | AC1 | HEK-293T | C61(1.01); C9(1.00); C122(0.97) | LDD1507 | [19] |
LDCM0215 | AC10 | HEK-293T | C61(0.99); C9(1.04); C158(0.96); C232(1.19) | LDD1508 | [19] |
LDCM0226 | AC11 | HEK-293T | C61(1.03); C9(0.99); C158(1.03); C232(0.94) | LDD1509 | [19] |
LDCM0237 | AC12 | HEK-293T | C61(1.08); C9(0.99); C122(0.90) | LDD1510 | [19] |
LDCM0259 | AC14 | HEK-293T | C61(1.04); C9(1.05); C122(0.93) | LDD1512 | [19] |
LDCM0270 | AC15 | HEK-293T | C61(0.96); C9(0.99); C158(1.04); C122(0.92) | LDD1513 | [19] |
LDCM0276 | AC17 | HEK-293T | C61(0.96); C9(1.02); C122(0.93) | LDD1515 | [19] |
LDCM0277 | AC18 | HEK-293T | C61(1.03); C9(1.00); C158(0.87); C232(1.23) | LDD1516 | [19] |
LDCM0278 | AC19 | HEK-293T | C61(0.87); C9(1.02); C158(0.91); C232(0.99) | LDD1517 | [19] |
LDCM0279 | AC2 | HEK-293T | C61(1.04); C9(0.98); C158(1.01); C232(1.12) | LDD1518 | [19] |
LDCM0280 | AC20 | HEK-293T | C61(0.95); C9(1.02); C122(0.98) | LDD1519 | [19] |
LDCM0281 | AC21 | HEK-293T | C61(0.90); C9(1.06); C122(0.94); C45(1.00) | LDD1520 | [19] |
LDCM0282 | AC22 | HEK-293T | C61(1.02); C9(1.02); C122(0.91) | LDD1521 | [19] |
LDCM0283 | AC23 | HEK-293T | C61(0.98); C9(1.10); C158(1.00); C122(0.95) | LDD1522 | [19] |
LDCM0284 | AC24 | HEK-293T | C61(0.96); C9(0.99); C158(1.06); C122(0.97) | LDD1523 | [19] |
LDCM0285 | AC25 | HEK-293T | C61(0.95); C9(1.00); C122(0.92) | LDD1524 | [19] |
LDCM0286 | AC26 | HEK-293T | C61(1.05); C9(0.98); C158(0.95); C232(1.06) | LDD1525 | [19] |
LDCM0287 | AC27 | HEK-293T | C61(0.99); C9(0.93); C158(0.97); C232(0.93) | LDD1526 | [19] |
LDCM0288 | AC28 | HEK-293T | C61(1.19); C9(0.96); C122(0.93) | LDD1527 | [19] |
LDCM0289 | AC29 | HEK-293T | C61(0.99); C9(1.02); C122(0.93); C45(0.92) | LDD1528 | [19] |
LDCM0290 | AC3 | HEK-293T | C61(1.05); C9(0.93); C158(1.00); C232(1.12) | LDD1529 | [19] |
LDCM0291 | AC30 | HEK-293T | C61(1.02); C9(1.03); C122(0.96) | LDD1530 | [19] |
LDCM0292 | AC31 | HEK-293T | C61(0.98); C9(0.95); C158(1.06); C122(0.93) | LDD1531 | [19] |
LDCM0293 | AC32 | HEK-293T | C61(0.98); C9(0.96); C158(1.12); C122(0.96) | LDD1532 | [19] |
LDCM0294 | AC33 | HEK-293T | C61(0.94); C9(1.06); C122(0.91) | LDD1533 | [19] |
LDCM0295 | AC34 | HEK-293T | C61(0.96); C9(0.94); C158(0.90); C232(1.10) | LDD1534 | [19] |
LDCM0296 | AC35 | HEK-293T | C61(0.97); C9(1.03); C158(0.90); C232(1.00) | LDD1535 | [19] |
LDCM0297 | AC36 | HEK-293T | C61(1.05); C9(1.00); C122(0.86) | LDD1536 | [19] |
LDCM0298 | AC37 | HEK-293T | C61(1.00); C9(1.04); C122(0.90); C45(0.95) | LDD1537 | [19] |
LDCM0299 | AC38 | HEK-293T | C61(1.12); C9(0.98); C122(0.86) | LDD1538 | [19] |
LDCM0300 | AC39 | HEK-293T | C61(1.03); C9(0.93); C158(1.03); C122(0.89) | LDD1539 | [19] |
