Details of the Target

General Information of Target

Target ID LDTP04064
Target Name Elongation factor Ts, mitochondrial (TSFM)
Gene Name TSFM
Gene ID 10102
Synonyms
Elongation factor Ts, mitochondrial; EF-Ts; EF-TsMt
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYS
FVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGNTTVLVE
VNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREG
SLKDQLALAIGKLGENMILKRAAWVKVPSGFYVGSYVHGAMQSPSLHKLVLGKYGALVIC
ETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYV
QPQGVSVVDFVRFECGEGEEAAETE
Target Bioclass
Other
Family
EF-Ts family
Subcellular location
Mitochondrion
Function
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. {|HAMAP-Rule:MF_03135}.
Uniprot ID
P43897
Ensemble ID
ENST00000323833.12
HGNC ID
HGNC:12367

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y159(20.00); Y234(20.00)  LDD0257  [1]
TH216
 Probe Info  		Y234(14.35)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K47(4.06); K96(2.78)  LDD0277  [3]
Probe 1
 Probe Info  		Y59(38.17); Y159(54.11)  LDD3495  [4]
m-APA
 Probe Info  		8.53  LDD0403  [5]
DBIA
 Probe Info  		C71(0.82); C149(1.81); C261(1.48)  LDD3311  [6]
BTD
 Probe Info  		C71(0.95)  LDD2093  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K76(0.00); K66(0.00); K183(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C71(0.00); C149(0.00); C64(0.00); C240(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C71(0.00); C149(0.00); C64(0.00)  LDD0037  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
IPM
 Probe Info  		C71(0.00); C64(0.00)  LDD0147  [15]
NHS
 Probe Info  		K84(0.00); K183(0.00)  LDD0010  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Acrolein
 Probe Info  		C240(0.00); C71(0.00); C64(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		C240(0.00); C71(0.00)  LDD0219  [19]
Methacrolein
 Probe Info  		C240(0.00); C71(0.00)  LDD0218  [19]
W1
 Probe Info  		C71(0.00); C64(0.00)  LDD0236  [20]
AOyne
 Probe Info  		5.90  LDD0443  [21]
NAIA_5
 Probe Info  		C71(0.00); C149(0.00); C64(0.00); C240(0.00)  LDD2223  [14]
HHS-465
 Probe Info  		N.A.  LDD2240  [22]
HHS-482
 Probe Info  		Y234(0.89)  LDD2239  [23]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]
DA-2
 Probe Info  		N.A.  LDD0072  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C64(0.94)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C71(1.31)  LDD2152  [7]
 LDCM0214  AC1 HEK-293T C64(0.82); C240(0.91); C149(1.01); C71(0.88)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C64(0.89); C240(1.07); C149(1.09); C71(0.82)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C64(0.98); C240(1.15); C149(1.01); C71(0.90)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C64(0.96); C240(0.97); C149(1.04); C71(0.89)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C64(0.93); C240(1.19); C149(1.07); C71(0.88)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C64(0.98); C240(0.97); C149(1.00); C71(1.01)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C64(0.93); C240(1.03); C149(0.98); C71(0.91)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C64(0.99); C240(1.05); C149(1.05); C71(0.94)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C64(0.75); C240(0.80); C149(0.96); C71(0.81)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C64(0.98); C240(1.10); C149(1.08); C71(0.89)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C64(1.01); C240(1.04); C149(1.08); C71(1.00)  LDD1519  [27]
 LDCM0281  AC21 HEK-293T C64(0.98); C149(0.97); C71(0.98)  LDD1520  [27]
 LDCM0282  AC22 HEK-293T C64(0.99); C240(0.91); C149(1.19); C71(0.94)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C64(1.10); C240(0.92); C149(1.05); C71(1.07)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C64(1.06); C149(1.10); C71(0.97); C315(0.96)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C64(0.88); C240(0.86); C149(0.98); C71(0.92)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C64(0.98); C240(1.03); C149(1.02); C71(0.91)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C64(0.98); C240(1.04); C149(1.01); C71(0.99)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C64(1.02); C240(1.06); C149(1.12); C71(0.97)  LDD1527  [27]
 LDCM0289  AC29 HEK-293T C64(1.01); C149(0.95); C71(0.97)  LDD1528  [27]
 LDCM0290  AC3 HEK-293T C64(0.95); C240(1.07); C149(0.96); C71(0.88)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C64(0.98); C240(0.90); C149(1.16); C71(0.92)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C64(1.01); C240(0.93); C149(1.07); C71(1.04)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C64(1.04); C149(0.98); C71(0.95); C315(0.89)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C64(0.87); C240(0.87); C149(1.07); C71(0.84)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C64(0.89); C240(1.03); C149(1.02); C71(0.82)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C64(0.95); C240(1.09); C149(0.78); C71(0.87)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C64(0.95); C240(1.12); C149(1.05); C71(0.90)  LDD1536  [27]
