Details of the Target

General Information of Target

Target ID LDTP03807
Target Name E3 ubiquitin-protein ligase TRIM23 (TRIM23)
Gene Name TRIM23
Gene ID 373
Synonyms
ARD1; ARFD1; RNF46; E3 ubiquitin-protein ligase TRIM23; EC 2.3.2.27; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; RING-type E3 ubiquitin transferase TRIM23; Tripartite motif-containing protein 23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDKVPRLLLCGHTVCHDCL
TRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIGIS
GESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHSTKTLAKHRRVPLADKPHEKTMCSQ
HQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTF
TEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGTAENARSCIRAYFYDLHETLC
RQEEMALSVVDAHVREKLIWLRQQQEDMTILLSEVSAACLHCEKTLQQDDCRVVLAKQEI
TRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIGPKMEIRVVTLGLDGAGKTTI
LFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVD
SSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGALSVEEITELLSLHKLCCGRS
WYIQGCDARSGMGLYEGLDWLSRQLVAAGVLDVA
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Subcellular location
Cytoplasm
Function
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.; (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.
Uniprot ID
P36406
Ensemble ID
ENST00000231524.14
HGNC ID
HGNC:660

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 Insertion: p.M403NfsTer21 .
MOLT4 SNV: p.V354F; p.S540I .
UMUC3 SNV: p.L410S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C351(1.15)  LDD0531  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C351(1.15)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C351(0.68)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C351(0.65)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C351(0.53)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C351(0.86)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C351(0.76)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C351(0.75)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C351(0.71)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C351(0.84)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C351(0.83)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C351(0.68)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C351(0.62)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C351(0.70)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C351(0.91)  LDD0546  [1]
 LDCM0279  AC2 HCT 116 C351(1.27)  LDD0596  [1]
 LDCM0285  AC25 HCT 116 C351(0.66)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C351(0.59)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C351(0.89)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C351(0.99)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C351(0.90)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C351(1.12)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C351(0.78)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C351(0.66)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C351(0.64)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C351(1.07)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C351(0.87)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C351(1.16)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C351(1.07)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C351(1.15)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C351(0.95)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C351(1.08)  LDD0898  [1]
 LDCM0301  AC4 HCT 116 C351(1.74)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C351(1.03)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C351(1.05)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C351(1.46)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C351(0.99)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C351(1.50)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C351(1.13)  LDD0905  [1]
 LDCM0308  AC46 HCT 116 C351(1.17)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C351(1.03)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C351(1.03)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C351(0.97)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C351(1.76)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C351(1.05)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C351(0.98)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C351(1.09)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C351(0.89)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C351(0.76)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C351(0.95)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C351(1.58)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C351(1.04)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C351(1.02)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C351(0.99)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C351(1.53)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C351(1.06)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C351(1.18)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C351(1.18)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C351(1.29)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C351(1.22)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C351(1.07)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C351(1.41)  LDD0648  [1]
 LDCM0332  AC68 HEK-293T C351(0.71)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C351(1.02)  LDD0931  [1]
 LDCM0335  AC70 HEK-293T C351(1.22)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C351(0.83)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C351(0.96)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C351(0.86)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C351(0.94)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C351(0.78)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C351(0.79)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C351(1.26)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C351(0.99)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C351(0.76)  LDD0942  [1]