LDCM0301 | AC4 | HEK-293T | C61(1.01); C9(0.96); C122(0.94) | LDD1540 | [19] |
LDCM0302 | AC40 | HEK-293T | C61(1.08); C9(0.96); C158(0.97); C122(0.93) | LDD1541 | [19] |
LDCM0303 | AC41 | HEK-293T | C61(1.02); C9(1.03); C122(0.92) | LDD1542 | [19] |
LDCM0304 | AC42 | HEK-293T | C61(0.94); C9(1.01); C158(1.03); C232(1.24) | LDD1543 | [19] |
LDCM0305 | AC43 | HEK-293T | C61(1.06); C9(1.03); C158(1.09); C232(1.13) | LDD1544 | [19] |
LDCM0306 | AC44 | HEK-293T | C61(0.94); C9(1.01); C122(0.83) | LDD1545 | [19] |
LDCM0307 | AC45 | HEK-293T | C61(0.90); C9(1.10); C122(0.89); C45(0.85) | LDD1546 | [19] |
LDCM0308 | AC46 | HEK-293T | C61(1.13); C9(0.99); C122(0.90) | LDD1547 | [19] |
LDCM0309 | AC47 | HEK-293T | C61(0.92); C9(1.06); C158(1.02); C122(0.94) | LDD1548 | [19] |
LDCM0310 | AC48 | HEK-293T | C61(0.99); C9(1.00); C158(1.10); C122(0.93) | LDD1549 | [19] |
LDCM0311 | AC49 | HEK-293T | C61(0.89); C9(1.05); C122(0.90) | LDD1550 | [19] |
LDCM0312 | AC5 | HEK-293T | C61(0.87); C9(1.02); C122(0.92); C45(0.86) | LDD1551 | [19] |
LDCM0313 | AC50 | HEK-293T | C61(0.96); C9(1.08); C158(1.09); C232(1.21) | LDD1552 | [19] |
LDCM0314 | AC51 | HEK-293T | C61(1.15); C9(1.06); C158(1.07); C232(0.96) | LDD1553 | [19] |
LDCM0315 | AC52 | HEK-293T | C61(0.98); C9(1.00); C122(0.89) | LDD1554 | [19] |
LDCM0316 | AC53 | HEK-293T | C61(1.08); C9(1.02); C122(0.94); C45(0.89) | LDD1555 | [19] |
LDCM0317 | AC54 | HEK-293T | C61(1.00); C9(1.01); C122(0.94) | LDD1556 | [19] |
LDCM0318 | AC55 | HEK-293T | C61(0.92); C9(1.08); C158(1.04); C122(0.92) | LDD1557 | [19] |
LDCM0319 | AC56 | HEK-293T | C61(0.95); C9(0.98); C158(1.00); C122(0.93) | LDD1558 | [19] |
LDCM0320 | AC57 | HEK-293T | C61(0.99); C9(1.01); C122(0.95) | LDD1559 | [19] |
LDCM0321 | AC58 | HEK-293T | C61(1.01); C9(0.96); C158(0.91); C232(1.22) | LDD1560 | [19] |
LDCM0322 | AC59 | HEK-293T | C61(0.91); C9(1.02); C158(1.21); C232(0.98) | LDD1561 | [19] |
LDCM0323 | AC6 | HEK-293T | C61(1.13); C9(0.98); C122(0.92) | LDD1562 | [19] |
LDCM0324 | AC60 | HEK-293T | C61(1.10); C9(0.96); C122(0.94) | LDD1563 | [19] |
LDCM0325 | AC61 | HEK-293T | C61(0.87); C9(1.07); C122(0.99); C45(0.95) | LDD1564 | [19] |
LDCM0326 | AC62 | HEK-293T | C61(1.00); C9(0.99); C122(0.96) | LDD1565 | [19] |
LDCM0327 | AC63 | HEK-293T | C61(0.99); C9(1.05); C158(1.05); C122(0.95) | LDD1566 | [19] |
LDCM0328 | AC64 | HEK-293T | C61(0.96); C9(1.02); C158(1.13); C122(0.93) | LDD1567 | [19] |
LDCM0334 | AC7 | HEK-293T | C61(0.98); C9(1.03); C158(0.95); C122(0.95) | LDD1568 | [19] |
LDCM0345 | AC8 | HEK-293T | C61(1.06); C9(0.98); C158(0.85); C122(1.00) | LDD1569 | [19] |
LDCM0545 | Acetamide | MDA-MB-231 | C9(0.88) | LDD2138 | [4] |
LDCM0248 | AKOS034007472 | HEK-293T | C61(1.07); C9(1.07); C122(0.96); C45(0.98) | LDD1511 | [19] |
