Details of the Target

General Information of Target

Target ID LDTP05085
Target Name Coxsackievirus and adenovirus receptor (CXADR)
Gene Name CXADR
Gene ID 1525
Synonyms
CAR; Coxsackievirus and adenovirus receptor; CAR; hCAR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLLCFVLLCGVVDFARSLSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLIS
PADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQC
KVKKAPGVANKKIHLVVLVKPSGARCYVDGSEEIGSDFKIKCEPKEGSLPLQYEWQKLSD
SQKMPTSWLAEMTSSVISVKNASSEYSGTYSCTVRNRVGSDQCLLRLNVVPPSNKAGLIA
GAIIGTLLALALIGLIIFCCRKKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGSNHS
SLGSMSPSNMEGYSKTQYNQVPSEDFERTPQSPTLPPAKVAAPNLSRMGAIPVMIPAQSK
DGSIV
Target Bioclass
Immunoglobulin
Subcellular location
Secreted; Cell membrane
Function
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.; (Microbial infection) Acts as a receptor for adenovirus type C.; (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Uniprot ID
P78310
Ensemble ID
ENST00000284878.12
HGNC ID
HGNC:2559
ChEMBL ID
CHEMBL4879448

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.Q69E .
HCT15 SNV: p.A125V .
HT115 SNV: p.V229A .
IPC298 SNV: p.R18K .
SUPT1 SNV: p.K66N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K88(1.11)  LDD3494  [1]
DBIA
 Probe Info  		C41(2.77)  LDD3342  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [4]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C159
 Probe Info  		8.40  LDD1839  [5]
C161
 Probe Info  		13.64  LDD1841  [5]
C170
 Probe Info  		7.89  LDD1850  [5]
C390
 Probe Info  		24.25  LDD2049  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C223(0.96)  LDD1507  [6]
 LDCM0226  AC11 HEK-293T C41(0.98); C223(0.95)  LDD1509  [6]
 LDCM0259  AC14 HEK-293T C41(1.00); C223(1.04)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C223(1.03)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C223(1.03)  LDD1515  [6]
 LDCM0278  AC19 HEK-293T C41(0.89); C223(1.00)  LDD1517  [6]
 LDCM0281  AC21 HEK-293T C41(0.94); C223(0.97)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C41(0.97); C223(0.95)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C223(0.94)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C223(0.90)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C223(1.11)  LDD1524  [6]
 LDCM0287  AC27 HEK-293T C41(1.04); C223(0.91)  LDD1526  [6]
 LDCM0289  AC29 HEK-293T C41(1.13); C223(1.01)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C41(1.02); C223(0.87)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C41(0.82); C223(1.02)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C223(0.92)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C223(0.97)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C223(1.05)  LDD1533  [6]
 LDCM0296  AC35 HEK-293T C41(0.93); C223(1.06)  LDD1535  [6]
 LDCM0298  AC37 HEK-293T C41(1.04); C223(1.03)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C41(0.91); C223(1.01)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C223(0.99)  LDD1539  [6]
 LDCM0302  AC40 HEK-293T C223(0.89)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C223(1.18)  LDD1542  [6]
 LDCM0305  AC43 HEK-293T C41(0.94); C223(1.16)  LDD1544  [6]
 LDCM0307  AC45 HEK-293T C41(0.87); C223(0.98)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C41(1.03); C223(1.00)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C223(0.94)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C223(0.91)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C223(1.01)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C41(0.99); C223(1.01)  LDD1551  [6]
 LDCM0314  AC51 HEK-293T C41(0.96); C223(0.98)  LDD1553  [6]
 LDCM0316  AC53 HEK-293T C41(0.85); C223(0.97)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C41(0.93); C223(0.95)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C223(1.01)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C223(0.91)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C223(1.03)  LDD1559  [6]
 LDCM0322  AC59 HEK-293T C41(0.94); C223(1.24)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C41(1.05); C223(0.99)  LDD1562  [6]
 LDCM0325  AC61 HEK-293T C41(1.09); C223(0.99)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C41(0.84); C223(0.95)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C223(0.94)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C223(0.86)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C223(1.02)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C223(0.97)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C41(1.06); C223(1.04)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C223(1.08)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C223(0.99)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C41(0.96)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C41(0.96); C223(1.37)  LDD1572  [6]
 LDCM0370  CL101 HEK-293T C41(1.03)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C223(1.02)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C41(1.01)  LDD1576  [6]
 LDCM0374  CL105 HEK-293T C41(1.00)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C223(0.98)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C41(1.00)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C41(1.12)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C223(1.19)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C223(0.97)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C41(1.02)  LDD1585  [6]
 LDCM0383  CL113 HEK-293T C41(0.98)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C223(1.01)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C41(0.95)  LDD1589  [6]