 LDCM0298  AC37 HEK-293T C64(1.00); C149(0.98); C71(0.95)  LDD1537  [27]
 LDCM0299  AC38 HEK-293T C64(0.99); C240(1.01); C149(1.14); C71(0.87)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C64(0.98); C240(1.01); C149(1.08); C71(1.03)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C64(1.00); C240(1.07); C149(1.10); C71(0.85)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C64(0.95); C149(1.04); C71(0.81); C315(1.11)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C64(0.85); C240(1.00); C149(0.99); C71(0.86)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C64(0.88); C240(1.06); C149(1.09); C71(0.79)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C64(0.96); C240(1.09); C149(0.89); C71(0.85)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C64(0.96); C240(1.07); C149(0.98); C71(0.88)  LDD1545  [27]
 LDCM0307  AC45 HEK-293T C64(0.95); C149(1.00); C71(0.95)  LDD1546  [27]
 LDCM0308  AC46 HEK-293T C64(0.95); C240(0.99); C149(1.15); C71(0.87)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C64(1.01); C240(0.98); C149(1.04); C71(1.04)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C64(0.99); C149(1.16); C71(0.84); C315(0.93)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C64(0.86); C240(0.98); C149(1.02); C71(0.87)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C64(1.01); C149(0.95); C71(1.01)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C64(0.97); C240(1.13); C149(1.11); C71(0.87)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C64(0.94); C240(1.04); C149(0.80); C71(0.89)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C64(0.95); C240(1.09); C149(1.08); C71(0.91)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C64(0.93); C149(0.96); C71(1.01)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C64(0.99); C240(1.09); C149(1.04); C71(0.89)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C64(0.98); C240(0.95); C149(1.01); C71(1.04)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C64(0.97); C149(1.02); C71(0.88); C315(1.05)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C64(0.83); C240(0.97); C149(0.99); C71(0.79)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C64(0.91); C240(1.16); C149(1.16); C71(0.88)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C64(0.93); C240(1.14); C149(1.08); C71(0.96)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C64(0.95); C240(1.11); C149(1.13); C71(0.84)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C64(0.94); C240(0.98); C149(1.12); C71(0.89)  LDD1563  [27]
 LDCM0325  AC61 HEK-293T C64(0.91); C149(0.98); C71(0.96)  LDD1564  [27]
 LDCM0326  AC62 HEK-293T C64(0.94); C240(1.11); C149(1.14); C71(0.80)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C64(0.96); C240(0.92); C149(1.09); C71(0.98)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C64(0.94); C149(1.15); C71(0.84); C315(1.37)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C64(1.07); C240(0.92); C149(1.02); C71(1.06)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C64(1.02); C149(1.11); C71(0.91); C315(1.04)  LDD1569  [27]
 LDCM0248  AKOS034007472 HEK-293T C64(0.93); C149(0.93); C71(1.03)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C64(0.91); C240(1.03); C149(0.95); C71(0.88)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C64(1.00); C149(1.09); C71(0.87); C315(0.96)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 8.53  LDD0403  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0367  CL1 HEK-293T C64(0.91); C240(1.00); C149(0.94); C71(0.84)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C64(0.72); C240(0.88); C149(0.53); C71(0.70)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C64(0.91); C240(1.19); C149(1.03); C71(0.94)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C64(0.90); C240(1.03); C149(0.95); C71(0.83)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C64(0.86); C240(1.00); C149(1.05); C71(0.81)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C64(0.97); C240(1.01); C149(1.00); C71(0.86)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C64(1.00); C240(1.15); C149(1.05); C71(0.97)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C64(0.93); C240(0.98); C149(0.96); C71(0.89)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C64(0.96); C240(1.02); C149(1.11); C71(0.95)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C64(1.07); C240(1.02); C149(1.08); C71(0.96)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C64(0.97); C240(1.09); C149(1.11); C71(1.00)