LDCM0356 | AKOS034007680 | HEK-293T | C61(1.03); C9(1.02); C122(0.89) | LDD1570 | [19] |
LDCM0275 | AKOS034007705 | HEK-293T | C61(1.04); C9(1.00); C158(1.28); C122(0.97) | LDD1514 | [19] |
LDCM0156 | Aniline | NCI-H1299 | 11.42 | LDD0403 | [1] |
LDCM0108 | Chloroacetamide | HeLa | C61(0.00); C9(0.00); C45(0.00); C46(0.00) | LDD0222 | [16] |
LDCM0367 | CL1 | HEK-293T | C61(1.05); C9(1.15); C122(0.90) | LDD1571 | [19] |
LDCM0368 | CL10 | HEK-293T | C61(1.08); C9(1.01); C122(0.94) | LDD1572 | [19] |
LDCM0369 | CL100 | HEK-293T | C61(1.02); C158(0.74); C122(0.89) | LDD1573 | [19] |
LDCM0370 | CL101 | HEK-293T | C61(1.03); C9(1.06); C122(0.88) | LDD1574 | [19] |
LDCM0371 | CL102 | HEK-293T | C61(0.93); C9(1.07); C158(0.95); C122(0.83) | LDD1575 | [19] |
LDCM0372 | CL103 | HEK-293T | C61(1.04); C9(1.03); C122(0.92) | LDD1576 | [19] |
LDCM0373 | CL104 | HEK-293T | C61(1.06); C158(0.78); C122(0.91) | LDD1577 | [19] |
LDCM0374 | CL105 | HEK-293T | C61(1.01); C9(1.14); C122(0.92) | LDD1578 | [19] |
LDCM0375 | CL106 | HEK-293T | C61(0.85); C9(0.96); C158(0.88); C122(0.86) | LDD1579 | [19] |
LDCM0376 | CL107 | HEK-293T | C61(0.93); C9(1.00); C122(0.92) | LDD1580 | [19] |
LDCM0377 | CL108 | HEK-293T | C61(0.90); C158(0.91); C122(0.92) | LDD1581 | [19] |
LDCM0378 | CL109 | HEK-293T | C61(1.04); C9(1.08); C122(0.95) | LDD1582 | [19] |
LDCM0379 | CL11 | HEK-293T | C61(1.08); C9(1.07); C158(1.09); C122(1.14) | LDD1583 | [19] |
LDCM0380 | CL110 | HEK-293T | C61(0.91); C9(1.03); C158(0.85); C122(0.89) | LDD1584 | [19] |
LDCM0381 | CL111 | HEK-293T | C61(0.94); C9(1.03); C122(0.87) | LDD1585 | [19] |
LDCM0382 | CL112 | HEK-293T | C61(1.11); C158(1.08); C122(0.90) | LDD1586 | [19] |
LDCM0383 | CL113 | HEK-293T | C61(0.90); C9(0.95); C122(0.91) | LDD1587 | [19] |
LDCM0384 | CL114 | HEK-293T | C61(0.99); C9(1.08); C158(0.85); C122(0.75) | LDD1588 | [19] |
LDCM0385 | CL115 | HEK-293T | C61(0.98); C9(1.02); C122(0.89) | LDD1589 | [19] |
LDCM0386 | CL116 | HEK-293T | C61(1.10); C158(0.92); C122(0.91) | LDD1590 | [19] |
LDCM0387 | CL117 | HEK-293T | C61(1.14); C9(1.05); C122(0.93) | LDD1591 | [19] |
LDCM0388 | CL118 | HEK-293T | C61(0.94); C9(1.06); C158(0.83); C122(0.87) | LDD1592 | [19] |
LDCM0389 | CL119 | HEK-293T | C61(1.04); C9(1.04); C122(0.95) | LDD1593 | [19] |
LDCM0390 | CL12 | HEK-293T | C61(0.98); C9(1.08); C158(1.30); C122(1.29) | LDD1594 | [19] |
LDCM0391 | CL120 | HEK-293T | C61(0.96); C158(0.90); C122(0.93) | LDD1595 | [19] |
LDCM0392 | CL121 | HEK-293T | C61(1.10); C9(1.02); C122(0.89) | LDD1596 | [19] |
LDCM0393 | CL122 | HEK-293T | C61(0.90); C9(1.01); C158(0.79); C122(0.87) | LDD1597 | [19] |
LDCM0394 | CL123 | HEK-293T | C61(1.00); C9(1.01); C122(0.83) | LDD1598 | [19] |