 LDCM0346  AC80 HEK-293T C351(0.75)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C351(0.82)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C351(0.73)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C351(0.99)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C351(1.52)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C351(1.49)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C351(1.21)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C351(1.60)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C351(1.77)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C351(1.42)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C351(1.66)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C351(1.33)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C351(1.32)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C351(1.42)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C351(1.32)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C351(1.60)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C351(1.85)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C351(2.24)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C351(1.11)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C351(0.83)  LDD0683  [1]
 LDCM0369  CL100 HCT 116 C351(1.37)  LDD0686  [1]
 LDCM0382  CL112 HCT 116 C351(0.57)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C351(0.77)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C351(0.70)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C351(0.72)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C351(0.90)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C351(1.24)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C351(1.15)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C351(1.29)  LDD0987  [1]
 LDCM0391  CL120 HEK-293T C351(1.24)  LDD0989  [1]
 LDCM0392  CL121 HCT 116 C351(0.63)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C351(0.82)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C351(0.84)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C351(0.81)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C351(1.28)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C351(0.90)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C351(1.15)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C351(1.00)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C351(0.96)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C351(0.98)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C351(1.28)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C351(1.14)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C351(1.00)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C351(2.25)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C351(1.53)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C351(1.06)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C351(1.01)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C351(1.22)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C351(1.40)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C351(0.89)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C351(1.05)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C351(1.44)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C351(1.04)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C351(0.87)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C351(1.05)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C351(1.64)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C351(1.46)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C351(0.95)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C351(1.16)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C351(1.31)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C351(1.26)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C351(1.18)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C351(1.21)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C351(1.96)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C351(1.52)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C351(0.98)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C351(1.41)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C351(0.88)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C351(1.00)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C351(1.22)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C351(0.88)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C351(1.29)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C351(1.26)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C351(1.03)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C351(0.89)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C351(0.69)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C351(0.81)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C351(1.08)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C351(0.79)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C351(0.87)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C351(0.85)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C351(1.22)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C351(1.03)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C351(1.76)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C351(0.85)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C351(1.31)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C351(1.20)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C351(1.71)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C351(1.56)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C351(2.04)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C351(1.11)  LDD1059  [1]
 LDCM0463  CL70 HEK-293T C351(2.11)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C351(1.70)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C351(1.72)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C351(2.29)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C351(2.02)  LDD1065  [1]
 LDCM0486  CL91 HCT 116 C351(0.86)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C351(0.96)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C351(1.72)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C351(1.79)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C351(0.81)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C351(1.49)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C351(1.01)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C351(1.08)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C351(1.60)  LDD0811  [1]
