Details of the Target

General Information of Target

Target ID LDTP04490
Target Name Serine/threonine-protein kinase Nek3 (NEK3)
Gene Name NEK3
Gene ID 4752
Synonyms
Serine/threonine-protein kinase Nek3; EC 2.7.11.1; HSPK 36; Never in mitosis A-related kinase 3; NimA-related protein kinase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI
ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
FEEEDDNPDWVSELKKRAGWQGLCDR
Target Bioclass
Enzyme
Family
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Subcellular location
Cytoplasm
Function
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
Uniprot ID
P51956
Ensemble ID
ENST00000610828.5
HGNC ID
HGNC:7746
ChEMBL ID
CHEMBL5679

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E50G .
J82 SNV: p.P60R .
KYSE180 Substitution: p.P155L .
OVK18 Insertion: .
SNV: p.T161A		 .
SKOV3 SNV: p.M32V .
SNU1196 SNV: p.G164R .
SW1116 Deletion: p.T373SfsTer18 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C504(2.41)  LDD0169  [1]
DBIA
 Probe Info  		C504(1.29)  LDD0533  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C504(2.41)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C264(0.89); C504(0.88)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C504(1.35)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C504(1.29)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C504(1.35)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C504(1.23)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C504(1.43)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C504(1.03)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C504(1.34)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C504(1.29)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C504(1.34)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C504(1.15)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C504(1.15)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C504(1.46)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C504(1.34)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C504(1.75)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C504(1.43)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C504(1.26)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C504(1.06)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C504(1.12)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C504(1.18)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C504(0.91)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C504(1.08)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C504(1.11)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C504(1.12)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C504(1.18)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C504(1.37)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C504(1.25)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C504(1.07)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C504(1.11)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C504(1.23)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C504(1.36)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C504(1.24)  LDD0843  [2]
 LDCM0246  AC128 HCT 116 C504(0.62)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C504(0.69)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C504(0.71)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C504(0.78)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C504(0.88)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C504(0.81)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C504(1.02)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C504(0.81)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C504(0.92)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C504(0.81)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C504(0.88)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C504(0.88)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C504(1.53)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C504(1.05)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C504(0.98)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C504(0.86)  LDD0579  [2]
 LDCM0263  AC143 HEK-293T C504(1.22)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C504(1.48)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C504(1.49)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C504(1.21)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C504(1.20)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C504(1.65)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C504(0.84)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C504(1.01)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C504(0.88)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C504(1.30)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C504(1.35)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C504(1.14)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C504(0.84)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C504(1.67)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C504(1.12)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C504(1.30)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C504(1.25)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C504(1.15)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C504(1.02)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C264(0.78); C504(1.06)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C504(1.10)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C504(1.07)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C504(0.94)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C504(0.92)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C504(1.07)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C264(0.92); C504(0.97)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C264(0.70); C504(1.07)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C264(1.21); C504(1.02); C160(1.37)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C264(0.94); C504(0.95)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C264(1.07); C504(1.02); C160(0.82)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C264(1.12); C504(0.98); C160(1.06)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C504(0.98); C160(0.89)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C112(0.85); C264(0.90); C504(0.85)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C264(0.90); C504(1.10)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C264(0.91); C504(1.04)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C264(0.89); C504(1.00)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C504(0.97)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C504(0.62)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C504(0.78)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C504(1.03)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C504(1.34)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C264(1.32); C504(0.90)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C504(0.86)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C504(1.45)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C504(0.85)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C504(1.08)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C504(1.15)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C504(1.38)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C504(0.94); C160(0.99)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C112(1.04); C264(0.89); C504(0.87)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C264(0.98); C504(1.07)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C264(0.84); C504(0.94)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C264(1.19); C504(1.03); C160(0.92)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C264(1.04); C504(1.03)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C264(1.42); C504(0.98); C160(1.46)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C264(0.74); C504(0.94)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C264(0.89); C504(1.01); C160(0.95)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C504(0.95); C160(1.00)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C112(0.94); C264(1.19); C504(0.93)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C264(1.04); C504(1.03)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C504(1.02)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C504(1.13)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C504(0.94)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C504(1.40)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C504(0.70)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C504(1.03)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C504(1.13)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C504(0.84)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C504(1.07)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C504(1.25)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C504(0.98)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C504(1.01)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C504(1.47)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C504(1.38)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C504(1.01)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C504(1.22)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C504(1.29)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C504(1.27)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C504(1.58)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C504(1.31)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C504(1.55)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C504(1.27)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C504(1.27)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C504(1.10)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C504(1.34)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C504(1.16)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C504(1.37)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C504(1.12)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C504(1.68)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C504(1.73)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C504(1.53)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C504(1.58)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C504(1.47)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C504(1.67)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C504(1.57)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C504(1.29)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C504(1.53)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C504(1.34