LDCM0395 | CL124 | HEK-293T | C61(1.03); C158(1.09); C122(0.92) | LDD1599 | [19] |
LDCM0396 | CL125 | HEK-293T | C61(1.07); C9(1.10); C122(1.00) | LDD1600 | [19] |
LDCM0397 | CL126 | HEK-293T | C61(0.94); C9(1.00); C158(0.92); C122(0.93) | LDD1601 | [19] |
LDCM0398 | CL127 | HEK-293T | C61(1.02); C9(1.07); C122(0.96) | LDD1602 | [19] |
LDCM0399 | CL128 | HEK-293T | C61(0.99); C158(0.89); C122(0.97) | LDD1603 | [19] |
LDCM0400 | CL13 | HEK-293T | C61(1.07); C9(1.07); C122(0.84) | LDD1604 | [19] |
LDCM0401 | CL14 | HEK-293T | C61(0.98); C9(1.04); C158(0.94); C122(0.87) | LDD1605 | [19] |
LDCM0402 | CL15 | HEK-293T | C61(1.03); C9(0.94); C122(0.83) | LDD1606 | [19] |
LDCM0403 | CL16 | HEK-293T | C61(1.15); C158(1.05); C122(1.01) | LDD1607 | [19] |
LDCM0404 | CL17 | HEK-293T | C61(0.96); C9(1.00); C122(0.86) | LDD1608 | [19] |
LDCM0405 | CL18 | HEK-293T | C61(1.05); C9(1.02); C158(1.19); C232(1.31) | LDD1609 | [19] |
LDCM0406 | CL19 | HEK-293T | C61(1.21); C9(1.10); C158(1.25); C232(1.10) | LDD1610 | [19] |
LDCM0407 | CL2 | HEK-293T | C61(1.00); C9(1.03); C158(0.94); C122(0.94) | LDD1611 | [19] |
LDCM0408 | CL20 | HEK-293T | C61(0.99); C9(1.00); C122(1.10) | LDD1612 | [19] |
LDCM0409 | CL21 | HEK-293T | C61(1.07); C9(1.06); C122(0.91); C45(0.90) | LDD1613 | [19] |
LDCM0410 | CL22 | HEK-293T | C61(1.06); C9(1.02); C122(1.11) | LDD1614 | [19] |
LDCM0411 | CL23 | HEK-293T | C61(1.07); C9(1.12); C158(1.20); C122(1.18) | LDD1615 | [19] |
LDCM0412 | CL24 | HEK-293T | C61(1.04); C9(1.04); C158(1.47); C122(1.31) | LDD1616 | [19] |
LDCM0413 | CL25 | HEK-293T | C61(1.00); C9(0.94); C122(0.84) | LDD1617 | [19] |
LDCM0414 | CL26 | HEK-293T | C61(0.88); C9(0.94); C158(0.81); C122(0.90) | LDD1618 | [19] |
LDCM0415 | CL27 | HEK-293T | C61(1.00); C9(1.03); C122(0.97) | LDD1619 | [19] |
LDCM0416 | CL28 | HEK-293T | C61(1.03); C158(0.87); C122(0.96) | LDD1620 | [19] |
LDCM0417 | CL29 | HEK-293T | C61(1.03); C9(1.00); C122(0.95) | LDD1621 | [19] |
LDCM0418 | CL3 | HEK-293T | C61(1.17); C9(0.95); C122(1.00) | LDD1622 | [19] |
LDCM0419 | CL30 | HEK-293T | C61(0.98); C9(1.00); C158(0.92); C232(1.17) | LDD1623 | [19] |
LDCM0420 | CL31 | HEK-293T | C61(1.12); C9(1.00); C158(1.03); C232(1.21) | LDD1624 | [19] |
LDCM0421 | CL32 | HEK-293T | C61(1.30); C9(1.01); C122(1.11) | LDD1625 | [19] |
LDCM0422 | CL33 | HEK-293T | C61(1.01); C9(0.97); C122(0.94); C45(0.95) | LDD1626 | [19] |
LDCM0423 | CL34 | HEK-293T | C61(1.07); C9(1.04); C122(1.11) | LDD1627 | [19] |
LDCM0424 | CL35 | HEK-293T | C61(1.03); C9(1.21); C158(1.06); C122(1.13) | LDD1628 | [19] |
LDCM0425 | CL36 | HEK-293T | C61(1.06); C9(1.12); C158(1.17); C122(1.20) | LDD1629 | [19] |
LDCM0426 | CL37 | HEK-293T | C61(1.05); C9(1.03); C122(0.95) | LDD1630 | [19] |