 LDCM0468  Fragment33 HEK-293T C351(2.85)  LDD1066  [1]
 LDCM0427  Fragment51 HCT 116 C351(1.54)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
RING-type E3 ubiquitin-protein ligase PPIL2 (PPIL2) Cyclophilin-type PPIase family Q13356
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
Caspase-6 (CASP6) Peptidase C14A family P55212
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Ubiquitin carboxyl-terminal hydrolase 20 (USP20) Peptidase C19 family Q9Y2K6
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Peptidase C64 family P21580
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
E3 SUMO-protein ligase PIAS2 (PIAS2) PIAS family O75928
Serine/threonine-protein kinase Nek6 (NEK6) NEK Ser/Thr protein kinase family Q9HC98
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
tRNA-splicing endonuclease subunit Sen54 (TSEN54) SEN54 family Q7Z6J9
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase HRas (HRAS) Ras family P01112
GTP-binding protein GEM (GEM) RGK family P55040
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Cell division cycle protein 20 homolog B (CDC20B) WD repeat CDC20/Fizzy family Q86Y33
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Germ cell-less protein-like 2 (GMCL2) . Q8NEA9
Josephin-1 (JOSD1) . Q15040
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Tripartite motif-containing protein 55 (TRIM55) . Q9BYV6
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
ADP/ATP translocase 3 (SLC25A6) Mitochondrial carrier (TC 2.A.29) family P12236
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
PHD finger protein 1 (PHF1) Polycomblike family O43189
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Zinc finger protein SNAI2 (SNAI2) Snail C2H2-type zinc-finger protein family O43623
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
Endothelial transcription factor GATA-2 (GATA2) . P23769
Zinc finger and BTB domain-containing protein 4 (ZBTB4) . Q9P1Z0
Zinc finger protein 408 (ZNF408) . Q9H9D4
Zinc finger protein 474 (ZNF474) . Q6S9Z5
Zinc finger protein 581 (ZNF581) . Q9P0T4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan and proteoglycan link protein 2 (HAPLN2) HAPLN family Q9GZV7
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 14 (CXCL14) Intercrine alpha (chemokine CxC) family O95715
Other
Click To Hide/Show 88 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-3 complex subunit mu-1 (AP3M1) Adaptor complexes medium subunit family Q9Y2T2
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Ataxin-1 (ATXN1) ATXN1 family P54253
Plakophilin-4 (PKP4) Beta-catenin family Q99569
Coiled-coil domain-containing protein 25 (CCDC25) CCDC25 family Q86WR0
Parafibromin (CDC73) CDC73 family Q6P1J9
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
EKC/KEOPS complex subunit LAGE3 (LAGE3) CTAG/PCC1 family Q14657
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Dedicator of cytokinesis protein 2 (DOCK2) DOCK family Q92608
ELL-associated factor 2 (EAF2) EAF family Q96CJ1
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM133A (FAM133A) FAM133 family Q8N9E0
Protein FAM83A (FAM83A) FAM83 family Q86UY5
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Large ribosomal subunit protein mL45 (MRPL45) Mitochondrion-specific ribosomal protein mL45 family Q9BRJ2
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Mitochondrial fission regulator 2 (MTFR2) MTFR1 family Q6P444
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) NifU family Q9UMS0
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) PPP1R15 family Q5SWA1
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
Calcipressin-3 (RCAN3) RCAN family Q9UKA8
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
U2 small nuclear ribonucleoprotein B'' (SNRPB2) RRM U1 A/B'' family P08579
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Translational activator of cytochrome c oxidase 1 (TACO1) TACO1 family Q9BSH4
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0
Large ribosomal subunit protein uL4m (MRPL4) Universal ribosomal protein uL4 family Q9BYD3
UPF0488 protein C8orf33 (C8orf33) UPF0488 family Q9H7E9
rRNA-processing protein UTP23 homolog (UTP23) UTP23/FCF1 family Q9BRU9
Transcription cofactor vestigial-like protein 1 (VGLL1) Vestigial family Q99990
Gelsolin (GSN) Villin/gelsolin family P06396
Zinc finger C2HC domain-containing protein 1C (ZC2HC1C) ZC2HC1 family Q53FD0
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) . Q8N6T3
AN1-type zinc finger protein 2A (ZFAND2A) . Q8N6M9
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
BAG family molecular chaperone regulator 1 (BAG1) . Q99933
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Cysteine and glycine-rich protein 2 (CSRP2) . Q16527
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Galectin-8 (LGALS8) . O00214
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Kelch-like protein 42 (KLHL42) . Q9P2K6
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
MORN repeat-containing protein 4 (MORN4) . Q8NDC4
Neuronal migration protein doublecortin (DCX) . O43602
NTF2-related export protein 2 (NXT2) . Q9NPJ8
Phostensin (PPP1R18) . Q6NYC8
Placental protein 13-like (LGALS14) . Q8TCE9
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) . Q9HB19
Putative ankyrin repeat domain-containing protein 26-like 1 (ANKRD36BP1) . Q96IX9
Putative uncharacterized protein encoded by LINC00526 (LINC00526) . Q96FQ7
Receptor-transporting protein 5 (RTP5) . Q14D33
Rho guanine nucleotide exchange factor 3 (ARHGEF3) . Q9NR81
Rhombotin-2 (LMO2) . P25791
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
TAR DNA-binding protein 43 (TARDBP) . Q13148
Tastin (TROAP) . Q12815
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquilin-1 (UBQLN1) . Q9UMX0
Uncharacterized protein EXOC3-AS1 (EXOC3-AS1) . Q8N2X6
Vinexin (SORBS3) . O60504
WD repeat-containing protein 25 (WDR25) . Q64LD2

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255