)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C504(1.32)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C504(1.41)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C504(1.03)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C504(1.54)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C504(1.17)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C504(1.95)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C504(1.34)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C504(1.42)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C504(1.13)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C504(1.01)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C504(1.29)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C112(0.80); C264(0.94); C504(1.06)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C504(1.14); C160(1.12)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C112(0.87); C504(0.91)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C504(1.34)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C504(1.03)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C504(0.92)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C504(1.25)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C504(1.17)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C504(1.09)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C504(0.96)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C504(1.10)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C504(1.13)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C112(1.00); C264(1.62); C504(1.08)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C504(1.01)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C504(1.03)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C112(0.88); C504(0.96)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C112(1.43); C264(0.95); C504(1.16)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C504(1.15)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C504(0.93)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C112(1.18); C504(0.96)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C504(1.17)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C504(0.82)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C504(0.96)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C264(1.01); C504(1.02)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C504(1.16)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C112(0.91); C264(1.00); C504(1.02)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C504(0.90)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C504(1.02)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C112(1.07); C504(0.90)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C504(1.04)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C504(0.94)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C504(0.90)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C504(1.16)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C112(0.98); C264(0.84); C504(0.99)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C504(0.85)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C504(1.01)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C112(1.84); C504(0.91)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C264(0.92); C504(1.07)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C264(0.75); C504(1.27)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C264(1.22); C504(0.97); C160(1.06)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C504(0.84)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C264(0.98); C504(1.05)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C264(1.32); C504(1.18); C160(1.05)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C504(1.00); C160(0.90)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C112(0.88); C264(0.90); C504(1.06)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C264(1.22); C504(1.27)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C112(1.32); C264(0.97); C504(1.00)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C504(0.90)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C504(1.00)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C112(2.31); C504(0.91)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C264(0.78); C504(1.11)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C504(0.92)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C264(0.88); C504(1.20)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C504(1.00)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C504(1.05)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C504(1.14)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C504(0.96)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C504(1.08)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C504(0.96)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C504(1.12)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C504(1.08)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C112(0.80); C504(1.01)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C504(1.04)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C504(0.96)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C504(1.03)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C504(1.06)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C504(1.03)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C504(0.83)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C504(0.91); C160(0.93)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C112(0.74); C264(1.32); C504(0.94)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C264(1.14); C504(0.96)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C112(1.30); C264(1.13); C504(1.00)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C264(1.16); C504(1.02)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C504(0.93)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C112(1.11); C504(0.94)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C264(0.96); C504(1.09)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C264(1.28); C504(1.01)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C264(1.45); C504(1.01); C160(0.81)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C264(1.27); C504(0.85)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C264(0.93); C504(1.25); C160(0.86)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C504(0.98); C160(0.83)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C112(0.85); C264(0.88); C504(1.08)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C264(0.65); C504(1.24)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C264(1.00); C504(1.06)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C112(1.06); C264(0.90); C504(1.04)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C504(0.99)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C504(1.13)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C112(1.16); C504(0.96)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C264(0.88); C504(1.11)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C264(1.07); C504(1.21)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C264(1.00); C504(1.07); C160(0.74)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C264(1.25); C504(0.98)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C264(0.94); C504(1.06); C160(0.80)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C264(1.19); C504(0.94); C160(1.14)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C504(1.12); C160(0.71)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C112(0.94); C264(1.25); C504(0.97)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C264(1.30); C504(1.25)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C112(0.96); C264(1.13); C504(0.87)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C504(0.89)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C112(1.68); C504(0.89)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C264(0.89); C504(1.03)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C264(0.84); C504(1.03)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C264(0.87); C504(1.00); C160(0.94)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C264(0.87); C504(1.20)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C264(0.80); C504(0.96)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C264(0.74); C504(1.17); C160(0.90)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C504(0.97); C160(0.73)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C112(0.92); C264(1.31); C504(0.99)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C264(0.86); C504(1.05)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C112(1.08); C264(1.01); C504(0.94)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C504(0.84)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C504(1.06)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C112(1.25); C504(0.98)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C264(0.74); C504(1.04)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C264(1.05); C504(1.13); C160(0.95)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C264(0.61); C504(1.43)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C264(1.28); C504(0.90); C160(1.27)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C264(0.96); C504(0.90)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C264(0.91); C504(1.11); C160(0.87)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C504(1.07); C160(0.95)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C112(0.94); C264(0.72); C504(1.22)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C264(1.01); C504(0.91)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C112(0.97); C264(0.81); C504(0.86)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C504(0.86)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C504(1.02)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C504(1.09)  LDD1698  [7]
 LDCM0625  F8 Ramos C504(2.16)  LDD2187  [8]
 LDCM0573  Fragment11 Ramos C504(10.63)  LDD2190  [8]
 LDCM0576  Fragment14 Ramos C504(0.87)  LDD2193  [8]
 LDCM0586  Fragment28 Ramos C504(0.74)  LDD2198  [8]
 LDCM0468  Fragment33 HEK-293T C504(1.02)  LDD1671  [7]
 LDCM0566  Fragment4 Ramos C504(1.79)  LDD2184  [8]
 LDCM0427  Fragment51 HEK-293T C504(0.93)  LDD1025  [2]
 LDCM0569  Fragment7 Ramos C504(1.16)  LDD2186  [8]
 LDCM0022  KB02 HEK-293T C160(1.35)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C160(1.17)  LDD1497  [7]
 LDCM0024  KB05 UACC-62 C504(2.31)  LDD3484  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C504(0.81)  LDD2207  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide exchange factor VAV2 (VAV2) . P52735

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.