LDCM0428 | CL39 | HEK-293T | C61(0.96); C9(1.16); C122(0.84) | LDD1632 | [19] |
LDCM0429 | CL4 | HEK-293T | C61(1.11); C158(0.63); C122(1.02) | LDD1633 | [19] |
LDCM0430 | CL40 | HEK-293T | C61(1.10); C158(0.86); C122(0.98) | LDD1634 | [19] |
LDCM0431 | CL41 | HEK-293T | C61(0.92); C9(1.04); C122(0.87) | LDD1635 | [19] |
LDCM0432 | CL42 | HEK-293T | C61(1.07); C9(1.12); C158(0.91); C232(0.87) | LDD1636 | [19] |
LDCM0433 | CL43 | HEK-293T | C61(1.11); C9(1.14); C158(1.29); C232(1.00) | LDD1637 | [19] |
LDCM0434 | CL44 | HEK-293T | C61(1.08); C9(1.12); C122(1.10) | LDD1638 | [19] |
LDCM0435 | CL45 | HEK-293T | C61(0.92); C9(1.18); C122(1.08); C45(0.93) | LDD1639 | [19] |
LDCM0436 | CL46 | HEK-293T | C61(1.14); C9(1.22); C122(1.14) | LDD1640 | [19] |
LDCM0437 | CL47 | HEK-293T | C61(0.95); C9(1.16); C158(1.12); C122(1.09) | LDD1641 | [19] |
LDCM0438 | CL48 | HEK-293T | C61(0.99); C9(1.14); C158(1.16); C122(1.16) | LDD1642 | [19] |
LDCM0439 | CL49 | HEK-293T | C61(1.09); C9(1.11); C122(0.85) | LDD1643 | [19] |
LDCM0440 | CL5 | HEK-293T | C61(0.99); C9(0.93); C122(1.06) | LDD1644 | [19] |
LDCM0441 | CL50 | HEK-293T | C61(0.98); C9(1.00); C158(0.83); C122(0.81) | LDD1645 | [19] |
LDCM0443 | CL52 | HEK-293T | C61(1.08); C158(0.84); C122(0.96) | LDD1646 | [19] |
LDCM0444 | CL53 | HEK-293T | C61(0.99); C9(1.08); C122(0.85) | LDD1647 | [19] |
LDCM0445 | CL54 | HEK-293T | C61(0.95); C9(0.99); C158(0.97); C232(1.30) | LDD1648 | [19] |
LDCM0446 | CL55 | HEK-293T | C61(1.05); C9(1.05); C158(0.99); C232(1.07) | LDD1649 | [19] |
LDCM0447 | CL56 | HEK-293T | C61(1.09); C9(1.12); C122(0.99) | LDD1650 | [19] |
LDCM0448 | CL57 | HEK-293T | C61(0.95); C9(1.14); C122(0.93); C45(0.94) | LDD1651 | [19] |
LDCM0449 | CL58 | HEK-293T | C61(1.24); C9(1.09); C122(1.01) | LDD1652 | [19] |
LDCM0450 | CL59 | HEK-293T | C61(1.13); C9(1.11); C158(1.10); C122(1.06) | LDD1653 | [19] |
LDCM0451 | CL6 | HEK-293T | C61(1.08); C9(1.01); C158(0.86); C232(1.27) | LDD1654 | [19] |
LDCM0452 | CL60 | HEK-293T | C61(1.05); C9(1.12); C158(1.45); C122(1.12) | LDD1655 | [19] |
LDCM0453 | CL61 | HEK-293T | C61(1.04); C9(1.01); C122(0.91) | LDD1656 | [19] |
LDCM0454 | CL62 | HEK-293T | C61(0.98); C9(1.05); C158(0.85); C122(0.87) | LDD1657 | [19] |
LDCM0455 | CL63 | HEK-293T | C61(0.90); C9(1.08); C122(0.88) | LDD1658 | [19] |
LDCM0456 | CL64 | HEK-293T | C61(1.12); C158(1.01); C122(0.87) | LDD1659 | [19] |
LDCM0457 | CL65 | HEK-293T | C61(1.03); C9(1.03); C122(0.91) | LDD1660 | [19] |
LDCM0458 | CL66 | HEK-293T | C61(1.02); C9(1.01); C158(0.85); C232(1.35) | LDD1661 | [19] |
LDCM0459 | CL67 | HEK-293T | C61(1.11); C9(1.06); C158(0.87); C232(1.08) | LDD1662 | [19] |
LDCM0460 | CL68 | HEK-293T | C61(1.02); C9(1.06); C122(0.98) | LDD1663 | [19] |