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C64(0.93); C240(0.94); C149(0.98); C71(0.88)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C64(0.90); C240(0.77); C149(0.92); C71(1.00)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C64(0.86); C240(0.97); C149(0.96); C71(0.85)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C64(0.95); C240(1.04); C149(0.99); C71(0.90)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C64(0.88); C240(1.05); C149(0.94); C71(0.82)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C64(0.94); C240(1.03); C149(1.02); C71(0.86)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C64(0.83); C240(0.99); C149(1.09); C71(0.75)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C64(1.01); C240(1.17); C149(0.98); C71(0.84)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C64(0.94); C240(1.28); C149(1.06); C71(0.93)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C64(0.95); C240(1.00); C149(1.00); C71(0.90)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C64(1.02); C240(0.99); C149(1.07); C71(0.92)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C64(1.02); C240(1.14); C149(0.95); C71(0.90)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C64(0.90); C149(1.10); C71(0.78); C315(1.13)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C64(0.90); C240(1.07); C149(1.05); C71(0.92)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C64(0.94); C240(1.02); C149(0.97); C71(0.94)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C64(0.95); C240(1.04); C149(1.08); C71(0.86)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C64(0.90); C240(1.03); C149(0.97); C71(0.80)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C64(0.94); C240(1.10); C149(1.01); C71(0.92)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C64(0.93); C240(1.00); C149(1.26); C71(0.90)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C64(0.88); C240(0.98); C149(1.23); C71(0.86)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C64(0.99); C240(1.01); C149(1.16); C71(0.89)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C64(0.90); C240(1.15); C149(1.15); C71(0.91)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C64(0.89); C240(0.99); C149(0.85); C71(0.83)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C64(0.97); C240(1.10); C149(1.11); C71(0.87)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C64(0.91); C240(1.03); C149(0.79); C71(0.73)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C64(0.98); C240(1.13); C149(1.13); C71(1.11)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C64(0.78); C240(0.87); C149(0.74); C71(0.81)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C64(1.00); C240(1.17); C149(1.01); C71(0.83)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C64(1.01); C240(1.11); C149(0.84); C71(0.96)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C64(0.94); C240(1.04); C149(1.03); C71(0.93)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C64(0.96); C240(1.14); C149(0.90); C71(0.91)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C64(0.83); C149(0.96); C71(0.95)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C64(0.96); C240(1.06); C149(1.06); C71(0.98)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C64(1.04); C240(0.96); C149(1.03); C71(1.06)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C64(0.92); C149(1.02); C71(0.78); C315(1.18)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C64(0.94); C240(1.04); C149(1.06); C71(0.96)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C64(1.06); C240(1.03); C149(1.01); C71(1.02)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C64(1.08); C240(1.04); C149(1.00); C71(1.02)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C64(1.01); C240(1.11); C149(0.98); C71(1.01)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C64(0.95); C240(0.98); C149(0.95); C71(1.02)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C64(0.98); C240(1.03); C149(0.95); C71(0.83)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C64(1.08); C240(1.11); C149(0.95); C71(1.02)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C64(1.00); C240(1.12); C149(0.81); C71(0.95)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C64(1.03); C240(1.06); C149(0.95); C71(0.92)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C64(0.84); C149(0.85); C71(0.97)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C64(1.05); C240(1.04); C149(1.02); C71(0.93)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C64(1.08); C240(0.99); C149(1.02); C71(1.11)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C64(0.97); C149(1.11); C71(0.86); C315(1.01)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C64(1.03); C240(1.13); C149(1.06); C71(1.03)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C64(1.05); C240(1.08); C149(1.04); C71(1.05)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C64(0.90); C240(1.26); C149(0.99); C71(1.00)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C64(1.05); C240(1.20); C149(1.01); C71(1.03)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C64(0.93); C240(0.89); C149(0.93); C71(0.90)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C64(1.05); C240(1.10); C149(1.12); C71(0.92)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C64(1.10); C240(1.35); C149(0.87); C71(1.09)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C64(0.94); C240(1.03); C149(0.93); C71(0.98)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C64(0.94); C149(0.97); C71(0.96)  