 LDCM0387  CL117 HEK-293T C41(0.97)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C223(0.98)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C41(0.96)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C223(0.98)  LDD1594  [6]
 LDCM0392  CL121 HEK-293T C41(0.87)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C223(1.06)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C41(0.96)  LDD1598  [6]
 LDCM0396  CL125 HEK-293T C41(0.88)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C223(0.92)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C41(0.96)  LDD1602  [6]
 LDCM0400  CL13 HEK-293T C41(1.05)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C223(0.94)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C41(1.05)  LDD1606  [6]
 LDCM0404  CL17 HEK-293T C223(1.15)  LDD1608  [6]
 LDCM0406  CL19 HEK-293T C41(1.15); C223(0.92)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C223(0.96)  LDD1611  [6]
 LDCM0409  CL21 HEK-293T C41(1.10); C223(1.18)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C41(1.54); C223(1.17)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C223(1.16)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C223(1.10)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C41(0.96)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C223(0.91)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C41(1.02)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C223(1.02)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C41(1.07)  LDD1622  [6]
 LDCM0420  CL31 HEK-293T C41(1.11); C223(1.03)  LDD1624  [6]
 LDCM0422  CL33 HEK-293T C41(1.11); C223(1.36)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C41(1.17); C223(1.18)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C223(1.13)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C223(1.16)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C41(1.00)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C41(1.03)  LDD1632  [6]
 LDCM0431  CL41 HEK-293T C223(0.93)  LDD1635  [6]
 LDCM0433  CL43 HEK-293T C41(1.06); C223(1.03)  LDD1637  [6]
 LDCM0435  CL45 HEK-293T C41(1.00); C223(1.13)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C41(1.04); C223(1.10)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C223(1.08)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C223(1.17)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C41(0.93)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C223(1.12)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C223(0.95)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C223(1.23)  LDD1647  [6]
 LDCM0446  CL55 HEK-293T C41(1.21); C223(1.02)  LDD1649  [6]
 LDCM0448  CL57 HEK-293T C41(1.37); C223(1.28)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C41(1.34); C223(1.21)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C223(1.07)  LDD1653  [6]
 LDCM0452  CL60 HEK-293T C223(1.07)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C41(0.95)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C223(0.99)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C41(0.94)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C223(1.09)  LDD1660  [6]
 LDCM0459  CL67 HEK-293T C41(1.14); C223(1.06)  LDD1662  [6]
 LDCM0461  CL69 HEK-293T C41(1.11); C223(1.29)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C41(1.14); C223(0.97)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C41(1.07); C223(1.10)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C223(1.14)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C223(1.12)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C41(0.91)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C223(0.92)  LDD1670  [6]
 LDCM0470  CL77 HEK-293T C223(1.12)  LDD1673  [6]
 LDCM0472  CL79 HEK-293T C41(1.05); C223(1.16)  LDD1675  [6]
 LDCM0475  CL81 HEK-293T C41(0.97); C223(1.10)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C41(1.22); C223(1.05)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C223(1.17)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C223(1.17)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C41(0.86)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C223(0.92)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C41(1.00)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C223(1.10)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C41(1.24); C223(1.16)  LDD1687  [6]
 LDCM0486  CL91 HEK-293T C41(1.04); C223(1.33)  LDD1689  [6]
 LDCM0488  CL93 HEK-293T C41(1.39); C223(1.14)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C41(1.09); C223(1.08)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C223(1.22)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C223(1.26)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C41(1.06)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C223(1.03)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C41(1.01)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C41(0.94)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C41(0.95)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C223(0.91)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C223(0.98); C41(0.97)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C223(0.99); C41(0.95)  LDD1497  [6]
 LDCM0024  KB05 NCI-H1155 C41(2.77)  LDD3342  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin and lymphocyte protein (MAL) MAL family P21145
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM3C (FAM3C) FAM3 family Q92520

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402