LDCM0461 | CL69 | HEK-293T | C61(1.04); C9(1.10); C122(1.02); C45(0.94) | LDD1664 | [19] |
LDCM0462 | CL7 | HEK-293T | C61(1.34); C9(1.08); C158(1.14); C232(1.13) | LDD1665 | [19] |
LDCM0463 | CL70 | HEK-293T | C61(1.07); C9(1.06); C122(1.07) | LDD1666 | [19] |
LDCM0464 | CL71 | HEK-293T | C61(0.96); C9(1.19); C158(1.08); C122(1.05) | LDD1667 | [19] |
LDCM0465 | CL72 | HEK-293T | C61(1.05); C9(1.06); C158(1.35); C122(1.16) | LDD1668 | [19] |
LDCM0466 | CL73 | HEK-293T | C61(1.06); C9(1.02); C122(0.91) | LDD1669 | [19] |
LDCM0467 | CL74 | HEK-293T | C61(0.96); C9(1.05); C158(0.94); C122(0.84) | LDD1670 | [19] |
LDCM0469 | CL76 | HEK-293T | C61(1.11); C158(0.96); C122(0.96) | LDD1672 | [19] |
LDCM0470 | CL77 | HEK-293T | C61(0.93); C9(1.09); C122(0.81) | LDD1673 | [19] |
LDCM0471 | CL78 | HEK-293T | C61(1.05); C9(1.07); C158(0.97); C232(1.29) | LDD1674 | [19] |
LDCM0472 | CL79 | HEK-293T | C61(1.15); C9(1.05); C158(0.94); C232(1.28) | LDD1675 | [19] |
LDCM0473 | CL8 | HEK-293T | C61(1.14); C9(1.01); C122(0.80) | LDD1676 | [19] |
LDCM0474 | CL80 | HEK-293T | C61(1.12); C9(1.08); C122(1.00) | LDD1677 | [19] |
LDCM0475 | CL81 | HEK-293T | C61(1.04); C9(1.07); C122(1.02); C45(0.92) | LDD1678 | [19] |
LDCM0476 | CL82 | HEK-293T | C61(1.06); C9(1.09); C122(1.10) | LDD1679 | [19] |
LDCM0477 | CL83 | HEK-293T | C61(1.09); C9(1.12); C158(1.06); C122(0.99) | LDD1680 | [19] |
LDCM0478 | CL84 | HEK-293T | C61(0.98); C9(1.10); C158(1.18); C122(1.07) | LDD1681 | [19] |
LDCM0479 | CL85 | HEK-293T | C61(1.01); C9(1.08); C122(0.92) | LDD1682 | [19] |
LDCM0480 | CL86 | HEK-293T | C61(0.96); C9(1.04); C158(0.97); C122(0.82) | LDD1683 | [19] |
LDCM0481 | CL87 | HEK-293T | C61(0.94); C9(1.05); C122(0.97) | LDD1684 | [19] |
LDCM0482 | CL88 | HEK-293T | C61(1.08); C158(0.91); C122(0.99) | LDD1685 | [19] |
LDCM0483 | CL89 | HEK-293T | C61(1.02); C9(1.02); C122(0.92) | LDD1686 | [19] |
LDCM0484 | CL9 | HEK-293T | C61(0.97); C9(1.02); C122(1.07); C45(0.95) | LDD1687 | [19] |
LDCM0485 | CL90 | HEK-293T | C61(1.04); C9(0.97); C158(0.88); C232(1.47) | LDD1688 | [19] |
LDCM0486 | CL91 | HEK-293T | C61(0.94); C9(1.02); C158(1.03); C232(1.13) | LDD1689 | [19] |
LDCM0487 | CL92 | HEK-293T | C61(1.13); C9(0.99); C122(0.92) | LDD1690 | [19] |
LDCM0488 | CL93 | HEK-293T | C61(1.04); C9(1.07); C122(0.99); C45(0.89) | LDD1691 | [19] |
LDCM0489 | CL94 | HEK-293T | C61(1.01); C9(1.11); C122(1.06) | LDD1692 | [19] |
LDCM0490 | CL95 | HEK-293T | C61(1.04); C9(0.99); C158(0.92); C122(0.89) | LDD1693 | [19] |
LDCM0491 | CL96 | HEK-293T | C61(0.99); C9(1.10); C158(0.44); C122(1.11) | LDD1694 | [19] |
LDCM0492 | CL97 | HEK-293T | C61(1.03); C9(1.05); C122(0.90) | LDD1695 | [19] |