LDD1639  [27]
 LDCM0436  CL46 HEK-293T C64(1.03); C240(1.06); C149(1.05); C71(0.92)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C64(1.04); C240(0.95); C149(0.99); C71(1.09)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C64(1.02); C149(1.18); C71(0.86); C315(0.98)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C64(1.01); C240(1.22); C149(1.10); C71(0.80)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C64(0.90); C240(0.93); C149(0.83); C71(0.91)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C64(0.98); C240(1.05); C149(1.03); C71(0.95)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C64(0.96); C240(1.19); C149(1.05); C71(0.95)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C64(0.79); C240(0.87); C149(0.86); C71(0.78)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C64(0.81); C240(1.16); C149(0.96); C71(0.68)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C64(0.97); C240(1.28); C149(0.83); C71(0.92)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C64(0.94); C240(1.06); C149(0.96); C71(0.84)  LDD1650  [27]
 LDCM0448  CL57 HEK-293T C64(0.85); C149(0.98); C71(0.91)  LDD1651  [27]
 LDCM0449  CL58 HEK-293T C64(0.93); C240(1.18); C149(1.00); C71(0.83)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C64(1.01); C240(0.98); C149(1.07); C71(1.07)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C64(0.87); C240(1.25); C149(1.01); C71(0.77)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C64(0.96); C149(1.08); C71(0.85); C315(1.20)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C64(1.08); C240(1.15); C149(1.09); C71(0.92)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C64(1.01); C240(1.08); C149(1.19); C71(0.97)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C64(1.05); C240(1.07); C149(0.96); C71(0.88)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C64(0.89); C240(1.16); C149(0.89); C71(0.90)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C64(0.88); C240(0.90); C149(0.94); C71(0.90)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C64(0.96); C240(1.11); C149(1.03); C71(0.85)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C64(0.98); C240(0.90); C149(0.86); C71(0.93)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C64(1.04); C240(1.14); C149(0.99); C71(0.92)  LDD1663  [27]
 LDCM0461  CL69 HEK-293T C64(0.96); C149(1.03); C71(1.02)  LDD1664  [27]
 LDCM0462  CL7 HEK-293T C64(0.96); C240(1.04); C149(0.86); C71(0.92)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C64(0.96); C240(1.24); C149(1.06); C71(0.87)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C64(0.97); C240(0.96); C149(1.03); C71(1.06)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C64(1.01); C149(1.00); C71(0.80); C315(1.29)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C64(0.97); C240(1.01); C149(1.05); C71(0.85)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C64(0.98); C240(1.03); C149(1.15); C71(1.01)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C64(0.97); C240(1.16); C149(0.97); C71(0.99)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C64(0.79); C240(0.87); C149(0.96); C71(0.80)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C64(1.04); C240(1.18); C149(1.09); C71(0.86)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C64(1.03); C240(1.13); C149(0.90); C71(0.87)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C64(0.58); C240(1.20); C149(1.07); C71(0.67)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C64(1.04); C240(1.11); C149(1.10); C71(1.00)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C64(0.97); C149(0.93); C71(1.00)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C64(0.97); C240(1.08); C149(1.13); C71(0.92)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C64(0.90); C240(0.94); C149(1.03); C71(1.06)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C64(0.89); C149(1.13); C71(0.84); C315(1.15)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C64(1.03); C240(1.08); C149(1.26); C71(0.88)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C64(1.02); C240(1.10); C149(1.19); C71(1.00)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C64(1.04); C240(1.14); C149(1.02); C71(0.86)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C64(0.95); C240(1.11); C149(1.06); C71(0.95)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C64(0.90); C240(0.98); C149(1.01); C71(0.89)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C64(0.92); C149(1.00); C71(0.98)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C64(0.69); C240(1.21); C149(0.47); C71(0.64)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C64(1.04); C240(1.22); C149(0.86); C71(0.98)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C64(0.90); C240(1.09); C149(0.99); C71(0.84)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C64(0.88); C149(0.96); C71(0.99)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C64(0.90); C240(1.00); C149(1.01); C71(0.93)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C64(0.71); C240(0.91); C149(0.93); C71(0.79)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C64(0.88); C149(1.17); C71(0.77); C315(1.46)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C64(0.90); C240(0.90); C149(0.95); C71(0.84)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C64(0.98); C240(1.02); C149(0.60); C71(0.91)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C64(0.94); C240(1.00); C149(1.12); C71(0.94)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C64(1.05); C240(1.07); C149(0.98); C71(0.85)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C64(0.94)  LDD1702  [7]
 LDCM0625  F8 Ramos C71(1.30); C315(0.84)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C71(0.77); C315(0.48)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C71(2.26); C315(20.00)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C71(0.90); C315(0.46)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C71(0.94); C315(0.80)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C71(0.73); C315(0.53)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C71(0.64); C315(0.32)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C71(1.42); C315(0.67)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C71(0.55); C315(0.29)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C71(1.26); C315(0.73)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C71(0.61); C315(1.19)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C71(1.31); C315(0.97)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C71(1.34); C315(0.78)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C71(0.71); C315(0.55)  LDD2201  [28]
 LDCM0468  Fragment33 HEK-293T C64(1.05); C240(1.02); C149(1.01); C71(0.95)  LDD1671  [27]
 LDCM0596  Fragment38 Ramos C71(1.30); C315(0.81)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C71(0.78); C315(0.50)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C64(1.04); C240(1.00); C149(1.05); C71(1.07)  LDD1631  [27]
 LDCM0610  Fragment52 Ramos C71(1.20); C315(0.99)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C71(1.59); C315(1.10)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C71(0.67); C315(0.54)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C71(0.76); C315(0.47)  LDD2188  [28]
 LDCM0107  IAA HeLa C240(0.00); C71(0.00)  LDD0221  [19]
 LDCM0022  KB02 HEK-293T C315(0.99); C71(0.96); C64(0.93); C240(1.07)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C315(1.12); C71(0.95); C64(0.95); C240(0.87)  LDD1497  [27]
 LDCM0024  KB05 G361 C71(0.82); C149(1.81); C261(1.48)  LDD3311  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C71(0.95)  LDD2093  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C71(1.27); C64(2.43)  LDD2099  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C71(0.94)  LDD2101  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C71(0.60)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C71(1.13)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C71(0.58)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C71(1.32)  LDD2111  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C71(1.45); C64(2.30)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C71(0.96)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C71(0.94)  LDD2125  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C71(1.54); C64(2.78)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C71(1.49)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C71(1.07)  LDD2137  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C71(2.28)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C71(1.04)  LDD2146  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 89 (CCDC89) CCDC89 family Q8N998
Complexin-2 (CPLX2) Complexin/synaphin family Q6PUV4
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
23 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578