General Information of Target

Target ID LDTP04955
Target Name Ras-related protein R-Ras2 (RRAS2)
Gene Name RRAS2
Gene ID 22800
Synonyms
TC21; Ras-related protein R-Ras2; EC 3.6.5.-; Ras-like protein TC21; Teratocarcinoma oncogene
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR
AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF
PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE
QECPPSPEPTRKEKDKKGCHCVIF
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ras family
Subcellular location
Cell membrane
Function
GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development.
Uniprot ID
P62070
Ensemble ID
ENST00000256196.9
HGNC ID
HGNC:17271
ChEMBL ID
CHEMBL4879446

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.Q72L .
CAL51 SNV: p.Q72L DBIA    Probe Info 
HUPT4 SNV: p.V19G DBIA    Probe Info 
JM1 SNV: p.V164L .
KO52 SNV: p.V19G DBIA    Probe Info 
NCIH1048 SNV: p.G23S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
10.30  LDD0402  [1]
CY-1
 Probe Info 
100.00  LDD0243  [2]
STPyne
 Probe Info 
K14(1.39)  LDD0277  [3]
DBIA
 Probe Info 
C61(1.86)  LDD3310  [4]
BTD
 Probe Info 
C55(1.09)  LDD2089  [5]
IPM
 Probe Info 
C55(1.79)  LDD1701  [5]
ATP probe
 Probe Info 
N.A.  LDD0199  [6]
IA-alkyne
 Probe Info 
C183(0.00); C55(0.00)  LDD0165  [7]
TFBX
 Probe Info 
N.A.  LDD0027  [8]
AOyne
 Probe Info 
13.50  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info 
5.31  LDD1733  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C55(1.38)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C183(0.89)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C55(1.10)  LDD0813  [12]
 LDCM0226  AC11 HEK-293T C55(1.14)  LDD0824  [12]
 LDCM0230  AC113 PaTu 8988t C183(0.86)  LDD1109  [12]
 LDCM0231  AC114 PaTu 8988t C183(1.04)  LDD1110  [12]
 LDCM0232  AC115 PaTu 8988t C183(0.81)  LDD1111  [12]
 LDCM0233  AC116 PaTu 8988t C183(0.85)  LDD1112  [12]
 LDCM0234  AC117 PaTu 8988t C183(0.84)  LDD1113  [12]
 LDCM0235  AC118 PaTu 8988t C183(1.19)  LDD1114  [12]
 LDCM0236  AC119 PaTu 8988t C183(1.04)  LDD1115  [12]
 LDCM0237  AC12 HEK-293T C55(0.95)  LDD0835  [12]
 LDCM0238  AC120 PaTu 8988t C183(1.00)  LDD1117  [12]
 LDCM0239  AC121 PaTu 8988t C183(1.08)  LDD1118  [12]
 LDCM0240  AC122 PaTu 8988t C183(0.96)  LDD1119  [12]
 LDCM0241  AC123 PaTu 8988t C183(0.92)  LDD1120  [12]
 LDCM0242  AC124 PaTu 8988t C183(1.38)  LDD1121  [12]
 LDCM0243  AC125 PaTu 8988t C183(0.93)  LDD1122  [12]
 LDCM0244  AC126 PaTu 8988t C183(0.94)  LDD1123  [12]
 LDCM0245  AC127 PaTu 8988t C183(1.14)  LDD1124  [12]
 LDCM0246  AC128 HEK-293T C55(0.66)  LDD0844  [12]
 LDCM0247  AC129 HEK-293T C55(0.69)  LDD0845  [12]
 LDCM0249  AC130 HEK-293T C55(0.69)  LDD0847  [12]
 LDCM0250  AC131 HEK-293T C55(0.62)  LDD0848  [12]
 LDCM0251  AC132 HEK-293T C55(0.91)  LDD0849  [12]
 LDCM0252  AC133 HEK-293T C55(0.80)  LDD0850  [12]
 LDCM0253  AC134 HEK-293T C55(1.14)  LDD0851  [12]
 LDCM0254  AC135 HEK-293T C55(1.41)  LDD0852  [12]
 LDCM0255  AC136 HEK-293T C55(0.69)  LDD0853  [12]
 LDCM0256  AC137 HEK-293T C55(1.20)  LDD0854  [12]
 LDCM0257  AC138 HEK-293T C55(0.71)  LDD0855  [12]
 LDCM0258  AC139 HEK-293T C55(0.68)  LDD0856  [12]
 LDCM0259  AC14 HEK-293T C55(1.09)  LDD0857  [12]
 LDCM0260  AC140 HEK-293T C55(0.67)  LDD0858  [12]
 LDCM0261  AC141 HEK-293T C55(1.05)  LDD0859  [12]
 LDCM0262  AC142 HEK-293T C55(0.94)  LDD0860  [12]
 LDCM0270  AC15 HEK-293T C55(1.24)  LDD0868  [12]
 LDCM0276  AC17 HEK-293T C55(0.57)  LDD0874  [12]
 LDCM0277  AC18 HEK-293T C55(0.72)  LDD0875  [12]
 LDCM0278  AC19 HEK-293T C55(0.66)  LDD0876  [12]
 LDCM0279  AC2 HEK-293T C183(0.99)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C55(0.55)  LDD0878  [12]
 LDCM0281  AC21 HEK-293T C55(0.72)  LDD0879  [12]
 LDCM0282  AC22 HEK-293T C55(0.60)  LDD0880  [12]
 LDCM0283  AC23 HEK-293T C55(0.67)  LDD0881  [12]
 LDCM0284  AC24 HEK-293T C55(0.60)  LDD0882  [12]
 LDCM0285  AC25 HEK-293T C183(0.76); C55(0.52)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C183(0.60); C55(0.59)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C183(0.72); C55(0.73)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C183(0.52); C55(0.78)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C183(0.60); C55(0.66)  LDD0887  [12]