LDCM0493 | CL98 | HEK-293T | C61(1.00); C9(1.06); C158(0.82); C122(0.85) | LDD1696 | [19] |
LDCM0494 | CL99 | HEK-293T | C61(0.98); C9(1.04); C122(0.88) | LDD1697 | [19] |
LDCM0495 | E2913 | HEK-293T | C61(0.99); C9(1.07); C122(0.86) | LDD1698 | [19] |
LDCM0625 | F8 | Ramos | C9(1.64); C61(1.51) | LDD2187 | [20] |
LDCM0572 | Fragment10 | Ramos | C9(2.04); C61(0.52) | LDD2189 | [20] |
LDCM0573 | Fragment11 | Ramos | C9(20.00); C61(1.83) | LDD2190 | [20] |
LDCM0574 | Fragment12 | Ramos | C9(0.95); C61(0.47) | LDD2191 | [20] |
LDCM0575 | Fragment13 | Ramos | C9(0.94); C61(0.72) | LDD2192 | [20] |
LDCM0576 | Fragment14 | Ramos | C9(1.21); C61(1.08) | LDD2193 | [20] |
LDCM0579 | Fragment20 | Ramos | C9(1.22); C61(0.37) | LDD2194 | [20] |
LDCM0580 | Fragment21 | Ramos | C9(0.86); C61(0.62) | LDD2195 | [20] |
LDCM0582 | Fragment23 | Ramos | C9(0.67); C61(0.91) | LDD2196 | [20] |
LDCM0578 | Fragment27 | Ramos | C9(0.91) | LDD2197 | [20] |
LDCM0586 | Fragment28 | Ramos | C9(1.07); C61(0.87) | LDD2198 | [20] |
LDCM0588 | Fragment30 | Ramos | C9(1.43); C61(0.77) | LDD2199 | [20] |
LDCM0589 | Fragment31 | Ramos | C9(1.02); C61(0.86) | LDD2200 | [20] |
LDCM0590 | Fragment32 | Ramos | C9(1.91); C61(0.53) | LDD2201 | [20] |
LDCM0468 | Fragment33 | HEK-293T | C61(1.09); C9(1.18); C122(0.90) | LDD1671 | [19] |
LDCM0596 | Fragment38 | Ramos | C9(1.17); C61(0.48) | LDD2203 | [20] |
LDCM0566 | Fragment4 | Ramos | C9(1.07); C61(0.87) | LDD2184 | [20] |
LDCM0427 | Fragment51 | HEK-293T | C61(0.89); C9(0.99); C158(0.92); C122(0.87) | LDD1631 | [19] |
LDCM0610 | Fragment52 | Ramos | C9(1.34); C61(0.82) | LDD2204 | [20] |
LDCM0614 | Fragment56 | Ramos | C9(1.25); C61(0.72) | LDD2205 | [20] |
LDCM0569 | Fragment7 | Ramos | C9(1.56); C61(0.52) | LDD2186 | [20] |
LDCM0571 | Fragment9 | Ramos | C9(1.39); C61(0.48) | LDD2188 | [20] |
LDCM0107 | IAA | HeLa | N.A. | LDD0221 | [16] |
LDCM0022 | KB02 | HEK-293T | C9(0.99); C61(1.00); C232(0.96); C158(1.00) | LDD1492 | [19] |
LDCM0023 | KB03 | Jurkat | C9(4.01) | LDD0209 | [5] |
LDCM0024 | KB05 | COLO792 | C9(2.71) | LDD3310 | [21] |
LDCM0509 | N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide | MDA-MB-231 | C9(0.78) | LDD2102 | [4] |
LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C9(0.87) | LDD2121 | [4] |
LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C9(0.80) | LDD2089 | [4] |
LDCM0497 | Nucleophilic fragment 11b | MDA-MB-231 | C9(1.05) | LDD2090 | [4] |
LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C9(0.70) | LDD2092 | [4] |
LDCM0500 | Nucleophilic fragment 13a | MDA-MB-231 | C9(0.87) | LDD2093 | [4] |
LDCM0501 | Nucleophilic fragment 13b | MDA-MB-231 | C9(0.97) | LDD2094 | [4] |
LDCM0503 | Nucleophilic fragment 14b | MDA-MB-231 | C9(0.70) | LDD2096 | [4] |
LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C9(0.95) | LDD2098 | [4] |
LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C9(0.94) | LDD2099 | [4] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C9(1.23) | LDD2100 | [4] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C9(0.96) | LDD2104 | [4] |
LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C9(1.17) | LDD2105 | [4] |
LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C9(1.06); C61(1.00) | LDD2107 | [4] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C9(1.11) | LDD2108 | [4] |
LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C9(0.78); C61(0.55) | LDD2109 | [4] |
LDCM0517 | Nucleophilic fragment 21b | MDA-MB-231 | C9(1.75) | LDD2110 | [4] |
LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C9(1.21) | LDD2111 | [4] |
LDCM0523 | Nucleophilic fragment 24b | MDA-MB-231 | C9(1.46) | LDD2116 | [4] |
LDCM0526 | Nucleophilic fragment 26a | MDA-MB-231 | C9(3.45) | LDD2119 | [4] |
LDCM0529 | Nucleophilic fragment 27b | MDA-MB-231 | C9(0.69); C250(0.16) | LDD2122 | [4] |
LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C9(1.04); C61(0.85) | LDD2123 | [4] |
LDCM0531 | Nucleophilic fragment 28b | MDA-MB-231 | C250(0.06) | LDD2124 | [4] |
LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C9(1.00); C61(0.70) | LDD2125 | [4] |
LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C9(1.22); C61(1.11) | LDD2127 | [4] |
LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C9(1.01) | LDD2129 | [4] |
LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C61(2.46) | LDD2134 | [4] |
LDCM0542 | Nucleophilic fragment 37 | MDA-MB-231 | C9(1.00); C61(1.65) | LDD2135 | [4] |
LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C9(1.17); C61(1.23) | LDD2136 | [4] |
LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C9(1.07); C61(1.07) | LDD2137 | [4] |
LDCM0211 | Nucleophilic fragment 3b | MDA-MB-231 | C9(1.03) | LDD1700 | [4] |
LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C9(0.95); C61(0.74) | LDD2140 | [4] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C9(1.04) | LDD2141 | [4] |
LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C9(3.96); C61(2.49) | LDD2144 | [4] |
LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C9(1.20) | LDD2146 | [4] |
LDCM0555 | Nucleophilic fragment 7b | MDA-MB-231 | C250(0.09) | LDD2149 | [4] |
LDCM0556 | Nucleophilic fragment 8a | MDA-MB-231 | C9(0.58) | LDD2150 | [4] |
LDCM0557 | Nucleophilic fragment 8b | MDA-MB-231 | C250(0.07) | LDD2151 | [4] |
LDCM0559 | Nucleophilic fragment 9b | MDA-MB-231 | C9(2.63) | LDD2153 | [4] |
LDCM0627 | NUDT7-COV-1 | HEK-293T | C9(0.15) | LDD2206 | [22] |
The Interaction Atlas With This Target
References