 LDCM0290  AC3 HEK-293T C183(1.13)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C183(0.68); C55(0.64)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C183(0.52); C55(0.64)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C183(0.61); C55(0.56)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C183(0.69); C55(0.63)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C183(0.58); C55(0.56)  LDD0893  [12]
 LDCM0296  AC35 PaTu 8988t C183(1.15)  LDD1175  [12]
 LDCM0297  AC36 PaTu 8988t C183(1.37)  LDD1176  [12]
 LDCM0298  AC37 PaTu 8988t C183(1.08)  LDD1177  [12]
 LDCM0299  AC38 PaTu 8988t C183(1.23)  LDD1178  [12]
 LDCM0300  AC39 PaTu 8988t C183(1.33)  LDD1179  [12]
 LDCM0301  AC4 HEK-293T C183(1.01)  LDD1540  [11]
 LDCM0302  AC40 PaTu 8988t C183(1.17)  LDD1181  [12]
 LDCM0303  AC41 PaTu 8988t C183(0.98)  LDD1182  [12]
 LDCM0304  AC42 PaTu 8988t C183(0.94)  LDD1183  [12]
 LDCM0305  AC43 PaTu 8988t C183(1.10)  LDD1184  [12]
 LDCM0306  AC44 PaTu 8988t C183(1.28)  LDD1185  [12]
 LDCM0307  AC45 PaTu 8988t C183(1.04)  LDD1186  [12]
 LDCM0308  AC46 HEK-293T C183(0.68)  LDD0906  [12]
 LDCM0309  AC47 HEK-293T C183(0.64)  LDD0907  [12]
 LDCM0310  AC48 HEK-293T C183(0.86)  LDD0908  [12]
 LDCM0311  AC49 HEK-293T C183(0.86)  LDD0909  [12]
 LDCM0312  AC5 HEK-293T C183(1.11)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C183(0.70)  LDD0911  [12]
 LDCM0314  AC51 HEK-293T C183(0.88)  LDD0912  [12]
 LDCM0315  AC52 HEK-293T C183(0.59)  LDD0913  [12]
 LDCM0316  AC53 HEK-293T C183(0.63)  LDD0914  [12]
 LDCM0317  AC54 HEK-293T C183(0.68)  LDD0915  [12]
 LDCM0318  AC55 HEK-293T C183(0.66)  LDD0916  [12]
 LDCM0319  AC56 HEK-293T C183(0.67)  LDD0917  [12]
 LDCM0320  AC57 HEK-293T C183(0.91); C55(1.29)  LDD0918  [12]
 LDCM0321  AC58 HEK-293T C183(1.13); C55(1.66)  LDD0919  [12]
 LDCM0322  AC59 HEK-293T C183(1.25); C55(1.43)  LDD0920  [12]
 LDCM0323  AC6 HEK-293T C55(1.10)  LDD0921  [12]
 LDCM0324  AC60 HEK-293T C183(0.80); C55(2.11)  LDD0922  [12]
 LDCM0325  AC61 HEK-293T C183(1.04); C55(1.08)  LDD0923  [12]
 LDCM0326  AC62 HEK-293T C183(1.06); C55(0.91)  LDD0924  [12]
 LDCM0327  AC63 HEK-293T C183(1.11); C55(1.10)  LDD0925  [12]
 LDCM0328  AC64 HEK-293T C183(1.12); C55(1.21)  LDD0926  [12]
 LDCM0329  AC65 HEK-293T C183(1.14); C55(1.20)  LDD0927  [12]
 LDCM0330  AC66 HEK-293T C183(1.06); C55(0.86)  LDD0928  [12]
 LDCM0331  AC67 HEK-293T C183(1.06); C55(0.81)  LDD0929  [12]
 LDCM0334  AC7 HEK-293T C55(1.03)  LDD0932  [12]
 LDCM0345  AC8 HEK-293T C55(0.90)  LDD0943  [12]
 LDCM0545  Acetamide MDA-MB-231 C55(0.99)  LDD2138  [5]
 LDCM0248  AKOS034007472 HEK-293T C55(1.17)  LDD0846  [12]
 LDCM0356  AKOS034007680 HEK-293T C55(1.04)  LDD0954  [12]
 LDCM0275  AKOS034007705 HEK-293T C55(1.06)  LDD0873  [12]
 LDCM0156  Aniline NCI-H1299 12.58  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C183(1.03)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C183(0.76)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C183(1.01)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C55(0.93)  LDD0968  [12]
 LDCM0371  CL102 HEK-293T C55(0.98)  LDD0969  [12]
 LDCM0372  CL103 HEK-293T C55(0.89)  LDD0970  [12]
 LDCM0373  CL104 HEK-293T C55(1.00)  LDD0971  [12]
 LDCM0374  CL105 HEK-293T C55(0.69)  LDD0972  [12]
 LDCM0375  CL106 HEK-293T C55(0.64)  LDD0973  [12]
 LDCM0376  CL107 HEK-293T C55(0.68)  LDD0974  [12]
 LDCM0377  CL108 HEK-293T C55(0.66)  LDD0975  [12]
 LDCM0378  CL109 HEK-293T C55(0.66)  LDD0976  [12]
 LDCM0379  CL11 HEK-293T C183(0.59)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C55(0.65)  LDD0978  [12]
 LDCM0381  CL111 HEK-293T C55(0.66)  LDD0979  [12]
 LDCM0382  CL112 HEK-293T C183(0.66); C55(0.63)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C183(0.66); C55(0.71)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C183(0.70); C55(0.52)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C183(0.59); C55(0.51)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C183(0.68); C55(0.55)  LDD0984  [12]
 LDCM0387  CL117 PaTu 8988t C183(0.93)  LDD1266  [12]
 LDCM0388  CL118 PaTu 8988t C183(0.96)  LDD1267  [12]
 LDCM0389  CL119 PaTu 8988t C183(1.06)  LDD1268  [12]
 LDCM0390  CL12 HEK-293T C183(1.03)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C183(1.12)  LDD1270  [12]
 LDCM0392  CL121 HEK-293T C183(0.64)  LDD0990  [12]
 LDCM0393  CL122 HEK-293T C183(0.61)  LDD0991  [12]
 LDCM0394  CL123 HEK-293T C183(0.73)  LDD0992  [12]
 LDCM0395  CL124 HEK-293T C183(0.77)  LDD0993  [12]
 LDCM0396  CL125 HEK-293T C183(1.05); C55(1.26)  LDD0994  [12]
 LDCM0397  CL126 HEK-293T C183(1.07); C55(1.21)  LDD0995  [12]
 LDCM0398  CL127 HEK-293T C183(0.92); C55(1.25)  LDD0996  [12]
 LDCM0399  CL128 HEK-293T C183(1.09); C55(1.17)  LDD0997  [12]
 LDCM0400  CL13 HEK-293T C183(1.02)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C183(0.96)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C183(0.86)  LDD1606  [11]
 LDCM0403  CL16 PaTu 8988t C183(1.53)  LDD1282  [12]
 LDCM0404  CL17 PaTu 8988t C183(1.10)  LDD1283  [12]
 LDCM0405  CL18 PaTu 8988t C183(1.07)  LDD1284  [12]
 LDCM0406  CL19 PaTu 8988t C183(1.00)  LDD1285  [12]
 LDCM0407  CL2 HEK-293T C183(0.95)  LDD1611  [11]
 LDCM0408  CL20 PaTu 8988t C183(1.13)  LDD1287  [12]
 LDCM0409  CL21 PaTu 8988t C183(0.87)  LDD1288  [12]
 LDCM0410  CL22 PaTu 8988t C183(0.97)  LDD1289  [12]
 LDCM0411  CL23 PaTu 8988t C183(1.13)  LDD1290  [12]
 LDCM0412  CL24 PaTu 8988t C183(1.06)  LDD1291  [12]
 LDCM0413  CL25 PaTu 8988t C183(0.97)  LDD1292  [12]
 LDCM0414  CL26 PaTu 8988t C183(1.08)  LDD1293  [12]
 LDCM0415  CL27 PaTu 8988t C183(1.16)  LDD1294  [12]
 LDCM0416  CL28 PaTu 8988t C183(1.32)  LDD1295  [12]
 LDCM0417  CL29 PaTu 8988t C183(0.94)  LDD1296  [12]
 LDCM0418  CL3 HEK-293T C183(0.92)  LDD1622  [11]
 LDCM0419  CL30 PaTu 8988t C183(1.34)  LDD1298  [12]
 LDCM0420  CL31 HEK-293T C183(0.77); C55(0.77)  LDD1018  [12]
 LDCM0421  CL32 HEK-293T C183(0.98); C55(0.78)  LDD1019  [12]
 LDCM0422  CL33 HEK-293T C183(0.79); C55(0.70)  LDD1020  [12]
 LDCM0423  CL34 HEK-293T C183(0.85); C55(0.97)  LDD1021  [12]
 LDCM0424  CL35 HEK-293T C183(0.93); C55(0.88)  LDD1022  [12]
 LDCM0425  CL36 HEK-293T C183(0.92); C55(0.79)  LDD1023  [12]
 LDCM0426  CL37 HEK-293T C183(0.86); C55(0.85)  LDD1024  [12]
 LDCM0428  CL39 HEK-293T C183(1.05); C55(0.85)  LDD1026  [12]
 LDCM0429  CL4 HEK-293T C183(1.03)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C183(0.97); C55(1.00)  LDD1028  [12]
 LDCM0431  CL41 HEK-293T C183(0.94); C55(0.83)  LDD1029  [12]
 LDCM0432  CL42 HEK-293T C183(0.93); C55(0.88)  LDD1030  [12]
 LDCM0433  CL43 HEK-293T C183(0.90); C55(0.98)  LDD1031  [12]
 LDCM0434  CL44 HEK-293T C183(1.04); C55(0.87)  LDD1032  [12]
 LDCM0435  CL45 HEK-293T C183(0.87); C55(0.80)  LDD1033  [12]
 LDCM0436  CL46 HEK-293T C183(0.82)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C183(0.55)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C183(1.00)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C183(1.09)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C183(0.99)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C183(0.85)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C183(1.01)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C183(0.95)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C183(0.89)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C183(0.97)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C183(0.98)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C183(0.90)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C183(0.83)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C183(0.60)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C183(0.93)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C183(0.96)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C183(1.15)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C183(0.95)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C183(1.02)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C183(1.00)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C183(1.05)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C183(0.99)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C183(1.01)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C183(1.02)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C183(0.92)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C183(1.01)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C183(0.83)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C183(0.61)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C183(1.00)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C183(1.03)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C183(0.99)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C183(1.06)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C183(0.87)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C183(0.98)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C183(1.01)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C183(0.77)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C183(1.08)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C183(0.98)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C183(0.88)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C183(0.69)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C183(0.90)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C183(1.16)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C183(1.00)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C183(1.28)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C183(1.12)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C183(1.04)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C183(0.99)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C183(0.86)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C183(1.13)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C183(0.96)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C183(0.93)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C183(0.93)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C183(0.72)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C183(0.90)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C183(1.00)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C183(0.93)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C183(1.07)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C183(1.01)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C55(4.89)  LDD1702  [5]
 LDCM0625  F8 Ramos C183(1.21)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C183(0.84)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C183(1.33)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C183(0.70)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C183(0.81)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C183(0.85)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C183(0.62)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C183(0.54)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C183(1.73)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C183(0.68)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C183(0.44)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C183(0.78)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C183(0.96)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C183(0.69)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C183(1.07)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C183(1.37)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C183(0.86)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C183(0.84); C55(0.69)  LDD1025  [12]
 LDCM0614  Fragment56 Ramos C183(0.94)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C183(0.57)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C183(0.56)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C183(1.07)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C183(1.06)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C61(1.86)  LDD3310  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C55(0.93)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C55(1.09)  LDD2089  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C55(1.24)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C55(1.29)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C55(1.19)  LDD2109  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C55(2.24)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C55(0.66)  LDD2120  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C55(0.93)  LDD2125  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C55(1.48)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C55(0.96)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C55(1.14)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C55(2.68)  LDD2144  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Ral guanine nucleotide dissociation stimulator-like 3 (RGL3) . Q3MIN7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578